Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: A systematic review and meta-analysis

Metabolism: Clinical and Experimental

Volumn 63, Issue 12, 2014, Pages 1503-1511

  Wu, Yi Le ^a   Hu, Cai Yun ^a   Lu, Shan Shan ^a   Gong, Feng Feng ^a   Feng, Fang ^a   Qian, Zhen Zhong ^a   Ding, Xiu Xiu ^a   Yang, Hui Yun ^a   Sun, Ye Huan ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Hypertension; Meta analysis; Methylenetetrahydrofolate reductase; MTHFR; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ARTICLE; DNA POLYMORPHISM; ESSENTIAL HYPERTENSION; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; META ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SYSTEMATIC REVIEW; GENETIC POLYMORPHISM; GENETICS; HYPERTENSION; SINGLE NUCLEOTIDE POLYMORPHISM;

GENOME-WIDE ASSOCIATION STUDY; HUMANS; HYPERTENSION; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84922211351     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.10.001     Document Type: Article

References (60)

1. P.M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223
2. M. Ezzati, A.D. Lopez, A. Rodgers, S. Vander Hoorn, C.J. Murray, and Comparative Risk Assessment Collaborating Group Selected major risk factors and global and regional burden of disease Lancet 360 2002 1347 1360
3. J. Kunes, and J. Zicha Developmental windows and environment as important factors in the expression of genetic information: a cardiovascular physiologist's view Clin Sci (Lond) 111 2006 295 305
4. M.O. Tanira, and K.A. Al Balushi Genetic variations related to hypertension: a review J Hum Hypertens 19 2005 7 19
5. M. Harrison, K. Maresso, and U. Broeckel Genetic determinants of hypertension: an update Curr Hypertens Rep 10 2008 488 495
6. P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, and R.G. Matthews A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
7. A.C. Pereira, I.T. Schettert, A.A. Morandini Filho, E.M. Guerra-Shinohara, and J.E. Krieger Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population Clin Chim Acta 340 2004 99 105
8. R. Dankner, A. Chetrit, H. Murad, B.A. Sela, J. Frystyk, and I. Raz Serum adiponectin is associated with homocysteine in elderly men and women, and with 5,10-methylenetetrahydrofolate reductase (MTHFR) in a sex-dependent manner Metabolism 59 2010 1767 1774
9. Y.Y. Li Methylenetetrahydrofolate reductase C677T gene polymorphism and coronary artery disease in a Chinese Han population: a meta-analysis Metabolism 61 2012 846 852
10. S. Yang, J. Zhang, C. Feng, and G. Huang MTHFR 677 T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: a meta-analysis Metabolism 62 2013 586 594
11. N.M. van der Put, F. Gabreëls, E.M. Stevens, J.A. Smeitink, F.J. Trijbels, and T.K. Eskes A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62 1998 1044 1051
12. K. Schroecksnadel, B. Frick, C. Winkler, B. Wirleitner, G. Weiss, and D. Fuchs Atorvastatin suppresses homocysteine formation in stimulated human peripheral blood mononuclear cells Clin Chem Lab Med 43 2005 1373 1376
13. E. Halilovic, E. Kabil, and E. Halilovic Homocysteine in angiographically proven coronary disease Med Arh 63 2009 252 256
14. M. Ghassibe-Sabbagh, D.E. Platt, S. Youhanna, A.B. Abchee, K. Stewart, and D.A. Badro Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk Atherosclerosis 222 2012 180 186
15. U. Lim, and P.A. Cassano Homocysteine and blood pressure in the Third National Health and Nutrition Examination Survey, 1988-1994 Am J Epidemiol 156 2002 1105 1113
16. J. Sundström, L. Sullivan, R.B. D'Agostino, P.F. Jacques, J. Selhub, and I.H. Rosenberg Plasma homocysteine, hypertension incidence, and blood pressure tracking: the Framingham Heart Study Hypertension 42 2003 1100 1105
17. R.A. van Dijk, J.A. Rauwerda, M. Steyn, J.W. Twisk, and C.D. Stehouwer Long-term homocysteine-lowering treatment with folic acid plus pyridoxine is associated with decreased blood pressure but not with improved brachial artery endothelium-dependent vasodilation or carotid artery stiffness: a 2-year, randomized, placebo-controlled trial Arterioscler Thromb Vasc Biol 21 2001 2072 2079
18. X. Qian, Z. Lu, M. Tan, H. Liu, and D. Lu A meta-analysis of association between C677T polymorphism in the methylenetetrahydrofolate reductase gene and hypertension Eur J Hum Genet 15 2007 1239 1245
19. D. Moher, A. Liberati, J. Tetzlaff, D.G. Altman, and PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement Ann Intern Med 151 2009 264 269
20. J.P. Higgins, S.G. Thompson, J.J. Deeks, and D.G. Altman Measuring inconsistency in meta-analyses BMJ 327 2003 557 560
21. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
22. N. Mantel, and W. Haenszel Statistical aspects of the analysis of data from retrospective studies of disease J Natl Cancer Inst 22 1959 719 748
23. J. Lau, E.M. Antman, J. Jimenez-Silva, B. Kupelnick, F. Mosteller, and T.C. Chalmers Cumulative meta-analysis of therapeutic trials for myocardial infarction N Engl J Med 327 1992 248 254
24. M. Egger, G. Davey Smith, M. Schneider, and C. Minder Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
25. H. Nishio, M.J. Lee, M. Fujii, K. Kario, K. Kayaba, and K. Shimada A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population Jpn J Hum Genet 41 1996 247 251
26. Y. Nakata, T. Katsuya, S. Takami, N. Sato, Y. Fu, and K. Ishikawa Methylenetetrahydrofolate reductase gene polymorphism: relation to blood pressure and cerebrovascular disease Am J Hypertens 11 1998 1019 1023
27. Y.Y. Gao, S.Y. Zhan, X.J. Yin, Y.H. Hu, and L.M. Li The relationship between methylenetetrahydrofolate reductase polymorphism and risk of essential hypertension J Beijing Med Univ 31 1999 370 372 [in Chinese]
28. P. Benes, K. Kanková, J. Muzík, L. Groch, J. Benedík, and L. Elbl Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population Mol Genet Metab 73 2001 188 195
29. L. Wang, H. Guo, and Y.M. Li MTHFR gene C 677 T polymorphisms and variation of plasma homocysteine levels in primary hypertension Tianjin Med J 30 2002 579 582 [in Chinese]
30. R. Kahleová, D. Palyzová, K. Zvára, J. Zvárová, K. Hrach, and I. Nováková Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins Am J Hypertens 15 2002 857 864
31. X.N. Sun, Y.M. Li, and H. Guo The gene polymorphisms of homocysteine metabolism-related enzymes and the associated factors in isolated systolic hypertension Chin J Cardiol 31 2003 269 273
32. F. Rodríguez-Esparragón, O. Hernández-Perera, J.C. Rodríguez-Pérez, A. Anábitarte, J.M. Díaz-Cremades, and A. Losada The effect of methylenetetrahydrofolate reductase C677T common variant on hypertensive risk is not solely explained by increased plasma homocysteine values Clin Exp Hypertens 25 2003 209 220
33. S. Heux, F. Morin, R.A. Lea, M. Ovcaric, L. Tajouri, and L.R. Griffiths The methylentetrahydrofolate reductase gene variant (C677T) as a risk factor for essential hypertension in Caucasians Hypertens Res 27 2004 663 667
34. L. Tylicki, M. Födinger, H. Puttinger, P. Rutkowski, P. Strozecki, and S. Tyszko Methylenetetrahydrofolate reductase gene polymorphisms in essential hypertension relation: with the development of hypertensive end-stage renal disease Am J Hypertens 18 2005 1442 1448
35. J.W. Liu, L. Ye, J. Liu, and X.Y. Li Study on homocysteine metabolism-related enzymes gene polymorphisms in elderly essential hypertension patients with peripheral arterial occlusive disease Chin J Geriatr 24 2005 332 335 [in Chinese]
36. H. Lwin, T. Yokoyama, N. Yoshiike, K. Saito, A. Yamamoto, and H. Tanaka Polymorphism of methylenetetrahydrofolate reductase gene (C677T MTHFR) is not a confounding factor of the relationship between serum uric acid level and the prevalence of hypertension in Japanese men Circ J 70 2006 83 87
37. X.J. Li, and W. Huang The analysis of MTHFR gene polymorphism in patients with renal damage caused by hypertension and patients with renal parenchymal hypertension J Cap Univ Med Sci 27 2006 497 500 [in Chinese]
38. R.L. Hu, G.M. Niu, S.G. Zhao, C.M. Zhang, R.L. Hu, and Z.G. Wang The association between gene polymorphisms of N5,10-methylenetetrahydrofolate reductase and Mongolian patients with primary hypertension ChinJ Hypertens 14 2006 274 276 [in Chinese]
39. P. Hui, T. Nakayama, A. Morita, N. Sato, M. Hishiki, and K. Saito Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption Hypertens Res 30 2007 585 592
40. S. Markan, M. Sachdeva, B.S. Sehrawat, S. Kumari, S. Jain, and M. Khullar MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians Mol Cell Biochem 302 2007 125 131
41. X.R. Xing, and Q. Hua Relationships between the polymorphism of methylenetetrahydrofolate reductase gene C677T and hypertension, cardiac structure and function Med J Chin People's Liberation Army 32 2007 741 744 [in Chinese]
42. Y. Tang, H. Chen, and X.Y. Wu The C677T point mutation of N5,10-methylene-tetrahydrofolate reductase (MTHFR) and essential hypertension Mol Cardiol China 7 2007 205 207 [in Chinese]
43. P.T. Lin, C.H. Cheng, J.C. Wei, and Y.C. Huang Low plasma pyridoxal 5'-phosphate concentration and MTHFR 677C- > T genotypes are associated with increased risk of hypertension Int J Vitam Nutr Res 78 2008 33 40
44. N. Ilhan, M. Kucuksu, D. Kaman, N. Ilhan, and Y. Ozbay The 677 C/T MTHFR polymorphism is associated with essential hypertension, coronary artery disease, and higher homocysteine levels Arch Med Res 39 2008 125 130
45. A. Deshmukh, K.M. Rodrigue, K.M. Kennedy, S. Land, B.S. Jacobs, and N. Raz Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation Biol Psychol 80 2009 240 245
46. X. Ng, L. Boyd, L. Dufficy, N. Naumovski, B. Blades, and C. Travers Folate nutritional genetics and risk for hypertension in an elderly population sample J Nutrigenet Nutrigenomics 2 2009 1 8
47. H. Wang, G.Z. Wu, Y. Zhang, X.Y. Zhang, Y.L. Chen, and S.K. Ai Association of homocysteine and its metabolic enzyme genes polymorphisms with essential hypertension in Xinjiang Kazakhs J Clin Rehab Tissue Eng Res 14 2010 6247 6252 [in Chinese]
48. H.Y. Liu, P. Ma, and Q.B. Xu The correlation between polymorphisms of N5,10-methylene-tetrahydrofolate reductase and essential hypertension in Han population in Ningxia Guangdong Med J 32 2011 1977 1980 [in Chinese]
49. Y. Demirel, S. Dogan, A. Uludag, C. Silan, S. Atik, and F. Silan Combined effect of Factor V Leiden, MTHFR, and angiotensin-converting enzyme (insertion/deletion) gene mutations in hypertensive adult individuals: a population-based study from Sivas and Canakkale, Turkey Genet Test Mol Biomarkers 15 2011 785 791
50. Y. Zhang, H. Wang, X.Y. Zhang, L. Wang, and G.Z. Wu Relationship between homocysteine, methylenetetrahydrofolate reductase C677T polymorphisms and essential hypertension in Kazak nationality in Xinjiang J Clin Cardiol 28 2012 570 573 [in Chinese]
51. Z.Y. Cao The association between methylenetetrahydrofolate reductase C677T polymorphism and elderly hypertension with acute myocardial infarction Chin J Gerontol 32 2012 5118 5120 [in Chinese]
52. R.X. Yin, J.Z. Wu, W.Y. Liu, D.F. Wu, X.L. Cao, and L. Miao Association of several lipid-related gene polymorphisms and blood pressure variation in the Bai Ku Yao population Am J Hypertens 25 2012 927 936
53. J.Y. Fowdar, M.V. Lason, A.L. Szvetko, R.A. Lea, and L.R. Griffiths Investigation of homocysteine-pathway-related variants in essential hypertension Int J Hypertens 2012 2012 190923
54. A. Bayramoglu, M. Urhan Kucuk, H.I. Guler, O. Abaci, Y. Kucukkaya, and E. Colak Is there any genetic predisposition of MMP-9 gene C1562T and MTHFR gene C677T polymorphisms with essential hypertension? 2013 [Epub ahead of print]
55. R. Yao, H.M. Zhang, J.L. Zhang, D.B. Li, and Y.Y. Fan Association of MTHFR C677T polymorphism with essential hypertension in Henan Hans of China Chin J Gerontol 33 2013 1001 1003 [in Chinese]
56. O. Fridman, R. Porcile, A.V. Morales, L.O. Gariglio, M.A. Potenzoni, and P.C. Turk Noceto Association of methylenetetrahydrofolate reductase gene 677C > T polymorphism with hypertension in older women in a population of Buenos Aires City Clin Exp Hypertens 35 2013 159 166
57. S. Muncer, S. Taylor, and M. Craigie Power dressing and meta-analysis: incorporating power analysis into meta-analysis J Adv Nurs 38 2002 274 280
58. B. Xi, X. Zhao, G.R. Chandak, Y. Shen, H. Cheng, and D. Hou Influence of obesity on association between genetic variants identified by genome-wide association studies and hypertension risk in Chinese children Am J Hypertens 26 2013 990 996
59. U. Sen, and S.C. Tyagi Homocysteine and hypertension in diabetes: does PPARgamma have a regulatory role? PPAR Res 2010 2010 806538
60. B. Xi, Y. Shen, K.H. Reilly, X. Wang, and J. Mi Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians Metabolism 62 2013 196 203