Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: Relationships with body mass index

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 307, Issue 10, 2014, Pages G958-G967

  Little, Tanya J ^a,b   Isaacs, Nicole J ^a   Young, Richard L ^a,b   Ott, Raffael ^a   Nguyen, Nam Q ^b,c   Rayner, Christopher K ^a,b,c   Horowitz, Michael ^a,b   Feinle Bisset, Christine ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

CD36; Free fatty acid; GPR119; GPR120; GPR40; Nutrient sensing; Receptor; Small intestine

Indexed keywords

CD36 ANTIGEN; CHOLECYSTOKININ; COMPLEMENTARY DNA; FATTY ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 119; G PROTEIN COUPLED RECEPTOR 120; G PROTEIN COUPLED RECEPTOR 40; GASTROINTESTINAL HORMONE; GLUCAGON LIKE PEPTIDE 1; MESSENGER RNA; RNA; UNCLASSIFIED DRUG; FFAR1 PROTEIN, HUMAN; GPR119 PROTEIN, HUMAN; O3FAR1 PROTEIN, HUMAN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; DUODENUM; DUODENUM BIOPSY; DUODENUM MUCOSA; ENTEROENDOCRINE CELL; FEMALE; GENE EXPRESSION; HORMONE RELEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NUTRIENT; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SMALL INTESTINE; BIOPSY; CALORIC INTAKE; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; FEEDING BEHAVIOR; GENETICS; HABIT; INTESTINE MUCOSA; METABOLISM; MIDDLE AGED; OVERWEIGHT;

ADULT; ANTIGENS, CD36; BIOPSY; BODY MASS INDEX; CASE-CONTROL STUDIES; DUODENUM; ENERGY INTAKE; ENTEROENDOCRINE CELLS; FATTY ACIDS; FEEDING BEHAVIOR; FEMALE; HABITS; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84922392813     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00134.2014     Document Type: Article

References (37)

1. Applied Biosystems. Creating Standard Curves with Genomic DNA Plasmid DNA Templates for Use in Quantitative PCR (Online). http:// www6.appliedbiosystems.com/support/tutorials/pdf/quant_pcr.pdf [2003].
2. Braam LA, Ocke MC, Bueno-de-Mesquita HB, Seidell JC. Determinants of obesity-related underreporting of energy intake. Am J Epidemiol 147: 1081-1086, 1998.
3. Chen M, Yang Y, Braunstein E, Georgeson KE, Harmon CM. Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes. Am J Physiol Endocrinol Metab 281: E916- E923, 2001.
4. Covasa M. Deficits in gastrointestinal responses controlling food intake and body weight. Am J Physiol Regul Integr Comp Physiol 299: R1423- R1439, 2010.
5. Duca FA, Swartz TD, Sakar Y, Covasa M. Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors. Int J Obes (Lond) 37: 375-381, 2013.
6. Edfalk S, Steneberg P, Edlund H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 57: 2280-2287, 2008.
7. Feinle C, O'Donovan DG, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans. Am J Physiol Gastrointest Liver Physiol 284: G798-G807, 2003.
8. Feltrin KL, Little TJ, Meyer JH, Horowitz M, Smout AJ, Wishart J, Pilichiewicz AN, Rades T, Chapman IM, Feinle-Bisset C. Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length. Am J Physiol Regul Integr Comp Physiol 287: R524-R533, 2004.
9. Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodriguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G, Piomelli D. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature 425: 90-93, 2003.
10. Giles GG, Ireland PD. Dietary Questionnaire for Epidemiological Studies (Version 2). Melbourne, Australia: Cancer Council Victoria, 1996.
11. Golay A, Bobbioni E. The role of dietary fat in obesity. Int J Obes Relat Metab Disord 21, Suppl 3: S2-11, 1997.
12. Goris AH, Westerterp-Plantenga MS, Westerterp KR. Undereating and underrecording of habitual food intake in obese men: selective underreporting of fat intake. Am J Clin Nutr 71: 130-134, 2000.
13. Habib AM, Richards P, Cairns LS, Rogers GJ, Bannon CA, Parker HE, Morley TC, Yeo GS, Reimann F, Gribble FM. Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry. Endocrinology 153: 3054-3065, 2012.
14. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med 11: 90-94, 2005.
15. Hodge A, Patterson AJ, Brown WJ, Ireland P, Giles G. The Anti Cancer Council of Victoria FFQ: relative validity of nutrient intakes compared with weighed food records in young to middle-aged women in a study of iron supplementation. Aust N Z J Public Health 24: 576-583, 2000.
16. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Korner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Levy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature 483: 350-354, 2012.
17. Lan H, Vassileva G, Corona A, Liu L, Baker H, Golovko A, Abbondanzo SJ, Hu W, Yang S, Ning Y, Del Vecchio RA, Poulet F, Laverty M, Gustafson EL, Hedrick JA, Kowalski TJ. GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis. J Endocrinol 201: 219-230, 2009.
18. Lauffer LM, Iakoubov R, Brubaker PL. GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell. Diabetes 58: 1058-1066, 2009.
19. le Roux CW, Batterham RL, Aylwin SJ, Patterson M, Borg CM, Wynne KJ, Kent A, Vincent RP, Gardiner J, Ghatei MA, Bloom SR. Attenuated peptide YY release in obese subjects is associated with reduced satiety. Endocrinology 147: 3-8, 2006.
20. Liou AP, Lu X, Sei Y, Zhao X, Pechhold S, Carrero RJ, Raybould HE, Wank S. The G-protein-coupled receptor GPR40 directly mediates longchain fatty acid-induced secretion of cholecystokinin. Gastroenterology 140: 903-912, 2011.
21. Lissner L, Heitmann BL. Dietary fat and obesity: evidence from epidemiology. Eur J Clin Nutr 49: 79-90, 1995.
22. Little TJ, Feinle-Bisset C. Effects of dietary fat on appetite and energy intake in health and obesity- oral and gastrointestinal sensory contributions. Physiol Behav 104: 613-620, 2011.
23. Little TJ, Feinle-Bisset C. Oral and gastrointestinal sensing of dietary fat and appetite regulation in humans: modification by diet and obesity. Front Neurosci 4: 178, 2010.
24. Lobo MV, Huerta L, Ruiz-Velasco N, Teixeiro E, de la Cueva P, Celdran A, Martin-Hidalgo A, Vega MA, Bragado R. Localization of the lipid receptors CD36 and CLA-1/SR-BI in the human gastrointestinal tract: towards the identification of receptors mediating the intestinal absorption of dietary lipids. J Histochem Cytochem 49: 1253-1260, 2001.
25. Mela DJ, Sacchetti DA. Sensory preferences for fats: relationships with diet and body composition. Am J Clin Nutr 53: 908-915, 1991.
26. Odori S, Hosoda K, Tomita T, Fujikura J, Kusakabe T, Kawaguchi Y, Doi R, Takaori K, Ebihara K, Sakai Y, Uemoto S, Nakao K. GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function. Metabolism 62: 70-78, 2013.
27. Poirier H, Degrace P, Niot I, Bernard A, Besnard P. Localization and regulation of the putative membrane fatty-acid transporter (FAT) in the small intestine. Comparison with fatty acid-binding proteins (FABP). Eur J Biochem 238: 368-373, 1996.
28. Ranganath LR, Beety JM, Morgan LM, Wright JW, Howland R, Marks V. Attenuated GLP-1 secretion in obesity: cause or consequence? Gut 38: 916-919, 1996.
29. Sagher FA, Dodge JA, Johnston CF, Shaw C, Buchanan KD, Carr KE. Rat small intestinal morphology and tissue regulatory peptides: effects of high dietary fat. Br J Nutr 65: 21-28, 1991.
30. Schwartz GJ, Fu J, Astarita G, Li X, Gaetani S, Campolongo P, Cuomo V, Piomelli D. The lipid messenger OEA links dietary fat intake to satiety. Cell Metab 8: 281-288, 2008.
31. Spannagel AW, Nakano I, Tawil T, Chey WY, Liddle RA, Green GM. Adaptation to fat markedly increases pancreatic secretory response to intraduodenal fat in rats. Am J Physiol Gastrointest Liver Physiol 270: G128-G135, 1996.
32. Steinert RE, Beglinger C. Nutrient sensing in the gut: interactions between chemosensory cells, visceral afferents and the secretion of satiation peptides. Physiol Behav 105: 62-70, 2011.
33. Stewart JE, Seimon RV, Otto B, Keast RS, Clifton PM, Feinle-Bisset C. Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese. Am J Clin Nutr 93: 703-711, 2011.
34. Sundaresan S, Shahid R, Riehl TE, Chandra R, Nassir F, Stenson WF, Liddle RA, Abumrad NA. CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J 27: 1191-1202, 2013.
35. Tanaka T, Katsuma S, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G. Free fatty acids induce cholecystokinin secretion through GPR120. Naunyn Schmiedebergs Arch Pharmacol 377: 523-527, 2008.
36. Theodorakis MJ, Carlson O, Michopoulos S, Doyle ME, Juhaszova M, Petraki K, Egan JM. Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab 290: E550-E559, 2006.
37. Wadden TA. Treatment of obesity by moderate and severe caloric restriction. Results of clinical research trials. Ann Intern Med 119: 688- 693, 1993.