Genome-wide CNV analysis in 221 unrelated patients and targeted high-throughput sequencing reveal novel causative candidate genes for colorectal adenomatous polyposis

International Journal of Cancer

Volumn 136, Issue 6, 2015, Pages E578-E589

  Horpaopan, Sukanya ^a   Spier, Isabel ^a   Zink, Alexer M ^a   Altmüller, Janine ^b   Holzapfel, Stefanie ^a   Laner, Andreas ^c   Vogt, Stefanie ^a,d   Uhlhaas, Siegfried ^a   Heilmann, Stefanie ^a   Stienen, Dietlinde ^a   Pasternack, Sra M ^a   Keppler, Kathleen ^a   Adam, Ronja ^a   Kayser, Katrin ^a   Moebus, Susanne ^e   Draaken, Markus ^a   Degenhardt, Franziska ^a   Engels, Hartmut ^a   Hofmann, Andrea ^a   Nöthen, Markus M ^a   Steinke, Verena ^a   Perez Bouza, Alberto ^f   Herms, Stefan ^a,g   Holinski Feder, Elke ^c,h   Fröhlich, Holger ^a   Thiele, Holger ^b   Hoffmann, Per ^a,g   Aretz, Stefan ^a   more..

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c MGZ Center of Medical Genetics   (Germany)

^d MVZ Labor Dr Eberhard and Partner   (Germany)

^e UNIVERSITY HOSPITAL ESSEN   (Germany)

^f UNIVERSITY HOSPITAL BONN   (Germany)

^g UNIVERSITY HOSPITAL BASEL   (Switzerland)

^h LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Candidate genes; Copy number variation; Gastrointestinal polyposis; Genetic cause; Hereditary colorectal cancer; Next generation sequencing; Unexplained polyposis

Indexed keywords

BETA CATENIN; GENOMIC DNA; WNT PROTEIN; CTNNB1 PROTEIN, HUMAN; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; HEAT SHOCK PROTEIN 110; HSPH1 PROTEIN, HUMAN; KIF26B PROTEIN, HUMAN; KINESIN; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE; TESK2 PROTEIN, HUMAN;

ADULT; AGED; APC GENE; ARHGAP GENE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; BREAST CANCER; CELL FUNCTION; CNTN6 GENE; COHORT ANALYSIS; COLON CARCINOGENESIS; COLORECTAL CANCER; COLORECTAL POLYP; CONTROLLED STUDY; COPY NUMBER VARIATION; FAMILIAL COLON POLYPOSIS; FOCAD GENE; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE SEGREGATION; GENE SEQUENCE; GENETIC CODE; GENETIC PREDISPOSITION; GENOME ANALYSIS; GENOTYPE; GERM LINE; GERMAN (CITIZEN); HIGH THROUGHPUT SEQUENCING; HSPH1 GENE; HUMAN; HUMAN GENOME; KIF26B GENE; MAJOR CLINICAL STUDY; MCM3AP GENE; MOLECULAR GENETICS; MULTIGENE FAMILY; MUTYH GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; ONCOGENE CTNNB1; ONSET AGE; POINT MUTATION; POPULATION GENETICS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR GENE; YBEY GENE; ADOLESCENT; CHILD; COLON POLYPOSIS; GENETIC ASSOCIATION; GENETICS; MIDDLE AGED;

ADENOMATOUS POLYPOSIS COLI; ADOLESCENT; ADULT; AGED; BETA CATENIN; CHILD; DNA COPY NUMBER VARIATIONS; DNA GLYCOSYLASES; GENOME-WIDE ASSOCIATION STUDY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HSP110 HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINESIN; MIDDLE AGED; PROTEIN-SERINE-THREONINE KINASES;

EID: 84922269040     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29215     Document Type: Article

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