Genome mining-directed activation of a silent angucycline biosynthetic gene cluster in Streptomyces chattanoogensis

ChemBioChem

Volumn 16, Issue 3, 2015, Pages 496-502

  Zhou, Zhenxing ^a   Xu, Qingqing ^a   Bu, Qingting ^a   Guo, Yuanyang ^a   Liu, Shuiping ^a   Liu, Yu ^a   Du, Yiling ^a,c   Li, Yongquan ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b Key Laboratory of Microbial Biochemistry and Metabolism Engineering of Zhejiang Province   (China)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antitumor agents; Gene engineering; Genome mining; Polyketides; Transcriptional regulator

Indexed keywords

ANTIBIOTIC AGENT; CHATTAMYCIN A; CHATTAMYCIN B; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; ANTINEOPLASTIC ANTIBIOTIC; BENZ[A]ANTHRACENE DERIVATIVE; GLYCOSIDE; OLIGOSACCHARIDE;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GENE; BACTERIAL GENOME; BIOINFORMATICS; CANCER CELL LINE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ESCHERICHIA COLI K 12; GENE CLUSTER; GENE OVEREXPRESSION; GENE SEQUENCE; HEPG2 CELL LINE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES CHATTANOOGENSIS; BIOSYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DATA MINING; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MCF 7 CELL LINE; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MULTIGENE FAMILY; PROCEDURES; PROMOTER REGION;

ACTINOBACTERIA (CLASS); STREPTOMYCES CHATTANOOGENSIS;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; BENZ(A)ANTHRACENES; COMPUTER SIMULATION; DATA MINING; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; GLYCOSIDES; HEP G2 CELLS; HUMANS; MCF-7 CELLS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; OLIGOSACCHARIDES; PROMOTER REGIONS, GENETIC; STREPTOMYCES;

EID: 84922311253     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402577     Document Type: Article

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