Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation

Nature Structural and Molecular Biology

Volumn 21, Issue 9, 2014, Pages 771-777

  Huo, Yanwu ^a   Nam, Ki Hyun ^a,d   Ding, Fang ^a   Lee, Heejin ^a   Wu, Lijie ^b   Xiao, Yibei ^a   Farchione, M Daniel ^a   Zhou, Sharleen ^c   Rajashankar, Kanagalaghatta ^a   Kurinov, Igor ^a   Zhang, Rongguang ^b   Ke, Ailong ^a  

^a Department of Obstetrics Gynecology   (United States)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CAS3 PROTEIN; HYDROGEN; PROTEIN; SINGLE STRANDED DNA; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; CRISPR ASSOCIATED PROTEIN; DNA HELICASE;

ARTICLE; BASE PAIRING; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRYSTAL; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA BINDING; DNA DEGRADATION; DNA DENATURATION; DNA STRAND; ENZYME ACTIVITY; GENE TARGETING; HYDROGEN BOND; HYDROLYSIS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; THERMOBIFIDA FUSCA; ACTINOMYCETALES; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

PROKARYOTA; THERMOBIFIDA FUSCA;

ACTINOMYCETALES; ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; CRISPR-ASSOCIATED PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA HELICASES; DNA, SINGLE-STRANDED; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

EID: 84921996108     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2875     Document Type: Article

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