Nanoparticle delivery of HIF1α siRNA combined with photodynamic therapy as a potential treatment strategy for head-and-neck cancer

Cancer Letters

Volumn 359, Issue 1, 2015, Pages 65-74

  Chen, Wei Hua ^a   Lecaros, Rumwald Leo G ^a   Tseng, Yu Cheng ^b   Huang, Leaf ^a,b   Hsu, Yih Chih ^a  

^a CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^b University of North Carolina   (United States)

Author keywords

Drug delivery; Gene silencing; Gene therapy; Nanoparticle; Photodynamic therapy

Indexed keywords

CASPASE 3; CD31 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPID CALCIUM PHOSPHATE NANOPARTICLE; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; HIF1A PROTEIN, HUMAN; SIGMA OPIATE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GENE THERAPY; CANCER INHIBITION; CANCER REGRESSION; CANCER TISSUE; CELL PROLIFERATION; CELL TRANSPORT; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; HEAD AND NECK CANCER; HIF1ALPHA GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NICK END LABELING; NONHUMAN; PHOTODYNAMIC THERAPY; PROTEIN EXPRESSION; TOXICITY ASSAY; TUMOR VOLUME; ANIMAL; CARCINOMA, SQUAMOUS CELL; DRUG SCREENING; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HEAD AND NECK NEOPLASMS; METABOLISM; MOUTH NEOPLASMS; MULTIMODALITY CANCER THERAPY; NUDE MOUSE; PATHOLOGY; PHOTOCHEMOTHERAPY; PROCEDURES; RNA INTERFERENCE; TIME; TUMOR CELL LINE;

MUS;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; FEMALE; GENETIC THERAPY; HEAD AND NECK NEOPLASMS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, NUDE; MOUTH NEOPLASMS; NANOPARTICLES; PHOTOCHEMOTHERAPY; RECEPTORS, SIGMA; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84922242351     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.12.052     Document Type: Article

References (27)

1. Wamakulasuriya S. Global epidemiology if oral and oropharyngeal cancer. Oral Oncol 2009, 45:309-316.
2. Dolmans D.E., Fukumura D., Jain R.K. Photodynamic therapy for cancer. Nat. Rev. Cancer 2003, 3:380-387.
3. Grant W.E., Hopper C., MacRobert A.J., Speight P.M., Bown S.G. Photodynamic therapy of oral cancer: photosensitisation with systemic aminolaevulinic acid. Lancet 1993, 342:147-148.
4. Fan K.F., Hopper C., Speight P.M., Buonaccorsi G., MacRobert A.J., Bown S.G. Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity. Cancer 1996, 78:1374-1383.
5. Chen H.M., Chen C.T., Yang H., Lee M.I., Kuo M.Y., Kuo Y.S., et al. Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy. J. Oral Pathol. Med 2005, 34:253-256.
6. Kalka K., Merk H., Mukhtar H. Photodynamic therapy in dermatology. J. Am. Acad. Dermatol 2000, 42:389-413.
7. Dolmans D.E., Kadambi A., Hill J.S., Waters C.A., Robinson B.C., Walker J.P., et al. Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy. Cancer Res 2002, 62:2151-2156.
8. Chiang C.P., Huang W.T., Lee J.W., Hsu Y.C. Effective treatment of DMBA-induced hamster buccal cancer lesions by topical photosan-mediated photodynamic therapy. Head Neck 2012, 34:505-512.
9. Zhang Q., Zhang Z.F., Rao J.Y., Sato D., Brown J., Messadi D.V., et al. Treatment with siRNA and antisense oligonucleotides targeted to HIF-1α induced apoptosis in human tongue squamous cell carcinoma. Int. J. Cancer 2004, 111:849-857.
10. Hsu Y.C., Yang D.F., Chiang C.P., Lee J.W., Tseng M.K. Successful treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical 5-aminolevulinic acid-mediated photodynamic therapy. Photodiagnosis Photodyn. Ther 2012, 9:310-318.
11. Yang Y., Li J., Liu F., Huang L. Systemic delivery of siRNA via LCP nanoparticle efficiently inhibits lung metastasis. Mol. Ther 2012, 20:609-615.
12. Li J., Chen Y.C., Tseng Y.C., Mozumdar S., Huang L. Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery. J. Control Release 2010, 142:416-421.
13. Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1984, 49:6449-6465.
14. Höckel M., Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst 2001, 93:266-276.
15. Li J., Yang Y., Huang L. Calcium phosphate nanoparticles with an asymmetric lipid bilayer coating for siRNA delivery to the tumor. J. Control. Release 2012, 158:108-214.
16. Zhang M., Ishii A., Nishiyama N., Matsumoto S., Ishii T., Yamasaki Y., et al. PEGylated calcium phosphate nanocomposites as smart environment-sensitive carriers for siRNA delivery. Adv. Mater 2009, 21:3520-3525.
17. Huang L., Liu Y. In vivo delivery of RNAi with lipid-based nanoparticles. Annu. Rev. Biomed. Eng 2011, 13:507-530.
18. Tabaković A., Kester M., Adair J.H. Calcium phosphate-based composite nanoparticles in bioimaging and therapeutic delivery applications. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol 2012, 4:96-112.
19. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100nm polymeric micelles in poorly permeable tumours depends on size. Nat. Nanotechnol 2011, 6:815-823.
20. Liu Y., Tseng Y.C., Huang L. Biodistribution studies of nanoparticles using fluorescence imaging: a qualitative or quantitative method?. Pharm. Res 2012, 29:3273-3277.
21. Maier A., Tomaselli F., Matzi V., Woltsche M., Anegg U., Fell B., et al. Comparison of 5-aminolaevulinic acid and porphyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study. Lasers Surg. Med 2002, 30:1-17.
22. Feyh J. Photodynamic treatment for cancers of the head and neck. J. Photochem. Photobiol. B, Biol 1996, 36:175-177.
23. Ferrario A., Tiehl K.F., Rucker N., Schwarz M.A., Gill P.S., Gomer C.J. Antiangiogenic treatment enhances photodynamic therapy responsiveness in a mouse mammary carcinoma. Cancer Res 2000, 60:4066-4069.
24. 2 from cells by photodynamic treatment in vitro. Cancer Res 1989, 49:6896-6900.
25. Kietzmann T., Gorlach A. Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression. Semin. Cell Dev. Biol 2005, 16:474-486.
26. Sasabe E., Tatemoto Y., Li D., Yamamoto T., Osaki T. Mechanism of HIF-1α-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci 2005, 96:394-402.
27. Sasabe E., Zhou X., Li D., Oku N., Yamamoto T., Osaki T. The involvement of hypoxia-inducible factor-1α in the susceptibility to γ-rays and chemotherapeutic drugs of oral squamous cell carcinoma cells. Int. J. Cancer 2006, 120:268-277.