Biased gene conversion skews allele frequencies in human populations, increasing the disease burden of recessive alleles

American Journal of Human Genetics

Volumn 95, Issue 4, 2014, Pages 408-420

  Lachance, Joseph ^a,b   Tishkoff, Sarah A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DNA BASE COMPOSITION; GENE CONVERSION; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DISORDER; GENETIC DISTANCE; GENETIC RECOMBINATION; GENETIC RISK; GENOME ANALYSIS; HOMOZYGOTE; HUMAN; HUMAN GENOME; NATURAL SELECTION; PLESIOMORPHY; POPULATION GENETICS; PRIORITY JOURNAL; RECESSIVE INHERITANCE; BIOLOGICAL MODEL; GENETIC SELECTION; GENETICS; MOLECULAR EVOLUTION; RECESSIVE GENE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL BIAS; THEORETICAL MODEL;

PRIMATES;

BIAS (EPIDEMIOLOGY); EVOLUTION, MOLECULAR; GENE CONVERSION; GENE FREQUENCY; GENES, RECESSIVE; GENETIC DISEASES, INBORN; GENETICS, POPULATION; GENOME, HUMAN; HUMANS; MODELS, GENETIC; MODELS, THEORETICAL; POLYMORPHISM, SINGLE NUCLEOTIDE; RECOMBINATION, GENETIC; SELECTION, GENETIC;

EID: 84921776131     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2014.09.008     Document Type: Article

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