MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways

Toxicology and Applied Pharmacology

Volumn 283, Issue 2, 2015, Pages 127-138

  Simões, Maylla Ronacher ^a,b   Aguado, Andrea ^b   Fiorim, Jonaína ^a   Silveira, Edna Aparecida ^a   Azevedo, Bruna Fernandes ^a   Toscano, Cindy Medice ^a   Zhenyukh, Olha ^b   Briones, Ana María ^b   Alonso, María Jesús ^d   Vassallo, Dalton Valentim ^a,c   Salaices, Mercedes ^b  

^a FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

^b HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^c Emescam College of Health Sciences of Vitoria   (Brazil)

^d UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

Blood pressure; Cyclooxygenase 2; Lead exposure; MAPK pathway; Oxidative stress; Vascular reactivity

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; APOCYNIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLYCOPROTEIN GP 91; INDOMETACIN; LEAD; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; N(G) NITROARGININE METHYL ESTER; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SUPEROXIDE; PTGS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD VESSEL REACTIVITY; CELL CULTURE; ENDOTHELIUM; ENZYME ACTIVITY; LEAD BLOOD LEVEL; LEISURE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR RING; VASCULAR SMOOTH MUSCLE; WISTAR RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; VASOCONSTRICTION;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; CELLS, CULTURED; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; LEAD; MALE; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; VASOCONSTRICTION;

EID: 84921713401     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.01.005     Document Type: Article

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