메뉴 건너뛰기




Volumn 112, Issue 5, 2015, Pages 1422-1427

Kinetics of sickle cell biorheology and implications for painful vasoocclusive crisis

Author keywords

Aes 103; Capillary obstruction ratio; Cell deformability; Sickle cell anemia; Vasoocclusion

Indexed keywords

HEMOGLOBIN S; HYDROXYUREA;

EID: 84922370758     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1424111112     Document Type: Article
Times cited : (92)

References (64)
  • 1
    • 84868582399 scopus 로고    scopus 로고
    • Sickle cell pain: A critical reappraisal
    • Ballas SK, Gupta K, Adams-Graves P (2012) Sickle cell pain: A critical reappraisal. Blood 120(18):3647-3656.
    • (2012) Blood , vol.120 , Issue.18 , pp. 3647-3656
    • Ballas, S.K.1    Gupta, K.2    Adams-Graves, P.3
  • 2
    • 0028234283 scopus 로고
    • The acute chest syndrome in sickle cell disease: Incidence and risk factors
    • Castro O, et al.; The Cooperative Study of Sickle Cell Disease (1994) The acute chest syndrome in sickle cell disease: Incidence and risk factors. Blood 84(2):643-649.
    • (1994) Blood , vol.84 , Issue.2 , pp. 643-649
    • The Cooperative Study of Sickle Cell Disease1    Castro, O.2
  • 3
    • 84922362377 scopus 로고    scopus 로고
    • Systematic evaluation of sickle cell-related organ damage and complications: Implications for sickle cell disease management
    • van Beers EJ, van der Giessen A, van Tuijn CFJ, Schnog JJ, Biemond BJ (2006) Systematic evaluation of sickle cell-related organ damage and complications: Implications for sickle cell disease management. Blood 108(11):25b.
    • (2006) Blood , vol.108 , Issue.11 , pp. 25b
    • Van Beers, E.J.1    Van Der Giessen, A.2    Van Tuijn, C.F.J.3    Schnog, J.J.4    Biemond, B.J.5
  • 4
    • 0031001007 scopus 로고    scopus 로고
    • Natural history of blood pressure in sickle cell disease: Risks for stroke and death associated with relative hypertension in sickle cell anemia
    • Pegelow CH, et al. (1997) Natural history of blood pressure in sickle cell disease: Risks for stroke and death associated with relative hypertension in sickle cell anemia. Am J Med 102(2):171-177.
    • (1997) Am J Med , vol.102 , Issue.2 , pp. 171-177
    • Pegelow, C.H.1
  • 5
    • 79960845387 scopus 로고    scopus 로고
    • NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease
    • Machado RF, et al. (2011) NT-pro brain natriuretic peptide levels and the risk of death in the cooperative study of sickle cell disease. Br J Haematol 154(4):512-520.
    • (2011) Br J Haematol , vol.154 , Issue.4 , pp. 512-520
    • Machado, R.F.1
  • 6
    • 8644241558 scopus 로고    scopus 로고
    • The not-so-simple process of sickle cell vasoocclusion
    • Embury SH (2004) The not-so-simple process of sickle cell vasoocclusion. Microcirculation 11(2):101-113.
    • (2004) Microcirculation , vol.11 , Issue.2 , pp. 101-113
    • Embury, S.H.1
  • 7
    • 0036177721 scopus 로고    scopus 로고
    • Sickle cell vaso-occlusion: Multistep and multicellular paradigm
    • Frenette PS (2002) Sickle cell vaso-occlusion: Multistep and multicellular paradigm. Curr Opin Hematol 9(2):101-106.
    • (2002) Curr Opin Hematol , vol.9 , Issue.2 , pp. 101-106
    • Frenette, P.S.1
  • 9
    • 0023572225 scopus 로고
    • Hemoglobin S gelation and sickle cell disease
    • Eaton WA, Hofrichter J (1987) Hemoglobin S gelation and sickle cell disease. Blood 70(5):1245-1266.
    • (1987) Blood , vol.70 , Issue.5 , pp. 1245-1266
    • Eaton, W.A.1    Hofrichter, J.2
  • 10
    • 0023195612 scopus 로고
    • Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo
    • Mozzarelli A, Hofrichter J, Eaton WA (1987) Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo. Science 237(4814):500-506.
    • (1987) Science , vol.237 , Issue.4814 , pp. 500-506
    • Mozzarelli, A.1    Hofrichter, J.2    Eaton, W.A.3
  • 11
    • 0016942493 scopus 로고
    • Editorial: Delay time of gelation: A possible determinant of clinical severity in sickle cell disease
    • Eaton WA, Hofrichter J, Ross PD (1976) Editorial: Delay time of gelation: A possible determinant of clinical severity in sickle cell disease. Blood 47(4):621-627.
    • (1976) Blood , vol.47 , Issue.4 , pp. 621-627
    • Eaton, W.A.1    Hofrichter, J.2    Ross, P.D.3
  • 13
    • 0020550534 scopus 로고
    • Pressure effects on the flow behavior of sickle (HbSS) red cells in isolated (ex-vivo) microvascular system
    • Kaul DK, Nagel RL, Baez S (1983) Pressure effects on the flow behavior of sickle (HbSS) red cells in isolated (ex-vivo) microvascular system. Microvasc Res 26(2):170-181.
    • (1983) Microvasc Res , vol.26 , Issue.2 , pp. 170-181
    • Kaul, D.K.1    Nagel, R.L.2    Baez, S.3
  • 14
    • 0025770390 scopus 로고
    • Pain in sickle cell disease. Rates and risk factors
    • Platt OS, et al. (1991) Pain in sickle cell disease. Rates and risk factors. N Engl J Med 325(1):11-16.
    • (1991) N Engl J Med , vol.325 , Issue.1 , pp. 11-16
    • Platt, O.S.1
  • 15
    • 0028291736 scopus 로고
    • Mortality in sickle cell disease. Life expectancy and risk factors for early death
    • Platt OS, et al. (1994) Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 330(23):1639-1644.
    • (1994) N Engl J Med , vol.330 , Issue.23 , pp. 1639-1644
    • Platt, O.S.1
  • 16
    • 0018843538 scopus 로고
    • Lack of influence of fetal hemoglobin levels or erythrocyte indices on the severity of sickle cell anemia
    • Powars DR, Schroeder WA, Weiss JN, Chan LS, Azen SP (1980) Lack of influence of fetal hemoglobin levels or erythrocyte indices on the severity of sickle cell anemia. J Clin Invest 65(3):732-740.
    • (1980) J Clin Invest , vol.65 , Issue.3 , pp. 732-740
    • Powars, D.R.1    Schroeder, W.A.2    Weiss, J.N.3    Chan, L.S.4    Azen, S.P.5
  • 17
    • 0032030655 scopus 로고    scopus 로고
    • Intracellular hemoglobin S polymerization and the clinical severity of sickle cell anemia
    • Poillon WN, Kim BC, Castro O (1998) Intracellular hemoglobin S polymerization and the clinical severity of sickle cell anemia. Blood 91(5):1777-1783.
    • (1998) Blood , vol.91 , Issue.5 , pp. 1777-1783
    • Poillon, W.N.1    Kim, B.C.2    Castro, O.3
  • 18
    • 0022454177 scopus 로고
    • The percentage of dense red cells does not predict incidence of sickle cell painful crisis
    • Billett HH, Kim K, Fabry ME, Nagel RL (1986) The percentage of dense red cells does not predict incidence of sickle cell painful crisis. Blood 68(1):301-303.
    • (1986) Blood , vol.68 , Issue.1 , pp. 301-303
    • Billett, H.H.1    Kim, K.2    Fabry, M.E.3    Nagel, R.L.4
  • 19
    • 0023223346 scopus 로고
    • The relationship between fetal hemoglobin and disease severity in children with sickle cell anemia
    • Odenheimer DJ, Sarnaik SA, Whitten CF, Rucknagel DL, Sing CF (1987) The relationship between fetal hemoglobin and disease severity in children with sickle cell anemia. Am J Med Genet 27(3):525-535.
    • (1987) Am J Med Genet , vol.27 , Issue.3 , pp. 525-535
    • Odenheimer, D.J.1    Sarnaik, S.A.2    Whitten, C.F.3    Rucknagel, D.L.4    Sing, C.F.5
  • 20
    • 79960147525 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia
    • Akinsheye I, et al. (2011) Fetal hemoglobin in sickle cell anemia. Blood 118(1):19-27.
    • (2011) Blood , vol.118 , Issue.1 , pp. 19-27
    • Akinsheye, I.1
  • 21
    • 0024209929 scopus 로고
    • The incidence of painful crisis in homozygous sickle cell disease: Correlation with red cell deformability
    • Lande WM, et al. (1988) The incidence of painful crisis in homozygous sickle cell disease: Correlation with red cell deformability. Blood 72(6):2056-2059.
    • (1988) Blood , vol.72 , Issue.6 , pp. 2056-2059
    • Lande, W.M.1
  • 22
    • 0023771546 scopus 로고
    • Rheologic predictors of the severity of the painful sickle cell crisis
    • Ballas SK, et al. (1988) Rheologic predictors of the severity of the painful sickle cell crisis. Blood 72(4):1216-1223.
    • (1988) Blood , vol.72 , Issue.4 , pp. 1216-1223
    • Ballas, S.K.1
  • 23
    • 0026774086 scopus 로고
    • Red blood cell changes during the evolution of the sickle cell painful crisis
    • Ballas SK, Smith ED (1992) Red blood cell changes during the evolution of the sickle cell painful crisis. Blood 79(8):2154-2163.
    • (1992) Blood , vol.79 , Issue.8 , pp. 2154-2163
    • Ballas, S.K.1    Smith, E.D.2
  • 24
  • 25
    • 77956304432 scopus 로고    scopus 로고
    • Sickling of red blood cells through rapid oxygen exchange in microfluidic drops
    • Abbyad P, Tharaux PL, Martin JL, Baroud CN, Alexandrou A (2010) Sickling of red blood cells through rapid oxygen exchange in microfluidic drops. Lab Chip 10(19):2505-2512.
    • (2010) Lab Chip , vol.10 , Issue.19 , pp. 2505-2512
    • Abbyad, P.1    Tharaux, P.L.2    Martin, J.L.3    Baroud, C.N.4    Alexandrou, A.5
  • 26
    • 84855468373 scopus 로고    scopus 로고
    • In vitromodeling of the microvascular occlusion and thrombosis that occur in hematologic diseases usingmicrofluidic technology
    • TsaiM, et al. (2012) In vitromodeling of the microvascular occlusion and thrombosis that occur in hematologic diseases usingmicrofluidic technology. J Clin Invest 122(1):408-418.
    • (2012) J Clin Invest , vol.122 , Issue.1 , pp. 408-418
    • Tsai, M.1
  • 27
    • 0028606494 scopus 로고
    • Partially oxygenated sickled cells: Sickle-shaped red cells found in circulating blood of patients with sickle cell disease
    • Asakura T, et al. (1994) Partially oxygenated sickled cells: Sickle-shaped red cells found in circulating blood of patients with sickle cell disease. Proc Natl Acad Sci USA 91(26):12589-12593.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.26 , pp. 12589-12593
    • Asakura, T.1
  • 28
    • 0026668481 scopus 로고
    • 2 and temperature control
    • 2 and temperature control. Blood 79(8):2141-2147.
    • (1992) Blood , vol.79 , Issue.8 , pp. 2141-2147
    • Itoh, T.1    Chien, S.2    Usami, S.3
  • 29
    • 0040255633 scopus 로고
    • Shape change of sickled erythrocytes induced by pulsed rf electrical fields
    • Takashima S, Chang S, Asakura T (1985) Shape change of sickled erythrocytes induced by pulsed rf electrical fields. Proc Natl Acad Sci USA 82(20):6860-6864.
    • (1985) Proc Natl Acad Sci USA , vol.82 , Issue.20 , pp. 6860-6864
    • Takashima, S.1    Chang, S.2    Asakura, T.3
  • 31
    • 21244477456 scopus 로고    scopus 로고
    • Understanding the shape of sickled red cells
    • Christoph GW, Hofrichter J, Eaton WA (2005) Understanding the shape of sickled red cells. Biophys J 88(2):1371-1376.
    • (2005) Biophys J , vol.88 , Issue.2 , pp. 1371-1376
    • Christoph, G.W.1    Hofrichter, J.2    Eaton, W.A.3
  • 32
    • 0019987431 scopus 로고
    • Kinetics of sickle haemoglobin polymerization in single red cells
    • Coletta M, Hofrichter J, Ferrone FA, Eaton WA (1982) Kinetics of sickle haemoglobin polymerization in single red cells. Nature 300(5888):194-197.
    • (1982) Nature , vol.300 , Issue.5888 , pp. 194-197
    • Coletta, M.1    Hofrichter, J.2    Ferrone, F.A.3    Eaton, W.A.4
  • 33
    • 79958170979 scopus 로고    scopus 로고
    • A microfluidic respiratory assist device with high gas permeance for artificial lung applications
    • Kniazeva T, Hsiao JC, Charest JL, Borenstein JT (2011) A microfluidic respiratory assist device with high gas permeance for artificial lung applications. Biomed Microdevices 13(2):315-323.
    • (2011) Biomed Microdevices , vol.13 , Issue.2 , pp. 315-323
    • Kniazeva, T.1    Hsiao, J.C.2    Charest, J.L.3    Borenstein, J.T.4
  • 34
    • 0025865231 scopus 로고
    • Rate of deoxygenation and rheologic behavior of blood in sickle cell anemia
    • Kaul DK, Xue H (1991) Rate of deoxygenation and rheologic behavior of blood in sickle cell anemia. Blood 77(6):1353-1361.
    • (1991) Blood , vol.77 , Issue.6 , pp. 1353-1361
    • Kaul, D.K.1    Xue, H.2
  • 36
    • 14144255089 scopus 로고    scopus 로고
    • 5-Hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells
    • Abdulmalik O, et al. (2005) 5-Hydroxymethyl-2-furfural modifies intracellular sickle haemoglobin and inhibits sickling of red blood cells. Br J Haematol 128(4):552-561.
    • (2005) Br J Haematol , vol.128 , Issue.4 , pp. 552-561
    • Abdulmalik, O.1
  • 37
    • 84900864121 scopus 로고    scopus 로고
    • Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease
    • van Beers EJ, et al. (2014) Imaging flow cytometry for automated detection of hypoxia-induced erythrocyte shape change in sickle cell disease. Am J Hematol 89(6):598-603.
    • (2014) Am J Hematol , vol.89 , Issue.6 , pp. 598-603
    • Van Beers, E.J.1
  • 38
    • 0028959353 scopus 로고
    • Effects of hemoglobin concentration on deformability of individual sickle cells after deoxygenation
    • Itoh T, Chien S, Usami S (1995) Effects of hemoglobin concentration on deformability of individual sickle cells after deoxygenation. Blood 85(8):2245-2253.
    • (1995) Blood , vol.85 , Issue.8 , pp. 2245-2253
    • Itoh, T.1    Chien, S.2    Usami, S.3
  • 39
    • 0032705873 scopus 로고    scopus 로고
    • Rate of deoxygenation modulates rheologic behavior of sickle red blood cells at a given mean corpuscular hemoglobin concentration
    • Kaul DK, Liu XD (1999) Rate of deoxygenation modulates rheologic behavior of sickle red blood cells at a given mean corpuscular hemoglobin concentration. Clin Hemorheol Microcirc 21(2):125-135.
    • (1999) Clin Hemorheol Microcirc , vol.21 , Issue.2 , pp. 125-135
    • Kaul, D.K.1    Liu, X.D.2
  • 40
    • 0028831256 scopus 로고
    • Effect of hemoglobin concentration on nucleation and polymer formation in sickle red blood cells
    • Corbett JD, Mickols WE, Maestre MF (1995) Effect of hemoglobin concentration on nucleation and polymer formation in sickle red blood cells. J Biol Chem 270(6):2708-2715.
    • (1995) J Biol Chem , vol.270 , Issue.6 , pp. 2708-2715
    • Corbett, J.D.1    Mickols, W.E.2    Maestre, M.F.3
  • 41
    • 0032535259 scopus 로고    scopus 로고
    • Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells
    • Schwartz RS, Musto S, Fabry ME, Nagel RL (1998) Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells. Blood 92(12):4844-4855.
    • (1998) Blood , vol.92 , Issue.12 , pp. 4844-4855
    • Schwartz, R.S.1    Musto, S.2    Fabry, M.E.3    Nagel, R.L.4
  • 42
    • 0029257716 scopus 로고
    • Erythrocyte dehydration in pathophysiology and treatment of sickle cell disease
    • Brugnara C (1995) Erythrocyte dehydration in pathophysiology and treatment of sickle cell disease. Curr Opin Hematol 2(2):132-138.
    • (1995) Curr Opin Hematol , vol.2 , Issue.2 , pp. 132-138
    • Brugnara, C.1
  • 43
    • 0028108649 scopus 로고
    • In vivo polymerization of sickle-cell hemoglobin: A theoretical study
    • discussion 184-190
    • Makhijani VB, Cokelet GR (1994) In vivo polymerization of sickle-cell hemoglobin: A theoretical study. Blood Cells 20(1):169-183, discussion 184-190.
    • (1994) Blood Cells , vol.20 , Issue.1 , pp. 169-183
    • Makhijani, V.B.1    Cokelet, G.R.2
  • 44
    • 34848813177 scopus 로고    scopus 로고
    • Sickle-cell haemoglobin polymerization: Is it the primary pathogenic event of sickle-cell anaemia?
    • Vekilov PG (2007) Sickle-cell haemoglobin polymerization: Is it the primary pathogenic event of sickle-cell anaemia? Br J Haematol 139(2):173-184.
    • (2007) Br J Haematol , vol.139 , Issue.2 , pp. 173-184
    • Vekilov, P.G.1
  • 45
    • 79960836434 scopus 로고    scopus 로고
    • F-cell levels are altered with erythrocyte density in sickle cell disease
    • Basu S, et al. (2011) F-cell levels are altered with erythrocyte density in sickle cell disease. Blood Cells Mol Dis 47(2):117-119.
    • (2011) Blood Cells Mol Dis , vol.47 , Issue.2 , pp. 117-119
    • Basu, S.1
  • 46
    • 0037902091 scopus 로고    scopus 로고
    • Phosphatidylserine externalization in sickle red blood cells: Associations with cell age, density, and hemoglobin F
    • Yasin Z, et al. (2003) Phosphatidylserine externalization in sickle red blood cells: Associations with cell age, density, and hemoglobin F. Blood 102(1):365-370.
    • (2003) Blood , vol.102 , Issue.1 , pp. 365-370
    • Yasin, Z.1
  • 47
    • 0028896264 scopus 로고
    • Sickle cell rheology is determined by polymer fraction-not cell morphology
    • Hiruma H, et al. (1995) Sickle cell rheology is determined by polymer fraction-not cell morphology. Am J Hematol 48(1):19-28.
    • (1995) Am J Hematol , vol.48 , Issue.1 , pp. 19-28
    • Hiruma, H.1
  • 48
    • 0029025475 scopus 로고
    • Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia
    • Charache S, et al.; Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia (1995) Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. N Engl J Med 332(20):1317-1322.
    • (1995) N Engl J Med , vol.332 , Issue.20 , pp. 1317-1322
    • Charache, S.1
  • 49
    • 0037409211 scopus 로고    scopus 로고
    • The role of hydroxyurea in the management of sickle cell disease
    • Davies SC, Gilmore A (2003) The role of hydroxyurea in the management of sickle cell disease. Blood Rev 17(2):99-109.
    • (2003) Blood Rev , vol.17 , Issue.2 , pp. 99-109
    • Davies, S.C.1    Gilmore, A.2
  • 50
    • 0025217816 scopus 로고
    • Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea
    • Rodgers GP, Dover GJ, Noguchi CT, Schechter AN, Nienhuis AW (1990) Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. N Engl J Med 322(15):1037-1045.
    • (1990) N Engl J Med , vol.322 , Issue.15 , pp. 1037-1045
    • Rodgers, G.P.1    Dover, G.J.2    Noguchi, C.T.3    Schechter, A.N.4    Nienhuis, A.W.5
  • 51
    • 0026631318 scopus 로고
    • Hydroxyurea: Effects on hemoglobin F production in patients with sickle cell anemia
    • Charache S, et al. (1992) Hydroxyurea: Effects on hemoglobin F production in patients with sickle cell anemia. Blood 79(10):2555-2565.
    • (1992) Blood , vol.79 , Issue.10 , pp. 2555-2565
    • Charache, S.1
  • 54
    • 79955711089 scopus 로고    scopus 로고
    • Should we still be focused on red cell hemoglobin F as the principal explanation for the salutary effect of hydroxyurea in sickle cell disease?
    • Segel GB, Simon W, Lichtman MA (2011) Should we still be focused on red cell hemoglobin F as the principal explanation for the salutary effect of hydroxyurea in sickle cell disease? Pediatr Blood Cancer 57(1):8-9.
    • (2011) Pediatr Blood Cancer , vol.57 , Issue.1 , pp. 8-9
    • Segel, G.B.1    Simon, W.2    Lichtman, M.A.3
  • 55
    • 0030893396 scopus 로고    scopus 로고
    • Fetal hemoglobin in sickle cell anemia: Determinants of response to hydroxyurea
    • Steinberg MH, et al.; Multicenter Study of Hydroxyurea (1997) Fetal hemoglobin in sickle cell anemia: Determinants of response to hydroxyurea. Blood 89(3):1078-1088.
    • (1997) Blood , vol.89 , Issue.3 , pp. 1078-1088
    • Multicenter Study of Hydroxyurea1    Steinberg, M.H.2
  • 56
    • 84904861589 scopus 로고    scopus 로고
    • Imaging flow cytometry documents incomplete resistance of human sickle F-cells to ex vivo hypoxia-induced sickling
    • Fertrin KY, et al. (2014) Imaging flow cytometry documents incomplete resistance of human sickle F-cells to ex vivo hypoxia-induced sickling. Blood 124(4):658-660.
    • (2014) Blood , vol.124 , Issue.4 , pp. 658-660
    • Fertrin, K.Y.1
  • 57
    • 0025821277 scopus 로고
    • Effects of hydroxyurea on hemoglobin F and water content in the red blood cells of dogs and of patients with sickle cell anemia
    • Orringer EP, et al. (1991) Effects of hydroxyurea on hemoglobin F and water content in the red blood cells of dogs and of patients with sickle cell anemia. Blood 78(1):212-216.
    • (1991) Blood , vol.78 , Issue.1 , pp. 212-216
    • Orringer, E.P.1
  • 58
    • 0024469605 scopus 로고
    • Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo
    • Ballas SK, Dover GJ, Charache S (1989) Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo. Am J Hematol 32(2):104-111.
    • (1989) Am J Hematol , vol.32 , Issue.2 , pp. 104-111
    • Ballas, S.K.1    Dover, G.J.2    Charache, S.3
  • 59
    • 67649406572 scopus 로고    scopus 로고
    • Effect of hemoglobin oxygenation level on red blood cell deformability and aggregation parameters
    • Uyuklu M, Meiselman HJ, Baskurt OK (2009) Effect of hemoglobin oxygenation level on red blood cell deformability and aggregation parameters. Clin Hemorheol Microcirc 41(3):179-188.
    • (2009) Clin Hemorheol Microcirc , vol.41 , Issue.3 , pp. 179-188
    • Uyuklu, M.1    Meiselman, H.J.2    Baskurt, O.K.3
  • 61
    • 0023186247 scopus 로고
    • Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow
    • Barabino GA, McIntire LV, Eskin SG, Sears DA, Udden M (1987) Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow. Blood 70(1):152-157.
    • (1987) Blood , vol.70 , Issue.1 , pp. 152-157
    • Barabino, G.A.1    McIntire, L.V.2    Eskin, S.G.3    Sears, D.A.4    Udden, M.5
  • 62
    • 0344812230 scopus 로고
    • Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: Pathophysiological implications
    • Kaul DK, Fabry ME, Nagel RL (1989) Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: Pathophysiological implications. Proc Natl Acad Sci USA 86(9):3356-3360.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.9 , pp. 3356-3360
    • Kaul, D.K.1    Fabry, M.E.2    Nagel, R.L.3
  • 63
    • 10244279286 scopus 로고    scopus 로고
    • In vivo studies of sickle red blood cells
    • Kaul DK, Fabry ME (2004) In vivo studies of sickle red blood cells. Microcirculation 11(2):153-165.
    • (2004) Microcirculation , vol.11 , Issue.2 , pp. 153-165
    • Kaul, D.K.1    Fabry, M.E.2
  • 64
    • 84879990944 scopus 로고    scopus 로고
    • Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations
    • Lei H, Karniadakis GE (2013) Probing vasoocclusion phenomena in sickle cell anemia via mesoscopic simulations. Proc Natl Acad Sci USA 110(28):11326-11330.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.28 , pp. 11326-11330
    • Lei, H.1    Karniadakis, G.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.