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Volumn 29, Issue 2, 2015, Pages 138-143

Schizophrenia biomarkers: Translating the descriptive into the diagnostic

Author keywords

biomarker; epigenetics; inflammation; metabolism; metabolomics; methylomics; microarray; neurodevelopment; oxidative stress; Schizophrenia; transcriptomics

Indexed keywords

ALLANTOIN; BIOLOGICAL MARKER; CITRIC ACID; CLOZAPINE; CYCLOOXYGENASE 2; CYSTEINE; GAMMA INTERFERON; GLUTAMIC ACID; HALOPERIDOL; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INOSITOL; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LACTIC ACID; PALMITIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROLINE; RISPERIDONE; TRANSFORMING GROWTH FACTOR BETA; TRIACYLGLYCEROL; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; URIC ACID;

EID: 84922229396     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881114566631     Document Type: Article
Times cited : (42)

References (45)
  • 1
    • 84871404318 scopus 로고    scopus 로고
    • Mbd-Seq as a cost-effective approach for methylome-wide association studies: Demonstration in 1500 case-control samples
    • Aberg KA, Mcclay JL, Nerella S, et al. Mbd-Seq as a cost-effective approach for methylome-wide association studies: Demonstration in 1500 case-control samples. Epigenomics. 2013 ; 4: 605-621
    • (2013) Epigenomics , vol.4 , pp. 605-621
    • Aberg, K.A.1    McClay, J.L.2    Nerella, S.3
  • 2
    • 84922250537 scopus 로고    scopus 로고
    • Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: Differential involvement of immune-related gene loci
    • Andreassen OA, Harbo HF, Wang Y, et al. Genetic pleiotropy between multiple sclerosis and schizophrenia but not bipolar disorder: differential involvement of immune-related gene loci. Mol Psychiatry. 2014 ;:
    • (2014) Mol Psychiatry
    • Andreassen, O.A.1    Harbo, H.F.2    Wang, Y.3
  • 3
    • 84888300066 scopus 로고    scopus 로고
    • Two gene co-expression modules differentiate psychotics and controls
    • Chen C, Cheng L, Grennan K, et al. Two gene co-expression modules differentiate psychotics and controls. Mol Psychiatry. 2012 ; 18: 1308-1314
    • (2012) Mol Psychiatry , vol.18 , pp. 1308-1314
    • Chen, C.1    Cheng, L.2    Grennan, K.3
  • 4
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. The Lancet. 2013 ; 381: 1371-1379
    • (2013) The Lancet , vol.381 , pp. 1371-1379
  • 5
    • 81255142524 scopus 로고    scopus 로고
    • Two patients walk into a clinic. A genomics perspective on the future of schizophrenia
    • Corvin AP. Two patients walk into a clinic. A genomics perspective on the future of schizophrenia. BMC Biol. 2012 ; 9: 77
    • (2012) BMC Biol , vol.9 , pp. 77
    • Corvin, A.P.1
  • 6
    • 84862992566 scopus 로고    scopus 로고
    • A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes
    • De Jong S, Boks MP, Fuller TF, et al. A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. PLoS One. 2012 ; 7: e39498
    • (2012) PLoS One , vol.7 , pp. 39498
    • De Jong, S.1    Boks, M.P.2    Fuller, T.F.3
  • 7
    • 84897021305 scopus 로고    scopus 로고
    • Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment
    • De Witte L, Tomasik J, Schwarz E, et al. Cytokine alterations in first-episode schizophrenia patients before and after antipsychotic treatment. Schizophr Res. 2014 ; 154: 23-29
    • (2014) Schizophr Res , vol.154 , pp. 23-29
    • De Witte, L.1    Tomasik, J.2    Schwarz, E.3
  • 8
    • 84895429352 scopus 로고    scopus 로고
    • Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: An observational study of 17,345 persons
    • Fischer K, Kettunen J, Wurtz P, et al. Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: An observational study of 17,345 persons. PLoS Med. 2014 ; 11: e1001606
    • (2014) PLoS Med , vol.11 , pp. 1001606
    • Fischer, K.1    Kettunen, J.2    Wurtz, P.3
  • 9
    • 84882647130 scopus 로고    scopus 로고
    • Meta-analysis of oxidative stress in schizophrenia
    • Flatow J, Buckley P, Miller BJ. Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry. 2013 ; 74: 400-409
    • (2013) Biol Psychiatry , vol.74 , pp. 400-409
    • Flatow, J.1    Buckley, P.2    Miller, B.J.3
  • 10
    • 84895756733 scopus 로고    scopus 로고
    • Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizophrenia
    • Garcia-Bueno B, Bioque M, Mac-Dowell KS, et al. Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull. 2013 ; 40: 376-387
    • (2013) Schizophr Bull , vol.40 , pp. 376-387
    • Garcia-Bueno, B.1    Bioque, M.2    Mac-Dowell, K.S.3
  • 11
    • 84874424599 scopus 로고    scopus 로고
    • Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    • Gardiner EJ, Cairns MJ, Liu B, et al. Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells. J Psychiatr Res. 2013 ; 47: 425-437
    • (2013) J Psychiatr Res , vol.47 , pp. 425-437
    • Gardiner, E.J.1    Cairns, M.J.2    Liu, B.3
  • 12
    • 84877038323 scopus 로고    scopus 로고
    • Schizophrenia: Metabolic aspects of aetiology, diagnosis and future treatment strategies
    • Harris LW, Guest PC, Wayland MT, et al. Schizophrenia: Metabolic aspects of aetiology, diagnosis and future treatment strategies. Psychoneuroendocrinology. 2013 ; 38: 752-766
    • (2013) Psychoneuroendocrinology , vol.38 , pp. 752-766
    • Harris, L.W.1    Guest, P.C.2    Wayland, M.T.3
  • 13
    • 84868112176 scopus 로고    scopus 로고
    • Comparison of peripheral and central schizophrenia biomarker profiles
    • Harris LW, Pietsch S, Cheng TM, et al. Comparison of peripheral and central schizophrenia biomarker profiles. PLoS One. 2012 ; 7: e46368
    • (2012) PLoS One , vol.7 , pp. 46368
    • Harris, L.W.1    Pietsch, S.2    Cheng, T.M.3
  • 14
    • 84869191745 scopus 로고    scopus 로고
    • Schizophrenia shows a unique metabolomics signature in plasma
    • He Y, Yu Z, Giegling I, et al. Schizophrenia shows a unique metabolomics signature in plasma. Transl Psychiatry. 2012 ; 2: e149
    • (2012) Transl Psychiatry , vol.2 , pp. 149
    • He, Y.1    Yu, Z.2    Giegling, I.3
  • 15
    • 84925341418 scopus 로고    scopus 로고
    • Plasma proteins predict conversion to dementia from prodromal disease
    • Hye A, Riddoch-Contreras J, Baird AL, et al. Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement. 2014 ; 10: 799-807
    • (2014) Alzheimers Dement , vol.10 , pp. 799-807
    • Hye, A.1    Riddoch-Contreras, J.2    Baird, A.L.3
  • 16
    • 84868642991 scopus 로고    scopus 로고
    • Impaired plasmalogens in patients with schizophrenia
    • Kaddurah-Daouk R, Mcevoy J, Baillie R, et al. Impaired plasmalogens in patients with schizophrenia. Psychiatry Res. 2012 ; 198: 347-352
    • (2012) Psychiatry Res , vol.198 , pp. 347-352
    • Kaddurah-Daouk, R.1    McEvoy, J.2    Baillie, R.3
  • 17
    • 84867570315 scopus 로고    scopus 로고
    • Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia
    • Kumarasinghe N, Tooney PA, Schall U. Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia. Aust N Z J Psychiatry. 2012 ; 46: 598-610
    • (2012) Aust N Z J Psychiatry , vol.46 , pp. 598-610
    • Kumarasinghe, N.1    Tooney, P.A.2    Schall, U.3
  • 18
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide Snps
    • Lee SH, Ripke S, Neale BM, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide Snps. Nat Genet. 2013 ; 45: 984-994
    • (2013) Nat Genet , vol.45 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3
  • 19
    • 84901246368 scopus 로고    scopus 로고
    • De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability
    • McCarthy SE, Gillis J, Kramer M, et al. De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability. Mol Psychiatry. 2014 ; 19: 652-658
    • (2014) Mol Psychiatry , vol.19 , pp. 652-658
    • McCarthy, S.E.1    Gillis, J.2    Kramer, M.3
  • 20
    • 84883066157 scopus 로고    scopus 로고
    • Coding and noncoding gene expression biomarkers in mood disorders and schizophrenia
    • Mamdani F, Martin MV, Lencz T, et al. Coding and noncoding gene expression biomarkers in mood disorders and schizophrenia. Dis Markers. 2013 ; 35: 11-21
    • (2013) Dis Markers , vol.35 , pp. 11-21
    • Mamdani, F.1    Martin, M.V.2    Lencz, T.3
  • 21
    • 84898447902 scopus 로고    scopus 로고
    • Plasma phospholipids identify antecedent memory impairment in older adults
    • Mapstone M, Cheema AK, Fiandaca MS, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014 ; 20: 415-418
    • (2014) Nat Med , vol.20 , pp. 415-418
    • Mapstone, M.1    Cheema, A.K.2    Fiandaca, M.S.3
  • 22
    • 84872370317 scopus 로고    scopus 로고
    • Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls
    • Maschietto M, Silva AR, Puga RD, et al. Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls. Psychiatry Res. 2012 ; 200: 1018-1021
    • (2012) Psychiatry Res , vol.200 , pp. 1018-1021
    • Maschietto, M.1    Silva, A.R.2    Puga, R.D.3
  • 23
    • 84861775810 scopus 로고    scopus 로고
    • Epigenetic aberrations in leukocytes of patients with schizophrenia: Association of global DNA methylation with antipsychotic drug treatment and disease onset
    • Melas PA, Rogdaki M, Osby U, et al. Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset. FASEB J. 2012 ; 26: 2712-2718
    • (2012) FASEB J , vol.26 , pp. 2712-2718
    • Melas, P.A.1    Rogdaki, M.2    Osby, U.3
  • 24
    • 84865837474 scopus 로고    scopus 로고
    • Immune system gene dysregulation in autism and schizophrenia
    • Michel M, Schmidt MJ, Mirnics K. Immune system gene dysregulation in autism and schizophrenia. Dev Neurobiol. 2013 ; 72: 1277-1287
    • (2013) Dev Neurobiol , vol.72 , pp. 1277-1287
    • Michel, M.1    Schmidt, M.J.2    Mirnics, K.3
  • 25
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • Mill J, Tang T, Kaminsky Z, et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet. 2008 ; 82: 696-711
    • (2008) Am J Hum Genet , vol.82 , pp. 696-711
    • Mill, J.1    Tang, T.2    Kaminsky, Z.3
  • 26
    • 80052853015 scopus 로고    scopus 로고
    • Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects
    • Miller BJ, Buckley P, Seabolt W, et al. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry. 2011 ; 70: 663-671
    • (2011) Biol Psychiatry , vol.70 , pp. 663-671
    • Miller, B.J.1    Buckley, P.2    Seabolt, W.3
  • 27
    • 84884556157 scopus 로고    scopus 로고
    • Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls
    • Mistry M, Gillis J, Pavlidis P. Meta-analysis of gene coexpression networks in the post-mortem prefrontal cortex of patients with schizophrenia and unaffected controls. BMC Neurosci. 2013 ; 14: 105
    • (2013) BMC Neurosci , vol.14 , pp. 105
    • Mistry, M.1    Gillis, J.2    Pavlidis, P.3
  • 28
    • 84880598197 scopus 로고    scopus 로고
    • DNA methylation in schizophrenia: Progress and challenges of epigenetic studies
    • Nishioka M, Bundo M, Kasai K, et al. DNA methylation in schizophrenia: Progress and challenges of epigenetic studies. Genome Med. 2013 ; 4: 96
    • (2013) Genome Med , vol.4 , pp. 96
    • Nishioka, M.1    Bundo, M.2    Kasai, K.3
  • 29
    • 84875422528 scopus 로고    scopus 로고
    • Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia
    • Nishioka M, Bundo M, Koike S, et al. Comprehensive DNA methylation analysis of peripheral blood cells derived from patients with first-episode schizophrenia. J Hum Genet. 2013 ; 58: 91-97
    • (2013) J Hum Genet , vol.58 , pp. 91-97
    • Nishioka, M.1    Bundo, M.2    Koike, S.3
  • 30
    • 79953072214 scopus 로고    scopus 로고
    • Metabolome in schizophrenia and other psychotic disorders: A general population-based study
    • Oresic M, Tang J, Seppanen-Laakso T, et al. Metabolome in schizophrenia and other psychotic disorders: A general population-based study. Genome Med. 2011 ; 3: 19
    • (2011) Genome Med , vol.3 , pp. 19
    • Oresic, M.1    Tang, J.2    Seppanen-Laakso, T.3
  • 31
    • 19944422061 scopus 로고    scopus 로고
    • A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
    • Paik S, Shak S, Tang G, et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med. 2004 ; 351: 2817-2826
    • (2004) N Engl J Med , vol.351 , pp. 2817-2826
    • Paik, S.1    Shak, S.2    Tang, G.3
  • 32
    • 84866919007 scopus 로고    scopus 로고
    • A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia
    • Perez-Santiago J, Diez-Alarcia R, Callado LF, et al. A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia. J Psychiatr Res. 2013 ; 46: 1464-1474
    • (2013) J Psychiatr Res , vol.46 , pp. 1464-1474
    • Perez-Santiago, J.1    Diez-Alarcia, R.2    Callado, L.F.3
  • 33
    • 80053446248 scopus 로고    scopus 로고
    • Progress in defining the biological causes of schizophrenia
    • Pickard B. Progress in defining the biological causes of schizophrenia. Expert Rev Mol Med. 2011 ; 13: e25
    • (2011) Expert Rev Mol Med , vol.13 , pp. 25
    • Pickard, B.1
  • 34
    • 84928650714 scopus 로고    scopus 로고
    • Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
    • Ruderfer DM, Fanous AH, Ripke S, et al. Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia. Mol Psychiatry. 2014 ; 19: 1017-1024
    • (2014) Mol Psychiatry , vol.19 , pp. 1017-1024
    • Ruderfer, D.M.1    Fanous, A.H.2    Ripke, S.3
  • 35
    • 84884672482 scopus 로고    scopus 로고
    • Inflammatory and immune response genes have significantly altered expression in schizophrenia
    • Sainz J, Mata I, Barrera J, et al. Inflammatory and immune response genes have significantly altered expression in schizophrenia. Mol Psychiatry. 2013 ; 18: 1056-1057
    • (2013) Mol Psychiatry , vol.18 , pp. 1056-1057
    • Sainz, J.1    Mata, I.2    Barrera, J.3
  • 36
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014 ; 511: 421-427
    • (2014) Nature , vol.511 , pp. 421-427
  • 37
    • 84902580183 scopus 로고    scopus 로고
    • Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways
    • Schwarz E, Van Beveren NJ, Ramsey J, et al. Identification of subgroups of schizophrenia patients with changes in either immune or growth factor and hormonal pathways. Schizophr Bull. 2014 ; 40: 787-795
    • (2014) Schizophr Bull , vol.40 , pp. 787-795
    • Schwarz, E.1    Van Beveren, N.J.2    Ramsey, J.3
  • 38
    • 77952674096 scopus 로고    scopus 로고
    • Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures
    • Takahashi M, Hayashi H, Watanabe Y, et al. Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures. Schizophr Res. 2010 ; 119: 210-218
    • (2010) Schizophr Res , vol.119 , pp. 210-218
    • Takahashi, M.1    Hayashi, H.2    Watanabe, Y.3
  • 39
    • 84883131934 scopus 로고    scopus 로고
    • Biomarkers in schizophrenia: A brief conceptual consideration
    • Weickert CS, Weickert TW, Pillai A, et al. Biomarkers in schizophrenia: A brief conceptual consideration. Dis Markers. 2013 ; 35: 3-9
    • (2013) Dis Markers , vol.35 , pp. 3-9
    • Weickert, C.S.1    Weickert, T.W.2    Pillai, A.3
  • 40
    • 0037452790 scopus 로고    scopus 로고
    • Individuality and variation in gene expression patterns in human blood
    • Whitney AR, Diehn M, Popper SJ, et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A. 2003 ; 100: 1896-1901
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1896-1901
    • Whitney, A.R.1    Diehn, M.2    Popper, S.J.3
  • 41
    • 84893135952 scopus 로고    scopus 로고
    • Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
    • Wockner LF, Noble EP, Lawford BR, et al. Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients. Transl Psychiatry. 2014 ; 4: e339
    • (2014) Transl Psychiatry , vol.4 , pp. 339
    • Wockner, L.F.1    Noble, E.P.2    Lawford, B.R.3
  • 42
    • 84899733036 scopus 로고    scopus 로고
    • The DNA Methylome and transcriptome of different brain regions in schizophrenia and bipolar disorder
    • Xiao Y, Camarillo C, Ping Y, et al. The DNA Methylome and transcriptome of different brain regions in schizophrenia and bipolar disorder. PLoS One. 2014 ; 9: e95875
    • (2014) PLoS One , vol.9 , pp. 95875
    • Xiao, Y.1    Camarillo, C.2    Ping, Y.3
  • 43
    • 84858150703 scopus 로고    scopus 로고
    • Methylomedb: A database of DNA methylation profiles of the brain
    • Xin Y, Chanrion B, O'Donnell AH, et al. Methylomedb: A database of DNA methylation profiles of the brain. Nucleic Acids Res. 2012 ; 40: D1245 - D1249
    • (2012) Nucleic Acids Res , vol.40 , pp. 1245-D1249
    • Xin, Y.1    Chanrion, B.2    O'Donnell, A.H.3
  • 44
    • 82755181967 scopus 로고    scopus 로고
    • Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action
    • Xuan J, Pan G, Qiu Y, et al. Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action. J Proteome Res. 2012 ; 10: 5433-5443
    • (2012) J Proteome Res , vol.10 , pp. 5433-5443
    • Xuan, J.1    Pan, G.2    Qiu, Y.3
  • 45
    • 84871291341 scopus 로고    scopus 로고
    • Potential metabolite markers of schizophrenia
    • Yang J, Chen T, Sun L, et al. Potential metabolite markers of schizophrenia. Mol Psychiatry. 2013 ; 18: 67-78
    • (2013) Mol Psychiatry , vol.18 , pp. 67-78
    • Yang, J.1    Chen, T.2    Sun, L.3


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