Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium

Biochemical Journal

Volumn 465, Issue , 2015, Pages 503-515

  Samak, Geetha ^a   Chaudhry, Kamaljit K ^a   Gangwar, Ruchika ^a   Narayanan, Damodaran ^a   Jaggar, Jonathan H ^a   Rao, RadhaKrishna ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Apoptosis signal regulated kinase 1 (Ask1); c Jun N terminal kinase (JNK); Calcium; Inflammation; Intestine; MKK7; Src; Tight junction

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; BETA CATENIN; CALCIUM; DEXTRAN SULFATE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MITOGEN ACTIVATED PROTEIN KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE P60; PROTEIN ZO1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THAPSIGARGIN; UVOMORULIN; MAP2K7 PROTEIN, HUMAN; MAP3K5 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 9;

ACTIN FILAMENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACO 2 CELL LINE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM SIGNALING; CELL DISRUPTION; CELL JUNCTION; COLITIS; CONTROLLED STUDY; FEMALE; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TIGHT JUNCTION; ANIMAL; C57BL MOUSE; DRUG EFFECTS; HUMAN; INTESTINE MUCOSA; METABOLISM; ONCOGENE SRC; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; CACO-2 CELLS; CALCIUM SIGNALING; DEXTRAN SULFATE; FEMALE; GENES, SRC; HUMANS; INTESTINAL MUCOSA; MAP KINASE KINASE 7; MAP KINASE KINASE KINASE 5; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 9; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 84921638171     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140450     Document Type: Article

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