Simultaneous determination of seven ginsenosides in rat plasma by high-performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection

Biomedical Chromatography

Volumn 29, Issue 2, 2015, Pages 167-175

  Li, Zhengguang ^a,b   Zhang, Rui ^b   Wang, Xiuping ^b   Hu, Xiaofei ^c   Chen, Yuguo ^a   Liu, Qingfei ^d  

^a SHANDONG UNIVERSITY   (China)

^b Qingdao Hiser Medical Center   (China)

^c QINGDAO UNIVERSITY   (China)

^d Tsinghua University   (China)

Author keywords

Ginsenoside; HPLC TOF MS; Pharmacokinetics; Shenfu injection

Indexed keywords

BODY FLUIDS; INDUCTIVELY COUPLED PLASMA; MASS SPECTROMETRY; PHARMACOKINETICS; RATS;

GINSENOSIDES; HALF LIVES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COUPLED TO TIME-OF-FLIGHT MASS SPECTROMETRY; INTRAVENOUS ADMINISTRATION; PHARMACOKINETIC PROFILES; RAT PLASMA; SHENFU INJECTION; SIMULTANEOUS DETERMINATIONS; TIME OF FLIGHT MASS SPECTROMETRY;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHIKUSETSU SAPONIN; CHINESE DRUG; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RB 2; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RF; SHENFU; UNCLASSIFIED DRUG; HERBACEOUS AGENT; SHEN-FU;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION CURRENT; MALE; MOLECULAR WEIGHT; NONHUMAN; PHARMACOKINETICS; PLASMA CONCENTRATION-TIME CURVE; RAT; TIME OF FLIGHT MASS SPECTROMETRY; ANIMAL; BLOOD; INTRAVENOUS DRUG ADMINISTRATION; PROCEDURES; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

RATTUS;

ADMINISTRATION, INTRAVENOUS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; GINSENOSIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84921612992     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3272     Document Type: Article

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