메뉴 건너뛰기




Volumn 1852, Issue 4, 2015, Pages 563-584

Diagnostic histochemistry and clinical-pathological testings as molecular pathways to pathogenesis and treatment of the ageing neuromuscular system: A personal view

Author keywords

Ageing muscle atrophy; Amyotrophic Lateral Sclerosis; Human muscle histochemistry; IVIG treatment; Multicramps; Treatable diabetic neuropathy

Indexed keywords

ACETAZOLAMIDE; ACID PHOSPHATASE; ALPHA2A INTERFERON; CALCIUM; GLUCOCORTICOID; IMMUNOGLOBULIN G; MYOSTATIN; PROTEASOME; TRANSCRIPTION FACTOR FOXO; UBIQUITIN;

EID: 84922331573     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.11.015     Document Type: Review
Times cited : (8)

References (134)
  • 4
    • 0000504097 scopus 로고
    • The essentiality of histo- and cytochemical studies of skeletal muscle in the investigation of neuromuscular disease
    • Engel W.K. The essentiality of histo- and cytochemical studies of skeletal muscle in the investigation of neuromuscular disease. Neurology 1962, 12:778-794.
    • (1962) Neurology , vol.12 , pp. 778-794
    • Engel, W.K.1
  • 5
    • 0001698695 scopus 로고
    • Rapid examination of muscle tissue and improved trichrome method for fresh-frozen biopsy sections
    • Engel W.K., Cunningham G.G. Rapid examination of muscle tissue and improved trichrome method for fresh-frozen biopsy sections. Neurology 1963, 13:919-923.
    • (1963) Neurology , vol.13 , pp. 919-923
    • Engel, W.K.1    Cunningham, G.G.2
  • 6
    • 0027240930 scopus 로고
    • Enhanced detection of congo-red-positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique
    • Askanas V., Engel W.K., Alvarez R.B. Enhanced detection of congo-red-positive amyloid deposits in muscle fibers of inclusion body myositis and brain of Alzheimer's disease using fluorescence technique. Neurology 1993, 43:1265-1267.
    • (1993) Neurology , vol.43 , pp. 1265-1267
    • Askanas, V.1    Engel, W.K.2    Alvarez, R.B.3
  • 7
    • 84882733761 scopus 로고    scopus 로고
    • Mechanisms regulating skeletal muscle growth and atrophy
    • Schiaffino S., Dyar K., Ciciliot S., Blaauw B., Sandri M. Mechanisms regulating skeletal muscle growth and atrophy. FEBS J. 2013, 280:4294-4314.
    • (2013) FEBS J. , vol.280 , pp. 4294-4314
    • Schiaffino, S.1    Dyar, K.2    Ciciliot, S.3    Blaauw, B.4    Sandri, M.5
  • 8
    • 0015223837 scopus 로고
    • Histochemical and functional correlations in anterior horn neurons of the cat spinal cord
    • Campa J.F., Engel W.K. Histochemical and functional correlations in anterior horn neurons of the cat spinal cord. Science 1971, 171:198-199.
    • (1971) Science , vol.171 , pp. 198-199
    • Campa, J.F.1    Engel, W.K.2
  • 9
    • 0014800606 scopus 로고
    • Histochemistry of motor neurons and interneurons in the cat lumbar spinal cord
    • Campa J.F., Engel W.K. Histochemistry of motor neurons and interneurons in the cat lumbar spinal cord. Neurology 1970, 20:559-568.
    • (1970) Neurology , vol.20 , pp. 559-568
    • Campa, J.F.1    Engel, W.K.2
  • 10
    • 0014771696 scopus 로고
    • Histochemical classification of anterior horn neurons
    • Campa J.F., Engel W.K. Histochemical classification of anterior horn neurons. Neurology 1970, 20:386.
    • (1970) Neurology , vol.20 , pp. 386
    • Campa, J.F.1    Engel, W.K.2
  • 11
    • 0015156701 scopus 로고
    • Mammalian motor units: physiological-histochemical correlation in three types in cat gastrocnemius
    • Burke R.E., Levine D.N., Zajac F.E. Mammalian motor units: physiological-histochemical correlation in three types in cat gastrocnemius. Science 1971, 174:709-712.
    • (1971) Science , vol.174 , pp. 709-712
    • Burke, R.E.1    Levine, D.N.2    Zajac, F.E.3
  • 12
    • 0345457743 scopus 로고
    • Direct correlation of physiological and histochemical characteristics of motor units of cat triceps surae muscle
    • Karger, Basel, J.E. Desmedt (Ed.)
    • Burke R.E., Tsairis P., Levine N. Direct correlation of physiological and histochemical characteristics of motor units of cat triceps surae muscle. New developments in electromyography and clinical neurophysiology 1973, 23-30. Karger, Basel. J.E. Desmedt (Ed.).
    • (1973) New developments in electromyography and clinical neurophysiology , pp. 23-30
    • Burke, R.E.1    Tsairis, P.2    Levine, N.3
  • 13
    • 26844522790 scopus 로고
    • Correlation of motor unit behavior with histochemical and myofiber type in humans by open-biopsy electromyography
    • Karger, Basel, J.E. Desmedt (Ed.)
    • Warmolts J.B., Engel W.K. Correlation of motor unit behavior with histochemical and myofiber type in humans by open-biopsy electromyography. New developments in electromyography and clinical neurophysiology 1973, 35-40. Karger, Basel. J.E. Desmedt (Ed.).
    • (1973) New developments in electromyography and clinical neurophysiology , pp. 35-40
    • Warmolts, J.B.1    Engel, W.K.2
  • 14
    • 0014118540 scopus 로고
    • A histochemical-physiological correlation of frog skeletal muscle fibers
    • Engel W.K., Irwin R.L. A histochemical-physiological correlation of frog skeletal muscle fibers. Am. J. Physiol. 1967, 213:511-518.
    • (1967) Am. J. Physiol. , vol.213 , pp. 511-518
    • Engel, W.K.1    Irwin, R.L.2
  • 15
    • 0015482130 scopus 로고
    • Open-biopsy electromyography. I. Correlation of motor unit behavior with histochemical muscle fiber type in human limb muscle
    • Warmolts J.R., Engel W.K. Open-biopsy electromyography. I. Correlation of motor unit behavior with histochemical muscle fiber type in human limb muscle. Arch. Neurol. 1972, 27:512-517.
    • (1972) Arch. Neurol. , vol.27 , pp. 512-517
    • Warmolts, J.R.1    Engel, W.K.2
  • 16
    • 84885540751 scopus 로고    scopus 로고
    • Aging of the human neuromuscular system: Pathological aspects
    • Wiley-Blackwell, V. Askanas, W.K. Engel (Eds.)
    • Engel W.K., Askanas V. Aging of the human neuromuscular system: Pathological aspects. Muscle aging, inclusion-body myositis and myopathies 2012, 3-32. Wiley-Blackwell. V. Askanas, W.K. Engel (Eds.).
    • (2012) Muscle aging, inclusion-body myositis and myopathies , pp. 3-32
    • Engel, W.K.1    Askanas, V.2
  • 17
    • 84885570707 scopus 로고    scopus 로고
    • Aging of the human neuromuscular system: clinical considerations
    • Wiley-Blackwell, V. Askanas, W.K. Engel (Eds.)
    • Engel W.K., Askanas V. Aging of the human neuromuscular system: clinical considerations. Muscle aging, inclusion-body myositis and myopathies 2012, 33-54. Wiley-Blackwell. V. Askanas, W.K. Engel (Eds.).
    • (2012) Muscle aging, inclusion-body myositis and myopathies , pp. 33-54
    • Engel, W.K.1    Askanas, V.2
  • 18
    • 0014009765 scopus 로고
    • Histochemical studies of denervated or tenotomized cat muscle: illustrating difficulties in relating experimental animal conditions to human neuromuscular diseases
    • Engel W.K., Brooke M.H., Nelson P.G. Histochemical studies of denervated or tenotomized cat muscle: illustrating difficulties in relating experimental animal conditions to human neuromuscular diseases. Ann. N. Y. Acad. Sci. 1966, 138:160-185.
    • (1966) Ann. N. Y. Acad. Sci. , vol.138 , pp. 160-185
    • Engel, W.K.1    Brooke, M.H.2    Nelson, P.G.3
  • 19
    • 84885176026 scopus 로고    scopus 로고
    • Molecular mechanisms of muscle atrophy in myotonic dystrophies
    • Timchenko L. Molecular mechanisms of muscle atrophy in myotonic dystrophies. Int. J. Biochem. Cell Biol. 2013, 45:2280-2287.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 2280-2287
    • Timchenko, L.1
  • 20
    • 84948724649 scopus 로고
    • Muscle fiber hypotrophy with central nuclei
    • Lea Febiger, Philadelphia, E.S. Goldensohn, S.H. Appel (Eds.)
    • Engel W.K. Muscle fiber hypotrophy with central nuclei. Scientific approaches to clinical neurology 1977, 1572-1600. Lea Febiger, Philadelphia. E.S. Goldensohn, S.H. Appel (Eds.).
    • (1977) Scientific approaches to clinical neurology , pp. 1572-1600
    • Engel, W.K.1
  • 21
    • 84863051998 scopus 로고    scopus 로고
    • Congenital myotubular myopathy with a novel MTM1 gene mutation in a premature infant presenting with ventilator dependency and intrahepatic cholestasis
    • Lee I.-C., Su P.-H., Chen J.-Y., Hu J.-M., Lu J.-J., Ng Y.-Y. Congenital myotubular myopathy with a novel MTM1 gene mutation in a premature infant presenting with ventilator dependency and intrahepatic cholestasis. J. Child Neurol. 2012, 27:99-104.
    • (2012) J. Child Neurol. , vol.27 , pp. 99-104
    • Lee, I.-C.1    Su, P.-H.2    Chen, J.-Y.3    Hu, J.-M.4    Lu, J.-J.5    Ng, Y.-Y.6
  • 22
    • 0000209971 scopus 로고
    • Factors affecting the activity of adenosine triphosphatase and other phosphatases as measured by histochemical techniques
    • Padykula H.A., Herman E. Factors affecting the activity of adenosine triphosphatase and other phosphatases as measured by histochemical techniques. J. Histochem. Cytochem. 1955, 3:161-169.
    • (1955) J. Histochem. Cytochem. , vol.3 , pp. 161-169
    • Padykula, H.A.1    Herman, E.2
  • 23
    • 0342777706 scopus 로고
    • Reversal of the ATPase reaction in muscle fibres by EDTA
    • Drews G.A., Engel W.K. Reversal of the ATPase reaction in muscle fibres by EDTA. Nature 1966, 212:1551-1553.
    • (1966) Nature , vol.212 , pp. 1551-1553
    • Drews, G.A.1    Engel, W.K.2
  • 25
    • 36949091352 scopus 로고
    • Direct relationship of phosphorylase and mitochondrial alpha-glycerophosphate dehydrogenase activity in skeletal muscle
    • Pearse A.G. Direct relationship of phosphorylase and mitochondrial alpha-glycerophosphate dehydrogenase activity in skeletal muscle. Nature 1961, 191:504.
    • (1961) Nature , vol.191 , pp. 504
    • Pearse, A.G.1
  • 26
    • 0014864488 scopus 로고
    • Muscle fiber types: how many and what kind?
    • Brooke M.H., Kaiser K.K. Muscle fiber types: how many and what kind?. Arch. Neurol. 1970, 23:369-379.
    • (1970) Arch. Neurol. , vol.23 , pp. 369-379
    • Brooke, M.H.1    Kaiser, K.K.2
  • 27
    • 0345716799 scopus 로고
    • Histochemistry and cytochemistry of experimentally denervated guinea Pig muscle. I. Histochemistry
    • Hogenhuis L.A., Engel W.K. Histochemistry and cytochemistry of experimentally denervated guinea Pig muscle. I. Histochemistry. Acta Anat. (Basel) 1965, 60:39-65.
    • (1965) Acta Anat. (Basel) , vol.60 , pp. 39-65
    • Hogenhuis, L.A.1    Engel, W.K.2
  • 28
    • 0014221536 scopus 로고
    • Transformation of the histochemical profile of skeletal muscle by "foreign" innervation
    • Karpati G., Engel W.K. Transformation of the histochemical profile of skeletal muscle by "foreign" innervation. Nature 1967, 215:1509-1510.
    • (1967) Nature , vol.215 , pp. 1509-1510
    • Karpati, G.1    Engel, W.K.2
  • 29
    • 0014314039 scopus 로고
    • Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section, and skeletal fixation
    • Karpati G., Engel W.K. Correlative histochemical study of skeletal muscle after suprasegmental denervation, peripheral nerve section, and skeletal fixation. Neurology 1968, 18:681-692.
    • (1968) Neurology , vol.18 , pp. 681-692
    • Karpati, G.1    Engel, W.K.2
  • 30
    • 0014282727 scopus 로고
    • "Type grouping" in skeletal muscles after experimental reinnervation
    • Karpati G., Engel W.K. "Type grouping" in skeletal muscles after experimental reinnervation. Neurology 1968, 18:447-455.
    • (1968) Neurology , vol.18 , pp. 447-455
    • Karpati, G.1    Engel, W.K.2
  • 31
    • 0014236649 scopus 로고
    • Histochemical investigation of fiber type ratios with the myofibrillar ATP-ase reaction in normal and denervated skeletal muscles of guinea pig
    • Karpati G., Engel W.K. Histochemical investigation of fiber type ratios with the myofibrillar ATP-ase reaction in normal and denervated skeletal muscles of guinea pig. Am. J. Anat. 1968, 122:145-155.
    • (1968) Am. J. Anat. , vol.122 , pp. 145-155
    • Karpati, G.1    Engel, W.K.2
  • 32
    • 0017003982 scopus 로고
    • Extrajunctional acetylcholine receptors on myogenously de-innervated muscle fibers
    • Ringel S.P., Engel W.K., Bender A.N. Extrajunctional acetylcholine receptors on myogenously de-innervated muscle fibers. J. Histochem. Cytochem. 1976, 24:1033-1034.
    • (1976) J. Histochem. Cytochem. , vol.24 , pp. 1033-1034
    • Ringel, S.P.1    Engel, W.K.2    Bender, A.N.3
  • 33
    • 0014709081 scopus 로고
    • Alkaline phosphatase-positive abnormal muscle fibers of humans
    • Engel W.K., Cunningham G.G. Alkaline phosphatase-positive abnormal muscle fibers of humans. J. Histochem. Cytochem. 1970, 18:55-57.
    • (1970) J. Histochem. Cytochem. , vol.18 , pp. 55-57
    • Engel, W.K.1    Cunningham, G.G.2
  • 34
    • 0015040683 scopus 로고
    • The fine structure of type II muscle fiber atrophy
    • Mendell J.R., Engel W.K. The fine structure of type II muscle fiber atrophy. Neurology 1971, 21:358-365.
    • (1971) Neurology , vol.21 , pp. 358-365
    • Mendell, J.R.1    Engel, W.K.2
  • 35
    • 0014739714 scopus 로고
    • Atrophy of skeletal muscle in patients with Cushing's syndrome
    • Pleasure D.E., Walsh G.O., Engel W.K. Atrophy of skeletal muscle in patients with Cushing's syndrome. Arch. Neurol. 1970, 22:118-125.
    • (1970) Arch. Neurol. , vol.22 , pp. 118-125
    • Pleasure, D.E.1    Walsh, G.O.2    Engel, W.K.3
  • 36
    • 0014738771 scopus 로고
    • Selective and nonselective susceptibility of muscle fiber types. A new approach to human neuromuscular diseases
    • Engel W.K. Selective and nonselective susceptibility of muscle fiber types. A new approach to human neuromuscular diseases. Arch. Neurol. 1970, 22:97-117.
    • (1970) Arch. Neurol. , vol.22 , pp. 97-117
    • Engel, W.K.1
  • 37
    • 0030593939 scopus 로고    scopus 로고
    • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway
    • Mitch W.E., Goldberg A.L. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N. Engl. J. Med. 1996, 335:1897-1905.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1897-1905
    • Mitch, W.E.1    Goldberg, A.L.2
  • 38
    • 84895751231 scopus 로고    scopus 로고
    • Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation
    • Cohen S., Lee D., Zhai B., Gygi S.P., Goldberg A.L. Trim32 reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation. J. Cell Biol. 2014, 204:747-758.
    • (2014) J. Cell Biol. , vol.204 , pp. 747-758
    • Cohen, S.1    Lee, D.2    Zhai, B.3    Gygi, S.P.4    Goldberg, A.L.5
  • 39
    • 79953825265 scopus 로고    scopus 로고
    • Multi-microcramps syndrome:a new pathogenic concept of subtle lower motor-neuron lability causing very disturbing, continuing muscle pains, sometimes gratifying treatable-but often misdinterpreted as mysterious "fibromyalgia" or "psychgenic"
    • Engel W.K. Multi-microcramps syndrome:a new pathogenic concept of subtle lower motor-neuron lability causing very disturbing, continuing muscle pains, sometimes gratifying treatable-but often misdinterpreted as mysterious "fibromyalgia" or "psychgenic". Neurology 2010, 74:A465.
    • (2010) Neurology , vol.74 , pp. A465
    • Engel, W.K.1
  • 40
    • 0016373423 scopus 로고
    • Neuromuscular disease in primary hyperparathyroidism.
    • Patten B., Bilezikian J.P., Mallette L.E., et al. Neuromuscular disease in primary hyperparathyroidism. Ann. Intern. Med. 1973, 80:182-193.
    • (1973) Ann. Intern. Med. , vol.80 , pp. 182-193
    • Patten, B.1    Bilezikian, J.P.2    Mallette, L.E.3
  • 41
    • 0000777328 scopus 로고
    • Muscle target fibres, a newly recognized sign of denervation
    • Engel W.K. Muscle target fibres, a newly recognized sign of denervation. Nature 1961, 191:389-390.
    • (1961) Nature , vol.191 , pp. 389-390
    • Engel, W.K.1
  • 42
    • 0009725548 scopus 로고    scopus 로고
    • Myotonic dystrophy muscle nuclei have features of apoptosis "Apoptosis-Lente", PS-1 accumulation, and contain filamentous inclusions and ubiquitin immunoreactivity
    • Askanas V., Engel W.K., Alvarez R.B., Broccolini A. Myotonic dystrophy muscle nuclei have features of apoptosis "Apoptosis-Lente", PS-1 accumulation, and contain filamentous inclusions and ubiquitin immunoreactivity. Neurology 1999, 52:94.
    • (1999) Neurology , vol.52 , pp. 94
    • Askanas, V.1    Engel, W.K.2    Alvarez, R.B.3    Broccolini, A.4
  • 46
    • 84922318481 scopus 로고    scopus 로고
    • New insight into the molecular mechanism of muscle atrophy
    • Goldberg A.L. New insight into the molecular mechanism of muscle atrophy. J. Neuromuscul. Dis. 2014, 1:s34.
    • (2014) J. Neuromuscul. Dis. , vol.1 , pp. s34
    • Goldberg, A.L.1
  • 47
    • 77953495952 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy
    • Brault J.J., Jespersen J.G., Goldberg A.L. Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. J. Biol. Chem. 2010, 285:19460-19471.
    • (2010) J. Biol. Chem. , vol.285 , pp. 19460-19471
    • Brault, J.J.1    Jespersen, J.G.2    Goldberg, A.L.3
  • 48
    • 84886899121 scopus 로고    scopus 로고
    • SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth
    • Lee D., Goldberg A.L. SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J Biol Chem. 2013, 288:30515-30526.
    • (2013) J Biol Chem. , vol.288 , pp. 30515-30526
    • Lee, D.1    Goldberg, A.L.2
  • 49
    • 80054760368 scopus 로고    scopus 로고
    • Fiber types in mammalian skeletal muscles
    • Schiaffino S., Reggiani C. Fiber types in mammalian skeletal muscles. Physiol. Rev. 2011, 91:1447-1531.
    • (2011) Physiol. Rev. , vol.91 , pp. 1447-1531
    • Schiaffino, S.1    Reggiani, C.2
  • 50
    • 84885174647 scopus 로고    scopus 로고
    • Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome
    • Sandri M. Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome. Int. J. Biochem. Cell Biol. 2013, 45:2121-2129.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 2121-2129
    • Sandri, M.1
  • 52
    • 41449113346 scopus 로고    scopus 로고
    • Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor
    • Zhao J., Brault J.J., Schild A., Goldberg A.L. Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy 2008, 4:378-380.
    • (2008) Autophagy , vol.4 , pp. 378-380
    • Zhao, J.1    Brault, J.J.2    Schild, A.3    Goldberg, A.L.4
  • 53
    • 84922297353 scopus 로고    scopus 로고
    • Special issue: Molecular basis of muscle wasting
    • Special issue: Molecular basis of muscle wasting. Int. J. Biochem. Cell Biol. 2013, 45.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45
  • 54
    • 0018344504 scopus 로고
    • Dagen des oordeels. Pathokinetic mechanisms and molecular messengers (a dramatic view)
    • Engel W.K. Dagen des oordeels. Pathokinetic mechanisms and molecular messengers (a dramatic view). Arch. Neurol. 1979, 36:329-339.
    • (1979) Arch. Neurol. , vol.36 , pp. 329-339
    • Engel, W.K.1
  • 55
    • 79953792495 scopus 로고    scopus 로고
    • Sporadic inclusion-body myositis: Conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-beta42 oligomers and phosphorylated tau
    • Askanas V., Engel W.K. Sporadic inclusion-body myositis: Conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-beta42 oligomers and phosphorylated tau. Presse Med. 2011, 40:e219-e235.
    • (2011) Presse Med. , vol.40 , pp. e219-e235
    • Askanas, V.1    Engel, W.K.2
  • 56
    • 33947622602 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis
    • Nogalska A., Wojcik S., Engel W.K., McFerrin J., Askanas V. Endoplasmic reticulum stress induces myostatin precursor protein and NF-kappaB in cultured human muscle fibers: relevance to inclusion body myositis. Exp. Neurol. 2007, 204:610-618.
    • (2007) Exp. Neurol. , vol.204 , pp. 610-618
    • Nogalska, A.1    Wojcik, S.2    Engel, W.K.3    McFerrin, J.4    Askanas, V.5
  • 57
    • 40949155609 scopus 로고    scopus 로고
    • Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy
    • Wojcik S., Nogalska A., Engel W.K., Askanas V. Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-II muscle fibre atrophy. Folia Morphol. (Warsz) 2008, 67:6-12.
    • (2008) Folia Morphol. (Warsz) , vol.67 , pp. 6-12
    • Wojcik, S.1    Nogalska, A.2    Engel, W.K.3    Askanas, V.4
  • 60
    • 0018693185 scopus 로고
    • Autoradiographic visualization of beta-adrenergic receptors in normal and denervated skeletal muscle
    • Lavenstein B., Engel W.K., Reddy N.B., Carroll S. Autoradiographic visualization of beta-adrenergic receptors in normal and denervated skeletal muscle. J. Histochem. Cytochem. 1979, 27:1308-1311.
    • (1979) J. Histochem. Cytochem. , vol.27 , pp. 1308-1311
    • Lavenstein, B.1    Engel, W.K.2    Reddy, N.B.3    Carroll, S.4
  • 61
    • 84885173789 scopus 로고    scopus 로고
    • Beta2-Adrenergic agonists and the treatment of skeletal muscle wasting disorders
    • Joassard O.R., Durieux A.C., Freyssenet D.G. beta2-Adrenergic agonists and the treatment of skeletal muscle wasting disorders. Int. J. Biochem. Cell Biol. 2013, 45:2309-2321.
    • (2013) Int. J. Biochem. Cell Biol. , vol.45 , pp. 2309-2321
    • Joassard, O.R.1    Durieux, A.C.2    Freyssenet, D.G.3
  • 62
    • 0029611201 scopus 로고
    • Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for A beta 40 and A beta 42: immunohistochemical evidence for amyloid beta protein
    • Tsuzuki K., Fukatsu R., Takamaru Y., Yoshida T., Hayashi Y., Yamaguchi H., Fujii N., Takahata N. Amyloid beta protein in rat soleus muscle in chloroquine-induced myopathy using end-specific antibodies for A beta 40 and A beta 42: immunohistochemical evidence for amyloid beta protein. Neurosci. Lett. 1995, 202:77-80.
    • (1995) Neurosci. Lett. , vol.202 , pp. 77-80
    • Tsuzuki, K.1    Fukatsu, R.2    Takamaru, Y.3    Yoshida, T.4    Hayashi, Y.5    Yamaguchi, H.6    Fujii, N.7    Takahata, N.8
  • 63
    • 0015513452 scopus 로고
    • Vascular deposits of immunoglobulin and complement in idiopathic inflammatory myopathy
    • Whitaker J.N., Engel W.K. Vascular deposits of immunoglobulin and complement in idiopathic inflammatory myopathy. N. Engl. J. Med. 1972, 286:333-338.
    • (1972) N. Engl. J. Med. , vol.286 , pp. 333-338
    • Whitaker, J.N.1    Engel, W.K.2
  • 64
    • 0015921717 scopus 로고
    • Mechanisms of muscle injury in idiopathic inflammatory myopathy
    • Whitaker J.N., Engel W.K. Mechanisms of muscle injury in idiopathic inflammatory myopathy. N. Engl. J. Med. 1973, 289:107-108.
    • (1973) N. Engl. J. Med. , vol.289 , pp. 107-108
    • Whitaker, J.N.1    Engel, W.K.2
  • 66
    • 33646676002 scopus 로고
    • "Ragged-red fibers" in opthamoplegia syndromes and their differential diagnosis
    • Engel W.K. "Ragged-red fibers" in opthamoplegia syndromes and their differential diagnosis. Excerpta Med. Int. Congr. Ser. 1971, 237.
    • (1971) Excerpta Med. Int. Congr. Ser. , vol.237
    • Engel, W.K.1
  • 67
    • 84885529926 scopus 로고    scopus 로고
    • Mitochondrial changes in aging wih particular reference to muscle, and possible clinical consequences
    • Wiley, V. Askanas, W.K. Engel (Eds.)
    • Di Mauro S., Schon E.A., Hirano M. Mitochondrial changes in aging wih particular reference to muscle, and possible clinical consequences. Muscle aging, inclusion-body myositis and myopathies 2011, Wiley. V. Askanas, W.K. Engel (Eds.).
    • (2011) Muscle aging, inclusion-body myositis and myopathies
    • Di Mauro, S.1    Schon, E.A.2    Hirano, M.3
  • 68
    • 0011228610 scopus 로고
    • Late-onset type of skeletal muscle phosphorylase deficiency: a new familial variety of completely or partially affected subjects
    • Engel W.K., Eyerman E.J., Williams H.E. Late-onset type of skeletal muscle phosphorylase deficiency: a new familial variety of completely or partially affected subjects. N. Engl. J. Med. 1963, 268:135-137.
    • (1963) N. Engl. J. Med. , vol.268 , pp. 135-137
    • Engel, W.K.1    Eyerman, E.J.2    Williams, H.E.3
  • 69
    • 56749104288 scopus 로고    scopus 로고
    • Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains
    • Askanas V., Engel W.K. Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains. Acta Neuropathol. 2008, 116:583-595.
    • (2008) Acta Neuropathol. , vol.116 , pp. 583-595
    • Askanas, V.1    Engel, W.K.2
  • 70
    • 66949145779 scopus 로고    scopus 로고
    • Inclusion body myositis: a degenerative muscle disease associated with intra-muscle fiber multi-protein aggregates, proteasome inhibition, endoplasmic reticulum stress and decreased lysosomal degradation
    • Askanas V., Engel W.K., Nogalska A. Inclusion body myositis: a degenerative muscle disease associated with intra-muscle fiber multi-protein aggregates, proteasome inhibition, endoplasmic reticulum stress and decreased lysosomal degradation. Brain Pathol. 2009, 19:493-506.
    • (2009) Brain Pathol. , vol.19 , pp. 493-506
    • Askanas, V.1    Engel, W.K.2    Nogalska, A.3
  • 71
    • 84885492217 scopus 로고    scopus 로고
    • Pathogenesis, including role of cellular aging, abnormal accumulation of proteins that are also accumulated in brains of neurodegenerative disorders, and possible treatment avenues
    • Wiley, V. Askanas, W.K. Engel (Eds.)
    • Askanas V., Engel W.K., Nogalska A. Pathogenesis, including role of cellular aging, abnormal accumulation of proteins that are also accumulated in brains of neurodegenerative disorders, and possible treatment avenues. Muscle aging, inclusion-body myositis and myopathies 2011, Wiley. V. Askanas, W.K. Engel (Eds.).
    • (2011) Muscle aging, inclusion-body myositis and myopathies
    • Askanas, V.1    Engel, W.K.2    Nogalska, A.3
  • 72
    • 84922306562 scopus 로고    scopus 로고
    • Abnormalities of mitophagy in sporadic inclusion-body myositis (s-IBM) muscle fibers
    • Nogalska A., D'Agostino C., Cacciottolo M., Engel W.K., Askanas V. Abnormalities of mitophagy in sporadic inclusion-body myositis (s-IBM) muscle fibers. Neurology 2014, 82:P3.288.
    • (2014) Neurology , vol.82 , pp. P3.288
    • Nogalska, A.1    D'Agostino, C.2    Cacciottolo, M.3    Engel, W.K.4    Askanas, V.5
  • 73
    • 84885546279 scopus 로고
    • Toxic role of long-chain fatty acids in muscle carnitine deficiency and other LCFA restriction associated with dramatic long-term improvemenet
    • Engel W.K., Askanas V. Toxic role of long-chain fatty acids in muscle carnitine deficiency and other LCFA restriction associated with dramatic long-term improvemenet. Neurology 1986, 36:94.
    • (1986) Neurology , vol.36 , pp. 94
    • Engel, W.K.1    Askanas, V.2
  • 74
    • 84922324713 scopus 로고    scopus 로고
    • Toxicity of long-chain fattty acids in muscle carnitine deficiency and remarkable improvement being sustained 21years by strict dietary restriction of LCFAs. An endodissolution phenomenon?
    • Engel W.K., Askanas V. Toxicity of long-chain fattty acids in muscle carnitine deficiency and remarkable improvement being sustained 21years by strict dietary restriction of LCFAs. An endodissolution phenomenon?. Neurology 2003, 60:A465.
    • (2003) Neurology , vol.60 , pp. A465
    • Engel, W.K.1    Askanas, V.2
  • 75
    • 0021042114 scopus 로고
    • Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy
    • Prockop L.D., Engel W.K., Shug A.L. Nearly fatal muscle carnitine deficiency with full recovery after replacement therapy. Neurology 1983, 33:1629-1631.
    • (1983) Neurology , vol.33 , pp. 1629-1631
    • Prockop, L.D.1    Engel, W.K.2    Shug, A.L.3
  • 76
    • 0021952576 scopus 로고
    • Autosomal dominant syndrome of lipid neuromyopathy with normal carnitine: successful treatment with long-chain fatty-acid-free diet
    • Askanas V., Engel W.K., Kwan H.H., Reddy N.B., Husainy T., Carlo J., Siddique T., Schwartzman R.J., Hanna C.J. Autosomal dominant syndrome of lipid neuromyopathy with normal carnitine: successful treatment with long-chain fatty-acid-free diet. Neurology 1985, 35:66-72.
    • (1985) Neurology , vol.35 , pp. 66-72
    • Askanas, V.1    Engel, W.K.2    Kwan, H.H.3    Reddy, N.B.4    Husainy, T.5    Carlo, J.6    Siddique, T.7    Schwartzman, R.J.8    Hanna, C.J.9
  • 77
    • 84922297350 scopus 로고    scopus 로고
    • Clinical and ethnic spectum, laboratory data and epidemiology of h-IBM due to GNE mutations
    • Wiley, V. Askanas, W.K. Engel (Eds.)
    • Argov Z., Nishino I., Nonaka I. Clinical and ethnic spectum, laboratory data and epidemiology of h-IBM due to GNE mutations. Muscle aging, inclusion-body myositis and myopathies 2011, Wiley. V. Askanas, W.K. Engel (Eds.).
    • (2011) Muscle aging, inclusion-body myositis and myopathies
    • Argov, Z.1    Nishino, I.2    Nonaka, I.3
  • 79
    • 0014818105 scopus 로고
    • Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness
    • Griggs R.C., Engel W.K., Resnick J.S. Acetazolamide treatment of hypokalemic periodic paralysis. Prevention of attacks and improvement of persistent weakness. Ann. Intern. Med. 1970, 73:39-48.
    • (1970) Ann. Intern. Med. , vol.73 , pp. 39-48
    • Griggs, R.C.1    Engel, W.K.2    Resnick, J.S.3
  • 80
    • 0014413462 scopus 로고
    • Acetazolamide prophylaxis in hypokalemic periodic paralysis
    • Resnick J.S., Engel W.K., Griggs R.C., Stam A.C. Acetazolamide prophylaxis in hypokalemic periodic paralysis. N. Engl. J. Med. 1968, 278:582-586.
    • (1968) N. Engl. J. Med. , vol.278 , pp. 582-586
    • Resnick, J.S.1    Engel, W.K.2    Griggs, R.C.3    Stam, A.C.4
  • 81
    • 0020582252 scopus 로고
    • Treatment of "permanent" muscle weakness in familial Hypokalemic Periodic Paralysis
    • Dalakas M.C., Engel W.K. Treatment of "permanent" muscle weakness in familial Hypokalemic Periodic Paralysis. Muscle Nerve 1983, 6:182-186.
    • (1983) Muscle Nerve , vol.6 , pp. 182-186
    • Dalakas, M.C.1    Engel, W.K.2
  • 82
    • 0014803187 scopus 로고
    • Tubular aggregates in type II muscle fibers: ultrastructural and histochemical correlation
    • Engel W.K., Bishop D.W., Cunningham G.G. Tubular aggregates in type II muscle fibers: ultrastructural and histochemical correlation. J. Ultrastruct. Res. 1970, 31:507-525.
    • (1970) J. Ultrastruct. Res. , vol.31 , pp. 507-525
    • Engel, W.K.1    Bishop, D.W.2    Cunningham, G.G.3
  • 84
    • 0026072318 scopus 로고
    • Does a retrovirus cause amyotrophic lateral sclerosis?
    • Engel W.K. Does a retrovirus cause amyotrophic lateral sclerosis?. Ann. Neurol. 1991, 30:431-433.
    • (1991) Ann. Neurol. , vol.30 , pp. 431-433
    • Engel, W.K.1
  • 85
    • 0025985493 scopus 로고
    • RNA metabolism in relation to amyotrophic lateral sclerosis
    • Engel W.K. RNA metabolism in relation to amyotrophic lateral sclerosis. Adv. Neurol. 1991, 56:125-153.
    • (1991) Adv. Neurol. , vol.56 , pp. 125-153
    • Engel, W.K.1
  • 86
    • 13344257516 scopus 로고
    • An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?
    • Engel W.K., Kurland L.T., Klatzo I. An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?. Brain 1959, 82:203-220.
    • (1959) Brain , vol.82 , pp. 203-220
    • Engel, W.K.1    Kurland, L.T.2    Klatzo, I.3
  • 87
    • 84922276526 scopus 로고
    • Current research approaches to the amyotrophic lateral sclerosis syndrome. Part I: General hypotheses, uridine, liver, dyslymphocytic mechanisms, B12 plus folate, parathyroid
    • Expansion Scientifique Francaise, Paris, G. Serratrice (Ed.)
    • Engel W.K., Askanas V. Current research approaches to the amyotrophic lateral sclerosis syndrome. Part I: General hypotheses, uridine, liver, dyslymphocytic mechanisms, B12 plus folate, parathyroid. Myélopathies, neuropathies Et myopathies. Advances in neuromuscular diseases 1989, 57-76. Expansion Scientifique Francaise, Paris. G. Serratrice (Ed.).
    • (1989) Myélopathies, neuropathies Et myopathies. Advances in neuromuscular diseases , pp. 57-76
    • Engel, W.K.1    Askanas, V.2
  • 88
    • 4243592450 scopus 로고    scopus 로고
    • Oxidative stress demonstrated histologically in ALS astrocytes, harmonizing with the hypothesis that malfunction of astrocytes may underlie sporadic ALS
    • Engel W.K., Askanas V., Alvarez R.B., Sarkozi E. Oxidative stress demonstrated histologically in ALS astrocytes, harmonizing with the hypothesis that malfunction of astrocytes may underlie sporadic ALS. Neurology 1998, 50:430.
    • (1998) Neurology , vol.50 , pp. 430
    • Engel, W.K.1    Askanas, V.2    Alvarez, R.B.3    Sarkozi, E.4
  • 89
    • 84922322262 scopus 로고    scopus 로고
    • In ALS, viral-dysmetabolic mechanism acting via neuronal-nurturing cells (NNCs) could portend replacement therapy and should be sought by multi-tissue screening for rev-transcriptase (RT) viral tracks
    • Engel W.K. In ALS, viral-dysmetabolic mechanism acting via neuronal-nurturing cells (NNCs) could portend replacement therapy and should be sought by multi-tissue screening for rev-transcriptase (RT) viral tracks. Neuromuscul. Disord. 2008, 74:A465.
    • (2008) Neuromuscul. Disord. , vol.74 , pp. A465
    • Engel, W.K.1
  • 91
    • 84922271822 scopus 로고    scopus 로고
    • Q-Fever IgM-Positivity in 3/5 sALS patients: any pathogenic significance regarding the XYZ Hypothesis
    • Engel W.K. Q-Fever IgM-Positivity in 3/5 sALS patients: any pathogenic significance regarding the XYZ Hypothesis. Ann. Neurol. 2012, 72(16):S68.
    • (2012) Ann. Neurol. , vol.72 , Issue.16 , pp. S68
    • Engel, W.K.1
  • 92
    • 0001940664 scopus 로고
    • Duschenne muscular dystrophy: a histologically based ischemia hypothesis and comparison with experimental ischemia myopathy
    • Wiliams & Wilkins Co, Baltimore
    • Engel W.K. Duschenne muscular dystrophy: a histologically based ischemia hypothesis and comparison with experimental ischemia myopathy. The Striated Muscle 1973, vol. 12:453-472. Wiliams & Wilkins Co, Baltimore.
    • (1973) The Striated Muscle , vol.12 , pp. 453-472
    • Engel, W.K.1
  • 93
    • 3543054982 scopus 로고
    • Integrative histochemical approach to the defect of Duschenne muscular dystrophy
    • American Elsevier Publishing Co, New York, L.P. Rowland (Ed.)
    • Engel W.K. Integrative histochemical approach to the defect of Duschenne muscular dystrophy. Pathogenesis of the human muscular dystrophies 1977, 277-309. American Elsevier Publishing Co, New York. L.P. Rowland (Ed.).
    • (1977) Pathogenesis of the human muscular dystrophies , pp. 277-309
    • Engel, W.K.1
  • 94
    • 0015219671 scopus 로고
    • Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions
    • Mendell J.R., Engel W.K., Derrer E.C. Duchenne muscular dystrophy: functional ischemia reproduces its characteristic lesions. Science 1971, 172:1143-1145.
    • (1971) Science , vol.172 , pp. 1143-1145
    • Mendell, J.R.1    Engel, W.K.2    Derrer, E.C.3
  • 95
    • 0015526126 scopus 로고
    • Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of Duchenne muscular dystrophy
    • Mendell J.R., Engel W.K., Derrer E.C. Increased plasma enzyme concentrations in rats with functional ischaemia of muscle provide a possible model of Duchenne muscular dystrophy. Nature 1972, 239:522-524.
    • (1972) Nature , vol.239 , pp. 522-524
    • Mendell, J.R.1    Engel, W.K.2    Derrer, E.C.3
  • 97
    • 33646708456 scopus 로고
    • Plasma-cell dyscrasic amyloid neuropathy: a parasparafucile phenomenon?
    • Masson Publishing Co, New York, G. Serratice, H. Roux (Eds.)
    • Engel W.K., Trotter J.L. Plasma-cell dyscrasic amyloid neuropathy: a parasparafucile phenomenon?. Peroneal atrophies and related disorders 1979, 339-347. Masson Publishing Co, New York. G. Serratice, H. Roux (Eds.).
    • (1979) Peroneal atrophies and related disorders , pp. 339-347
    • Engel, W.K.1    Trotter, J.L.2
  • 98
    • 1542433326 scopus 로고    scopus 로고
    • Intravenous immunoglobulin (IVIG) - an aften overlooked treatment- produces rapid, remarkable, sustained benefit in "Diabetic Neuropathy Complex", suggesting a dysimmune mechanism
    • Engel W.K. Intravenous immunoglobulin (IVIG) - an aften overlooked treatment- produces rapid, remarkable, sustained benefit in "Diabetic Neuropathy Complex", suggesting a dysimmune mechanism. Ann. Neurol. 1997, 42:414.
    • (1997) Ann. Neurol. , vol.42 , pp. 414
    • Engel, W.K.1
  • 99
    • 1542720562 scopus 로고    scopus 로고
    • Intravenous immunoglobulin G is remarkably beneficial in chronic immune dysschwannian/dysneuronal polyneuropathy, diabetes-2 neuropathy, and potentially in severe acute respiratory syndrome
    • Engel W.K. Intravenous immunoglobulin G is remarkably beneficial in chronic immune dysschwannian/dysneuronal polyneuropathy, diabetes-2 neuropathy, and potentially in severe acute respiratory syndrome. Acta Myol. 2003, 22:97-103.
    • (2003) Acta Myol. , vol.22 , pp. 97-103
    • Engel, W.K.1
  • 100
    • 84885489520 scopus 로고    scopus 로고
    • Longer-term (>3months), IVIG treatment to optimize clinical benefit and cellular protection usually requires an individualized adjustable schedule- not fixed regimentation
    • Engel W.K. Longer-term (>3months), IVIG treatment to optimize clinical benefit and cellular protection usually requires an individualized adjustable schedule- not fixed regimentation. Neuromuscul. Disord. 2006, 16:703-704.
    • (2006) Neuromuscul. Disord. , vol.16 , pp. 703-704
    • Engel, W.K.1
  • 101
    • 84922290538 scopus 로고    scopus 로고
    • Adult onset rod myopathy syndrome: sustained benefit from IVIG and rituximab
    • Mahajan S., Engel W.K., Askanas V., Luthra I., Gupta V. Adult onset rod myopathy syndrome: sustained benefit from IVIG and rituximab. Ann. Neurol. 2011, 70:s39.
    • (2011) Ann. Neurol. , vol.70 , pp. s39
    • Mahajan, S.1    Engel, W.K.2    Askanas, V.3    Luthra, I.4    Gupta, V.5
  • 104
    • 0019434866 scopus 로고
    • Polyneuropathy with monoclonal gammopathy: studies of 11 patients
    • Dalakas M.C., Engel W.K. Polyneuropathy with monoclonal gammopathy: studies of 11 patients. Ann. Neurol. 1981, 10:45-52.
    • (1981) Ann. Neurol. , vol.10 , pp. 45-52
    • Dalakas, M.C.1    Engel, W.K.2
  • 105
    • 0019421476 scopus 로고
    • Chronic relapsing (dysimmune) polyneuropathy: pathogenesis and treatment
    • (Suppl.)
    • Dalakas M.C., Engel W.K. Chronic relapsing (dysimmune) polyneuropathy: pathogenesis and treatment. Ann. Neurol. 1981, 9:134-145. (Suppl.).
    • (1981) Ann. Neurol. , vol.9 , pp. 134-145
    • Dalakas, M.C.1    Engel, W.K.2
  • 107
    • 84885548507 scopus 로고    scopus 로고
    • "Pseudo-lupus", benign neutropenia, and other probable non-worrisome blood-component chantges due to IVIG treatment
    • Engel W.K. "Pseudo-lupus", benign neutropenia, and other probable non-worrisome blood-component chantges due to IVIG treatment. Neuromuscul. Disord. 2006, 16:647-648.
    • (2006) Neuromuscul. Disord. , vol.16 , pp. 647-648
    • Engel, W.K.1
  • 108
    • 25344453063 scopus 로고    scopus 로고
    • In Type-2 Diabetes (D2), diabetic neuropathy and diabeto-2-genetic (D2-Gen) neuropathy are often dysimmune and respond to intravenous IGG (IVIG) treatment
    • Engel W.K. In Type-2 Diabetes (D2), diabetic neuropathy and diabeto-2-genetic (D2-Gen) neuropathy are often dysimmune and respond to intravenous IGG (IVIG) treatment. Neuroscience 2001, A27.
    • (2001) Neuroscience , pp. A27
    • Engel, W.K.1
  • 109
    • 84922332962 scopus 로고    scopus 로고
    • The use of intravenous immunoglobulins in neurology
    • The Parthenon Publishing Group, M.C. Dalakas (Ed.)
    • Engel W.K., Spath The use of intravenous immunoglobulins in neurology. Intravenous immunoglobulins in the third millinnium 2004, 377-382. The Parthenon Publishing Group. M.C. Dalakas (Ed.).
    • (2004) Intravenous immunoglobulins in the third millinnium , pp. 377-382
    • Engel, W.K.1    Spath2
  • 110
    • 0009013271 scopus 로고
    • Diabetic neuropathy
    • W.B. Saunders Company, Philadelphia
    • Thomas P.K., Eliasson S.G. Diabetic neuropathy. Peripheral Neuropathy 1975, vol. 2:956-981. W.B. Saunders Company, Philadelphia.
    • (1975) Peripheral Neuropathy , vol.2 , pp. 956-981
    • Thomas, P.K.1    Eliasson, S.G.2
  • 112
    • 0000345901 scopus 로고
    • Some polyneuropathies (PNs) in insulin-requiring adult-onset diabetes (IRAOD) an benefit remarkably from anti-dysiimune treatments
    • Engel W.K., Prentice A.F. Some polyneuropathies (PNs) in insulin-requiring adult-onset diabetes (IRAOD) an benefit remarkably from anti-dysiimune treatments. Neurology 1993, 43:255-256.
    • (1993) Neurology , vol.43 , pp. 255-256
    • Engel, W.K.1    Prentice, A.F.2
  • 114
    • 0014028306 scopus 로고
    • Muscle lesions in myasthenia gravis. Discussion
    • Engel W.K., McFarlin D.E. Muscle lesions in myasthenia gravis. Discussion. Ann. N. Y. Acad. Sci. 1966, 135:68-78.
    • (1966) Ann. N. Y. Acad. Sci. , vol.135 , pp. 68-78
    • Engel, W.K.1    McFarlin, D.E.2
  • 115
    • 0017096564 scopus 로고
    • Extrajunctional acetylcholine receptors. Alterations in human and experimental neuromuscular diseases
    • Ringel S.P., Bender A.N., Engel W.K. Extrajunctional acetylcholine receptors. Alterations in human and experimental neuromuscular diseases. Arch. Neurol. 1976, 33:751-758.
    • (1976) Arch. Neurol. , vol.33 , pp. 751-758
    • Ringel, S.P.1    Bender, A.N.2    Engel, W.K.3
  • 116
    • 0016904312 scopus 로고
    • Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis
    • Bender A.N., Ringel S.P., Engel W.K., Vogel Z., Daniels M.P. Immunoperoxidase localization of alpha bungarotoxin: a new approach to myasthenia gravis. Ann. N. Y. Acad. Sci. 1976, 274:20-30.
    • (1976) Ann. N. Y. Acad. Sci. , vol.274 , pp. 20-30
    • Bender, A.N.1    Ringel, S.P.2    Engel, W.K.3    Vogel, Z.4    Daniels, M.P.5
  • 117
    • 0017778351 scopus 로고
    • Thymic epithelial cell contains acetylocholine receptor
    • Engel W.K., Trotter J.L., McFarlin D.E. Thymic epithelial cell contains acetylocholine receptor. Lancet 1977, 1:1310-1311.
    • (1977) Lancet , vol.1 , pp. 1310-1311
    • Engel, W.K.1    Trotter, J.L.2    McFarlin, D.E.3
  • 118
    • 0015226910 scopus 로고
    • Myasthenia gravis: a new hypothesis of the pathogenesis and a new form of treatment
    • Engel W.K., Warmolts J.R. Myasthenia gravis: a new hypothesis of the pathogenesis and a new form of treatment. Ann. N. Y. Acad. Sci. 1971, 183:72-87.
    • (1971) Ann. N. Y. Acad. Sci. , vol.183 , pp. 72-87
    • Engel, W.K.1    Warmolts, J.R.2
  • 119
    • 0015495496 scopus 로고
    • Benefit from alternate-day prednisone in myasthenia gravis
    • Warmolts J.R., Engel W.K. Benefit from alternate-day prednisone in myasthenia gravis. N. Engl. J. Med. 1972, 286:17-20.
    • (1972) N. Engl. J. Med. , vol.286 , pp. 17-20
    • Warmolts, J.R.1    Engel, W.K.2
  • 120
    • 0014934129 scopus 로고
    • Alternate-dy prednisone in a patient with myasthenia gravis
    • Warmolts J.R., Engel W.K., Whitaker J.N. Alternate-dy prednisone in a patient with myasthenia gravis. Lancet 1970, 2:1198-1199.
    • (1970) Lancet , vol.2 , pp. 1198-1199
    • Warmolts, J.R.1    Engel, W.K.2    Whitaker, J.N.3
  • 121
    • 0343989909 scopus 로고
    • Total body irradiation in the treatment od intractable polymyosistis and dermatomyositis
    • Butterworths, Boston, M. Dalakas (Ed.)
    • Dalakas M., Engel W.K. Total body irradiation in the treatment od intractable polymyosistis and dermatomyositis. Polymyosistis 1988, 281-292. Butterworths, Boston. M. Dalakas (Ed.).
    • (1988) Polymyosistis , pp. 281-292
    • Dalakas, M.1    Engel, W.K.2
  • 122
    • 0019885782 scopus 로고
    • Polymyositis: remarkable response to total body irradiation
    • Engel W.K., Lichter A.S., Galdi A.P. Polymyositis: remarkable response to total body irradiation. Lancet 1981, 1:658.
    • (1981) Lancet , vol.1 , pp. 658
    • Engel, W.K.1    Lichter, A.S.2    Galdi, A.P.3
  • 123
    • 8544222493 scopus 로고
    • Remarkable improvement sustained 1-2 years following total body irradiation treatment of otherwise intractable adult polymyositis/dermatomyositis
    • Engel W.K., Lichter A.S., Siddique T. Remarkable improvement sustained 1-2 years following total body irradiation treatment of otherwise intractable adult polymyositis/dermatomyositis. Neurology 1982, 32:120.
    • (1982) Neurology , vol.32 , pp. 120
    • Engel, W.K.1    Lichter, A.S.2    Siddique, T.3
  • 124
    • 84885508247 scopus 로고    scopus 로고
    • Fever-responsive dysschwannian neuropathy (FRDN): Interferon-alpha 2a (Interferon α- 2a (Iα)treatment has produced remarkable recovery from total quadriplegia, the benefit now persisting 4years beyond the 14years of therapy
    • Engel W.K. Fever-responsive dysschwannian neuropathy (FRDN): Interferon-alpha 2a (Interferon α- 2a (Iα)treatment has produced remarkable recovery from total quadriplegia, the benefit now persisting 4years beyond the 14years of therapy. Neuromuscul. Disord. 2007, 17:885.
    • (2007) Neuromuscul. Disord. , vol.17 , pp. 885
    • Engel, W.K.1
  • 125
    • 84885508148 scopus 로고
    • Fever-responsive neuropathy (FRN) benefited by long-term interferon alpha-2A (Iα) treatment
    • Engel W.K., Adornato B. Fever-responsive neuropathy (FRN) benefited by long-term interferon alpha-2A (Iα) treatment. Can. J. Neurol. Sci. 1993, 4:S44.
    • (1993) Can. J. Neurol. Sci. , vol.4 , pp. S44
    • Engel, W.K.1    Adornato, B.2
  • 126
    • 0017310212 scopus 로고
    • Letter: Overlooked avian oncornavirus in cultured muscle-functionally significant?
    • Engel W.K., Askanas V. Letter: Overlooked avian oncornavirus in cultured muscle-functionally significant?. Science 1976, 192:1252-1253.
    • (1976) Science , vol.192 , pp. 1252-1253
    • Engel, W.K.1    Askanas, V.2
  • 127
    • 0001313262 scopus 로고
    • Nemaline myopathy. A new congenital myopathy
    • Shy G.M., Engel W.K., Somers J.E., Wanko T. Nemaline myopathy. A new congenital myopathy. Brain 1963, 86:793-810.
    • (1963) Brain , vol.86 , pp. 793-810
    • Shy, G.M.1    Engel, W.K.2    Somers, J.E.3    Wanko, T.4
  • 131
    • 84922297347 scopus 로고    scopus 로고
    • Nemaline myopathy and related diseases: genetics, diagnosis and theraphy
    • Laing N.G. Nemaline myopathy and related diseases: genetics, diagnosis and theraphy. J. Neuromuscul. Dis. 2014, 1:S38-S39.
    • (2014) J. Neuromuscul. Dis. , vol.1 , pp. S38-S39
    • Laing, N.G.1
  • 132
    • 79953830103 scopus 로고    scopus 로고
    • Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
    • Mahajan S., Engel W.K. Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2010, 75:1397-1398.
    • (2010) Neurology , vol.75 , pp. 1397-1398
    • Mahajan, S.1    Engel, W.K.2
  • 133
    • 84885562354 scopus 로고
    • Syndrome of continuous motor unit activity responsible to immunosupression suggest dysimmune pathogenesis
    • Engel W.K., Misra A.K., Alexander S.J. Syndrome of continuous motor unit activity responsible to immunosupression suggest dysimmune pathogenesis. Neurology 1990, 40:118.
    • (1990) Neurology , vol.40 , pp. 118
    • Engel, W.K.1    Misra, A.K.2    Alexander, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.