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Volumn 118, Issue 3, 2015, Pages 331-343

Inhaled nitric oxide alters the distribution of blood flow in the healthy human lung, suggesting active hypoxic pulmonary vasoconstriction in normoxia

Author keywords

Arterial spin labeling; Hypoxic pulmonary vasoconstriction; MRI; Nitric oxide; Pulmonary blood flow

Indexed keywords

NITRIC OXIDE; SPIN LABEL;

EID: 84922370060     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01354.2013     Document Type: Article
Times cited : (31)

References (47)
  • 3
    • 0027935877 scopus 로고
    • Nitric oxide and cGMP cause vasorelaxation by activation of a charyb-dotoxin-sensitive K channel by cGMP-dependent protein kinase
    • Archer SL, Huang JM, Hampl V, Nelson DP, Shultz PJ, Weir EK. Nitric oxide and cGMP cause vasorelaxation by activation of a charyb-dotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci USA 91: 7583-7587, 1994.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7583-7587
    • Archer, S.L.1    Huang, J.M.2    Hampl, V.3    Nelson, D.P.4    Shultz, P.J.5    Weir, E.K.6
  • 4
    • 0024426035 scopus 로고
    • Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor
    • Archer SL, Tolins JP, Raij L, Weir EK. Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun 164: 1198-1205, 1989.
    • (1989) Biochem Biophys Res Commun , vol.164 , pp. 1198-1205
    • Archer, S.L.1    Tolins, J.P.2    Raij, L.3    Weir, E.K.4
  • 6
    • 0014878542 scopus 로고
    • Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia
    • Barer GR, Howard P, Shaw JW. Stimulus-response curves for the pulmonary vascular bed to hypoxia and hypercapnia. J Physiol 211: 139-155, 1970.
    • (1970) J Physiol , vol.211 , pp. 139-155
    • Barer, G.R.1    Howard, P.2    Shaw, J.W.3
  • 8
    • 84863312421 scopus 로고    scopus 로고
    • Assessing potential errors of MRI-based measurements of pulmonary blood flow using a detailed network flow model
    • Burrowes KS, Buxton RB, Prisk GK. Assessing potential errors of MRI-based measurements of pulmonary blood flow using a detailed network flow model. J Appl Physiol 113: 130-141, 2012.
    • (2012) J Appl Physiol , vol.113 , pp. 130-141
    • Burrowes, K.S.1    Buxton, R.B.2    Prisk, G.K.3
  • 10
    • 84881173107 scopus 로고    scopus 로고
    • Variations in alveolar partial pressure for carbon dioxide and oxygen have additive not synergistic acute effects on human pulmonary vasoconstriction
    • Croft QPP, Formenti F, Talbot NP, Lunn D, Robbins PA, Dorrington KL. Variations in alveolar partial pressure for carbon dioxide and oxygen have additive not synergistic acute effects on human pulmonary vasoconstriction. PLos One 8: e67886, 2013.
    • (2013) PLos One , vol.8
    • Croft, Q.P.P.1    Formenti, F.2    Talbot, N.P.3    Lunn, D.4    Robbins, P.A.5    Dorrington, K.L.6
  • 11
    • 0029379840 scopus 로고
    • Age-related changes in vascular smooth muscle and endothelium
    • Dohi Y, Kojima M, Sato K, Lüscher T. Age-related changes in vascular smooth muscle and endothelium. Drugs Aging 7: 278-291, 1995.
    • (1995) Drugs Aging , vol.7 , pp. 278-291
    • Dohi, Y.1    Kojima, M.2    Sato, K.3    Lüscher, T.4
  • 12
    • 84980110245 scopus 로고
    • Observations on the pulmonary arterial blood pressure in the cat
    • Euler USV, Liljestrand G. Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12: 301-320, 1946.
    • (1946) Acta Physiol Scand , vol.12 , pp. 301-320
    • Euler, U.S.V.1    Liljestrand, G.2
  • 13
    • 6344235032 scopus 로고    scopus 로고
    • Acute hypoxia and pulmonary vasoconstriction in humans: Uncovering the mechanism of the pressor response
    • Fishman AP. Acute hypoxia and pulmonary vasoconstriction in humans: uncovering the mechanism of the pressor response. Am J Physiol Lung Cell Mol Physiol 287: L893-L894, 2004.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. L893-L894
    • Fishman, A.P.1
  • 14
    • 0027418979 scopus 로고
    • Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation
    • Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 78: 427-435, 1993.
    • (1993) Anesthesiology , vol.78 , pp. 427-435
    • Frostell, C.G.1    Blomqvist, H.2    Hedenstierna, G.3    Lundberg, J.4    Zapol, W.M.5
  • 15
    • 2942544581 scopus 로고    scopus 로고
    • Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension
    • Galiè N, Seeger W, Naeije R, Simonneau G, Rubin LJ. Comparative analysis of clinical trials and evidence-based treatment algorithm in pulmonary arterial hypertension. J Am Coll Cardiol 43: S81-S88, 2004.
    • (2004) J Am Coll Cardiol , vol.43 , pp. S81-S88
    • Galiè, N.1    Seeger, W.2    Naeije, R.3    Simonneau, G.4    Rubin, L.J.5
  • 16
    • 0033675580 scopus 로고    scopus 로고
    • Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia
    • Glenny RW, Robertson HT, Hlastala MP. Vasomotor tone does not affect perfusion heterogeneity and gas exchange in normal primate lungs during normoxia. J Appl Physiol 89: 2263-2267, 2000.
    • (2000) J Appl Physiol , vol.89 , pp. 2263-2267
    • Glenny, R.W.1    Robertson, H.T.2    Hlastala, M.P.3
  • 17
    • 79954623691 scopus 로고    scopus 로고
    • Spatial distribution of ventilation and perfusion: Mechanisms and regulation
    • Hoboken, NJ: Wiley
    • Glenny RW, Robertson HT. Spatial Distribution of Ventilation and Perfusion: Mechanisms and Regulation. In: Comprehensive Physiology. Hoboken, NJ: Wiley, 2011, p. 16-30.
    • (2011) Comprehensive Physiology , pp. 16-30
    • Glenny, R.W.1    Robertson, H.T.2
  • 18
    • 0017228763 scopus 로고
    • Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coatimundi
    • Grant BJ, Davies EE, Jones HA, Hughes JM. Local regulation of pulmonary blood flow and ventilation-perfusion ratios in the coatimundi. J Appl Physiol 40: 216-228, 1976.
    • (1976) J Appl Physiol , vol.40 , pp. 216-228
    • Grant, B.J.1    Davies, E.E.2    Jones, H.A.3    Hughes, J.M.4
  • 20
    • 72749120111 scopus 로고    scopus 로고
    • Characterizing pulmonary blood flow distribution measured using arterial spin labeling
    • Henderson AC, Prisk GK, Levin DL, Hopkins SR, Buxton RB. Characterizing pulmonary blood flow distribution measured using arterial spin labeling. NMR Biomed 22: 1025-1035, 2009.
    • (2009) NMR Biomed , vol.22 , pp. 1025-1035
    • Henderson, A.C.1    Prisk, G.K.2    Levin, D.L.3    Hopkins, S.R.4    Buxton, R.B.5
  • 21
    • 84881456457 scopus 로고    scopus 로고
    • The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung
    • Henderson AC, Sá RC, Theilmann RJ, Buxton RB, Prisk GK, Hopkins SR. The gravitational distribution of ventilation-perfusion ratio is more uniform in prone than supine posture in the normal human lung. J Appl Physiol 115: 313-324, 2013.
    • (2013) J Appl Physiol , vol.115 , pp. 313-324
    • Henderson, A.C.1    Sá, R.C.2    Theilmann, R.J.3    Buxton, R.B.4    Prisk, G.K.5    Hopkins, S.R.6
  • 22
    • 0014819637 scopus 로고
    • Cardiac output during submaximal and maximal treadmill and bicycle exercise
    • Hermansen L, Ekblom B, Saltin B. Cardiac output during submaximal and maximal treadmill and bicycle exercise. J Appl Physiol 29: 82-86, 1970.
    • (1970) J Appl Physiol , vol.29 , pp. 82-86
    • Hermansen, L.1    Ekblom, B.2    Saltin, B.3
  • 23
    • 78649713697 scopus 로고    scopus 로고
    • Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans
    • Hopkins SR, Arai TJ, Henderson AC, Levin DL, Buxton RB, Prisk GK. Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans. J Physiol 588: 4759-4768, 2010.
    • (2010) J Physiol , vol.588 , pp. 4759-4768
    • Hopkins, S.R.1    Arai, T.J.2    Henderson, A.C.3    Levin, D.L.4    Buxton, R.B.5    Prisk, G.K.6
  • 24
    • 78649677882 scopus 로고    scopus 로고
    • Lung perfusion measured using magnetic resonance imaging: New tools for physiological insights into the pulmonary circulation
    • Hopkins SR, Prisk GK. Lung perfusion measured using magnetic resonance imaging: new tools for physiological insights into the pulmonary circulation. J Magn Reson Imaging 32: 1287-1301, 2010.
    • (2010) J Magn Reson Imaging , vol.32 , pp. 1287-1301
    • Hopkins, S.R.1    Prisk, G.K.2
  • 26
    • 0030955773 scopus 로고    scopus 로고
    • Nitric oxide and prostacyclin as test agents of vasoreactivity in severe precapillary pulmonary hypertension: Predictive ability and consequences on haemodynamics and gas exchange
    • Jolliet P, Bulpa P, Thorens JB, Ritz M, Chevrolet JC. Nitric oxide and prostacyclin as test agents of vasoreactivity in severe precapillary pulmonary hypertension: predictive ability and consequences on haemodynamics and gas exchange. Thorax 52: 369-372, 1997.
    • (1997) Thorax , vol.52 , pp. 369-372
    • Jolliet, P.1    Bulpa, P.2    Thorens, J.B.3    Ritz, M.4    Chevrolet, J.C.5
  • 27
    • 0027513903 scopus 로고
    • Gas uptake from an unventilated area of lung: Computer model of absorption atelectasis
    • Joyce CJ, Baker AB, Kennedy RR. Gas uptake from an unventilated area of lung: computer model of absorption atelectasis. J Appl Physiol 74: 1107-1116, 1993.
    • (1993) J Appl Physiol , vol.74 , pp. 1107-1116
    • Joyce, C.J.1    Baker, A.B.2    Kennedy, R.R.3
  • 28
    • 0027260899 scopus 로고
    • Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
    • Kourembanas S, McQuillan LP, Leung GK, Faller DV. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J Clin Invest 92: 99-104, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 99-104
    • Kourembanas, S.1    McQuillan, L.P.2    Leung, G.K.3    Faller, D.V.4
  • 29
    • 67649624517 scopus 로고    scopus 로고
    • Pulmonary arterial pressure during rest and exercise in healthy subjects: A systematic review
    • Kovacs G, Berghold A, Scheidl S, Olschewski H. Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur Respir J 34: 888-894, 2009.
    • (2009) Eur Respir J , vol.34 , pp. 888-894
    • Kovacs, G.1    Berghold, A.2    Scheidl, S.3    Olschewski, H.4
  • 30
    • 34547159345 scopus 로고    scopus 로고
    • Bootstrap hypothesis testing for some common statistical problems: A critical evaluation of size and power properties
    • Martin MA. Bootstrap hypothesis testing for some common statistical problems: a critical evaluation of size and power properties. Comput Stat Data Analysis 51: 6321-6342, 2007.
    • (2007) Comput Stat Data Analysis , vol.51 , pp. 6321-6342
    • Martin, M.A.1
  • 31
    • 0023093017 scopus 로고
    • Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man
    • Mélot C, Naeije R, Hallemans R, Lejeune P, Mols P. Hypoxic pulmonary vasoconstriction and pulmonary gas exchange in normal man. Respir Physiol 68: 11-27, 1987.
    • (1987) Respir Physiol , vol.68 , pp. 11-27
    • Mélot, C.1    Naeije, R.2    Hallemans, R.3    Lejeune, P.4    Mols, P.5
  • 32
    • 0025883342 scopus 로고
    • Nitric oxide: Physiology, pathophysiology, pharmacology
    • Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophysiology, pharmacology. Pharmacol Rev 43: 109-142, 1991.
    • (1991) Pharmacol Rev , vol.43 , pp. 109-142
    • Moncada, S.1    Palmer, R.M.2    Higgs, E.A.3
  • 33
    • 0000707862 scopus 로고
    • The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man
    • Motley HL, Cournand A, Werko L, Himmelstein A, Dresdale D. The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150: 315-320, 1947.
    • (1947) Am J Physiol , vol.150 , pp. 315-320
    • Motley, H.L.1    Cournand, A.2    Werko, L.3    Himmelstein, A.4    Dresdale, D.5
  • 35
    • 0035065615 scopus 로고    scopus 로고
    • Physiology in medicine: Importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure
    • Naeije R, Brimioulle S. Physiology in medicine: importance of hypoxic pulmonary vasoconstriction in maintaining arterial oxygenation during acute respiratory failure. Crit Care 5: 67-71, 2001.
    • (2001) Crit Care , vol.5 , pp. 67-71
    • Naeije, R.1    Brimioulle, S.2
  • 36
    • 0019902327 scopus 로고
    • Effects of vasodilators on hypoxic pulmonary vasoconstriction in normal man
    • Naeije R, Mols P, Hallemans R, Mélot C. Effects of vasodilators on hypoxic pulmonary vasoconstriction in normal man. Chest 82: 404-410, 1982.
    • (1982) Chest , vol.82 , pp. 404-410
    • Naeije, R.1    Mols, P.2    Hallemans, R.3    Mélot, C.4
  • 37
    • 0027537605 scopus 로고
    • Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange
    • Pison U, Lopez FA, Heidelmeyer CF, Rossaint R, Falke KJ. Inhaled nitric oxide reverses hypoxic pulmonary vasoconstriction without impairing gas exchange. J Appl Physiol 74: 1287-1292, 1993.
    • (1993) J Appl Physiol , vol.74 , pp. 1287-1292
    • Pison, U.1    Lopez, F.A.2    Heidelmeyer, C.F.3    Rossaint, R.4    Falke, K.J.5
  • 39
    • 77049132927 scopus 로고
    • Effect of unilateral hypoxia on gas exchange and calculated pulmonary blood flow in each lung
    • Rahn H, Bahnson HT. Effect of unilateral hypoxia on gas exchange and calculated pulmonary blood flow in each lung. J Appl Physiol 6: 105-112, 1953.
    • (1953) J Appl Physiol , vol.6 , pp. 105-112
    • Rahn, H.1    Bahnson, H.T.2
  • 40
    • 0027278227 scopus 로고
    • Inhaled nitric oxide: Selective pulmonary vasodilation in cardiac surgical patients
    • Rich GF, Murphy GDJ, Roos CM, Johns RA. Inhaled nitric oxide: selective pulmonary vasodilation in cardiac surgical patients. Anesthesiology 78, 1993.
    • (1993) Anesthesiology , pp. 78
    • Rich, G.F.1    Murphy, G.D.J.2    Roos, C.M.3    Johns, R.A.4
  • 41
    • 0037371755 scopus 로고    scopus 로고
    • Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation
    • Silvennoinen MJ, Kettunen MI, Kauppinen RA. Effects of hematocrit and oxygen saturation level on blood spin-lattice relaxation. Magn Reson Med 49: 568-571, 2003.
    • (2003) Magn Reson Med , vol.49 , pp. 568-571
    • Silvennoinen, M.J.1    Kettunen, M.I.2    Kauppinen, R.A.3
  • 43
    • 0035095912 scopus 로고    scopus 로고
    • Water proton MR properties of human blood at 1.5 Tesla: Magnetic susceptibility, T1, T2, T&z.ast;2, and non-Lorentzian signal behavior
    • Spees WM, Yablonskiy DA, Oswood MC, Ackerman JJH. Water proton MR properties of human blood at 1.5 Tesla: Magnetic susceptibility, T1, T2, T&z.ast;2, and non-Lorentzian signal behavior. Magn Reson Med 45: 533-542, 2001.
    • (2001) Magn Reson Med , vol.45 , pp. 533-542
    • Spees, W.M.1    Yablonskiy, D.A.2    Oswood, M.C.3    Ackerman, J.J.H.4
  • 46
    • 0029085284 scopus 로고
    • Vulnerability of pulmonary capillaries in heart disease
    • West JB, Mathieu-Costello O. Vulnerability of pulmonary capillaries in heart disease. Circulation 92: 622-631, 1995.
    • (1995) Circulation , vol.92 , pp. 622-631
    • West, J.B.1    Mathieu-Costello, O.2
  • 47
    • 0013514321 scopus 로고
    • Bioengineering aspects of the lung
    • edited by West JB. New York: Dekker
    • West JB, Wagner PD. Bioengineering aspects of the lung. In: Lung Biology in Health and Disease, edited by West JB. New York: Dekker, 1977, vol 3.
    • (1977) Lung Biology in Health and Disease , vol.3
    • West, J.B.1    Wagner, P.D.2


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