Phospholipid-binding sites of phosphatase and tensin homolog (PTEN): Exploring the mechanism of phosphatidylinositol 4,5-bisphosphate activation

Journal of Biological Chemistry

Volumn 290, Issue 3, 2015, Pages 1592-1606

  Wei, Yang ^a   Stec, Boguslaw ^a   Redfield, Alfred G ^b   Weerapana, Eranthie ^a   Roberts, Mary F ^a  

^a BOSTON COLLEGE   (United States)

^b BRANDEIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAINS; ENZYME KINETICS; ENZYMES; INTERFACES (MATERIALS); NUCLEAR MAGNETIC RESONANCE; PHOSPHATASES; PHOSPHOLIPIDS; PROTEINS;

BIOLOGICAL PRODUCTS; PHOSPHATASE ACTIVITY; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PHOSPHOINOSITIDES; PHOSPHOLIPID BINDING; SPIN LATTICE RELAXATION RATES; SPIN-LABELED PROTEINS; TUMOR SUPPRESSOR PHOSPHATASE;

BINDING SITES;

ARGININE; LYSINE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; MICELLE; PHOSPHATIDYLINOSITOL; PHOSPHOLIPID; PROTEIN BINDING; PTEN PROTEIN, HUMAN; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME SUBSTRATE; LIGAND BINDING; MEMBRANE BINDING; MICELLE; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; WILD TYPE; CHEMISTRY; HUMAN; HYDROLYSIS; MASS SPECTROMETRY; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION;

ALLOSTERIC SITE; CATALYTIC DOMAIN; HUMANS; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICELLES; MUTATION; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOLS; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS;

EID: 84922158420     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.588590     Document Type: Article

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