Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs

Epigenetics

Volumn 9, Issue 12, 2014, Pages 1613-1625

  Svoboda, Laurie K ^a   Harris, Ashley ^a   Bailey, Natashay J ^a   Schwentner, Raphaela ^b   Tomazou, Eleni ^b   von Levetzow, Cornelia ^a   Magnuson, Brian ^a   Ljungman, Mats ^a   Kovar, Heinrich ^b,c   Lawlor, Elizabeth R ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b ST ANNA CHILDREN S HOSPITAL   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Epigenetic; Ewing sarcoma; HOX; Polycomb

Indexed keywords

BMI-1; HOMEODOMAIN PROTEIN; POLYCOMB GROUP PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG; EWS-FLI FUSION PROTEIN; HOXD10 PROTEIN, HUMAN; HOXD11 PROTEIN, HUMAN; HOXD13 PROTEIN, HUMAN; ONCOPROTEIN; RNA BINDING PROTEIN EWS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FLI 1;

ARTICLE; CELL DIFFERENTIATION; DOWN REGULATION; EWING SARCOMA; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC REGULATION; HISTONE MODIFICATION; HOX GENE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MESENCHYMAL STEM CELL; NEURAL CREST CELL; OSTEOSARCOMA; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; UPREGULATION; BONE TUMOR; CYTOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HOMEOBOX; MULTIGENE FAMILY; PHYSIOLOGY; TUMOR CELL LINE;

BONE NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; MULTIGENE FAMILY; ONCOGENE PROTEINS, FUSION; POLYCOMB-GROUP PROTEINS; PROTO-ONCOGENE PROTEIN C-FLI-1; RNA-BINDING PROTEIN EWS; SARCOMA, EWING; STEM CELLS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 84922041577     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/15592294.2014.988048     Document Type: Article

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