5-HT1A receptor agonist befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats

Anesthesiology

Volumn 122, Issue 2, 2015, Pages 424-434

  Ren, Jun ^a   Ding, Xiuqing ^a   Greer, John J ^a,b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b Alberta Innovation and Science   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BEFIRADOL; FENTANYL CITRATE; FENTANYL; INTRAVENOUS ANESTHETIC AGENT; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 AGONIST; SEROTONIN 1A RECEPTOR;

ADULT; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY PLETHYSMOGRAPHY; BRAIN STEM; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; HYPERALGESIA; HYPERVENTILATION; IN VITRO STUDY; LUNG MINUTE VOLUME; MALE; MEDULLA OBLONGATA; NEWBORN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; RIGHTING REFLEX; SEDATION; SPINAL CORD; AGING; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; AROUSAL; CHEMICALLY INDUCED; CONSCIOUS SEDATION; DRUG EFFECTS; PAIN MEASUREMENT; PHYSIOLOGY; RESPIRATORY INSUFFICIENCY; SPRAGUE DAWLEY RAT;

AGING; ANALGESIA; ANESTHETICS, INTRAVENOUS; ANIMALS; AROUSAL; BEHAVIOR, ANIMAL; BRAIN STEM; CONSCIOUS SEDATION; FENTANYL; IN VITRO TECHNIQUES; MEDULLA OBLONGATA; PAIN MEASUREMENT; PIPERIDINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RESPIRATORY INSUFFICIENCY; SEROTONIN 5-HT1 RECEPTOR AGONISTS; SPINAL CORD;

EID: 84922055723     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0000000000000490     Document Type: Article

References (57)

1. Thompson CA: Prevention of respiratory depression becomes safety foundation's new goal. Am J Health Syst Pharm 2007; 64:798-9
2. Greer JJ, Smith JC, Feldman JL: Generation of respiratory and locomotor patterns by an in vitro brainstem-spinal cord fetal rat preparation. J Neurophysiol 1992; 67:996-9
3. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL: Pre-Bötzinger complex: A brainstem region that may generate respiratory rhythm in mammals. Science 1991; 254:726-9
4. Funk GD, Smith JC, Feldman JL: Generation and transmission of respiratory oscillations in medullary slices: Role of excitatory amino acids. J Neurophysiol 1993; 70:1497-515
5. Funk GD, Smith JC, Feldman JL: Modulation of neural network activity in vitro by cyclothiazide, a drug that blocks desensitization of AMPA receptors. J Neurosci 1995; 15(5 Pt 2):4046-56
6. Ren J, Poon BY, Tang Y, Funk GD, Greer JJ: Ampakines alleviate respiratory depression in rats. Am J Respir Crit Care Med 2006; 174:1384-91
7. Ren J, Ding X, Funk GD, Greer JJ: Ampakine CX717 protects against fentanyl-induced respiratory depression and lethal apnea in rats. Anesthesiology 2009; 110:1364-70
8. Ren J, Ding X, Greer JJ: Respiratory depression in rats induced by alcohol and barbiturate and alleviation by ampakine CX717. J Appl Physiol 2012; 113:1004-11
9. Ren J, Lenal F, Yang M, Ding X, Greer JJ: Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas. Anesthesiology 2013; 118:1437-45
10. Oertel BG, Schneider A, Rohrbacher M, Schmidt H, Tegeder I, Geisslinger G, Lötsch J: The partial 5-hydroxytryptamine1A receptor agonist buspirone does not antagonize morphineinduced respiratory depression in humans. Clin Pharmacol Ther 2007; 81:59-68
11. S ahibzada N, Ferreira M, Wasserman AM, Taveira-DaSilva AM, Gillis RA: Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. J Pharmacol Exp Ther 2000; 292:704-13
12. Guenther U, Manzke T, Wrigge H, Dutschmann M, Zinserling J, Putensen C, Hoeft A: The counteraction of opioidinduced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo. Anesth Analg 2009; 108:1169-76
13. G uenther U, Wrigge H, Theuerkauf N, Boettcher MF, Wensing G, Zinserling J, Putensen C, Hoeft A: Repinotan, a selective 5-HT1A-R-agonist, antagonizes morphine-induced ventilatory depression in anesthetized rats. Anesth Analg 2010; 111:901-7
14. G uenther U, Theuerkauf NU, Huse D, Boettcher MF, Wensing G, Putensen C, Hoeft A: Selective 5-HT (1A)-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception. Anesthesiology 2012; 116:56-64
15. Kimura S, Ohi Y, Haji A: Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats. Eur J Pharmacol 2013; 703:33-41
16. Berge OG, Fasmer OB, Ogren SO, Hole K: The putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin antagonizes the antinociceptive effect of morphine. Neurosci Lett 1985; 54:71-5
17. Millan MJ, Colpaert FC: Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat. Neuropharmacology 1990; 29:315-8
18. Millan MJ, Colpaert FC: 5-hydroxytryptamine (HT )1A receptors and the tail-flick response. II High efficacy 5-HT 1A agonists attenuate morphine-induced antinociception in mice in a competitive-like manner. J Pharmacol Exp Ther 1991; 256:983-92
19. Millan MJ, Colpaert FC: 5-hydroxytryptamine (HT )1A receptors and the tail-flick response. III Structurally diverse 5-HT1A partial agonists attenuate mu-but not kappa-opioid antinociception in mice and rats. J Pharmacol Exp Ther 1991; 256:993-1001
20. Alhaider AA, Wilcox GL: Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice. J Pharmacol Exp Ther 1993; 265:378-85
21. Powell KR, Dykstra LA: The role of serotonergic receptors in the effects of mu opioids in squirrel monkeys responding under a titration procedure. Psychopharmacology (Berl) 1996; 126:42-9
22. Millan MJ, Bervoets K, Colpaert FC: Apparent hyperalgesic action of the 5-HT1A agonist, 8-OH-DPAT, in the rat reflects induction of spontaneous tail-flicks. Neurosci Lett 1989; 107:227-32
23. Colpaert FC, Tarayre JP, Koek W, Pauwels PJ, Bardin L, Xu XJ, Wiesenfeld-Hallin Z, Cosi C, Carilla-Durand E, Assié MB, Vacher B: Large-amplitude 5-HT1A receptor activation: A new mechanism of profound, central analgesia. Neuropharmacology 2002; 43:945-58
24. Kiss I, Degryse AD, Bardin L, Gomez de Segura IA, Colpaert FC: The novel analgesic, F 13640, produces intra-and postoperative analgesia in a rat model of surgical pain. Eur J Pharmacol 2005; 523:29-39
25. Buritova J, Berrichon G, Cathala C, Colpaert F, Cussac D: Region-specific changes in 5-HT1A agonist-induced extracellular signal-regulated kinases phosphorylation in rat brain: A quantitative ELIS A study. Neuropharmacology 2009; 56:350-61
26. L ladó-Pelfort L, Assié MB, Newman-Tancredi A, Artigas F, Celada P: In vivo electrophysiological and neurochemical effects of the selective 5-HT1A receptor agonist, F13640, at pre-and postsynaptic 5-HT1A receptors in the rat. Psychopharmacology (Berl) 2012; 221:261-72
27. Colpaert FC: 5-HT (1A) receptor activation: New molecular and neuroadaptive mechanisms of pain relief. Curr Opin Investig Drugs 2006; 7:40-7
28. S mith JC, Greer JJ, Liu GS, Feldman JL: Neural mechanisms generating respiratory pattern in mammalian brain stem-spinal cord in vitro. I. Spatiotemporal patterns of motor and medullary neuron activity. J Neurophysiol 1990; 64:1149-69
29. Deakin JF, Green AR: The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats. Br J Pharmacol 1978; 64:201-9
30. Johnson SM, Turner SM, Huxtable AG, Ben-Mabrouk F: Isolated in vitro brainstem-spinal cord preparations remain important tools in respiratory neurobiology. Respir Physiol Neurobiol 2012; 180:1-7
31. Funk GD, Greer JJ: The rhythmic, transverse medullary slice preparation in respiratory neurobiology: Contributions and caveats. Respir Physiol Neurobiol 2013; 186:236-53
32. Greer JJ, Carter JE, al-Zubaidy Z: Opioid depression of respiration in neonatal rats. J Physiol 1995; 485(Pt 3):845-55
33. O nimaru H, Shamoto A, Homma I: Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat. Pflugers Arch 1998; 435:485-94
34. Schwarzacher SW, Pestean A, Günther S, Ballanyi K: Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats. Neuroscience 2002; 115:1247-59
35. Corcoran AE, Commons KG, Wu Y, Smith JC, Harris MB, Richerson GB: Dual effects of 5-HT (1a) receptor activation on breathing in neonatal mice. J Neurosci 2014; 34:51-9
36. Hodges MR, Richerson GB: The role of medullary serotonin (5-HT ) neurons in respiratory control: Contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation. J Appl Physiol (1985) 2010; 108:1425-32
37. Toppin VA, Harris MB, Kober AM, Leiter JC, St-John WM: Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation. J Appl Physiol (1985) 2007; 103:220-7
38. St-John WM, Li A, Leiter JC: Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse. J Appl Physiol (1985) 2009; 107:679-85
39. Levitt ES, Hunnicutt BJ, Knopp SJ, Williams JT, Bissonnette JM: A selective 5-HT1a receptor agonist improves respiration in a mouse model of Rett syndrome. J Appl Physiol (1985) 2013; 115:1626-33
40. Manzke T, Guenther U, Ponimaskin EG, Haller M, Dutschmann M, Schwarzacher S, Richter DW: 5-HT 4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science 2003; 301:226-9
41. Lötsch J, Skarke C, Schneider A, Hummel T, Geisslinger G: The 5-hydroxytryptamine 4 receptor agonist mosapride does not antagonize morphine-induced respiratory depression. Clin Pharmacol Ther 2005; 78:278-87
42. Pattinson KT: Opioids and the control of respiration. Br J Anaesth 2008; 100:747-58
43. Montandon G, Qin W, Liu H, Ren J, Greer JJ, Horner RL: A critical site in the medulla mediates opioid-induced respiratory depression. J Neurosci 2011; 31:1292-301
44. Barnes NM, Sharp T: A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38:1083-152
45. Richter DW, Manzke T, Wilken B, Ponimaskin E: Serotonin receptors: Guardians of stable breathing. Trends Mol Med 2003; 9:542-8
46. T alley EM, Sadr NN, Bayliss DA: Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. J Neurosci 1997; 17:4473-85
47. Lalley PM, Bischoff AM, Richter DW: 5-HT-1A receptor-mediated modulation of medullary expiratory neurones in the cat. J Physiol 1994; 476:117-30
48. Manzke T, Niebert M, Koch UR, Caley A, Vogelgesang S, Hülsmann S, Ponimaskin E, Müller U, Smart TG, Harvey RJ, Richter DW: Serotonin receptor 1A-modulated phosphorylation of glycine receptor α3 controls breathing in mice. J Clin Invest 2010; 120:4118-28
49. Ren J, Greer JJ: Modulation of respiratory rhythmogenesis by chloride-mediated conductances during the perinatal period. J Neurosci 2006; 26:3721-30
50. Brockhaus J, Ballanyi K, Smith JC, Richter DW: Microenvironment of respiratory neurons in the in vitro brainstem-spinal cord of neonatal rats. J Physiol 1993; 462:421-45
51. Monti JM, Jantos H: Dose-dependent effects of the 5-HT1A receptor agonist 8-OH-DPAT on sleep and wakefulness in the rat. J Sleep Res 1992; 1:169-75
52. Jarzyna D, Jungquist CR, Pasero C, Willens JS, Nisbet A, Oakes L, Dempsey SJ, Santangelo D, Polomano RC: American Society for Pain Management Nursing guidelines on monitoring for opioid-induced sedation and respiratory depression. Pain Manag Nurs 2011; 12:118-145.e10
53. Tricklebank MD, Forler C, Fozard JR: The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(din-propylamino)tetralin in the rat. Eur J Pharmacol 1984; 106:271-82
54. Bardin L, Assié MB, Pélissou M, Royer-Urios I, Newman-Tancredi A, Ribet JP, Sautel F, Koek W, Colpaert FC: Dual, hyperalgesic, and analgesic effects of the high-efficacy 5-hydroxytryptamine 1A (5-HT 1A) agonist F 13640 [(3-chloro-4-fluoro-phenyl)-[4-fluoro-4-{[(5-methyl-pyridin-2-ylmethyl)-amino]-methyl}piperidin-1-yl]methanone, fumaric acid salt]: Relationship with 5-HT1A receptor occupancy and kinetic parameters. J Pharmacol Exp Ther 2005; 312:1034-42
55. Oertel BG, Felden L, Tran PV, Bradshaw MH, Angst MS, Schmidt H, Johnson S, Greer JJ, Geisslinger G, Varney MA, Lötsch J: Selective antagonism of opioid-induced ventilatory depression by an ampakine molecule in humans without loss of opioid analgesia. Clin Pharmacol Ther 2010; 87:204-11
56. Newman-Tancredi A, Martel JC, Assié MB, Buritova J, Lauressergues E, Cosi C, Heusler P, Bruins Slot L, Colpaert FC, Vacher B, Cussac D: Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1A receptor agonist. Br J Pharmacol 2009; 156:338-53
57. L ladó-Pelfort L, Assié MB, Newman-Tancredi A, Artigas F, Celada P: Preferential in vivo action of F15599, a novel 5-HT (1A) receptor agonist, at postsynaptic 5-HT (1A) receptors. Br J Pharmacol 2010; 160:1929-40