Selective 5-HT1A-R-agonist repinotan prevents remifentanil-induced ventilatory depression and prolongs antinociception

Anesthesiology

Volumn 116, Issue 1, 2012, Pages 56-64

  Guenther, Ulf ^a   Theuerkauf, Nils U ^a   Huse, Daniel ^a   Boettcher, Michael F ^b   Wensing, Georg ^b   Putensen, Christian ^a   Hoeft, Andreas ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

REMIFENTANIL; REPINOTAN; SEROTONIN 1A AGONIST; BENZOPYRAN DERIVATIVE; HYPNOTIC SEDATIVE AGENT; INTRAVENOUS ANESTHETIC AGENT; NARCOTIC ANALGESIC AGENT; PIPERIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST; THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CARDIOVASCULAR EFFECT; CONTINUOUS INFUSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG WITHDRAWAL; HEART RATE; LATENT PERIOD; LUNG MINUTE VOLUME; MALE; MEAN ARTERIAL PRESSURE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; SINGLE DRUG DOSE; TAIL FLICK TEST; ANIMAL; BLOOD PRESSURE; BREATHING MECHANICS; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; HEMODYNAMICS; PAIN ASSESSMENT; RESPIRATORY FAILURE; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANESTHETICS, INTRAVENOUS; ANIMALS; BENZOPYRANS; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HEMODYNAMICS; HYPNOTICS AND SEDATIVES; MALE; PAIN MEASUREMENT; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RESPIRATORY INSUFFICIENCY; RESPIRATORY MECHANICS; SEROTONIN RECEPTOR AGONISTS; THIAZOLES;

EID: 84655163981     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e31823d08fa     Document Type: Article

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