Copper-obatoclax derivative complexes mediate DNA cleavage and exhibit anti-cancer effects in hepatocellular carcinoma

Chemico-Biological Interactions

Volumn 228, Issue , 2015, Pages 108-113

  Su, Jung Chen ^a   Chang, Jung Hua ^a   Huang, Jui Wen ^b   Chen, Peter P Y ^c   Chen, Kuen Feng ^d   Tseng, Ping Hui ^a   Shiau, Chung Wai ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Copper; DNA cleavage; Obatoclax

Indexed keywords

1,3 DITHIANE DERIVATIVE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC METAL COMPLEX; COPPER CHLORIDE; FREE RADICAL; INDOLE; NUCLEASE; OBATOCLAX; OBATOCLAX COBALT COMPLEX; OBATOCLAX COPPER COMPLEX; OBATOCLAX ZINC COMPLEX; PRODIGIOSIN; THIOPHENE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; COPPER; ORGANOMETALLIC COMPOUND; PYRROLE DERIVATIVE;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; DNA CLEAVAGE; DOSE RESPONSE; DRUG ABSORPTION; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; IN VITRO STUDY; LIVER CELL CARCINOMA; MTT ASSAY; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; GENETICS; HUMAN; LIVER NEOPLASMS; PATHOLOGY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COPPER; DNA CLEAVAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIVER NEOPLASMS; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84922387390     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.12.026     Document Type: Article

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