Two distinct pathways mediate the formation of intermediate density cells and hyperdense cells from normal density sickle red blood cells

Blood

Volumn 92, Issue 12, 1998, Pages 4844-4855

  Schwartz, Robert S ^a   Musto, Sylvia ^a   Fabry, Mary E ^a   Nagel, Ronald L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CHLORIDE ION; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; POTASSIUM ION; SODIUM ION;

ARTICLE; CELL DENSITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; ION TRANSPORT; MEAN CORPUSCULAR HEMOGLOBIN; OXYGENATION; PRIORITY JOURNAL; SICKLE CELL ANEMIA;

EID: 0032535259     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v92.12.4844.424k29_4844_4855     Document Type: Article

References (15)

1. Herrick JB: Peculiar elongated and sickle-shaped red blood corpuscles in a case of severe anemia. Trans Assoc Am Physicians 25:553, 1910
2. Evans EA, Narla M, Leung A: Static and dynamic rigidities of normal and sickle erythrocytes: Major influence of cell hemoglobin concentration. J Clin Invest 73:477, 1984
3. 51Cr. Am J Med 64:253, 1978
4. Eaton WA, Hofrichter J, Ross PD: Delay time of gelation: A possible determinant of clinical severity in sickle cell disease. Blood 47:621, 1976
5. Kaul DK, Fabry ME, Windisch P, Baez S, Nagel RL: Erythrocytes in sickle cell anemia are heterogeneous in their Theological and hemodynamic characteristics. J Clin Invest 72:22, 1983
6. Kaul DK, Fabry ME, Nagel RL: Vaso-occlusion by sickle cells: Evidence for selective trapping of dense red cells. Blood 68:1162,1986
7. Kaul DK, Fabry ME, Nagel RL: Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: Pathophysiological implications. Proc Natl Acad Sci USA 86:3356, 1989
8. Canessa M: Red cell volume-related ion transport systems in hemoglobinopathies. Hematol Oncol Clin North Am 5:495, 1991
9. Fabry ME, Romero JS, Buchanan ID, Suzuka SM, Stamatoyannopoulos G, Nagel RL, Canessa M: Rapid increase in red blood cell density driven by K:Cl cotransport in a subset of sickle cell anemia reticulocytes and discocytes. Blood 78:217, 1991
10. Clark MR, Morrison CE, Shohet SB: Monovalent cation transport in irreversibly sickled cells. J Clin Invest 62:329, 1978
11. Keidan AJ, Noguchi CT, Player M, Chalder SM, Stuart J: Erythrocyte heterogeneity in sickle cell disease: Effect of deoxygenation on intracellular polymer formation and rheology of subpopulations. Br J Haematol 72:254, 1989
12. Ortiz OE, Lew VL, Bookchin RM: Deoxygenation permeabilizes sickle cell anemia red cells to magnesium and reverses its gradient in the dense cells. J Physiol 427:211, 1990
13. Horiuchi K, Stephens MJ, Adachi K, Asakura T, Schwartz E, Ohene-Frempong K: Image analysis studies of the degree of irreversible deformation of sickle cells in relation to cell density and Hb F level. Br J Haematol 85:356, 1993
14. Apovo M, Gascard P, Rhoda MD, Beuzard Y, Giraud F: Alteration in protein kinase C activity and subcellular distribution in sickle erythrocytes. Biochim Biophys Acta 984:26, 1989
15. Ballas SK: Sickle cell anemia with few painful crises is characterized by decreased red cell deformability and increased number of dense cells. Am J Hematol 36:122, 1991