Lead stimulates lymphocyte proliferation through enhanced T cell-B cell interaction

Journal of Pharmacology and Experimental Therapeutics

Volumn 288, Issue 2, 1999, Pages 714-719

  Razani Boroujerdi, Seddigheh ^a   Edwards, Bruce ^a   Sopori, Mohan L ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL 1,4,5 TRISPHOSPHATE; LEAD; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL INTERACTION; CONTROLLED STUDY; IMMUNE DEFICIENCY; IMMUNOSTIMULATION; IMMUNOTOXICITY; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN CELL; T LYMPHOCYTE ACTIVATION;

ANIMALS; B-LYMPHOCYTES; CELL COMMUNICATION; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; INOSITOL 1,4,5-TRISPHOSPHATE; LEAD; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; PROTEIN-TYROSINE KINASES; RATS; RATS, INBRED STRAINS; SPLEEN; STIMULATION, CHEMICAL; T-LYMPHOCYTES;

EID: 0033063817     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Berridge MJ (1993) Inositol trisphosphate and calcium signaling. Nature (London) 361:315-325.
2. Bressler J, Forman S and Goldstein, GW (1994) Phospholipid metabolism in neural microvascular endothelial cells after exposure to lead in vitro. Toxicol Appl Pharmacol 126:352-360.
3. Cambier JC, Pleiman CM and Clark, MR (1994) Signal transduction by the B cell antigen receptor and its co-receptors. Annu Rev Immunol 12:457-486.
4. Chan A, Desai D and Weiss, A (1994) The role of tyrosine kinases and protein tyrosine phosphatases in the antigen receptor signal transduction. Annu Rev Immunol 12:555-592.
5. Cohen J and Coryslechta DA (1994) Lead exposure potentiates the effects of NMDA on repeated learning. Neurotoxicol Teratol 16:455-465.
6. Cohen MD, Yang Z and Zelikoff JT (1994) Immunotoxicity of particulate lead: In vitro exposure alters pulmonary macrophage tumor necrosis factor production and activity. J Toxicol Environ Health 42:377-392.
7. Crabtree GR and Clipstone NA (1994) Signal transmission between the plasma membrane and nucleus of T-lymphocytes. Annu Rev Biochem 63:1045-1083.
8. Dave V, Vitarella D, Aschner JL, Fletcher P, Kimelberg HK, and Aschner M (1993): Lead increases inositol 1,4,5-trisphospate levels but does not interfere with calcium transient in primary rat astrocytes. Brain Res 618:9-18.
9. Feldman RG and White RF (1992) Lead neurotoxicity and disorders of learning. J Child Neurol 7:354-359.
10. Fischbein A, Tsang P, Luo JJ and Bekesi JG (1993) The immune system as target for subclinical lead related toxicity. Br J Int Med 50:185-186.
11. Fowler BA, Kahng MW and Smith DR (1994) Role of lead-binding proteins in renal cancer. Environ Health Perspect 102 (Suppl 3):115-116.
12. Gainer JH (1974) Lead aggravates viral diseases and represses antiviral activity. Environ Health Perspect 7:113-119.
13. 3H-thymidine uptake in lymphocytes. Toxicol Appl Pharmacol 46:305-313.
14. Geng Y, Savage SM, Razani-Boroujerdi S, and Sopori ML (1996) Effects of nicotine on the immune response. II. Chronic nicotine treatment induces T cell anergy. J Immunol 156:2384-2390.
15. Gennart JP, Bernard A and Lauwerys R (1992) Assessment of thyroid, testes, kidney, and autonomic nervous system function in lead-exposed workers. Int Arch Occup Environ Health 64:49-57.
16. Gilman AG (1987) G-protein: transducer of receptor-generated signals. Annu Rev Biochem 56:615-627.
17. Hemphil FE, Kaeberle ML and Buck WB (1971) Lead suppression of mouse resistance to Salmonella typhimurium. Science (Wash DC) 172:1031-1032.
18. Koller LD and Kovacic S (1974) Decreased antibody formation in mice exposed to lead. Nature (London) 250:148-149.
19. Kusewitt DF, Budge CL, Nolla HA, Edwards BS and Ley RD (1992) Cell cycle progression in denV-transfected murine fibroblasts exposed to ultraviolet radiation. Mutat Res DNA Repair 274:163-176.
20. Lawrence DA (1981) Heavy metal modulation of lymphocyte activities: II. Lead, an in vitro mediator of B-cell activation. Int J Immunopharmac 3:153-161.
21. Lawrence DA (1985) Immunotoxicity of heavy metals, in Immunotoxicology and Immunopharmacology (Dean JH, Luster Ml, Munson AE and Amos H eds) pp 341-353, Raven Press, New York.
22. Luster MI, Faith RE and Kimmel CA (1978) Depression of humoral immunity in rats following chronic developmental lead exposure. J Environ Pathol Toxicol 1:397-402.
23. McCabe MJ (1994) Mechanisms and consequences of immunomodulation by lead, in Immunotoxicology and Immunopharmacology 2nd ed., (Dean JH, Luster MI, Munson AE and Kimber I eds) pp 143-162, Raven Press, New York.
24. McCabe MJ and Lawrence DA (1990) The heavy metal lead exhibits B cell-stimulatory factor activity by enhancing B cell 1a expression and differentiation. J Immunol 145:671-677.
25. Rajanna B, Chetty CS, Rajanna S, Hall E, Fail S and Yallapragada PR (1995) Modulation of protein kinase C by heavy metals. Toxicol Lett 81:197-203.
26. Razani-Boroujerdi S, Savage SM and Sopori ML (1994) Alcohol-induced changes in the immune responses: Immunological effects of chronic ethanol intake are genetically regulated. Toxicol Appl Pharmacol 127:37-43.
27. Robey E and Allison JP (1995) T cell activation: Integration of signals from the antigen receptor and costimulatory molecules. Immunol Today 16:306-310.
28. Rosen FS (1987) Autoimmunity and immunodeficiency disease. Ciba Found Symp 129:135-148.
29. Saijoh K, Inoue Y, Katsuyama H and Sumino K (1988) The interaction of cations with activity of soluble protein kinase C from mouse brain. Pharmacol Toxicol 63:221-224.
30. Savage SM, Donaldson LA and Sopori, ML (1993) Autoreactive T cells recognize B cells through terminal mannose-containing superantigen-like glycoprotein. Cell Immunol 146:11-27.
31. Schanne FA, Moskal JR and Gupta PK (1989) Effect of lead on intracellular free calcium ion concentration in a presynaptic neuronal model: 19F-NMR study of NG108-15 cells. Brain Res 503:308-311.
32. Shenker BJ, Matarazzo WJ, Hirsch RL and Gray I (1977) Trace metal modification of immunocompetence: I. Effect of trace metals in the culture on in vitro transformation of B lymphocytes. Cell Immunol 34:19-24.
33. Singer A and Hodes RJ (1983) Mechanisms of T cell-B cell interaction. Annu Rev Immunol 1:211-241.
34. Sopori ML, Cohen DA, Cherian S, Roszman TL and Kaplan A (1984) T lymphocyte heterogeneity in the rat: Separation of distinct rat T lymphocyte populations which respond in syngeneic and allogeneic mixed lymphocyte reactions. Cell Immunol 87:295-303.
35. Sopori ML, Donaldson LA and Savage SM (1990) T lymphocyte heterogeneity in the rat: III. Autoreactive T cells are activated by B cells. Cell Immunol 128:427-437.
36. Sopori ML, Perrone RS, Cherian S, Cross RJ and Kaplan AM (1985) Immunoregulation in the rat: characterization of a suppressor T cell that inhibits antigen-dependent cell proliferation. J Immunol 135:80-86.
37. Struzynska L and Rafalowska U (1994) The effect of lead on dopamine, GABA and histidine spontaneous and KCl-dependent release from rat brain synaptosomes. Acta Neurobiol Exp 54:201-207.
38. Warner GL and Lawrence DA (1986) Cell surface and cell cycle analysis of metal-induced murine T cell proliferation. Eur J Immunol 16:1337-1342-
39. Wedeen RP, Mallik DK and Batuman V (1979) Detection and treatment of occupational lead nephropathy. Arch Intern Med 139:53-57.
40. Xuezhi J, Youxin L and Yilan W (1992) Studies of lead exposure on the reproductive system: a review of work in China. Biomed Environ Sci 5:266-275.