Prevalence of dyslipidemia in middle-aged adults with NOS3 gene polymorphism and low cardiorespiratory fitness;Prevalência de dislipidemia em adultos de meia-idade com polimorfismo do gene NOS3 e baixa aptidão cardiorrespiratória

Arquivos Brasileiros de Endocrinologia e Metabologia

Volumn 57, Issue 1, 2013, Pages 33-43

  Malagrino, Pamella A ^a   Sponton, Carlos H G ^a   Esposti, Rodrigo D ^a   Franco Penteado, Carla F ^a,b   Fernandes, Romulo A ^a   Bezerra, Marcos André C ^a,b   Albuquerque, Dulcinéia M ^a,b   Rodovalho, Cynara M ^a   Bacci, Maurício ^a   Zanesco, Angelina ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Adults; Cardiorespiratory fitness; Dyslipidemia; Polymorphism

Indexed keywords

CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUTAMIC ACID; NITRATE; NITRITE; NOS3 PROTEIN, HUMAN;

ARTICLE; BLOOD; CARDIOVASCULAR SYSTEM; DYSLIPIDEMIA; EPIDEMIOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; INTRON; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PROMOTER REGION; RESPIRATORY SYSTEM;

CARDIOVASCULAR SYSTEM; CHOLESTEROL; DYSLIPIDEMIAS; EPIDEMIOLOGIC METHODS; FEMALE; GENOTYPE; GLUTAMIC ACID; HUMANS; INTRONS; MALE; MIDDLE AGED; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; OXYGEN CONSUMPTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RESPIRATORY SYSTEM;

EID: 84874550810     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302013000100005     Document Type: Article

References (34)

1. Moncada S, Higgs EA. Nitric oxide and the vascular endothelium. Handb Exp Pharmacol. 2006;176:213-54.
2. Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G. Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem. 2006;17(9):571-88.
3. Balligand JL, Feron O, Dessy C. eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues. Physiol Rev. 2009;89(2):481-534.
4. Zanesco A, Antunes E. Effects of exercise training on the c -r diovascular system: pharmacological approaches. Pharmacol Ther. 2007;114(3):307-17.
5. Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829-37, 837a-837d.
6. Casas JP, Cavalleri GL, Bautista LE, Smeeth L, Humphries SE, Hingorani AD. Endothelial nitric oxide synthase gene polymorphisms and cardiovascular disease: a HuGE review. Am J Epidemiol. 2006;164(10):921-35.
7. Sandrim VC, Yugar-Toledo JC, Desta Z, Flockhart DA, Moreno H Jr, Tanus-Santos JE. Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy. J Hypertens. 2006;24(12):2393-7.
8. Sandrim VC, de Syllos RW, Lisboa HR, Tres GS, Tanus-Santos JE. Influence of eNOS haplotypes on the plasma nitric oxide products concentrations in hypertensive and type 2 diabetes mellitus patients. Nitric Oxide. 2007;16(3):348-55.
9. Zaros PR, Pires CE, Bacci M Jr, Moraes C, Zanesco A. Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC Womens Health. 2009;19:9-17.
10. Claudino MA, Delbin MA, Franco-Penteado CF, Priviero FB, De Nucci G, Antunes E, et al. Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats. Life Sci. 2011;31(88):272-7.
11. Kimura T, Yokoyama T, Matsumura Y, Yoshiike N, Date C, Muramatsu M, et al. NOS3 genotype-dependent correlation between blood pressure and physical activity. Hypertension. 2003;41(2):355-60.
12. Sarzynski MA, Rankinen T, Sternfeld B, Fornage M, Sidney S, Bouchard C. SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study. J Hum Hypertens. 2011;25(8):509-18.
13. Rankinen T, Rice T, Pérusse L, Chagnon YC, Gagnon J, Leon AS, et al. NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study. Hypertension. 2000;36(5):885-9.
14. Negrao MV, Alves CR, Alves GB, Pereira AC, Dias RG, Laterza MC, et al. Exercise training improves muscle vasodilatation in individuals with T786C polymorphism of endothelial nitric oxide synthase gene. Physiol Genomics. 2010;42A(1):71-7.
15. Sponton CH, Rezende TM, Mallagrino PA, Franco-Penteado CF, Bezerra MA, Zanesco A. Women with TT genotype for eNOS gene are more responsive in lowering blood pressure in response to exercise. Eur J Cardiovasc Prev Rehabil. 2010;17(6):676-81.
16. Esposti RD, Sponton CH, Malagrino PA, Carvalho FC, Peres E, Puga GM, et al. Influence of eNOS gene polymorphism on cardiometabolic parameters in response to physical training in postmenopausal women. Braz J Med Biol Res. 2011;44(9):855-63.
17. Kline GM, Porcari JP, Hintermeister R, Freedson PS, Ward A, McCarron RF, et al. Estimation of VO2max from a one-mile track walk, gender, age, and body weight. Med Sci Sports Exerc. 1987;19(3):253-9.
18. Pulkkinen A, Viitanen L, Kareinen A, Lehto S, Vauhkonen I, Laakso M. Intron 4b/a polymorphism of the endothelial nitric oxide synthase gene is associated with elevated blood pressure in type 2 diabetic patients with coronary heart disease. J Mol Med. 2000;78(7):372-9.
19. IV Brazilian Guideline for Dyslipidemia and Atherosclerosis prevention. Arq Bras Cardiol. 2007;88(Suppl 1):2-19.
20. Cattaruzza M, Guzik TJ, Słodowski W, Pelvan A, Becker J, Halle M, et al. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res. 2004;95(8):841-7.
21. Dosenko VE, Zagoriy VY, Haytovich NV, Gordok OA, Moibenko AA. Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations. Acta Biochim Pol. 2006;53:299-302.
22. Wang XL, Wang J. Endothelial nitric oxide synthase gene sequence variations and vascular disease. Mol Genet Metab. 2000;70:241-51.
23. Miyamoto Y, Saito Y, Nakayama M, Shimasaki Y, Yoshimura T, Yoshimura M, et al. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T--->C mutation associated with coronary spastic angina. Hum Mol Genet. 2000;9(18):2629-37.
24. Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary disease: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci U S A. 2000;14(6):2832-5.
25. Lakoski SG, Barlow CE, Farrell SW, Berry JD, Morrow JR Jr, Haskell WL. Impact of body mass index, physical activity, and other clinical factors on cardiorespiratory fitness (from the Cooper Center longitudinal study). Am J Cardiol. 2011;108(1):34-9.
26. Gupta S, Rohatgi A, Ayers CR, Willis BL, Haskell WL, Khera A, et al. Cardiorespiratory fitness and classification of risk of cardiovascular disease mortality. Circulation. 2011;5(13):1377-83.
27. Aspenes ST, Nilsen TI, Skaug EA, Bertheussen GF, Ellingsen Ø, Vatten L, et al. Peak oxygen uptake and cardiovascular risk factors in 4631 healthy women and men. Med Sci Sports Exerc. 2011;43(8):1465-73.
28. Keteyian SJ, Brawner CA, Savage PD, Ehrman JK, Schairer J, Divine G, et al. Peak aerobic capacity predicts prognosis in patients with coronary heart disease. Am Heart J. 2008;156(2):292-300.
29. Han Y, Xu W, Zhang W, Liu N, Ji Y. T-786C polymorphism in the endothelial nitric oxide synthase gene is associated with increased risk of coronary artery disease in a Chinese population. Pharmacology. 2010;85(4):211-6.
30. Hoffmann IS, Tavares-Mordwinkin R, Castejon AM, Alfieri AB, Cubeddu LX. Endothelial nitric oxide synthase polymorphism, nitric oxide production, salt sensitivity and cardiovascular risk factors in Hispanics. J Hum Hypertens. 2005;19(3):233-40.
31. Imamura A, Takahashi R, Murakami R, Kataoka H, Cheng XW, Numaguchi Y, et al. The effects of endothelial nitric oxide synthase gene polymorphisms on endothelial function and metabolic risk factors in healthy subjects: the significance of plasma adiponectin levels. Eur J Endocrinol. 2008;158(2):189-95.
32. Joshi MS, Mineo C, Shaul PW, Bauer JA. Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear. FASEB J. 2007;21(11):2655-63.
33. Zanesco A, Silva CP, Delbin MA, La Guardia PG, Davel AP, Priviero FB. Mitochondrial biogenesis and redox state in gastrocnemius muscle from trained rats supplemented with L-arginine. Free Radic Biol Med. 2011;51(Suppl 1).
34. Frayn KN, Fielding BA, Karpe F. Adipose tissue fatty acid metabolism and cardiovascular disease. Curr Opin Lipidol. 2005;16(4):409-15.