A comparison of the pharmacokinetics of three different preparations of total flavones of Hippophae rhamnoides in beagle dogs after oral administration

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 41, Issue 3, 2016, Pages 239-249

  Duan, Jingze ^a   Dang, Yang ^a   Meng, Houjun ^a   Wang, Huizhen ^a   Ma, Ping ^b   Li, Guowen ^a,c   Wu, Tao ^a   Xie, Yan ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Hospira Inc   (United States)

^c Shanghai TCM Integrated Hospital   (China)

Author keywords

Beagle dogs; Pharmacokinetics; Self emulsifying; Solid dispersion; Total flavones of Hippophae rhamnoides; UPLC MS

Indexed keywords

ISORHAMNETIN; KAEMPFEROL; QUERCETIN; 3-METHYLQUERCETIN; EMULSION; FLAVONE DERIVATIVE; KAEMPFEROL DERIVATIVE;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BEAGLE; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; HIPPOPHAE RHAMNOIDES; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CHEMISTRY; COMPARATIVE STUDY; DOG; EMULSION; HIPPOPHAE; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DOGS; EMULSIONS; FLAVONES; HIPPOPHAE; KAEMPFEROLS; MALE; QUERCETIN;

EID: 84921845290     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-015-0254-9     Document Type: Article

References (43)

1. Alexopoulou E, Georgopoulos A, Kagkadis KA, Demetzos C (2006) Preparation and characterization of lyophilized liposomes with incorporated quercetin. J Liposome Res 16:17–25
2. Basu M, Prasad R, Jayamurthy P, Pal K, Arumughan C, Sawhney RC (2007) Anti-atherogenic effects of seabuckthorn (Hippophaea rhamnoides) seed oil. Phytomedicine 14:770–777
3. Bose S, Michniak-Kohn B (2012) Preparation and characterization of lipid based nanosystems for topical delivery of quercetin. Eur J Pharm Sci 48:442–452
4. Cermak R, Landgraf S, Wolffram S (2003) The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 133:2802–2807
5. Chauhan AS, Negi PS, Rarnteke RS (2007) Antioxidant and antibacterial activities of aqueous extract of Seabuckthorn (Hippophae rhamnoides) seeds. Fitoterapia 78:590–592
6. Cornaire G, Woodley J, Hermann P, Cloarec A, Arellano C, Houin G (2004) Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int J Pharm 278:119–131
7. Costa ARD, Marquiafavel FS, Vaz MMDLL, Rocha BA, Bueno PCP, Amaral PLM, Barud HD, Berreta-Silva AA (2011) Quercetin-PVP K25 solid dispersions: preparation, thermal characterization and antioxidant activity. J Therm Anal Calorim 104:273–278
8. Gugler R, Leschik M, Dengler HJ (1975) Disposition of quercetin in man after single oral and intravenous doses. Eur J Clin Pharmacol 9:229–234
9. Hsu YW, Tsai CF, Chen WK, Lu FJ (2009) Protective effects of seabuckthorn (Hippophae rhamnoides L.) seed oil against carbon tetrachloride-induced hepatotoxicity in mice. Food Chem Toxicol 47:2281–2288
10. Iosio T, Voinovich D, Perissutti B, Serdoz F, Hasa D, Grabnar I, Acqua SD, Zara GP, Muntoni E, Pinto JF (2011) Oral bioavailability of silymarin phytocomplex formulated as self-emulsifying pellets. Phytomedicine 18:505–512
11. Kakran M, Shegokar R, Sahoo NG, Shaal LA, Li L, Muller RH (2012) Fabrication of quercetin nanocrystals: comparison of different methods. Eur J Pharm Biopharm 80:113–121
12. Khaled KA, El-Sayed YM, Al-Hadiya BM (2003) Disposition of the flavonoid quercetin in rats after single intravenous and oral doses. Drug Dev Ind Pharm 29:397–403
13. Li W, Yi S, Wang Z, Chen S, Xin S, Xie J, Zhao C (2011) Self-nanoemulsifying drug delivery system of persimmon leaf extract: optimization and bioavailability studies. Int J Pharm 420:161–171
14. Maheshwari DT, Kumar MSY, Verma SK, Singh VK, Singh SN (2011) Antioxidant and hepatoprotective activities of phenolic rich fraction of Seabuckthorn (Hippophae rhamnoides L.) leaves. Food Chem Toxicol 49:2422–2428
15. Martignoni M, Groothuis GM, de Kanter R (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2:875–894
16. Moon YJ, Wang L, DiCenzo R, Morris ME (2008) Quercetin pharmacokinetics in humans. Biopharm Drug Dispos 29:205–217
17. Morand C, Manach C, Crespy V, Remesy C (2000) Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic Res 33:667–676
18. Ofer M, Wolffram S, Koggel A, Spahn-Langguth H, Langguth P (2005) Modulation of drug transport by selected flavonoids: involvement of P-gp and OCT? Eur J Pharm Sci 25:263–271
19. Piskula MK (2000) Factors affecting flavonoids absorption. BioFactors 12:175–180
20. Plotas P, Anastasopoulos C, Makri OE, Leotsinidis M, Georgakopoulos CD (2014) A UPLC–MS method for the determination of ofloxacin concentrations in aqueous humor. Anal Chem Insights 9:27–32
21. ®. Planta Med 76:1683–1690
22. Reinboth M, Wolffram S, Abraham G, Ungemach FR, Cermak R (2010) Oral bioavailability of quercetin from different quercetin glycosides in dogs. Br J Nutr 104:198–203
23. Shi R, Qiao S, Yu DQ, Shi XW, Liu M, Jiang XJ, Wang Q, Zhang LT (2011) Simultaneous determination of five flavonoids from Scutellaria Barbata extract in rat plasma by LC-MS/MS and its application to pharmacokinetic study. J Chromatogr B Anal Technol Biomed Life Sci 879:1625–1632
24. Shukla SK, Chaudhary P, Kumar IP, Samanta N, Afrin F, Gupta ML, Sharma UK, Sinha AK, Sharma YK, Sharma RK (2006) Protection from radiation-induced mitochondrial and genomic DNA damage by an extract of Hippophae rhamnoides. Environ Mol Mutagen 47:647–656
25. Smith AJ, Kavuru P, Wojtas L, Zaworotko MJ, Shytle RD (2011) Cocrystals of quercetin with improved solubility and oral bioavailability. Mol Pharm 8:1867–1876
26. Sun B, Sun GB, Xiao J, Chen RC, Wang X, Wu Y, Cao L, Yang ZH, Sun XB (2012) Isorhamnetin inhibits H(2)O(2)-induced activation of the intrinsic apoptotic pathway in H9c2 cardiomyocytes through scavenging reactive oxygen species and ERK inactivation. J Cell Biochem 113:473–485
27. Tian S, He G, Song J, Wang S, Xin W, Zhang D, Du G (2012) Pharmacokinetic study of baicalein after oral administration in monkeys. Fitoterapia 83:532–540
28. Vo CL, Park C, Lee BJ (2013) Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs. Eur J Pharm Biopharm 85:799–813
29. Walle T, Otake Y, Walle UK, Wilson FA (2000) Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J Nutr 130:2658–2661
30. Wang Y, Cao J, Zeng S (2005) Involvement of P-glycoprotein in regulating cellular levels of Ginkgo flavonols: quercetin, kaempferol, and isorhamnetin. J Pharm Pharmacol 57:751–758
31. Wang XD, Xia HJ, Xing F, Deng GF, Shen Q, Zeng S (2009) A highly sensitive and robust UPLC-MS with electrospray ionization method for quantitation of taxifolin in rat plasma. J Chromatogr B Anal J Mol Biol 877:1778–1786
32. Williams HD, Trevaskis NL, Charman SA, Shanker RM, Charman WN, Pouton CW, Porter CJ (2013) Strategies to address low drug solubility in discovery and development. Pharmacol Rev 65:315–499
33. Wu J, Xing H, Tang D, Gao Y, Yin X, Du Q, Jiang X, Yang D (2012) Simultaneous determination of nine flavonoids in beagle dog by HPLC with DAD and application of Ginkgo biloba extracts on the pharmacokinetic. Acta Chromatogr 24:627–642
34. Xie Y, Li G, Yuan X, Cai Z, Rong R (2009a) Preparation and in vitro evaluation of solid dispersions of total flavones of Hippophae rhamnoides L. AAPS PharmSciTech 10:631–640
35. Xie Y, Rong R, Li G, Yuan X, Wang J (2009b) Studies on self-microemulsifying drug preparations of total flavones of Hippophae rhamnoides. Zhongguo Zhong Yao Za Zhi 34:43–46
36. Xu J, Zhang Q, Zhao L, Wang Y, Xue L, Han T, Zheng C, Qin L (2012) Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography–mass spectrometry. J Pharm Biomed Anal 61:242–246
37. Yue ME, Jiang TF, Shi YP (2004) Fast determination of flavonoids in Hippophae rhamnoides and its medicinal preparation by capillary zone electrophoresis using dimethyl-beta-cyclodextrin as modifier. Talanta 62:695–699
38. Zhang Q, Cui H (2005) Simultaneous determination of quercetin, kaempferol, and isorhamnetin in phytopharmaceuticals of Hippophae rhamnoides L. by high-performance liquid chromatography with chemiluminescence detection. J Sep Sci 28:1171–1178
39. Zhang L, Lin G, Zuo Z (2004) High-performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma. J Pharm Biomed Anal 36:637–641
40. Zhang QY, Kaminsky LS, Dunbar D, Zhang J, Ding X (2007) Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine. Drug Metab Dispos 35:1617–1623
41. Zhang HS, Zhang M, Yu LH, Zhao Y, He NW, Yang XB (2012) Antitumor activities of quercetin and quercetin-5′,8-disulfonate in human colon and breast cancer cell lines. Food Chem Toxicol 50:1589–1599
42. Zhao G, Duan J, Xie Y, Lin G, Luo H, Li G, Yuan X (2013) Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L. Drug Dev Ind Pharm 39:1037–1045
43. Zuo Z, Zhang L, Zhou L, Chang Q, Chow M (2006) Intestinal absorption of hawthorn flavonoids—in vitro, in situ and in vivo correlations. Life Sci 79:2455–2462