The relationship between inflammation, dyslipidemia and physical exercise: From the epidemiological to molecular approach

Current Diabetes Reviews

Volumn 10, Issue 6, 2014, Pages 391-396

  Lira, F S ^a   Rosa Neto, J C ^b   Antunes, B M M ^a   Fernandes, R A ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dyslipidemia; Epidemiology; Inflammation; Molecular pathway; Physical exercise

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL ESTER TRANSFER PROTEIN; CYTOKINE; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

AEROBIC EXERCISE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CACHEXIA; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DYSLIPIDEMIA; ENERGY EXPENDITURE; EPIDEMIOLOGICAL DATA; EXERCISE; GLUCONEOGENESIS; GLUCOSE TRANSPORT; HEART INFARCTION; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID METABOLISM; LIPOLYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PHYSICAL INACTIVITY; PRIORITY JOURNAL; RESISTANCE TRAINING; SKELETAL MUSCLE; WHITE ADIPOSE TISSUE; ANIMAL; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; EXERCISE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-6; OBESITY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84921903900     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/1573399810666141122210135     Document Type: Article

References (71)

1. Misra A, Shrivastava U. Obesity and dyslipidemia in South Asians. Nutrients 2013; 5(7): 2708-33.
2. Tabatabaei-Malazy O, Qorbani M, Samavat T, Sharifi F, Larijani B, Fakhrzadeh H. Prevalence of dyslipidemia in Iran: a systematic review and meta-analysis study. Int J Prev Med 2014; 5(4): 373-93.
3. Gigante DP, Moura EC, Sardinha LM. Prevalence of overweight and obesity and associated factors, Brazil, 2006. Rev Saude Publica 2009; 43(supl.2): 83-9.
4. Fernandes RA, Christofaro DG, Casonatto J, et al. Prevalence of dyslipidemia in individuals physically active during childhood, adolescence and adult age. Arq Bras Cardiol 2011; 97(4): 317-23.
5. Goff DC Jr, Bertoni AG, Kramer H, et al. Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation 2006; 113(5): 647-56.
6. Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants. Lancet 2011; 377(9765): 557-67.
7. Huang PL. eNOS. Metabolic syndrome and cardiovascular disease. Trends Endocrinol Metab 2009; 20(6): 295-302.
8. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444(7121): 875-80.
9. Freitas Júnior IF, Christofaro DG, Codogno JS, Monteiro PA, Silveira LS, Fernandes RA. The association between skipping breakfast and biochemical variables in sedentary obese children and adolescents. J Pediatr 2012; 161(5): 871-4.
10. Aatola H, Koivistoinen T, Hutri-Kähönen N, et al. Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2010; 122(24): 2521-8.
11. Lee IM, Djoussé L, Sesso HD, Wang L, Buring JE. Physical activity and weight gain prevention. JAMA 2010; 303(12): 1173-9.
12. Friedenreich CM, Woolcott CG, McTiernan A, et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int J Obes (Lond) 2011; 35(3): 427-35.
13. Kraus WE, Slentz CA. Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect. Obesity (Silver Spring) 2009; 17 Suppl 3: S21-6.
14. Moore SC, Patel AV, Matthews CE, et al. Leisure time physical activity of moderate to vigorous intensity and mortality: a large pooled cohort analysis. PLoS Med 2012; 9(11): e1001335.
15. Zaros PR, Pires CE, Bacci M Jr, Moraes C, Zanesco A. Effect of 6- months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC Womens Health 2009; 9: 17.
16. Balducci S, Zanuso S, Nicolucci A, et al. Anti-inflammatory effect of exercise training in subjects with type 2 diabetes and the metabolic syndrome is dependent on exercise modalities and independent of weight loss. Nutr Metab Cardiovasc Dis 2010; 20: 608-17.
17. Teixeira-Lemos E, Nunes S, Teixeira F, Reis F. Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovasc Diabetol 2011; 10: 12
18. Malagrino PA, Sponton CH, Esposti RD, et al. Prevalence of dyslipidemia in middle-aged adults with NOS3 gene polymorphism and low cardiorespiratory fitness. Arq Bras Endocrinol Metabol 2013; 57(1): 33-43.
19. Kimura T, Yokoyama T, Matsumura Y, et al. NOS3 genotypedependent correlation between blood pressure and physical activity. Hypertension 2003; 41(2): 355-60.
20. Xi B, Cheng H, Shen Y, et al. Physical activity modifies the associations between genetic variants and hypertension in the Chinese children. Atherosclerosis 2012; 225: 376-80.
21. White AJ, Sandler DP, Bolick SC, Xu Z, Taylor JA, DeRoo LA. Recreational and household physical activity at different time points and DNA global methylation. Eur J Cancer 2013; 49(9): 2199-206.
22. Lima MCS, Barbosa MF, Diniz TA, Codogno JS, Freitas Júnior IF, Fernandes RA. Early and current physical activity: relationship with intima-media thickness and metabolic variables in adulthood. Braz J Phys Ther 2014; 18(5): 462-9.
23. Strong WB, Malina RM, Blimkie CJ, et al. Evidence based physical activity for school-age youth. J Pediatr 2005; 146(6): 732-7.
24. Knittle JL, Timmers K, Ginsberg-Fellner F, Brown RE, Katz DP. The growth of adipose tissue in children and adolescents. Crosssectional and longitudinal studies of adipose cell number and size. J Clin Invest 1979; 63(2): 239-46.
25. Fernandes RA, Zanesco A. Early physical activity promotes lower prevalence of chronic diseases in adulthood. Hypertens Res 2010; 33(9): 926-31.
26. Sinaiko AR, Donahue RP, Jacobs DR Jr, Prineas RJ. Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study. Circulation 1999; 99(11): 1471-6.
27. Guo SS, Wu W, Chumlea WC, Roche AF. Predicting overweight and obesity in adulthood from body mass index values in childhood and adolescence. Am J Clin Nutr 2002; 76(3): 653-8.
28. Juonala M, Viikari JS, Kähönen M, et al. Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study. Eur Heart J 2010; 31(14): 1745-51.
29. Nagy C, Turecki G. Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes. Epigenomics 2012; 4(4): 445-57.
30. Aguiar FJ, Ferreira-Júnior M, Sales MM, et al. C-reactive protein: clinical applications and proposals for a rational use. Rev Assoc Med Bras 2013; 59(1): 85-92.
31. Nazmi A, Oliveira IO, Victora CG. Correlates of C-reactive protein levels in young adults: a population-based cohort study of 3827 subjects in Brazil. Braz J Med Biol Res. 2008; 41(5): 357-67.
32. Lai MM, Li CI, Kardia SL, et al. Sex difference in the association of metabolic syndrome with high sensitivity C-reactive protein in a Taiwanese population. BMC Public Health 2010; 10: 429.
33. Loprinzi P, Cardinal B, Crespo C, et al. Objectively measured physical activity and C-reactive protein: National Health and Nutrition Examination Survey 2003-2004. Scand J Med Sci Sports 2013; 23(2): 164-70.
34. Cao JJ, Arnold AM, Manolio TA, et al. Association of carotid artery intima-media thickness, plaques, and C-reactive protein with future cardiovascular disease and all-cause mortality: the Cardiovascular Health Study. Circulation 2007; 116(1): 32-8.
35. Yamashita AS, Lira FS, Rosa JC, et al. Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: the effect of aerobic training and energy restriction. Cytokine 2010; 52(3): 168-74.
36. Lira FS, Rosa JC, Pimentel GD, et al. Inflammation and adipose tissue: effects of progressive load training in rats. Lipids Health Dis. 2010 Oct 4;9:109. doi: 10.1186/1476-511X-9-109.
37. Lira FS, Zanchi NE, Lima-Silva AE, et al. Acute high-intensity exercise with low energy expenditure reduced LDL-c and total cholesterol in men. Eur J Appl Physiol. 2009 Sep;107(2):203-10. doi: 10.1007/s00421-009-1115-5. Epub 2009 Jun 24.
38. Lira FS, Koyama CH, Yamashita AS, et al. Chronic exercise decreases cytokine production in healthy rat skeletal muscle. Cell Biochem Funct 2009; 27(7): 458-61.
39. Madge LA, Pober JS. TNF Signaling in vascular endothelial cells. Exp Mol Pathol 2001; 70: 317-325
40. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D, Maniatis T. Transcriptional regulation of endothelial cell adhesion molecules: NF-kappaB and cytokine-inducible enhancers. FASEB J 1995; 9 (10): 899-909
41. Nascimento MA, Higa EMS, de Mello MT, et al. Effects of shortterm l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men. e-SPEN Journal, Volume 9, Issue 3, June 2014, Pages e141-e145.
42. Pedersen BK, Febbraio MA. Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 2008; 88(4): 1379- 406.
43. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin- 10 during Pregnancy. Front Immunol 2014; 5: 253.
44. Grant RW, Dixit VD. Mechanisms of disease: inflammasome activation and the development of type 2 diabetes. Front Immunol 2013; 4: 50.
45. Tanti JF, Ceppo F, Jager J, Berthou F. Implication of inflammatory signaling pathways in obesity-induced insulin resistance. Front Endocrinol (Lausanne) 2013; 3: 181.
46. Schroder K, Tschopp J. The inflammasomes. Cell 2010; 140(6): 821-32.
47. Prajapati B, Jena PK, Rajput P, Purandhar K, Seshadri S. Understanding and modulating the Toll like Receptors (TLRs) and NOD like Receptors (NLRs) cross talk in type 2 diabetes. Curr Diabetes Rev. 2014 May; 10(3): 190-200.
48. Benetti E, Chiazza F, Patel NS, Collino M. The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders. Mediators Inflamm 2013; 2013: 678627.
49. Spranger J, Kroke A, Möhlig M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population- based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003; 52(3): 812-7.
50. Jager J, Grémeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1β-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 2007; 148(1): 241-51.
51. Hahn WS, Kuzmicic J, Burrill JS, et al. Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Am J Physiol Endocrinol Metab 2014; 306(9): E1033-45
52. Nov O, Shapiro H, Ovadia H, et al. Interleukin-1β regulates fatliver crosstalk in obesity by auto-paracrine modulation of adipose tissue inflammation and expandability. PLoS One 2013; 8(1): e53626.
53. Kanemaki T, Kitade H, Kaibori M, et al. Interleukin 1beta and interleukin 6, but not tumor necrosis factor alpha, inhibit insulinstimulated glycogen synthesis in rat hepatocytes. Hepatology 1998; 27(5): 1296-303.
54. Negrin KA, Roth Flach RJ, DiStefano MT, et al. IL-1 Signaling in Obesity-Induced Hepatic Lipogenesis and Steatosis. PLoS One 2014; 9(9): e107265.
55. Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994; 43(11): 1271-8.
56. Stephens JM, Pekala PH. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factoralpha. J Biol Chem 1991; 266(32): 21839-45.
57. Ling PR, Bistrian BR, Mendez B, Istfan NW. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism 1994; 43(3): 279-84.
58. Pedersen BK. The diseasome of physical inactivity--and the role of myokines in muscle--fat cross talk. J Physiol 2009; 587: 5559-68.
59. Steensberg A, Fischer CP, Keller C, Møller K, Pedersen BK. IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 2003; 285(2): E433-7.
60. Petersen AM, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol (1985). 2005; 98(4): 1154-62.
61. Zanchi NE, Lira FS, de Siqueira Filho MA, et al. Chronic low frequency/low volume resistance training reduces proinflammatory cytokine protein levels and TLR4 mRNA in rat skeletal muscle. Eur J Appl Physiol. 2010; 109(6): 1095-102.
62. Ho RC, Hirshman MF, Li Y, et al. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am J Physiol Cell Physiol 2005; 289(4): C794-801
63. Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol (1985) 2008; 105(2): 473-8.
64. Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 2010; 16: 105-18.
65. Batista ML Jr, Rosa JC, Lopes RD, et al. Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. Cytokine 2010; 49(1): 102-8.
66. Ribeiro F, Alves AJ, Teixeira M, et al. Exercise training increases interleukin-10 after an acute myocardial infarction: a randomised clinical trial. Int J Sports Med 2012; 33(3): 192-8
67. Balen S, Vukelić-Damijani N, Persić V, et al. Anti-inflammatory effects of exercise training in the early period after myocardial infarction. Coll Antropol 2008; 32(1): 285-91
68. Samaan MC, Marcinko K, Sikkema S, et al. Endurance interval training in obese mice reduces muscle inflammation and macrophage content independently of weight loss. Physiol Rep 2014; 2(5). pii: e12012.
69. Kawanishi N, Mizokami T, Yano H, Suzuki K. Exercise attenuates M1 macrophages and CD8+ T cells in the adipose tissue of obese mice. Med Sci Sports Exerc 2013; 45(9): 1684-93.
70. Crissey JM, Jenkins NT, Lansford KA, et al. Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats. Am J Physiol Regul Integr Comp Physiol 2014; 306(8): R596-606.
71. Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: a 12-week randomized intervention study. Am J Physiol Endocrinol Metab 2010; 298(4): E824-31.