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Volumn 108, Issue 5, 2010, Pages 1425-1432

The role of medullary serotonin (5-HT) neurons in respiratory control: Contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation

Author keywords

Control of breathing; Temperature control

Indexed keywords

CARBON DIOXIDE; SEROTONIN;

EID: 77951972560     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01270.2009     Document Type: Review
Times cited : (112)

References (69)
  • 1
    • 0014941792 scopus 로고
    • Serotonin-containing neurons in brain: Depression of firing by monoamine oxidase inhibitors
    • Aghajanian GK, Graham AW, Sheard MH. Serotonin-containing neurons in brain: depression of firing by monoamine oxidase inhibitors. Science 169: 1100-1102, 1970.
    • (1970) Science , vol.169 , pp. 1100-1102
    • Aghajanian, G.K.1    Graham, A.W.2    Sheard, M.H.3
  • 4
    • 0030050524 scopus 로고    scopus 로고
    • Evidence for central chemoreception in the midline raphe
    • Bernard DG, Li A, Nattie EE. Evidence for central chemoreception in the midline raphe. J Appl Physiol. 80: 108-115, 1996.
    • (1996) J Appl Physiol. , vol.80 , pp. 108-115
    • Bernard, D.G.1    Li, A.2    Nattie, E.E.3
  • 7
    • 0025613417 scopus 로고
    • Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: Electrophysiological studies in the rat central nervous system
    • Chaput Y, Lesieur P, de MC. Effects of short-term serotonin depletion on the efficacy of serotonin neurotransmission: electrophysiological studies in the rat central nervous system. Synapse 6: 328-337, 1990.
    • (1990) Synapse , vol.6 , pp. 328-337
    • Chaput, Y.1    Lesieur, P.2    De, M.C.3
  • 8
    • 0024459633 scopus 로고
    • Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat?
    • Connelly CA, Ellenberger HH, Feldman JL. Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat? Neurosci Lett 105: 34-40, 1989.
    • (1989) Neurosci Lett , vol.105 , pp. 34-40
    • Connelly, C.A.1    Ellenberger, H.H.2    Feldman, J.L.3
  • 12
    • 0022254019 scopus 로고
    • Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius
    • Dekin MS, Richerson GB, Getting PA. Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius. Science 229: 67-69, 1985.
    • (1985) Science , vol.229 , pp. 67-69
    • Dekin, M.S.1    Richerson, G.B.2    Getting, P.A.3
  • 13
    • 0242573129 scopus 로고    scopus 로고
    • Development of the blood-brain barrier
    • Engelhardt B. Development of the blood-brain barrier. Cell Tissue Res 314: 119-129, 2003.
    • (2003) Cell Tissue Res , vol.314 , pp. 119-129
    • Engelhardt, B.1
  • 14
    • 34548828248 scopus 로고    scopus 로고
    • Arrest of 5-HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges
    • Erickson JT, Shafer G, Rossetti MD, Wilson CG, Deneris ES. Arrest of 5-HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges. Respir Physiol Neurobiol 159: 85-101, 2007.
    • (2007) Respir Physiol Neurobiol , vol.159 , pp. 85-101
    • Erickson, J.T.1    Shafer, G.2    Rossetti, M.D.3    Wilson, C.G.4    Deneris, E.S.5
  • 15
    • 0037441964 scopus 로고    scopus 로고
    • Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus
    • Fenik P, Veasey SC. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J Respir Crit Care Med 167: 563-569, 2003.
    • (2003) Am J Respir Crit Care Med , vol.167 , pp. 563-569
    • Fenik, P.1    Veasey, S.C.2
  • 16
    • 0035122950 scopus 로고    scopus 로고
    • Modifications of the serotonergic system in mice lacking serotonin transporters: An in vivo electrophysiological study
    • Gobbi G, Murphy DL, Lesch K, Blier P. Modifications of the serotonergic system in mice lacking serotonin transporters: an in vivo electrophysiological study. J Pharmacol Exp Ther 296: 987-995, 2001. (Pubitemid 32187374)
    • (2001) Journal of Pharmacology and Experimental Therapeutics , vol.296 , Issue.3 , pp. 987-995
    • Gobbi, G.1    Murphy, D.L.2    Lesch, K.-P.3    Blier, P.4
  • 18
    • 0020540303 scopus 로고
    • Effects of TRH and TRH analogues on the central regulation of breathing in the rat
    • Hedner J, Hedner T, Wessberg P, Lundberg D, Jonason J. Effects of TRH and TRH analogues on the central regulation of breathing in the rat. Acta Physiol Scand 117: 427-437, 1983. (Pubitemid 13125060)
    • (1983) Acta Physiologica Scandinavica , vol.117 , Issue.3 , pp. 427-437
    • Hedner, J.1    Hedner, T.2    Wessberg, P.3
  • 20
    • 77951943805 scopus 로고    scopus 로고
    • Adult Pet-1 knockout mice exhibit an attenuated hypercapnic ventilatory response
    • Program no. 352. 4. Washington, DC: Society for Neuroscience
    • Hodges MR, Best S, Deneris ES, Richerson GB. Adult Pet-1 knockout mice exhibit an attenuated hypercapnic ventilatory response. Program no. 352. 4. 2005 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2005.
    • (2005) 2005 Neuroscience Meeting Planner.
    • Hodges, M.R.1    Best, S.2    Deneris, E.S.3    Richerson, G.B.4
  • 22
    • 9244258595 scopus 로고    scopus 로고
    • Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats
    • DOI 10.1152/japplphysiol.00645.2004
    • Hodges MR, Martino P, Davis S, Opansky C, Pan LG, Forster HV. Effects on breathing of focal acidosis at multiple medullary raphe sites in awake goats. J Appl Physiol 97: 2303-2309, 2004. (Pubitemid 39552471)
    • (2004) Journal of Applied Physiology , vol.97 , Issue.6 , pp. 2303-2309
    • Hodges, M.R.1    Martino, P.2    Davis, S.3    Opansky, C.4    Pan, L.G.5    Forster, H.V.6
  • 24
    • 56449121657 scopus 로고    scopus 로고
    • Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons
    • Hodges MR, Richerson GB. Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons. Respir Physiol Neurobiol 164: 350-357, 2008.
    • (2008) Respir Physiol Neurobiol , vol.164 , pp. 350-357
    • Hodges, M.R.1    Richerson, G.B.2
  • 25
    • 53849110593 scopus 로고    scopus 로고
    • Contributions of 5-HT neurons to respiratory control: Neuromodulatory and trophic effects
    • Hodges MR, Richerson GB. Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects. Respir Physiol Neurobiol 164: 222-232, 2008.
    • (2008) Respir Physiol Neurobiol , vol.164 , pp. 222-232
    • Hodges, M.R.1    Richerson, G.B.2
  • 27
    • 69049111812 scopus 로고    scopus 로고
    • Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development
    • Hodges MR, Wehner M, Aungst J, Smith JC, Richerson GB. Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J Neurosci 29: 10341-10349, 2009.
    • (2009) J Neurosci , vol.29 , pp. 10341-10349
    • Hodges, M.R.1    Wehner, M.2    Aungst, J.3    Smith, J.C.4    Richerson, G.B.5
  • 28
    • 0023244922 scopus 로고
    • Sudden infant death syndrome: 1987 perspective
    • Hunt CE, Brouillette RT. Sudden infant death syndrome: 1987 perspective. J Pediatr 110: 669-678, 1987.
    • (1987) J Pediatr , vol.110 , pp. 669-678
    • Hunt, C.E.1    Brouillette, R.T.2
  • 31
    • 0022923919 scopus 로고
    • Serotoninergic and non-serotoninergic responses of phrenic motoneurones to raphe stimulation in the cat
    • Lalley PM. Serotoninergic and non-serotoninergic responses of phrenic motoneurones to raphe stimulation in the cat. J Physiol 380: 373-385, 1986.
    • (1986) J Physiol , vol.380 , pp. 373-385
    • Lalley, P.M.1
  • 32
    • 0028325754 scopus 로고
    • C-fos-like immuno-reactivity in the cat's neuraxis following moderate hypoxia or hypercapnia
    • Larnicol N, Wallois F, Berquin P, Gros F, Rose D. c-fos-like immuno-reactivity in the cat's neuraxis following moderate hypoxia or hypercapnia. J Physiol (Paris) 88: 8.1-88, 1994.
    • (1994) J Physiol (Paris) , vol.88 , pp. 81-88
    • Larnicol, N.1    Wallois, F.2    Berquin, P.3    Gros, F.4    Rose, D.5
  • 33
    • 50249125895 scopus 로고    scopus 로고
    • Serotonergic transcriptional programming determines maternal behavior and offspring survival
    • Lerch-Haner JK, Frierson D, Crawford LK, Beck SG, Deneris ES. Serotonergic transcriptional programming determines maternal behavior and offspring survival. Nat Neurosci 11: 1001-1003, 2008.
    • (2008) Nat Neurosci , vol.11 , pp. 1001-1003
    • Lerch-Haner, J.K.1    Frierson, D.2    Crawford, L.K.3    Beck, S.G.4    Deneris, E.S.5
  • 34
    • 42949136397 scopus 로고    scopus 로고
    • Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia
    • Li A, Nattie E. Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J Physiol 586: 2321-2329, 2008.
    • (2008) J Physiol , vol.586 , pp. 2321-2329
    • Li, A.1    Nattie, E.2
  • 35
    • 77951943275 scopus 로고    scopus 로고
    • SERT knock-out mice have altered control of breathing and thermoregulation
    • Li A, Nattie EE. SERT knock-out mice have altered control of breathing and thermoregulation. FASEB J 21: 2007.
    • (2007) FASEB J , vol.21
    • Li, A.1    Nattie, E.E.2
  • 36
    • 34147114722 scopus 로고    scopus 로고
    • The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm
    • Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell 129: 371-383, 2007.
    • (2007) Cell , vol.129 , pp. 371-383
    • Lu, B.1    Su, Y.2    Das, S.3    Liu, J.4    Xia, J.5    Ren, D.6
  • 37
    • 10344221595 scopus 로고    scopus 로고
    • Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression
    • Mathews TA, Fedele DE, Coppelli FM, Avila AM, Murphy DL, Andrews AM. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Methods 140: 169-181, 2004.
    • (2004) J Neurosci Methods , vol.140 , pp. 169-181
    • Mathews, T.A.1    Fedele, D.E.2    Coppelli, F.M.3    Avila, A.M.4    Murphy, D.L.5    Andrews, A.M.6
  • 38
    • 2342574895 scopus 로고    scopus 로고
    • Central pathways controlling brown adipose tissue thermogenesis
    • Morrison SF. Central pathways controlling brown adipose tissue thermogenesis. News Physiol Sci 19: 67-74, 2004.
    • (2004) News Physiol Sci , vol.19 , pp. 67-74
    • Morrison, S.F.1
  • 39
    • 0025641537 scopus 로고
    • Body growth, lung and heart weight, and DNA content in newborn rats exposed to different levels of chronic hypoxia
    • Mortola JP, Xu LJ, Lauzon AM. Body growth, lung and heart weight, and DNA content in newborn rats exposed to different levels of chronic hypoxia. Can J Physiol Pharmacol 68: 1590-1594, 1990.
    • (1990) Can J Physiol Pharmacol , vol.68 , pp. 1590-1594
    • Mortola, J.P.1    Xu, L.J.2    Lauzon, A.M.3
  • 40
    • 0021227930 scopus 로고
    • Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats
    • Mueller RA, Towle AC, Breese GR. Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats. Brain Res 298: 370-373, 1984.
    • (1984) Brain Res , vol.298 , pp. 370-373
    • Mueller, R.A.1    Towle, A.C.2    Breese, G.R.3
  • 41
    • 0034745476 scopus 로고    scopus 로고
    • 2 dialysis in the medullary raphe of the rat increases ventilation in sleep
    • 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 90: 1247-1257, 2001.
    • (2001) J Appl Physiol , vol.90 , pp. 1247-1257
    • Nattie, E.E.1    Li, A.2
  • 42
    • 1942485936 scopus 로고    scopus 로고
    • Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo
    • Nattie EE, Li A, Richerson G, Lappi DA. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J Physiol 556: 235-253, 2004.
    • (2004) J Physiol , vol.556 , pp. 235-253
    • Nattie, E.E.1    Li, A.2    Richerson, G.3    Lappi, D.A.4
  • 43
    • 69949102053 scopus 로고    scopus 로고
    • Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network
    • Nuding SC, Segers LS, Shannon R, O'Connor R, Morris KF, Lindsey BG. Central and peripheral chemoreceptors evoke distinct responses in simultaneously recorded neurons of the raphe-pontomedullary respiratory network. Philos Trans R Soc Land B Biol Sci 364: 2501-2516, 2009.
    • (2009) Philos Trans R Soc Land B Biol Sci , vol.364 , pp. 2501-2516
    • Nuding, S.C.1    Segers, L.S.2    Shannon, R.3    O'Connor, R.4    Morris, K.F.5    Lindsey, B.G.6
  • 44
  • 46
    • 0037114964 scopus 로고    scopus 로고
    • Endogenous activation of serotonin-2A receptors is required for respiratory rhytm generation in vitro
    • Pena F, Ramirez JM. Endogenous activation of serotonin-2A receptors is required for respiratory rhytm generation in vitro. J Neurosci 22: 11055-11064, 2002.
    • (2002) J Neurosci , vol.22 , pp. 11055-11064
    • Pena, F.1    Ramirez, J.M.2
  • 47
    • 4444226344 scopus 로고    scopus 로고
    • Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network
    • DOI 10.1523/JNEUROSCI.1871-04.2004
    • Pena F, Ramirez JM. Substance P-mediated modulation of pacemaker properties in the mammalian respiratory network. J Neurosci 24: 7549-7556, 2004. (Pubitemid 39166746)
    • (2004) Journal of Neuroscience , vol.24 , Issue.34 , pp. 7549-7556
    • Pena, F.1    Ramirez, J.-M.2
  • 49
    • 64849101288 scopus 로고    scopus 로고
    • Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P
    • Ptak K, Yamanishi T, Aungst J, Milescu LS, Zhang R, Richerson GB, Smith JC. Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J Neurosci 29: 3720-3737 2009.
    • (2009) J Neurosci , vol.29 , pp. 3720-3737
    • Ptak, K.1    Yamanishi, T.2    Aungst, J.3    Milescu, L.S.4    Zhang, R.5    Richerson, G.B.6    Smith, J.C.7
  • 50
    • 2642547405 scopus 로고    scopus 로고
    • Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis
    • Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 5: 449-461, 2004.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 449-461
    • Richerson, G.B.1
  • 51
    • 18844427059 scopus 로고    scopus 로고
    • Homing in on the specific phenotype(s) of central respiratory chemoreceptors
    • DOI 10.1113/expphysiol.2005.029843
    • Richerson GB, Wang W, Hodges MR, Dohle CI, ez-Sampedro A. Homing in on the specific phenotype(s) of central respiratory chemoreceptors. Exp Physiol 90: 259-266, 2005. (Pubitemid 40685835)
    • (2005) Experimental Physiology , vol.90 , Issue.3 , pp. 259-266
    • Richerson, G.B.1    Wang, W.2    Hodges, M.R.3    Dohle, C.I.4    Diez-Sampedro, A.5
  • 52
    • 0035185087 scopus 로고    scopus 로고
    • Chemosensitivity of serotonergic neurons in the rostral ventral medulla
    • DOI 10.1016/S0034-5687(01)00289-4, PII S0034568701002894
    • Richerson GB, Wang W, Tiwari J, Bradley SR. Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 129: 175-189, 2001. (Pubitemid 33103926)
    • (2001) Respiration Physiology , vol.129 , Issue.1-2 , pp. 175-189
    • Richerson, G.B.1    Wang, W.2    Tiwari, J.3    Bradley, S.R.4
  • 54
    • 66749129488 scopus 로고    scopus 로고
    • Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse
    • St-John WM, Li A, Leiter JC. Genesis of gasping is independent of levels of serotonin in the Pet-1 knockout mouse. J Appl Physiol 107: 679-685, 2009.
    • (2009) J Appl Physiol , vol.107 , pp. 679-685
    • St-John, W.M.1    Li, A.2    Leiter, J.C.3
  • 55
    • 0019464864 scopus 로고
    • Distribution of serotonin-immunoreactivity in the central nervous system of the rat. Cell bodies and terminals
    • DOI 10.1016/0306-4522(81)90146-9
    • Steinbusch HW. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6: 557-618, 1981. (Pubitemid 11102583)
    • (1981) Neuroscience , vol.6 , Issue.4 , pp. 557-618
    • Steinbusch, H.W.M.1
  • 56
    • 0034894597 scopus 로고    scopus 로고
    • Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats
    • Stunden CE, Filosa JA, Garcia AJ, Dean JB, Putnam RW. Development of in vivo ventilatory and single chemosensitive neuron responses to hypercapnia in rats. Respir Physiol 127: 135-155, 2001.
    • (2001) Respir Physiol , vol.127 , pp. 135-155
    • Stunden, C.E.1    Filosa, J.A.2    Garcia, A.J.3    Dean, J.B.4    Putnam, R.W.5
  • 57
    • 0033757904 scopus 로고    scopus 로고
    • + channel, is modulated by multiple neurotransmitters in motoneurons
    • + channel, is modulated by multiple neurotransmitters in motoneurons. Neuron 25: 399-410, 2000.
    • (2000) Neuron , vol.25 , pp. 399-410
    • Talley, E.M.1    Lei, Q.2    Sirois, J.E.3    Bayliss, D.A.4
  • 58
    • 34447631375 scopus 로고    scopus 로고
    • Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation
    • Toppin VA, Harris MB, Kober AM, Leiter JC, St-John WM. Persistence of eupnea and gasping following blockade of both serotonin type 1 and 2 receptors in the in situ juvenile rat preparation. J Appl Physiol. 103: 220-227, 2007.
    • (2007) J Appl Physiol. , vol.103 , pp. 220-227
    • Toppin, V.A.1    Harris, M.B.2    Kober, A.M.3    Leiter, J.C.4    St-John, W.M.5
  • 59
    • 33644820352 scopus 로고    scopus 로고
    • 2A receptors
    • DOI 10.1523/JNEUROSCI.4186-05.2006
    • Tryba AK, Pena F, Ramirez JM. Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors. J Neurosci 26: 2623-2634, 2006. (Pubitemid 43357845)
    • (2006) Journal of Neuroscience , vol.26 , Issue.10 , pp. 2623-2634
    • Tryba, A.K.1    Pena, F.2    Ramirez, J.-M.3
  • 60
    • 0029051506 scopus 로고
    • Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats
    • Veasey SC, Fornal CA, Metzler CW, Jacobs BL. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J Neurosci 15: 5346-5359, 1995.
    • (1995) J Neurosci , vol.15 , pp. 5346-5359
    • Veasey, S.C.1    Fornal, C.A.2    Metzler, C.W.3    Jacobs, B.L.4
  • 62
    • 0025214714 scopus 로고
    • Serotonin immunoreactive boutons form close appositions with respiratory neurons of the dorsal respiratory group in the cat
    • Voss MD, De CD, Lipski J, Pilowsky PM, Jiang C. Serotonin immunoreactive boutons form close appositions with respiratory neurons of the dorsal respiratory group in the cat. J Comp Neurol 295: 208-218, 1990. (Pubitemid 20148256)
    • (1990) Journal of Comparative Neurology , vol.295 , Issue.2 , pp. 208-218
    • Voss, M.D.1    De, C.D.2    Lipski, J.3    Pilowsky, P.M.4    Jiang, C.5
  • 63
    • 0018218120 scopus 로고
    • Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: Pharmacological evidence
    • Wang RY, Aghajanian GK. Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: pharmacological evidence. Neuropharmacology 17: 819-825, 1978.
    • (1978) Neuropharmacology , vol.17 , pp. 819-825
    • Wang, R.Y.1    Aghajanian, G.K.2
  • 64
    • 0017687166 scopus 로고
    • Antidromically identified serotonergic neurons in the rat midbrain raphe: Evidence for collateral inhibition
    • Wang RY, Aghajanian GK. Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Res 132: 186-193, 1977.
    • (1977) Brain Res , vol.132 , pp. 186-193
    • Wang, R.Y.1    Aghajanian, G.K.2
  • 65
    • 0032169807 scopus 로고    scopus 로고
    • Chemosensitivity of rat medullary raphe neurones in primary tissue culture
    • DOI 10.1111/j.1469-7793.1998.433bh.x
    • Wang W, Pizzonia JH, Richerson GB. Chemosensitivity of rat medullary raphe neurones in primary tissue culture. J Physiol 511: 433-450, 1998. (Pubitemid 28444613)
    • (1998) Journal of Physiology , vol.511 , Issue.2 , pp. 433-450
    • Wang, W.1    Pizzonia, J.H.2    Richerson, G.B.3
  • 66
    • 0032947693 scopus 로고    scopus 로고
    • Development of chemosensitivity of rat medullary raphe neurons
    • DOI 10.1016/S0306-4522(98)00505-3, PII S0306452298005053
    • Wang W, Richerson GB. Development of chemosensitivity of rat medullary raphe neurons. Neuroscience 90: 1001-1011, 1999. (Pubitemid 29156764)
    • (1999) Neuroscience , vol.90 , Issue.3 , pp. 1001-1011
    • Wang, W.1    Richerson, G.B.2
  • 68
    • 0019781861 scopus 로고
    • Effects of substance P and TRH on ventilation and pattern of breathing in newborn rabbits
    • Yamamoto Y, Lagercrantz H, von Euler C. Effects of substance P and TRH on ventilation and pattern of breathing in newborn rabbits. Acta Physiol Scand 113: 541-543, 1981. (Pubitemid 12183355)
    • (1981) Acta Physiologica Scandinavica , vol.113 , Issue.4 , pp. 541-543
    • Yamamoto, Y.1    Lagercrantz, H.2    Von Euler, C.3
  • 69
    • 33845423914 scopus 로고    scopus 로고
    • Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity
    • DOI 10.1523/JNEUROSCI.4143-06.2006
    • Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW, Johnson RL, Deneris ES, Chen ZF. Lm×1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci 26: 12781-12788, 2006. (Pubitemid 44904573)
    • (2006) Journal of Neuroscience , vol.26 , Issue.49 , pp. 12781-12788
    • Zhao, Z.-Q.1    Scott, M.2    Chiechio, S.3    Wang, J.-S.4    Renner, K.J.5    Gereau IV, R.W.6    Johnson, R.L.7    Deneris, E.S.8    Chen, Z.-F.9


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