MTHFR 677 T variant contributes to diabetic nephropathy risk in Caucasian individuals with type 2 diabetes: A meta-analysis

Metabolism: Clinical and Experimental

Volumn 62, Issue 4, 2013, Pages 586-594

  Yang, Sheng ^a   Zhang, Jingwen ^b   Feng, Chang ^a   Huang, Guoliang ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Meta analysis; MTHFR C677T; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN;

ARTICLE; CAUCASIAN; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; META ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR; SENSITIVITY ANALYSIS; AGED; CONFIDENCE INTERVAL; FEMALE; GENETICS; MALE; MIDDLE AGED; PUBLISHING; REVIEW; RISK;

AGED; CONFIDENCE INTERVALS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; ODDS RATIO; PUBLICATION BIAS; RISK;

MLCS; MLOWN;

EID: 84875418478     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2012.10.004     Document Type: Article

References (49)

1. G. Remuzzi, A. Schieppati, and P. Ruggenenti Clinical practice. Nephropathy in patients with type 2 diabetes N Engl J Med 346 2002 1145 1151
2. A.A. Tahrani, C.J. Bailey, and S. Del Prato Management of type 2 diabetes: new and future developments in treatment Lancet 378 2011 182 197
3. E.A. Nyenwe, T.W. Jerkins, and G.E. Umpierrez Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes Metabolism 60 2011 1 23
4. M.I. McCarthy Genomics, type 2 diabetes, and obesity N Engl J Med 363 2010 2339 2350
5. A.I. Adler, R.J. Stevens, and S.E. Manley Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64) Kidney Int 63 2003 225 232
6. R.C. Stanton, and G.L. King A complex interplay of factors causes diabetic nephropathy Metabolism 60 2011 591 593
7. M. Fodinger, W.H. Horl, and G. Sunder-Plassmann Molecular biology of 5,10-methylenetetrahydrofolate reductase J Nephrol 13 2000 20 33
8. P. Goyette, J.S. Sumner, and R. Milos Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification Nat Genet 7 1994 195 200
9. P. Frosst, H.J. Blom, and R. Milos A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nat Genet 10 1995 111 113
10. C.A. Boger, M. Stubanus, and T. Haak Effect of MTHFR C677T genotype on survival in type 2 diabetes patients with end-stage diabetic nephropathy Nephrol Dial Transplant 22 2007 154 162
11. M. Bluthner, A. Bruntgens, and S. Schmidt Association of methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy in type 2 diabetes? Nephrol Dial Transplant 14 1999 56 57
12. P. Ksiazek, A. Bednarek-Skublewska, and M. Buraczynska The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus Med Sci Monit 10 2004 BR47 BR51
13. V. Shpichinetsky, I. Raz, and Y. Friedlander The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients J Nutr 130 2000 2493 2497
14. K. Ukinc, H.O. Ersoz, and C. Karahan Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy Endocrine 36 2009 255 261
15. N. Mtiraoui, I. Ezzidi, and M. Chaieb MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients Diabetes Res Clin Pract 75 2007 99 106
16. Z. Eroglu, M. Erdogan, and A. Tetik The relationship of the methylenetetrahydrofolate reductase C677T gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy Diabetes Metab Res Rev 23 2007 621 624
17. R. Nemr, R.A. Salman, and L.H. Jawad Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs Clin Chem Lab Med 48 2010 1091 1094
18. M. Rahimi, A. Hasanvand, and Z. Rahimi Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus Clin Biochem 43 2010 1333 1339
19. E. Zintzaras, K. Uhlig, and G.N. Koukoulis Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis J Hum Genet 52 2007 881 890
20. W. Niu, and Y. Qi An updated meta-analysis of methylenetetrahydrofolate reductase gene 677C/T polymorphism with diabetic nephropathy and diabetic retinopathy Diabetes Res Clin Pract 95 2012 110 118
21. J.P. Higgins, S.G. Thompson, and J.J. Deeks Measuring inconsistency in meta-analyses BMJ 327 2003 557 560
22. W.G. Cochran The combination of estimates from different experiments Biometrics 10 1954 101 129
23. R. DerSimonian, and N. Laird Meta-analysis in clinical trials Control Clin Trials 7 1986 177 188
24. N. Mantel, and W. Haenszel Statistical aspects of the analysis of data from retrospective studies of disease J Natl Cancer Inst 22 1959 719 748
25. S.G. Thompson, and J. Higgins How should meta-regression analyses be undertaken and interpreted? Stat Med 21 2002 1559 1573
26. A. Tobias Assessing the influence of a single study in the meta-analysis estimate Stata Tech Bull 8 1999 15 17
27. A.E. Stuck, L.Z. Rubenstein, and D. Wieland Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ 316 1998 469
28. M. Egger, G. Davey Smith, and M. Schneider Bias in meta-analysis detected by a simple, graphical test BMJ 315 1997 629 634
29. Y. Jafari, Z. Rahimi, and A. Vaisi-Raygani Interaction of eNOS polymorphism with MTHFR variants increase the risk of diabetic nephropathy and its progression in type 2 diabetes mellitus patients Mol Cell Biochem 353 2011 23 34
30. Z. Rahimi, A. Hasanvand, and V. Felehgari Interaction of MTHFR 1298C with ACE D Allele Augments the Risk of Diabetic Nephropathy in Western Iran DNA Cell Biol 2011
31. E.J. Wiltshire, F. Mohsin, and A. Chan Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes Pediatr Diabetes 9 2008 348 353
32. N.S. Shcherbak, Z.V. Shutskaya, and A.M. Sheidina Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in IDDM patients Mol Genet Metab 68 1999 375 378
33. J.S. Smyth, D.A. Savage, and A.P. Maxwell MTHFR gene polymorphism and diabetic nephropathy in type 1 diabetes Lancet 353 1999 1156 1157
34. Y. Makita, D.K. Moczulski, and J. Bochenski Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes Am J Kidney Dis 41 2003 1189 1194
35. D. Moczulski, H. Fojcik, and E. Zukowska-Szczechowska Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy Nephrol Dial Transplant 18 2003 1535 1540
36. M.E. Hellemons, J. Kerschbaum, and S.J. Bakker Validity of biomarkers predicting onset or progression of nephropathy in patients with type 2 diabetes: a systematic review Diabet Med 29 2012 567 577
37. V. Vallon, and S.C. Thomson Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney Annu Rev Physiol 74 2012 351 375
38. T. Wada, M. Shimizu, and T. Toyama Clinical impact of albuminuria in diabetic nephropathy Clin Exp Nephrol 16 2012 96 101
39. K. Yoshioka, T. Yoshida, and T. Umekawa Adiponectin gene polymorphism (G276T) is not associated with incipient diabetic nephropathy in Japanese type 2 diabetic patients Metabolism 53 2004 1223 1226
40. M.C. Thomas, P.H. Groop, and K. Tryggvason Towards understanding the inherited susceptibility for nephropathy in diabetes Curr Opin Nephrol Hypertens 21 2012 195 202
41. J.L. Gross, M.J. de Azevedo, and S.P. Silveiro Diabetic nephropathy: diagnosis, prevention, and treatment Diabetes Care 28 2005 164 176
42. S.S. Kang, J. Zhou, and P. Wong Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase Am J Hum Genet 43 1988 414
43. M.V. Holmes, P. Newcombe, and J.A. Hubacek Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials Lancet 378 2011 584 594
44. I. Weisberg, P. Tran, and B. Christensen A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity Mol Genet Metab 64 1998 169 172
45. G. Friedman, N. Goldschmidt, and Y. Friedlander A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations J Nutr 129 1999 1656 1661
46. H. Fujita, H. Fujishima, and K. Takahashi SOD1, but not SOD3, deficiency accelerates diabetic renal injury in C57BL/6-Ins2(Akita) diabetic mice Metabolism 2012 [Epub ahead of print]
47. Z. Szilvassy, J. Nemeth, and P. Kovacs Insulin resistance occurs in parallel with sensory neuropathy in streptozotocin-induced diabetes in rats: differential response to early vs late insulin supplementation Metabolism 61 2012 776 786
48. D. Daneman Type 1 diabetes Lancet 367 2006 847 858
49. P. Concannon, S.S. Rich, and G.T. Nepom Genetics of type 1A diabetes N Engl J Med 360 2009 1646 1654