The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 31866-31876

  Osteresch, Christin ^a   Bender, Tobias ^b,c   Grond, Stephanie ^c   Von Zezschwitz, Paultheo ^c   Kunze, Brigitte ^d   Jansen, Rolf ^d   Huss, Markus ^a   Wieczorek, Helmut ^a  

^a UNIVERSITY OF OSNABRÜCK   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BAFILOMYCIN; BENZOIC ACID; CONCANAMYCIN; ENAMIDES; FUNGAL SOURCES; HOMO SAPIENS; MANDUCA SEXTA; MEMBRANE SPANNING; PHOTOAFFINITY LABELING; SACCHAROMYCES CEREVISIAE STRAINS; SPECIFIC INHIBITORS; THERAPEUTIC DRUGS; V-ATPASE;

CARBOXYLIC ACIDS; GENE EXPRESSION; YEAST;

DISEASES;

4 (3 TRIFLUOROMETHYLDIAZIRIN 3 YL)BENZOIC ACID; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; APICULAREN DERIVATIVE; ARCHAZOLID DERIVATIVE; BAFILOMYCIN; BENZOIC ACID DERIVATIVE; CONCANAMYCIN; MACROLIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME INHIBITION; HUMAN; IC 50; MANDUCA SEXTA; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; ENZYME INHIBITORS; MACROLIDES; MANDUCA; MOLECULAR CONFORMATION; MUTATION; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; SACCHAROMYCES CEREVISIAE; THIAZOLES; VACUOLAR PROTON-TRANSLOCATING ATPASES;

HOMO SAPIENS; MANDUCA SEXTA; SACCHAROMYCES CEREVISIAE;

EID: 84866382218     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.372169     Document Type: Article

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