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Volumn 119, Issue 9, 2012, Pages 2171-2172

Experience with obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist in patients with relapsed or refractory classical Hodgkin lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; OBATOCLAX; PROTEIN BCL 2;

EID: 84857753714     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-11-391037     Document Type: Letter
Times cited : (62)

References (10)
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    • Expression of bcl-2 in classical Hodgkin's lymphoma: An independent predictor of poor outcome
    • Sup SJ, Alemany CA, Pohlman B, et al. Expression of bcl-2 in classical Hodgkin's lymphoma: an independent predictor of poor outcome. J Clin Oncol. 2005; 23(16):3773-3779.
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  • 5
    • 37649023004 scopus 로고    scopus 로고
    • Small molecule obatoclax (GX15- 070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
    • Nguyen M, Marcellus RC, Roulston A, et al. Small molecule obatoclax (GX15- 070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis. Proc Natl Acad Sci U S A. 2007;104(49):19512-19517.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.49 , pp. 19512-19517
    • Nguyen, M.1    Marcellus, R.C.2    Roulston, A.3
  • 6
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • DOI 10.1182/blood-2006-10-047951
    • Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood. 2007;109(12):5430-5438. (Pubitemid 46890566)
    • (2007) Blood , vol.109 , Issue.12 , pp. 5430-5438
    • Trudel, S.1    Zhi, H.L.2    Rauw, J.3    Tiedemann, R.E.4    Xiao, Y.W.5    Stewart, A.K.6
  • 7
    • 58849164097 scopus 로고    scopus 로고
    • Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia
    • O'Brien SM, Claxton DF, Crump M, et al. Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia. Blood. 2009;113(2):299-305.
    • (2009) Blood , vol.113 , Issue.2 , pp. 299-305
    • O'Brien, S.M.1    Claxton, D.F.2    Crump, M.3
  • 8
    • 58149340656 scopus 로고    scopus 로고
    • A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
    • Schimmer AD, O'Brien S, Kantarjian H, et al. A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies. Clin Cancer Res. 2008;14(24):8295-8301.
    • (2008) Clin Cancer Res , vol.14 , Issue.24 , pp. 8295-8301
    • Schimmer, A.D.1    O'Brien, S.2    Kantarjian, H.3
  • 9
    • 0042449063 scopus 로고    scopus 로고
    • Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas
    • NCI Sponsored International Working Group
    • Cheson BD, Horning SJ, Coiffier B, et al. Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas. NCI Sponsored International Working Group. J Clin Oncol. 1999;17(4):1244.
    • (1999) J Clin Oncol , vol.17 , Issue.4 , pp. 1244
    • Cheson, B.D.1    Horning, S.J.2    Coiffier, B.3
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    • Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis
    • Parikh SA, Kantarjian H, Schimmer A, et al. Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010;10(4):285-289.
    • (2010) Clin Lymphoma Myeloma Leuk , vol.10 , Issue.4 , pp. 285-289
    • Parikh, S.A.1    Kantarjian, H.2    Schimmer, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.