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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 2, 2015, Pages 372-377

Liver X Receptor (LXR) partial agonists: Biaryl pyrazoles and imidazoles displaying a preference for LXRβ

(20) Kick, Ellen a Martin, Richard b Xie, Yinong b Flatt, Brenton b Schweiger, Edwin b Wang, Tie Lin b Busch, Brett b Nyman, Michael b Gu, Xiao Hui b Yan, Grace b Wagner, Brandee b Nanao, Max b Nguyen, Lam b Stout, Thomas b Plonowski, Artur b Schulman, Ira b Ostrowski, Jacek a Kirchgessner, Todd a Wexler, Ruth a Mohan, Raju b

a BRISTOL MYERS SQUIBB (United States)

b EXELIXIS INC (United States)

Author keywords

ABCA1; Liver X Receptor; LXR; Nuclear hormone receptor; Partial agonist

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; BIARYL PYRAZOLE DERIVATIVE; IMIDAZOLE DERIVATIVE; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR BETA; LIVER X RECEPTOR PARTIAL AGONIST; PYRAZOLE DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 2-(2-(1-(2-CHLOROPHENYL)-1-METHYLETHYL)-1-(3'-(METHYLSULFONYL)-4-BIPHENYLYL)-1H-IMIDAZOL-4-YL)-2-PROPANOL; LIVER X RECEPTOR; ORPHAN NUCLEAR RECEPTOR; SULFONE;

ARTICLE; BLOOD; DRUG SYNTHESIS; EC50; HUMAN; MOUSE; NONHUMAN; PLASMA; AGONISTS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; LIVER; METABOLISM; PARTIAL AGONISM; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

MUS;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; DRUG PARTIAL AGONISM; HUMANS; IMIDAZOLES; LIVER; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORPHAN NUCLEAR RECEPTORS; PLASMA; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES; TISSUE DISTRIBUTION; TRIGLYCERIDES;

EID: 84922309746 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.11.029 Document Type: Article

Times cited : (37)

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