An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 23, 2014, Pages 6552-6563

  Reddy, Kummetha Indrasena ^b   Srihari, Konduri ^b   Renuka, Janupally ^a   Sree, Komanduri Shruthi ^a   Chuppala, Aruna ^b   Jeankumar, Variam Ullas ^a   Sridevi, Jonnalagadda Padma ^a   Babu, Kondra Sudhakar ^b   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b SRI KRISHNADEVARAYA UNIVERSITY   (India)

Author keywords

Antitubercular; Benzofuran; Benzo d isothiazole; Cytotoxicity; DNA gyrase; Tuberculosis

Indexed keywords

4 (BENZO[D]ISOTHIAZOL 3 YL) N (4 CHLOROPHENYL)PIPERAZINE 1 CARBOTHIOIC ACID(4 NITRO PHENYL) AMIDE; 4 (BENZO[D]ISOTHIAZOL 3 YL) N (4 CHLOROPHENYL)PIPERAZINE 1 CARBOXAMIDE; 4 (BENZO[D]ISOTHIAZOL 3 YL) N (4 METHOXYPHENYL)PIPERAZINE 1 CARBOXAMIDE; 4 (BENZO[D]ISOTHIAZOL 3 YL) N BENZYLPIPERAZINE 1 CARBOXAMIDE; 4 (BENZO[D]ISOTHIAZOL 3 YL) N PHENYLPIPERAZINE 1 CARBOXAMIDE; 5 [4 (4 NITRO PHENYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; 5 [4 (4 NITRO PHENYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLIC ACID ETHYL ESTER; ANTIMYCOBACTERIAL AGENT; BENZOFURAN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ETHAMBUTOL; ETHYL 5 [4 (4 ACETYLPHENYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 ACETYLPHENYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 CHLOROBENZYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 CHLOROBENZYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 CHLOROPHENYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 CHLOROPHENYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 METHOXYPHENYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (4 METHOXYPHENYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (BENZYLCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (BENZYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (PHENYLCARBAMOYL) PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (PHENYLTHIOCARBAMOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ISONIAZID; ISOTHIAZOLE DERIVATIVE; N (4 ACETYLPHENYL) 4 (BENZO[D]ISOTHIAZOL 3 YL)PIPERAZINE 1 CARBOXAMIDE; NOVOBIOCIN; OFLOXACIN; RIFAMPICIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; 4-(BENZO(D)ISOTHIAZOL-3-YL)-N-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXAMIDE; BENZOFURAN; BENZOTHIAZOLE DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; PIPERAZINE DERIVATIVE; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC50; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR HYBRIDIZATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMOSTABILITY; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; HUMAN; MACROPHAGE; METABOLISM; MICROBIAL SENSITIVITY TEST; SYNTHESIS;

EUKARYOTA; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BENZOFURANS; BENZOTHIAZOLES; CELL LINE; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MACROPHAGES; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84921984497     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.10.016     Document Type: Article

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