Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum

Biochemical Pharmacology

Volumn 91, Issue 4, 2014, Pages 490-500

  Scherer, Olga ^a   Steinmetz, Heinrich ^b   Kaether, Christoph ^c   Weinigel, Christina ^d   Barz, Dagmar ^d   Kleinert, Hartmut ^e   Menche, Dirk ^f   Müller, Rolf ^g   Pergola, Carlo ^a   Werz, Oliver ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c FRITZ LIPMANN INSTITUTE   (Germany)

^d JENA UNIVERSITY HOSPITAL   (Germany)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

^f UNIVERSITY OF BONN   (Germany)

^g SAARLAND UNIVERSITY   (Germany)

Author keywords

Archazolid; Cytokines; Inflammation; Interleukin; Monocytes; Vacuolar type H(+) ATPase

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; APICULAREN; ARCHAZOLID; BAFILOMYCIN; CYTOKINE; GLUCOSE REGULATED PROTEIN 78; I KAPPA B ALPHA; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MACROLIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; PRIMER DNA;

ARTICLE; CELL PH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENCY; DRUG TARGETING; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN SECRETION; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; FLUORESCENCE MICROSCOPY; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

BASE SEQUENCE; CELL LINE; CYTOKINES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; HUMANS; MACROLIDES; MICROSCOPY, FLUORESCENCE; MONOCYTES; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84921665372     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.07.028     Document Type: Article

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