Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: A pilot study

Bone

Volumn 74, Issue , 2015, Pages 140-145

  Schafer, A L ^a,b   Li, X ^a   Schwartz, A V ^a   Tufts, L S ^a   Wheeler, A L ^a,b   Grunfeld, C ^a,b   Stewart, L ^a,b   Rogers, S J ^a   Carter, J T ^a   Posselt, A M ^a   Black, D M ^a   Shoback, D M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bariatric surgery; Bone marrow fat; Diabetes; Gastric bypass surgery

Indexed keywords

CITRATE CALCIUM; ESTRADIOL; VITAMIN D; GLYCOSYLATED HEMOGLOBIN;

ADULT; ARTICLE; BODY FAT; BONE DENSITY; BONE MARROW; BONE MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC OBESITY; DIABETIC PATIENT; FAT MASS; FEMALE; FEMUR NECK; HIP; HUMAN; LIPID STORAGE; MORBID OBESITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PILOT STUDY; ROUX EN Y GASTRIC BYPASS SURGERY; SPINE; STOMACH BYPASS; VERTEBRA; VERTEBRAL BONE MARROW FAT; VOLUMETRY; CLINICAL TRIAL; DIABETES MELLITUS; METABOLISM; MIDDLE AGED; OBESITY; PATHOLOGY;

ADIPOSITY; ADULT; BONE DENSITY; BONE MARROW; DIABETES MELLITUS; FEMALE; GASTRIC BYPASS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; MIDDLE AGED; PILOT PROJECTS; SPINE;

EID: 84922385447     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.01.010     Document Type: Article

References (38)

1. Rosen C.J., Bouxsein M.L. Mechanisms of disease: is osteoporosis the obesity of bone?. Nat Clin Pract Rheumatol 2006, 2:35-43.
2. Fazeli P.K., Horowitz M.C., MacDougald O.A., Scheller E.L., Rodeheffer M.S., Rosen C.J., et al. Marrow fat and bone-new perspectives. J Clin Endocrinol Metab 2013, 98:935-945.
3. Sheu Y., Cauley J.A. The role of bone marrow and visceral fat on bone metabolism. Curr Osteoporos Rep 2011, 9:67-75.
4. Cohen A., Dempster D.W., Stein E.M., Nickolas T.L., Zhou H., McMahon D.J., et al. Increased marrow adiposity in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab 2012, 97:2782-2791.
5. Meunier P., Aaron J., Edouard C., Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 1971, 80:147-154.
6. Schellinger D., Lin C.S., Hatipoglu H.G., Fertikh D. Potential value of vertebral proton MR spectroscopy in determining bone weakness. AJNR Am J Neuroradiol 2001, 22:1620-1627.
7. Shen W., Chen J., Punyanitya M., Shapses S., Heshka S., Heymsfield S.B. MRI-measured bone marrow adipose tissue is inversely related to DXA-measured bone mineral in Caucasian women. Osteoporos Int 2007, 18:641-647.
8. Griffith J.F., Yeung D.K., Leung J.C., Kwok T.C., Leung P.C. Prediction of bone loss in elderly female subjects by MR perfusion imaging and spectroscopy. Eur Radiol 2011, 21:1160-1169.
9. Schwartz A.V., Sigurdsson S., Hue T.F., Lang T.F., Harris T.B., Rosen C.J., et al. Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults. J Clin Endocrinol Metab 2013, 98:2294-2300.
10. Cawthorn W.P., Scheller E.L., Learman B.S., Parlee S.D., Simon B.R., Mori H., et al. Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction. Cell Metab 2014, 20:368-375.
11. Devlin M.J., Cloutier A.M., Thomas N.A., Panus D.A., Lotinun S., Pinz I., et al. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res 2010, 25:2078-2088.
12. Bredella M.A., Fazeli P.K., Miller K.K., Misra M., Torriani M., Thomas B.J., et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 2009, 94:2129-2136.
13. Devlin M.J. Why does starvation make bones fat?. Am J Hum Biol 2011, 23:577-585.
14. Scheller E.L., Rosen C.J. What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health. Ann N Y Acad Sci 2014, 1311:14-30.
15. Chao D., Espeland M.A., Farmer D., Register T.C., Lenchik L., Applegate W.B., et al. Effect of voluntary weight loss on bone mineral density in older overweight women. J Am Geriatr Soc 2000, 48:753-759.
16. Ensrud K.E., Ewing S.K., Stone K.L., Cauley J.A., Bowman P.J., Cummings S.R. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc 2003, 51:1740-1747.
17. Villareal D.T., Shah K., Banks M.R., Sinacore D.R., Klein S. Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab 2008, 93:2181-2187.
18. Ensrud K.E., Fullman R.L., Barrett-Connor E., Cauley J.A., Stefanick M.L., Fink H.A., et al. Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fractures in men study. J Clin Endocrinol Metab 2005, 90:1998-2004.
19. Botolin S., McCabe L.R. Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endocrinology 2007, 148:198-205.
20. Devlin M., Vliet M.V., Motyl K., Karim L., Brooks D., Louis L., et al. Early onset type 2 diabetes impairs skeletal acquisition in the male TALLYHO/JngJ mouse. Endocrinology 2014, 155:3806-3816.
21. Baum T., Yap S.P., Karampinos D.C., Nardo L., Kuo D., Burghardt A.J., et al. Does vertebral bone marrow fat content correlate with abdominal adipose tissue, lumbar spine bone mineral density, and blood biomarkers in women with type 2 diabetes mellitus?. J Magn Reson Imaging 2012, 35:117-124.
22. Sjostrom L., Narbro K., Sjostrom C.D., Karason K., Larsson B., Wedel H., et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007, 357:741-752.
23. Buchwald H., Avidor Y., Braunwald E., Jensen M.D., Pories W., Fahrbach K., et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004, 292:1724-1737.
24. A.L. Schafer, C.M. Weaver, D.M. Black, A.L. Wheeler, H. Chang, G.V. Szefc, et al., Intestinal calcium absorption decreases dramatically after gastric bypass surgery despite optimization of vitamin D status, J Bone Miner Res, in press.
25. Naressi A., Couturier C., Castang I., de Beer R., Graveron-Demilly D. Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med 2001, 31:269-286.
26. Li X., Kuo D., Schafer A.L., Porzig A., Link T.M., Black D., et al. Quantification of vertebral bone marrow fat content using 3Tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis. J Magn Reson Imaging 2011, 33:974-979.
27. Tataranni P.A., Ravussin E. Use of dual-energy X-ray absorptiometry in obese individuals. Am J Clin Nutr 1995, 62:730-734.
28. Lang T.F., Li J., Harris S.T., Genant H.K. Assessment of vertebral bone mineral density using volumetric quantitative CT. J Comput Assist Tomogr 1999, 23:130-137.
29. Khoo B.C., Brown K., Cann C., Zhu K., Henzell S., Low V., et al. Comparison of QCT-derived and DXA-derived areal bone mineral density and T scores. Osteoporos Int 2009, 20:1539-1545.
30. Harris T.B., Launer L.J., Eiriksdottir G., Kjartansson O., Jonsson P.V., Sigurdsson G., et al. Age, Gene/environment susceptibility-Reykjavik study: multidisciplinary applied phenomics. Am J Epidemiol 2007, 165:1076-1087.
31. Craig C.L., Marshall A.L., Sjostrom M., Bauman A.E., Booth M.L., Ainsworth B.E., et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003, 35:1381-1395.
32. Fazeli P.K., Bredella M.A., Freedman L., Thomas B.J., Breggia A., Meenaghan E., et al. Marrow fat and preadipocyte factor-1 levels decrease with recovery in women with anorexia nervosa. J Bone Miner Res 2012, 27:1864-1871.
33. Thaler J.P., Cummings D.E. Minireview: hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology 2009, 150:2518-2525.
34. Sheu Y., Schwartz A.V., Armati F., Goodpaster B., Li X., Bauer D., et al. Bone marrow adiposity is elevated in older men with type 2 diabetes. Program of the 72nd Scientific Sessions of the American Diabetes Association, Philadelphia, PA, 2012 (Abstract 1412-P) 2012.
35. Yu E.W. Bone metabolism after bariatric surgery. J Bone Miner Res 2014, 29:1507-1518.
36. Stein E.M., Silverberg S.J. Bone loss after bariatric surgery: causes, consequences, and management. Lancet Diab Endocrinol 2014, 2:165-174.
37. Bolotin H.H. DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling. Bone 2007, 41:138-154.
38. Blake G.M., Griffith J.F., Yeung D.K., Leung P.C., Fogelman I. Effect of increasing vertebral marrow fat content on BMD measurement, T-score status and fracture risk prediction by DXA. Bone 2009, 44:495-501.