Effects of solid dispersion and self-emulsifying formulations on the solubility, dissolution, permeability and pharmacokinetics of isorhamnetin, quercetin and kaempferol in total flavones of Hippophae rhamnoides L.

Drug Development and Industrial Pharmacy

Volumn 39, Issue 7, 2013, Pages 1037-1045

  Zhao, Guoying ^a   Duan, Jingze ^a   Xie, Yan ^a   Lin, Guobei ^a   Luo, Huilin ^a   Li, Guowen ^a   Yuan, Xiurong ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Dissolution rate; Pharmacokinetics; Self emulsifying; Solid dispersion; Solubility; Total flavones of Hippophae rhamnoides L.

Indexed keywords

ISORHAMNETIN; KAEMPFEROL; QUERCETIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DISSOLUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG PENETRATION; DRUG SOLUBILITY; DRUG STRUCTURE; ENTEROHEPATIC CIRCULATION; HIPPOPHAE RHAMNOIDES; IN VITRO STUDY; INTESTINE ABSORPTION; MALE; MEAN RESIDENCE TIME; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; FLAVONES; HIPPOPHAE; INTESTINES; KAEMPFEROLS; MALE; PERMEABILITY; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84878839242     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.699066     Document Type: Article

References (35)

1. He J, Lan K, Jiang X. (2008). Identification and content determination of β-sitosterol-β-D-glycoside in total flavones of Hippophae rhamnoides. West China J Pharmaceut Sci, 23: 298-300.
2. Suomela JP, Ahotupa M, Yang B, Vasankari T, Kallio H. (2006). Absorption of flavonols derived from sea buckthorn (Hippophaë rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. J Agric Food Chem, 54:7364-7369.
3. Pang X, Zhao J, Zhang W, Zhuang X, Wang J, Xu R et al. (2008). Antihypertensive effect of total flavones extracted from seed residues of Hippophae rhamnoides L. in sucrose-fed rats. J Ethnopharmacol, 117:325-331.
4. Zhang W, Zhao J, Wang J, Pang X, Zhuang X, Zhu X et al. (2010). Hypoglycemic effect of aqueous extract of seabuckthorn (Hippophae rhamnoides L.) seed residues in streptozotocininduced diabetic rats. Phytother Res, 24:228-232.
5. Cheng J, Kondo K, Suzuki Y, Ikeda Y, Meng X, Umemura K. (2003). Inhibitory effects of total flavones of Hippophae Rhamnoides L on thrombosis in mouse femoral artery and in vitro platelet aggregation. Life Sci, 72:2263-2271.
6. Zhang Q, Cui H. (2005). Simultaneous determination of quercetin, kaempferol, and isorhamnetin in phytopharmaceuticals of Hippophae rhamnoides L. by high-performance liquid chromatography with chemiluminescence detection. J Sep Sci, 28:1171-1178.
7. Yue ME, Jiang TF, Shi YP. (2004). Fast determination of flavonoids in Hippophae rhamnoides and its medicinal preparation by capillary zone electrophoresis using dimethyl-β-cyclodextrin as modifier. Talanta, 62:695-699.
8. Kim MK, Park KS, Yeo WS, Choo H, Chong Y. (2009). In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates. Bioorg Med Chem, 17:1164-1171.
9. Shah TJ, Amin AF, Parikh JR, Parikh RH. (2007). Process optimization and characterization of poloxamer solid dispersions of a poorly water-soluble drug. AAPS PharmSciTech, 8:Article 29.
10. Buyukozturk F, Benneyan JC, Carrier RL. (2010). Impact of emulsion-based drug delivery systems on intestinal permeability and drug release kinetics. J Control Release, 142:22-30.
11. Kang MJ, Kim HS, Jeon HS, Park JH, Lee BS, Ahn BK et al. (2012). In situ intestinal permeability and in vivo absorption characteristics of olmesartan medoxomil in self-microemulsifying drug delivery system. Drug Dev Ind Pharm, 38:587-596.
12. Carrier RL, Miller LA, Ahmed I. (2007). The utility of cyclodextrins for enhancing oral bioavailability. J Control Release, 123:78-99.
13. Yue PF, Yuan HL, Li XY, Yang M, Zhu WF. (2010). Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex. Int J Pharm, 387:139-146.
14. Li H, Zhao X, Ma Y, Zhai G, Li L, Lou H. (2009). Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. J Control Release, 133:238-244.
15. Sticher O. (1993). Quality of Ginkgo preparations. Planta Med, 59:2-11.
16. Chen C, Zhang H, Xiao W, Yong ZP, Bai N. (2007). High-performance liquid chromatographic fingerprint analysis for different origins of sea buckthorn berries. J Chromatogr A, 1154:250-259.
17. Serajuddin AT. (1999). Solid dispersion of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J Pharm Sci, 88:1058-1066.
18. Laitinen R, Suihko E, Bjorkqvist M, Riikonen J, Lehto VP, Jarvinen K et al. (2010). Perphenazine solid dispersions for orally fastdisintegrating tablets: Physical stability and formulation. Drug Dev Ind Pharm, 36:601-613.
19. Chen ZP, Sun J, Chen HX, Xiao YY, Liu D, Chen J et al. (2010). Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Fitoterapia, 81:1045-1052.
20. Qin F, Hu Q, Liang W, Xu T. (2007). Preparation of silymarin selfmicroemulsifying capsules and its pharmacokinetics study in rats. Chin Pharm J, 42:1551-1555.
21. Xie Y, Li G, Yuan X, Cai Z, Rong R. (2009). Preparation and in vitro evaluation of solid dispersions of total flavones of Hippophae rhamnoides L. AAPS PharmSciTech, 10:631-640.
22. Xie Y, Rong R, Li G, Yuan X, Wang J. (2009). [Studies on selfmicroemulsifying drug preparations of total flavones of Hippophae rhamnoides]. Zhongguo Zhong Yao Za Zhi, 34:43-46.
23. Asare-Addo K, Levina M, Rajabi-Siahboomi AR, Nokhodchi A. (2010). Study of dissolution hydrodynamic conditions versus drug release from hypromellose matrices: The influence of agitation sequence. Colloids Surf B Biointerfaces, 81:452-460.
24. Bravo-Osuna I, Ferrero C, Jiménez-Castellanos MR. (2008). Drug release behaviour from methyl methacrylate-starch matrix tablets: Effect of polymer moisture content. Eur J Pharm Biopharm, 69:285-293.
25. Xie Y, Zeng X, Li G, Cai Z, Ding N, Ji G. (2010). Assessment of intestinal absorption of total flavones of Hippophae rhamnoides L. in rat using in situ absorption models. Drug Dev Ind Pharm, 36:787-794.
26. Li G, Zeng X, Xie Y, Cai Z, Moore JC, Yuan X et al. (2012). Pharmacokinetic properties of isorhamnetin, kaempferol and quercetin after oral gavage of total flavones of Hippophae rhamnoides L. in rats using a UPLC-MS method. Fitoterapia, 83:182-191.
27. Pillay V, Fassihi R. (1998). Evaluation and comparison of dissolution data derived from different modified release dosage forms: An alternative method. J Control Release, 55:45-55.
28. Janssens S, Van den Mooter G. (2009). Review: Physical chemistry of solid dispersions. J Pharm Pharmacol, 61:1571-1586.
29. Zheng RX, Xu XD, Tian Z. Yang JS. (2009). Chemical constituents from the fruits of Hippophae rhamnoides. Nat Prod Res, 23:1451-1456.
30. Han HK, Lee BJ, Lee HK. (2011). Enhanced dissolution and bioavailability of biochanin A via the preparation of solid dispersion: In vitro and in vivo evaluation. Int J Pharm, 415:89-94.
31. He CX, He ZG, Gao JQ. (2010). Microemulsions as drug delivery systems to improve the solubility and the bioavailability of poorly water-soluble drugs. Expert Opin Drug Deliv, 7:445-460.
32. Wang L, Li CR, Jiang XH. (2007). In situ intestinal absorption behaviors of Tanshionoe IIA from its inclusion complex with hydroxypropyl-β- cyclodextrin. Biol Pharm Bull, 30:1918-1922.
33. Rabba AK, Si L, Xue K, Li M, Li G. (2011). In situ intestinal perfusion of irinotecan: Application to P-gp mediated drug interaction and introduction of an improved HPLC assay. J Pharm Pharm Sci, 14:138-147.
34. Makris DP, Rossiter JT. (2000). Heat-induced, metal-catalyzed oxidative degradation of quercetin and rutin (Quercetin 3-O-rhamnosylglucoside) in aqueous model systems. J Agric Food Chem, 48:3830-3838.
35. Rubas W, Jezyk N, Grass GM. (1993). Comparison of the permeability characteristics of a human colonic epithelial (Caco- 2) cell line to colon of rabbit, monkey, and dog intestine and human drug absorption. Pharm Res, 10:113-118.