7α,15α-Ethano bridged steroids. Synthesis and progesterone receptor interaction

Tetrahedron

Volumn 55, Issue 37, 1999, Pages 11267-11274

  Egner, Ursula ^a   Fritzemeier, Karl Heinrich ^a   Halfbrodt, Wolfgang ^a   Heinrich, Nikolaus ^a   Kuhnke, Joachim ^a   Müller Fahmow, Anke ^a   Neef, Günter ^a   Schöllkopf, Klaus ^a   Schwede, Wolfgang ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROGESTERONE RECEPTOR; STEROID;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; STEROIDOGENESIS; STRUCTURE ACTIVITY RELATION;

BETULACEAE;

EID: 0033543478     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(99)00638-9     Document Type: Article

References (18)

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3. a. These investigations were stimulated by a result recently obtained in our laboratories. Diels-Alder reaction of 17-acetoxy 14,16-dienes with ethylene under high pressure allowed a very efficient approach to 14,17-bridged steroids. see: Halfbrodt, W.; Schöllkopf, K. DE 19531947 (1997).
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17. The atomic coordinates and anisotropic displacement coefficients for this work are available on request from the Director of the Cambridge Crystallographic Data Centre, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW. Any request should be accompanied by the full literature citation for this publication.
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