Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 17, 2014, Pages 4924-4934

  Renuka, Janupally ^a   Reddy, Kummetha Indrasena ^b   Srihari, Konduri ^b   Jeankumar, Variam Ullas ^a   Shravan, Morla ^a   Sridevi, Jonnalagadda Padma ^a   Yogeeswari, Perumal ^a   Babu, Kondra Sudhakar ^b   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b SRI KRISHNADEVARAYA UNIVERSITY   (India)

Author keywords

Antibacterial activity; Cytotoxicity; DNA gyraseB; Tuberculosis

Indexed keywords

5 NITRO SALICYLALDEHYDE; 5 [4 (3 TRIFLUOROMETHYLPYRIDINE 2 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLICACIDETHYL ESTER; BENZOFURAN DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING) B; ETHAMBUTOL; ETHYL 5 (PIPERAZIN 1 YL)BENZOFURAN 2 CARBOXYLATE; ETHYL 5 AMINOBENZOFURAN 2 CARBOXYLATE; ETHYL 5 NITROBENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2 ADAMANTAN 1 YL ACETYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2 CHLOROPYRIDINE 3 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2 CYCLOHEXYLACETYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2 PHENOXYACETYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2 PHENYLACETYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2,3 DIHYDRO 1H INDOLE 2 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (2,6 DIFLUOROBENZOYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLICACIDETHYL ESTER; ETHYL 5 [4 (3 CHLOROPYRAZINE 2 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (FURAN 2 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 (NAPHTHALENE 1 CARBONYL)PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [2 (2,4,6 TRIFLUOROPHENYL)ACETYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [2 (4 BROMOPHENYL)ACETYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [2 (4 CHLOROPHENYL)ACETYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [2 (4 FLUOROPHENYL)ACETYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [2 (4 METHOXYPHENYL)ACETYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [3 (4 FLUOROPHENYL)PROPANOYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ETHYL 5 [4 [4 (TETRAHYDROPYRAN 4 YL)BENZOYL]PIPERAZIN 1 YL]BENZOFURAN 2 CARBOXYLATE; ISONIAZID; MOXIFLOXACIN; NOVOBIOCIN; OFLOXACIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; DNA TOPOISOMERASE (ATP HYDROLYSING); GYRASE INHIBITOR; TUBERCULOSTATIC AGENT;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DNA SUPERCOILING; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HYDROPHOBICITY; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; MOLECULAR HYBRIDIZATION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; THERMOSTABILITY; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DOCKING; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; BENZOFURANS; CELL LINE; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84906936667     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.06.041     Document Type: Article

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