메뉴 건너뛰기




Volumn 8, Issue 12, 2014, Pages

High Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery

Author keywords

[No Author keywords available]

Indexed keywords

AMIODARONE; ANTITRICHOMONAL AGENT; BENZNIDAZOLE; BISOPROLOL; CARVEDILOL; E 1224; ML 341; NEU 321; NIFURTIMOX; POSACONAZOLE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; PROTOZOAL DNA;

EID: 84922212134     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0003259     Document Type: Article
Times cited : (37)

References (60)
  • 1
    • 77954187759 scopus 로고    scopus 로고
    • Chagas disease: a new worldwide challenge
    • Coura JR, Vinas PA, (2010) Chagas disease: a new worldwide challenge. Nature 465: S6–7.
    • (2010) Nature , vol.465 , pp. 6-7
    • Coura, J.R.1    Vinas, P.A.2
  • 5
    • 78751534394 scopus 로고    scopus 로고
    • Trypanocidal drugs: mechanisms, resistance and new targets
    • Wilkinson SR, Kelly JM, (2009) Trypanocidal drugs: mechanisms, resistance and new targets. Expert Rev Mol Med 11: e31.
    • (2009) Expert Rev Mol Med , vol.11 , pp. 31
    • Wilkinson, S.R.1    Kelly, J.M.2
  • 6
    • 85015540767 scopus 로고    scopus 로고
    • WHO (2014) Chagas disease (American trypanosomiasis). Available: http://www.who.int/mediacentre/factsheets/fs340/en/. Accessed 10 November 2014.
  • 7
    • 84886923918 scopus 로고    scopus 로고
    • A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention
    • Machado-de-Assis GF, Diniz GA, Montoya RA, Dias JC, Coura JR, et al. (2013) A serological, parasitological and clinical evaluation of untreated Chagas disease patients and those treated with benznidazole before and thirteen years after intervention. Mem Inst Oswaldo Cruz 108: 873–880.
    • (2013) Mem Inst Oswaldo Cruz , vol.108 , pp. 873-880
    • Machado-de-Assis, G.F.1    Diniz, G.A.2    Montoya, R.A.3    Dias, J.C.4    Coura, J.R.5
  • 9
    • 84892734618 scopus 로고    scopus 로고
    • Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study
    • Andrade MC, Oliveira Mde F, Nagao-Dias AT, Coêlho IC, Cândido Dda S, et al. (2013) Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study. Rev Soc Bras Med Trop 46: 776–778.
    • (2013) Rev Soc Bras Med Trop , vol.46 , pp. 776-778
    • Andrade, M.C.1    Oliveira Mde, F.2    Nagao-Dias, A.T.3    Coêlho, I.C.4    Cândido Dda, S.5
  • 10
    • 84882989819 scopus 로고    scopus 로고
    • Clinical characteristics and outcome of 107 adult patients with chronic Chagas disease and parasitological cure criteria
    • Bertocchi GL, Vigliano CA, Lococo BG, Petti MA, Viotti RJ, (2013) Clinical characteristics and outcome of 107 adult patients with chronic Chagas disease and parasitological cure criteria. Trans R Soc Trop Med Hyg 107: 372–376.
    • (2013) Trans R Soc Trop Med Hyg , vol.107 , pp. 372-376
    • Bertocchi, G.L.1    Vigliano, C.A.2    Lococo, B.G.3    Petti, M.A.4    Viotti, R.J.5
  • 12
    • 84891355403 scopus 로고    scopus 로고
    • New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection on mice
    • Bustamante JM, Craft JM, Crowe BD, Ketchie SA, Tarleton RL, (2014) New, combined, and reduced dosing treatment protocols cure Trypanosoma cruzi infection on mice. J Infect Dis 209: 150–162.
    • (2014) J Infect Dis , vol.209 , pp. 150-162
    • Bustamante, J.M.1    Craft, J.M.2    Crowe, B.D.3    Ketchie, S.A.4    Tarleton, R.L.5
  • 13
    • 45549100534 scopus 로고    scopus 로고
    • Rationale and design of a randomized placebo-controlled trial assessing the effects of ethiological treatment in Chagas' cardiomyopathy: the benznidazole evaluation for interrupting trypanosomiasis (BENEFIT)
    • Marin-Neto JA, Rassi A, JrMorillo CA, Avezum A, Connolly SJ, et at, (2008) Rationale and design of a randomized placebo-controlled trial assessing the effects of ethiological treatment in Chagas' cardiomyopathy: the benznidazole evaluation for interrupting trypanosomiasis (BENEFIT). Am Heart J 156: 37–43.
    • (2008) Am Heart J , vol.156 , pp. 37-43
    • Marin-Neto, J.A.1    Rassi, A.2    Morillo, C.A.3    Avezum, A.4    Connolly, S.J.5
  • 14
    • 85015524118 scopus 로고    scopus 로고
    • Bayer (2014) Study to Assess Bioequivalence of 30 and 120 mg Nifurtimox Tablets in Chronic Chagas' Patients. ClinicalTrials.gov identifier: NCT01927224. Available: http://clinicaltrials.gov/show/NCT01927224. Accessed 5 November 2014.
  • 15
    • 85015512242 scopus 로고    scopus 로고
    • Hospital Universitari Vall d'Hebron Research Institute (2013) Clinical Trial For The Treatment Of Chronic Chagas Disease With Posaconazole And Benznidazole (CHAGASAZOL). ClinicalTrials.gov identifier: NCT01162967. Available: http://clinicaltrials.gov/show/NCT01162967. Accessed 5 November 2014.
  • 16
    • 85015516516 scopus 로고    scopus 로고
    • Merck Sharp & Dohme Corp. (2014) A Study of the Use of Oral Posaconazole (POS) in the Treatment of Asymptomatic Chronic Chagas Disease (P05267) (STOP CHAGAS). ClinicalTrials.gov identifier: NCT01377480. Available: http://clinicaltrials.gov/show/NCT01377480. Accessed 5 November 2014.
  • 17
    • 85015537048 scopus 로고    scopus 로고
    • Drugs for Neglected Diseases (2014) Proof-of-Concept Study of E1224 to Treat Adult Patients With Chagas Disease. ClinicalTrials.gov identifier: NCT01489228Available: http://clinicaltrials.gov/show/NCT01489228. Accessed 5 November 2014.
  • 18
    • 84888636795 scopus 로고    scopus 로고
    • Chronic use of amiodarone against implantable cardioverter-defibrillator therapy for primary prevention of death in patients with Chagas cardiomyopathy: study rational and design of a randomized clinical trial
    • Martinelli M, Rassi A, JrMarin-Neto JA, de Paola AA, Berwanger O, et al. (2013) Chronic use of amiodarone against implantable cardioverter-defibrillator therapy for primary prevention of death in patients with Chagas cardiomyopathy: study rational and design of a randomized clinical trial. Am Heart J 166: 976–982.
    • (2013) Am Heart J , vol.166 , pp. 976-982
    • Martinelli, M.1    Rassi, A.2    Marin-Neto, J.A.3    de Paola, A.A.4    Berwanger, O.5
  • 19
    • 33947328740 scopus 로고    scopus 로고
    • A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy
    • Botoni FA, Poole-Wilson PA, Ribeiro AL, Okondo DO, Oliveira BM, et al. (2007) A randomized trial of carvedilol after renin-angiotensin system inhibition in chronic Chagas cardiomyopathy. Am Heart J 153: 544.e1–8.
    • (2007) Am Heart J , vol.153 , pp. 1-8
    • Botoni, F.A.1    Poole-Wilson, P.A.2    Ribeiro, A.L.3    Okondo, D.O.4    Oliveira, B.M.5
  • 20
    • 85015517897 scopus 로고    scopus 로고
    • Fundación Cardiovascular de Colombia (2010) Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity. ClinicalTrials.gov identifier: NCT00323973Available: http://clinicaltrials.gov/show/NCT00323973. Accessed 5 November 2014.
  • 21
    • 69049116505 scopus 로고    scopus 로고
    • Ergosterol biosynthesis and drug development for Chagas disease
    • Urbina JA, (2009) Ergosterol biosynthesis and drug development for Chagas disease. Mem Inst Oswaldo Cruz 104: 311–318.
    • (2009) Mem Inst Oswaldo Cruz , vol.104 , pp. 311-318
    • Urbina, J.A.1
  • 22
    • 77950961025 scopus 로고    scopus 로고
    • Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus
    • Pinazo MJ, Espinosa G, Gállego M, López-Chejade PL, Urbina JA, et al. (2010) Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus. Am J Trop Med Hyg 82: 583–587.
    • (2010) Am J Trop Med Hyg , vol.82 , pp. 583-587
    • Pinazo, M.J.1    Espinosa, G.2    Gállego, M.3    López-Chejade, P.L.4    Urbina, J.A.5
  • 23
    • 85015513302 scopus 로고    scopus 로고
    • VandeBerg JL (2012) Treatment trials and efficacy determination in non-human primates with chronic T. cruzi infections. Chagas Drug Discovery Consortium (CDDC) 2012 Meeting. Available: https://sites.google.com/site/chagasddc/. Accessed 5 November 2014.
  • 24
    • 85015524540 scopus 로고    scopus 로고
    • Molina I (2012) First clinical trial with posaconazole and benznidazole for the treatment of Chagas disease. International Congress of Tropical Medicine. Available: http://ictmm2012.ioc.fiocruz.br/program_25_sept.html. Accessed 5 November 2014.
  • 25
    • 85015513724 scopus 로고    scopus 로고
    • DNDi (14 November 2013) Drug Trial for Leading Parasitic Killer of the Americas Shows Mixed Results but Provides New Evidence for Improved Therapy. Available: http://www.dndi.org/media-centre/press-releases/1700-e1224.html. Accessed 5 November 2014.
  • 26
    • 0029861640 scopus 로고    scopus 로고
    • Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase
    • Buckner FS, Verlinde CL, La Flamme AC, Van Voorhis WC, (1996) Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase. Antimicrob Agents Chemother 40: 2592–2597.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 2592-2597
    • Buckner, F.S.1    Verlinde, C.L.2    La Flamme, A.C.3    Van Voorhis, W.C.4
  • 27
    • 65549111678 scopus 로고    scopus 로고
    • Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening
    • Bettiol E, Samanovic M, Murkin AS, Raper J, Buckner F, et al. (2009) Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. PLoS Negl Trop Dis 3: e384.
    • (2009) PLoS Negl Trop Dis , vol.3 , pp. 384
    • Bettiol, E.1    Samanovic, M.2    Murkin, A.S.3    Raper, J.4    Buckner, F.5
  • 29
    • 84857233757 scopus 로고    scopus 로고
    • Transgenic parasites accelerate drug discovery
    • Rodriguez A, Tarleton RL, (2012) Transgenic parasites accelerate drug discovery. Trends Parasitol 28: 90–92.
    • (2012) Trends Parasitol , vol.28 , pp. 90-92
    • Rodriguez, A.1    Tarleton, R.L.2
  • 30
    • 79960986078 scopus 로고    scopus 로고
    • High content screening in infectious diseases
    • Brodin P, Christophe T, (2011) High content screening in infectious diseases. Curr Opin Chem Biol 15: 534–539.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 534-539
    • Brodin, P.1    Christophe, T.2
  • 31
    • 77955402138 scopus 로고    scopus 로고
    • Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease
    • Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, et al. (2010) Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrob Agents Chemother 54: 3326–3334.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3326-3334
    • Engel, J.C.1    Ang, K.K.2    Chen, S.3    Arkin, M.R.4    McKerrow, J.H.5
  • 32
    • 84895199058 scopus 로고    scopus 로고
    • An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi
    • Moon S, Siquiera-Neto JL, Moraes CB, Yang G, Kang M, et al. (2014) An image-based algorithm for precise and accurate high throughput assessment of drug activity against the human parasite Trypanosoma cruzi. PLoS ONE 9(2): e87188.
    • (2014) PLoS ONE , vol.9 , Issue.2 , pp. 87188
    • Moon, S.1    Siquiera-Neto, J.L.2    Moraes, C.B.3    Yang, G.4    Kang, M.5
  • 33
    • 84886501314 scopus 로고    scopus 로고
    • Approaches to protozoan drug discovery: phenotypic screening
    • Sykes ML, Avery VM, (2013) Approaches to protozoan drug discovery: phenotypic screening. J Med Chem 56: 7727–7740.
    • (2013) J Med Chem , vol.56 , pp. 7727-7740
    • Sykes, M.L.1    Avery, V.M.2
  • 34
    • 79960945898 scopus 로고    scopus 로고
    • A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit
    • De Muylder G, Ang KK, Arkin MR, Engel JC, McKerrow JH, (2011) A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop Dis 5: e1253.
    • (2011) PLoS Negl Trop Dis , vol.5 , pp. 1253
    • De Muylder, G.1    Ang, K.K.2    Arkin, M.R.3    Engel, J.C.4    McKerrow, J.H.5
  • 35
    • 79957580079 scopus 로고    scopus 로고
    • Methodological advances in drug discovery for Chagas disease
    • Bustamante JM, Tarleton RL, (2011) Methodological advances in drug discovery for Chagas disease. Expert Opin Drug Discov 6: 653–661.
    • (2011) Expert Opin Drug Discov , vol.6 , pp. 653-661
    • Bustamante, J.M.1    Tarleton, R.L.2
  • 36
    • 77954207000 scopus 로고    scopus 로고
    • Chagas disease: pushing through the pipeline
    • Clayton J, (2010) Chagas disease: pushing through the pipeline. Nature 465: S12–15.
    • (2010) Nature , vol.465 , pp. 12-15
    • Clayton, J.1
  • 37
    • 79961011258 scopus 로고    scopus 로고
    • Genetic techniques in Trypanosoma cruzi
    • Taylor MC, Huang H, Kelly JM, (2011) Genetic techniques in Trypanosoma cruzi. Adv Parasitol 75: 231–250.
    • (2011) Adv Parasitol , vol.75 , pp. 231-250
    • Taylor, M.C.1    Huang, H.2    Kelly, J.M.3
  • 39
    • 85015514084 scopus 로고    scopus 로고
    • Carmody LC, Germain A, Barker D, Galan-Rodriguez C, Bettiol E, et al. (2010) Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection. In: (2010) Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda, MD: National Center for Biotechnology Information (US). Available: http://www.ncbi.nlm.nih.gov/books/NBK55071/. Accessed 10 November 2014.
  • 40
    • 85015510777 scopus 로고    scopus 로고
    • Rodriguez A (2013) HTS for T. cruzi infection of mammalian cells through GSK-Open Lab. 62nd Annual Meeting of the American Society of Tropical Medicine and Hygene.[Abstract] Available: http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=3336&sKey=5789c358-2171-43ef-a40a-6bc1c5741e22&cKey=94f790cd-cc53-47e9-9e2e-7255bb58a6af&mKey=ceafe81a-9b33-4623-a1bb-85d31108b94b#. Accessed 5 November 2014.
  • 43
    • 85015522905 scopus 로고    scopus 로고
    • Broad Institute (2013) NIH/3T3 (mouse embryonic fibroblast) toxicity Measured in Cell-Based System Using Plate Reader - 2138-02_Inhibitor_Dose_DryPowder_Activity. PubChem BioAssay AID: 651844. Available: http://pubchem.ncbi.nlm.nih.gov/assay/assay.cgi?aid=651844. Accessed 5 November 2014.
  • 44
    • 84875755952 scopus 로고    scopus 로고
    • Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth
    • Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, et al. (2013) Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth. J Med Chem 56: 2556–2667.
    • (2013) J Med Chem , vol.56 , pp. 2556-2667
    • Andriani, G.1    Amata, E.2    Beatty, J.3    Clements, Z.4    Coffey, B.J.5
  • 45
    • 84894050488 scopus 로고    scopus 로고
    • Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease
    • Dandapani S, Germain AR, Jewett I, Le Quement S, Marie JC, et al. (2014) Diversity-oriented synthesis yields a new drug lead for treatment of Chagas disease. ACS Med Chem Lett 5(2): 149–153.
    • (2014) ACS Med Chem Lett , vol.5 , Issue.2 , pp. 149-153
    • Dandapani, S.1    Germain, A.R.2    Jewett, I.3    Le Quement, S.4    Marie, J.C.5
  • 46
    • 77951975169 scopus 로고    scopus 로고
    • High content screening: seeing is believing
    • Zanella F, Lorens JB, Link W, (2010) High content screening: seeing is believing. Trends Biotechnol 28: 237–245.
    • (2010) Trends Biotechnol , vol.28 , pp. 237-245
    • Zanella, F.1    Lorens, J.B.2    Link, W.3
  • 47
    • 84863673241 scopus 로고    scopus 로고
    • An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages
    • Siqueira-Neto JL, Moon S, Jang J, Yang G, Lee C, et al. (2012) An image-based high-content screening assay for compounds targeting intracellular Leishmania donovani amastigotes in human macrophages. PLoS Negl Trop Dis 6: e1671.
    • (2012) PLoS Negl Trop Dis , vol.6 , pp. 1671
    • Siqueira-Neto, J.L.1    Moon, S.2    Jang, J.3    Yang, G.4    Lee, C.5
  • 48
    • 84876852795 scopus 로고    scopus 로고
    • High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery
    • Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, et al. (2013) High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. PLoS Negl Trop Dis 7: e2154.
    • (2013) PLoS Negl Trop Dis , vol.7 , pp. 2154
    • Aulner, N.1    Danckaert, A.2    Rouault-Hardoin, E.3    Desrivot, J.4    Helynck, O.5
  • 49
    • 84879030428 scopus 로고    scopus 로고
    • Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay
    • De Rycker M, Hallyburton I, Thomas J, Campbell L, Wyllie S, et al. (2013) Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. Antimicrob Agents Chemother 57: 2913–2922.
    • (2013) Antimicrob Agents Chemother , vol.57 , pp. 2913-2922
    • De Rycker, M.1    Hallyburton, I.2    Thomas, J.3    Campbell, L.4    Wyllie, S.5
  • 50
    • 77958509445 scopus 로고    scopus 로고
    • High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi
    • Nohara LL, Lema C, Bader JO, Aguilera RJ, Almeida IC, (2010) High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi. Parasitol Int 59: 565–570.
    • (2010) Parasitol Int , vol.59 , pp. 565-570
    • Nohara, L.L.1    Lema, C.2    Bader, J.O.3    Aguilera, R.J.4    Almeida, I.C.5
  • 51
    • 85015536546 scopus 로고    scopus 로고
    • Buchser W, Collins M, Garyantes T, Guha R, Haney S, et al. (2012) Assay development guidelines for image-based high content screening, high content analysis and high content imaging. Assay guidance manual Available: http://www.ncbi.nlm.nih.gov/books/NBK100913/. Accessed 5 November 2014.
  • 52
    • 70449640250 scopus 로고    scopus 로고
    • Advancing drug innovation for neglected diseases-criteria for lead progression
    • Nwaka S, Ramirez B, Brun R, Maes L, Douglas F, et al. (2009) Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop Dis 3: e440.
    • (2009) PLoS Negl Trop Dis , vol.3 , pp. 440
    • Nwaka, S.1    Ramirez, B.2    Brun, R.3    Maes, L.4    Douglas, F.5
  • 53
    • 79961012880 scopus 로고    scopus 로고
    • Advances in imaging of animal models of Chagas disease
    • Jelicks LA, Tanowitz HB, (2011) Advances in imaging of animal models of Chagas disease. Adv Parasitol 75: 193–208.
    • (2011) Adv Parasitol , vol.75 , pp. 193-208
    • Jelicks, L.A.1    Tanowitz, H.B.2
  • 54
    • 77951917759 scopus 로고    scopus 로고
    • In vitro and in vivo experimental models for drug screening and development for Chagas disease
    • Romanha AJ, Castro SL, Soeiro MdeN, Lannes-Vieira J, Ribeiro I, et al. (2010) In vitro and in vivo experimental models for drug screening and development for Chagas disease. Mem Inst Oswaldo Cruz 105: 233–238.
    • (2010) Mem Inst Oswaldo Cruz , vol.105 , pp. 233-238
    • Romanha, A.J.1    Castro, S.L.2    Soeiro, M.N.3    Lannes-Vieira, J.4    Ribeiro, I.5
  • 55
    • 84888132089 scopus 로고    scopus 로고
    • In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy
    • Goyard S, Dutra PL, Deolindo P, Autherman D, D′Archivio S, et al. (2014) In vivo imaging of trypanosomes for a better assessment of host-parasite relationships and drug efficacy. Parasitol Int 63: 260–268.
    • (2014) Parasitol Int , vol.63 , pp. 260-268
    • Goyard, S.1    Dutra, P.L.2    Deolindo, P.3    Autherman, D.4    D′Archivio, S.5
  • 56
    • 84904610210 scopus 로고    scopus 로고
    • Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disese in the absence of locally persistent infection
    • Lewis MD, Fortes Francisco A, Taylor MC, Burrell-Saward H, McLathie AP, et al. (2014) Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disese in the absence of locally persistent infection. Cell Microbiol 16: 1285–1300 doi:11.1111/cmi.12297
    • (2014) Cell Microbiol , vol.16 , pp. 1285-1300
    • Lewis, M.D.1    Fortes Francisco, A.2    Taylor, M.C.3    Burrell-Saward, H.4    McLathie, A.P.5
  • 57
    • 0036361425 scopus 로고    scopus 로고
    • Animal experimentation in sciences: sadistic nonsense or indispensable necessity?
    • Brune K, (2002) Animal experimentation in sciences: sadistic nonsense or indispensable necessity? ALTEX 19: 130–136.
    • (2002) ALTEX , vol.19 , pp. 130-136
    • Brune, K.1
  • 58
    • 85015525738 scopus 로고    scopus 로고
    • http://ocs.med.nyu.edu/anti-infectives-screening
  • 59
    • 43249116465 scopus 로고    scopus 로고
    • Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease
    • Bustamante JM, Bixby LM, Tarleton RL, (2008) Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med 14: 542–550.
    • (2008) Nat Med , vol.14 , pp. 542-550
    • Bustamante, J.M.1    Bixby, L.M.2    Tarleton, R.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.