Androgen (dihydrotestosterone)-mediated regulation of food intake and obesity in female mice

Journal of Steroid Biochemistry and Molecular Biology

Volumn 138, Issue , 2013, Pages 100-106

  Kanaya, Noriko ^a   Vonderfecht, Steven ^a   Chen, Shiuan ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Androgen; Dihydrotestosterone; Females; Food intake; Obesity; Ovariectomized mice

Indexed keywords

ALANINE AMINOTRANSFERASE; ANDROGEN; ANDROSTANOLONE; GLUCOSE; LEPTIN; PLACEBO;

ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CELL VACUOLE; CONTROLLED STUDY; DIET RESTRICTION; FATTY ACID SYNTHESIS; FEEDING; FEMALE; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HORMONE ACTION; HORMONE RESISTANCE; HORMONE SENSITIVITY; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; LIVER FUNCTION; LIVER WEIGHT; MOUSE; NONHUMAN; OBESITY; OVARIECTOMY; PHENOTYPE; WEIGHT GAIN;

ANIMALIA; MUS;

EID: 84878403670     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2013.04.001     Document Type: Article

References (26)

1. S. Naessen, K. Carlstrom, L. Garoff, R. Glant, and A.L. Hirschberg Polycystic ovary syndrome in bulimic women - an evaluation based on the new diagnostic criteria Gynecological Endocrinology 22 2006 388 394 (Pubitemid 44180266)
2. T.M. Barber, M.I. McCarthy, J.A. Wass, and S. Franks Obesity and polycystic ovary syndrome Clinical Endocrinology 65 2006 137 145 (Pubitemid 44079674)
3. A.L. Hirschberg, S. Naessen, M. Stridsberg, B. Bystrom, and J. Holtet Impaired cholecystokinin secretion and disturbed appetite regulation in women with polycystic ovary syndrome Gynecological Endocrinology 19 2004 79 87 (Pubitemid 39331408)
4. S. Naessen, K. Carlstrom, B. Bystrom, Y. Pierre, and A.L. Hirschberg Effects of an antiandrogenic oral contraceptive on appetite and eating behavior in bulimic women Psychoneuroendocrinology 32 2007 548 554 (Pubitemid 46756011)
5. P. Cotrufo, P. Monteleone, M. d'Istria, A. Fuschino, I. Serino, and M. Maj Aggressive behavioral characteristics and endogenous hormones in women with Bulimia nervosa Neuropsychobiology 42 2000 58 61 (Pubitemid 30665976)
6. C. Sundblad, L. Bergman, and E. Eriksson High levels of free testosterone in women with bulimia nervosa Acta Psychiatrica Scandinavica 90 1994 397 398 (Pubitemid 24331615)
7. A. Dunaif, M. Graf, J. Mandeli, V. Laumas, and A. Dobrjansky Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia The Journal of Clinical Endocrinology and Metabolism 65 1987 499 507 (Pubitemid 17131438)
8. M.F. Sowers, J.L. Beebe, D. McConnell, J. Randolph, and M. Jannausch Testosterone concentrations in women aged 25-50 years: associations with lifestyle, body composition, and ovarian status American Journal of Epidemiology 153 2001 256 264 (Pubitemid 32958650)
9. A.L. Hirschberg Sex hormones, appetite and eating behaviour in women Maturitas 71 2012 248 256
10. J.W. Hill Gene expression and the control of food intake by hypothalamic POMC/CART neurons The Open Neuroendocrinology Journal 3 2010 21 27
11. A.P. Coll, I.S. Farooqi, and S. O'Rahilly The hormonal control of food intake Cell 129 2007 251 262 (Pubitemid 46574977)
12. Q. Mo, S. Lu, C. Garippa, M.J. Brownstein, and N.G. Simon Genome-wide analysis of DHEA- and DHT-induced gene expression in mouse hypothalamus and hippocampus Journal of Steroid Biochemistry and Molecular Biology 114 2009 135 143
13. L. Manneras, S. Cajander, A. Holmang, Z. Seleskovic, T. Lystig, M. Lonn, and E. Stener-Victorin A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome Endocrinology 148 2007 3781 3791 (Pubitemid 47105840)
14. M. Fraenkel, J. Caloyeras, S.G. Ren, and S. Melmed Sex-steroid milieu determines diabetes rescue in pttg-null mice Journal of Endocrinology 189 2006 519 528
15. L.M. Brown, and D.J. Clegg Central effects of estradiol in the regulation of food intake, body weight, and adiposity Journal of Steroid Biochemistry and Molecular Biology 122 2010 65 73
16. K.N. Hewitt, W.C. Boon, Y. Murata, M.E. Jones, and E.R. Simpson The aromatase knockout mouse presents with a sexually dimorphic disruption to cholesterol homeostasis Endocrinology 144 2003 3895 3903 (Pubitemid 37088744)
17. F. Saad, and L. Gooren The role of testosterone in the metabolic syndrome: a review Journal of Steroid Biochemistry and Molecular Biology 114 2009 40 43
18. L. Asarian, and N. Geary Modulation of appetite by gonadal steroid hormones Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences 361 2006 1251 1263
19. N.H. Rogers, J.W. Perfield 2nd, K.J. Strissel, M.S. Obin, and A.S. Greenberg Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity Endocrinology 150 2009 2161 2168
20. K.J. McInnes, A. Corbould, E.R. Simpson, and M.E. Jones Regulation of adenosine 5′-monophosphate-activated protein kinase and lipogenesis by androgens contributes to visceral obesity in an estrogen-deficient state Endocrinology 147 2006 5907 5913 (Pubitemid 44833508)
21. C.C. Douglas, L.E. Norris, R.A. Oster, B.E. Darnell, R. Azziz, and B.A. Gower Difference in dietary intake between women with polycystic ovary syndrome and healthy controls Fertility and Sterility 86 2006 411 417 (Pubitemid 44118944)
22. S.S. Lim, R.J. Norman, P.M. Clifton, and M. Noakes Hyperandrogenemia, psychological distress, and food cravings in young women Physiology and Behavior 98 2009 276 280
23. R. Matyskova, B. Zelezna, J. Maixnerova, D. Koutova, M. Haluzik, and L. Maletinska Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet Hormone and Metabolic Research 42 2010 182 186
24. M. Pusalkar, P. Meherji, J. Gokral, L. Savardekar, S. Chinnaraj, and A. Maitra Obesity and polycystic ovary syndrome: association with androgens, leptin and its genotypes Gynecological Endocrinology 26 2010 874 882
25. C.H. Jung, and M.S. Kim Molecular mechanisms of central leptin resistance in obesity Archives of Pharmacal Research 36 2013 201 207
26. J.A. Johnson, S. Calo, L. Nair, H.B. IglayReger, M. Greenwald-Yarnell, J. Skorupski, M.G. Myers, and P.F. Bodary Jr. Testosterone interacts with the feedback mechanisms engaged by Tyr985 of the leptin receptor and diet-induced obesity Journal of Steroid Biochemistry and Molecular Biology 132 2012 212 219