Kinase activator-receiver preference in erbb heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry

Journal of Biological Chemistry

Volumn 290, Issue 3, 2015, Pages 1570-1579

  Ward, Matthew D ^a   Leahy, Daniel J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL SIGNALING; ENZYME ACTIVITY; LIGANDS; PROTEINS;

ASYMMETRIC DIMERS; ESSENTIAL FEATURES; EXTRACELLULAR; EXTRACELLULAR REGION; HETERODIMERS; RECEIVER ORIENTATION; RECEPTOR TYROSINE KINASE; TYROSINE KINASE;

ENZYMES;

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; HETERODIMER; ERBB2 PROTEIN, HUMAN; ERBB4 PROTEIN, HUMAN; LIGAND; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CELLULAR PARAMETERS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STABILITY; EXTRACELLULAR ASYMMETRY; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR INTERACTION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL MEMBRANE; DROSOPHILA MELANOGASTER; HUMAN; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PLASMID; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; RAT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CELL MEMBRANE; DROSOPHILA MELANOGASTER; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-4; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 84922243676     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.612085     Document Type: Article

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