Advances in Imaging of Animal Models of Chagas Disease

Advances in Parasitology

Volumn 75, Issue , 2011, Pages 193-208

  Jelicks, Linda A ^a   Tanowitz, Herbert B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

(MRI), MicroPET, Echocardiography, Megasyndromes; Chagas disease; Chagasic cardiomyopathy; Electrocardiography (ECG); Magnetic resonance imaging; Trypanosoma cruzi

Indexed keywords

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BOOK; CHAGAS DISEASE; CHRONIC DISEASE; CONTROLLED STUDY; DOG; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; GASTROINTESTINAL TRACT; GENETIC MANIPULATION; IMAGING; IMMUNOLOGY; INFECTION; MOLECULAR IMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOGENESIS; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RABBIT;

ANIMALIA; MUS; TRYPANOSOMA CRUZI;

EID: 79961012880     PISSN: 0065308X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-385863-4.00009-5     Document Type: Chapter

References (64)

1. Adesse D., Iacobas D.A., Iacobas S., Garzoni L.R., Meirelles Mde N., Tanowitz H.B., et al. Transcriptomic signatures of alterations in a myoblast cell line infected with four distinct strains of Trypanosoma cruzi. Am. J. Trop. Med. Hyg. 2010, 82:846-854.
2. Amrein Y.U. Effects of environmental temperature on Trypanosoma cruzi infection in mice. J. Parasitol. 1967, 53:1160.
3. Anderson K.J., Kuhn R.E. Elevated environmental temperature enhances immunity in experimental Chagas' disease. Infect. Immun. 1989, 57:13-17.
4. Barbabosa-Pliego A., Diaz-Albiter H.M., Ochoa-Garcia L., Aparicio-Burgos E., Lopez-Heydeck S.M., Velasquez-Ordonez V., et al. Trypanosoma cruzi circulating in the southern region of the State of Mexico (Zumpahuacan) are pathogenic: a dog model. Am. J. Trop. Med. Hyg. 2009, 81:390-395.
5. Barr S.C., Schmidt S.P., Brown C.C., Klei T.R. Pathologic features of dogs inoculated with North American Trypanosoma cruzi isolates. Am. J. Vet. Res. 1991, 52:2033-2039.
6. Boczko J., Tar M., Melman A., Jelicks L.A., Wittner M., Factor S.M., et al. Trypanosoma cruzi infection induced changes in the innervation, structure and function of the murine bladder. J. Urol. 2005, 173:1784-1788.
7. Bonecini-Almeida Mda G., Galvao-Castro B., Pessoa M.H., Pirmez C., Laranja F. Experimental Chagas' disease in rhesus monkeys. I. Clinical, parasitological, hematological and anatomo-pathological studies in the acute and indeterminate phase of the disease. Mem. Inst. Oswaldo Cruz 1990, 85:163-171.
8. Bouzahzah B., Jelicks L.A., Morris S.A., Weiss L.M., Tanowitz H.B. Risedronate in the treatment of Murine Chagas' disease. Parasitol. Res. 2005, 96:184-187.
9. Brewer S., McPherson M., Fujiwara D., Turovskaya O., Ziring D., Chen L., et al. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro-d-glucose and positron emission tomography. Gastroenterology 2008, 135:744-755.
10. Buckner F.S., Navabi N. Advances in Chagas disease drug development: 2009-2010. Curr. Opin. Infect. Dis. 2010, 23:609-616.
11. Chandra M., Shirani J., Shtutin V., Weiss L.M., Factor S.M., Petkova S.B., et al. Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study. Int. J. Parasitol. 2002, 32:207-215.
12. Chandra M., Tanowitz H.B., Petkova S.B., Huang H., Weiss L.M., Wittner M., et al. Significance of inducible nitric oxide synthase in acute myocarditis caused by Trypanosoma cruzi (Tulahuen strain). Int. J. Parasitol. 2002, 32:897-905.
13. Chandrasekar B., Melby P.C., Troyer D.A., Colston J.T., Freeman G.L. Temporal expression of pro-inflammatory cytokines and inducible nitric oxide synthase in experimental acute Chagasic cardiomyopathy. Am. J. Pathol. 1998, 152:925-934.
14. Chen G., Barr S., Walsh D., Rohde S., Brewer A., Bilezikian J.P., et al. Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease. J. Mol. Cell. Cardiol. 1996, 28:931-941.
15. Combs T.P., Nagajyothi, Mukherjee S., de Almeida C.J., Jelicks L.A., Schubert W., et al. The adipocyte as an important target cell for Trypanosoma cruzi infection. J. Biol. Chem. 2005, 280:24085-24094.
16. Cruz-Chan J.V., Bolio-Gonzalez M., Colin-Flores R., Ramirez-Sierra M.J., Quijano-Hernandez I., Dumonteil E. Immunopathology of natural infection with Trypanosoma cruzi in dogs. Vet. Parasitol. 2009, 162:151-155.
17. da Silva A.M., Eduardo Ramirez L., Vargas M., Chapadeiro E., Brener Z. Evaluation of the rabbit as a model for Chagas disease. II. Histopathologic studies of the heart, digestive tract and skeletal muscle. Mem. Inst. Oswaldo Cruz 1996, 91:199-206.
18. de Almeida E.A., Navarro M.R., Guariento M.E., Carvalhal Sdos S. The experimental infection of Cebus apella sp. monkeys with Trypanosoma cruzi. Its clinical, electrocardiographic and anatomicopathological assessment. Rev. Soc. Bras. Med. Trop. 1992, 25:7-12.
19. de Meirelles Mde N., Bonecini-Almeida Mda G., Pessoa M.H., Galvao-Castro B. Trypanosoma cruzi: experimental Chagas' disease in rhesus monkeys. II. Ultrastructural and cytochemical studies of peroxidase and acid phosphatase activities. Mem. Inst. Oswaldo Cruz 1990, 85:173-181.
20. de Oliveira G.M., de Melo Medeiros M., da Silva Batista W., Santana R., Araujo-Jorge T.C., de Souza A.P. Applicability of the use of charcoal for the evaluation of intestinal motility in a murine model of Trypanosoma cruzi infection. Parasitol. Res. 2008, 102:747-750.
21. de Souza E.M., Rivera M.T., Araujo-Jorge T.C., de Castro S.L. Modulation induced by estradiol in the acute phase of Trypanosoma cruzi infection in mice. Parasitol. Res. 2001, 87:513-520.
22. de Souza A.P., Tang B., Tanowitz H.B., Factor S.M., Shtutin V., Shirani J., et al. Absence of interferon-gamma-inducible gene IGTP does not significantly alter the development of chagasic cardiomyopathy in mice infected with Trypanosoma cruzi (Brazil strain). J. Parasitol. 2003, 89:1237-1239.
23. De Souza A.P., Tanowitz H.B., Chandra M., Shtutin V., Weiss L.M., Morris S.A., et al. Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection. Parasitol. Res. 2004, 92:496-501.
24. de Souza A.P., Tang B., Tanowitz H.B., Araujo-Jorge T.C., Jelicks E.L. Magnetic resonance imaging in experimental Chagas disease: a brief review of the utility of the method for monitoring right ventricular chamber dilatation. Parasitol. Res. 2005, 97:87-90.
25. de Souza A.P., Sieberg R., Li H., Cahill H.R., Zhao D., Araujo-Jorge T.C., et al. The role of selenium in intestinal motility and morphology in a murine model of Trypanosoma cruzi infection. Parasitol. Res. 2010, 106:1293-1298.
26. Dimock K.A., Davis C.D., Kuhn R.E. Changes in humoral responses to Trypanosoma cruzi during the course of infection in mice held at elevated temperature. J. Parasitol. 1992, 78:687-696.
27. Durand J.L., Tang B., Gutstein D.E., Petkova S., Teixeira M.M., Tanowitz H.B., et al. Dyskinesis in Chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of mice. Magn. Reson. Imaging 2006, 24:1051-1057.
28. Eickhoff C.S., Lawrence C.T., Sagartz J.E., Bryant L.A., Labovitz A.J., Gala S.S., et al. ECG detection of murine chagasic cardiomyopathy. J. Parasitol. 2010, 96:758-764.
29. Figueiredo F., Marin-Neto J.A., Rossi M.A. The evolution of experimental Trypanosoma cruzi cardiomyopathy in rabbits: further parasitological, morphological and functional studies. Int. J. Cardiol. 1986, 10:277-290.
30. Goldenberg R.C., Jelicks L.A., Fortes F.S., Weiss L.M., Rocha L.L., Zhao D., et al. Bone marrow cell therapy ameliorates and reverses chagasic cardiomyopathy in a mouse model. J. Infect. Dis. 2008, 197:544-547.
31. Guedes P.M., Veloso V.M., Tafuri W.L., Galvao L.M., Carneiro C.M., Lana M., et al. The dog as model for chemotherapy of the Chagas' disease. Acta Trop. 2002, 84:9-17.
32. Guedes P.M., Veloso V.M., Afonso L.C., Caliari M.V., Carneiro C.M., Diniz L.F., et al. Development of chronic cardiomyopathy in canine Chagas disease correlates with high IFN-gamma, TNF-alpha, and low IL-10 production during the acute infection phase. Vet. Immunol. Immunopathol. 2009, 130:43-52.
33. Guillen-Pernia B., Lugo-Yarbuh A., Moreno E. Digestive tract dilation in mice infected with Trypanosoma cruzi. Invest. Clin. 2001, 42:195-209.
34. Gupta S., Garg N.J. Prophylactic efficacy of TcVac2 against Trypanosoma cruzi in mice. PLoS Negl. Trop. Dis. 2010, 4:e797.
35. Huang H., Chan J., Wittner M., Jelicks L.A., Morris S.A., Factor S.M., et al. Expression of cardiac cytokines and inducible form of nitric oxide synthase (NOS2) in Trypanosoma cruzi-infected mice. J. Mol. Cell. Cardiol. 1999, 31:75-88.
36. Huang H., Yanagisawa M., Kisanuki Y.Y., Jelicks L.A., Chandra M., Factor S.M., et al. Role of cardiac myocyte-derived endothelin-1 in chagasic cardiomyopathy: molecular genetic evidence. Clin. Sci. (Lond.) 2002, 103(Suppl. 48):263S-266S.
37. Jelicks L.A., Shirani J., Wittner M., Chandra M., Weiss L.M., Factor S.M., et al. Application of cardiac gated magnetic resonance imaging in murine Chagas' disease. Am. J. Trop. Med. Hyg. 1999, 61:207-214.
38. Jelicks L.A., Chandra M., Shirani J., Shtutin V., Tang B., Christ G.J., et al. Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease. Int. J. Parasitol. 2002, 32:1497-1506.
39. Jelicks L.A., Chandra M., Shtutin V., Petkova S.B., Tang B., Christ G.J., et al. Phosphoramidon treatment improves the consequences of chagasic heart disease in mice. Clin. Sci. (Lond.) 2002, 103(Suppl. 48):267S-271S.
40. Judenhofer M.S., Wehrl H.F., Newport D.F., Catana C., Siegel S.B., Becker M., et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat. Med. 2008, 14:459-465.
41. Junqueira Junior L.F., Beraldo P.S., Chapadeiro E., Jesus P.C. Cardiac autonomic dysfunction and neuroganglionitis in a rat model of chronic Chagas' disease. Cardiovasc. Res. 1992, 26:324-329.
42. Kierszenbaum F. Protection of congenitally athymic mice against Trypanosoma cruzi infection by passive antibody transfer. J. Parasitol. 1980, 66:673-675.
43. Koeberle F. Chagas' disease and Chagas' syndromes: the pathology of American trypanosomiasis. Adv. Parasitol. 1968, 6:63-116.
44. Labrador-Hernandez M., Suarez-Graterol O., Romero-Contreras U., Rumenoff L., Rodriguez-Bonfante C., Bonfante-Cabarcas R. The cholinergic system in cyclophosphamide-induced Chagas dilated myocardiopathy in Trypanosoma cruzi-infected rats: an electrocardiographic study. Invest. Clin. 2008, 49:207-224.
45. Maletto B.A., Gruppi A., Moron G., Pistoresi-Palencia M.C. Age-associated changes in lymphoid and antigen-presenting cell functions in mice immunized with Trypanosoma cruzi antigens. Mech. Ageing Dev. 1996, 88:39-47.
46. McHardy N. Effect of sex of mice in relation to their response to immunization with vaccines prepared from Trypanosoma cruzi. Trans. R. Soc. Trop. Med. Hyg. 1978, 72:201-202.
47. Milei J., Bolomo N.J., Vazquez A., Nagle C.A. Normal and pathological electrocardiographic patterns in the Cebus monkey. J. Med. Primatol. 1982, 11:10-19.
48. Mori T., Yoon H.S., Iizuka F.H., Myung J.M., Sato H.R., Silva M.F., et al. Intestinal transit and opaque enema study in chagasic mice. Rev. Hosp. Clin. Fac. Med. Sao Paulo 1995, 50:63-66.
49. Morris S.A., Barr S., Weiss L., Tanowitz H., Wittner M., Bilezikian J.P. Myocardial beta-adrenergic adenylate cyclase complex in a canine model of chagasic cardiomyopathy. Circ. Res. 1991, 69:185-195.
50. Nagajyothi F., Zhao D., Machado F.S., Weiss L.M., Schwartz G.J., Desruisseaux M.S., et al. Crucial role of the central leptin receptor in murine Trypanosoma cruzi (Brazil strain) infection. J. Infect. Dis. 2010, 202:1104-1113.
51. Ny L., Li H., Mukherjee S., Persson K., Holmqvist B., Zhao D., et al. A magnetic resonance imaging study of intestinal dilation in Trypanosoma cruzi-infected mice deficient in nitric oxide synthase. Am. J. Trop. Med. Hyg. 2008, 79:760-767.
52. Perez A.R., Fontanella G.H., Nocito A.L., Revelli S., Bottasso O.A. Short treatment with the tumour necrosis factor-alpha blocker infliximab diminishes chronic chagasic myocarditis in rats without evidence of Trypanosoma cruzi reactivation. Clin. Exp. Immunol. 2009, 157:291-299.
53. Petkova S.B., Huang H., Factor S.M., Pestell R.G., Bouzahzah B., Jelicks L.A., et al. The role of endothelin in the pathogenesis of Chagas' disease. Int. J. Parasitol. 2001, 31:499-511.
54. Postan M., Bailey J.J., Dvorak J.A., McDaniel J.P., Pottala E.W. Studies of Trypanosoma cruzi clones in inbred mice. III. Histopathological and electrocardiographical responses to chronic infection. Am. J. Trop. Med. Hyg. 1987, 37:541-549.
55. Prado C.M., Fine E.J., Koba W., Zhao D., Rossi M.A., Tanowitz H.B., et al. Micro-positron emission tomography in the evaluation of Trypanosoma cruzi-induced heart disease: comparison with other modalities. Am. J. Trop. Med. Hyg. 2009, 81:900-905.
56. Ramirez L.E., Brener Z. Evaluation of the rabbit as a model for Chagas' disease. I. Parasitological studies. Mem. Inst. Oswaldo Cruz 1987, 82:531-536.
57. Scremin L.H., Corbett C.E., Laurenti M.D., Nunes E.V., Gama-Rodrigues J.J., Okumura M. Megabladder in experimental Chagas disease: pathological features of the bladder wall. Rev. Hosp. Clin. Fac. Med. Sao Paulo 1999, 54:43-46.
58. Souza A.P., Jelicks L.A., Tanowitz H.B., Olivieri B.P., Medeiros M.M., Oliveira G.M., et al. The benefits of using selenium in the treatment of Chagas disease: prevention of right ventricle chamber dilatation and reversion of Trypanosoma cruzi-induced acute and chronic cardiomyopathy in mice. Mem. Inst. Oswaldo Cruz 2010, 105:746-751.
59. Tanowitz H.B., Wittner M., Morris S.A., Zhao W., Weiss L.M., Hatcher V.B., et al. The putative mechanistic basis for the modulatory role of endothelin-1 in the altered vascular tone induced by Trypanosoma cruzi. Endothelium 1999, 6:217-230.
60. Tanowitz H.B., Huang H., Jelicks L.A., Chandra M., Loredo M.L., Weiss L.M., et al. Role of endothelin 1 in the pathogenesis of chronic chagasic heart disease. Infect. Immun. 2005, 73:2496-2503.
61. Taylor-Robinson A. Validity of modelling cerebral malaria in mice: argument and counter argument. J. Neuroparasitol. 2010, 1. Article ID N100601.
62. Teixeira A.R., Figueiredo F., Rezende Filho J., Macedo V. Chagas' disease: a clinical, parasitological, immunological, and pathological study in rabbits. Am. J. Trop. Med. Hyg. 1983, 32:258-272.
63. Trischmann T., Tanowitz H., Wittner M., Bloom B. Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice. Exp. Parasitol. 1978, 45:160-168.
64. Zabalgoitia M., Ventura J., Lozano J.L., Anderson L., Carey K.D., Hubbard G.B., et al. Myocardial contrast echocardiography in assessing microcirculation in baboons with Chagas disease. Microcirculation 2004, 11:271-278.