In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA Target

Journal of Biological Chemistry

Volumn 288, Issue 31, 2013, Pages 22184-22192

  Mulepati, Sabin ^a   Bailey, Scott ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TARGETS; E. COLI; IN-VITRO;

DNA; ESCHERICHIA COLI;

IMMUNE SYSTEM;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; COBALT; CRISPR ASSOCIATED PROTEIN 3; DEOXYRIBONUCLEASE; HELICASE; NUCLEASE; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; DNA CLEAVAGE; DNA DEGRADATION; ESCHERICHIA COLI; HYDROLYSIS; IMMUNE SYSTEM; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; RNA SEQUENCE; STREPTOCOCCUS THERMOPHILUS;

CAS3; CASCADE; CRISPR; DNA; DNA HELICASE; DNA-BINDING PROTEIN; NUCLEASE; RNA; RNA-BINDING PROTEIN;

ADENOSINE TRIPHOSPHATE; BASE SEQUENCE; DNA PRIMERS; DNA, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; IMMUNE SYSTEM; PLASMIDS; RECOMBINANT PROTEINS; RNA, BACTERIAL;

EID: 84881256166     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.472233     Document Type: Article

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