Simultaneous determination of ginsenoside (G-Re, G-Rg1, G-Rg2, G-F1, G-Rh1) and protopanaxatriol in human plasma and urine by LC-MS/MS and its application in a pharmacokinetics study of G-Re in volunteers

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 22, 2011, Pages 2011-2017

  Liu, Lei ^a   Huang, Jianquan ^b   Hu, Xin ^a   Li, Kexin ^a   Sun, Chunhua ^a  

^a BEIJING HOSPITAL   (China)

^b AEROSPACE CENTER HOSPITAL   (China)

Author keywords

Ginsenoside Re; LC MS MS; Metabolite; Pharmacokinetics

Indexed keywords

ANALYTES; ANALYTICAL METHOD; CO-DETECTION; EXPERIMENTAL ANIMALS; GINSENOSIDE RE; GINSENOSIDES; GRADIENT ELUTION; HUMAN PLASMAS; LC-MS/MS; LINEAR RANGE; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MEMORY FUNCTIONS; ORGANIC PHASE; PRECLINICAL STUDIES; REACTION MODES; RETENTION TIME; SAMPLE PREPARATION; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; STANDARD CURVES; URINE SAMPLE;

ACETONITRILE; ANIMALS; BIOMOLECULES; BODY FLUIDS; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; PHARMACOKINETICS;

EXTRACTION;

ACETONITRILE; DIGOXIN; FORMIC ACID; GINSENOSIDE F 1; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 2; GINSENOSIDE RH 1; METHANOL; PROTOPANAXATRIOL; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG STABILITY; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FEMALE; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIMIT OF QUANTITATION; MALE; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; VALIDATION STUDY;

CHROMATOGRAPHY, LIQUID; DRUG STABILITY; GINSENOSIDES; HUMANS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SAPOGENINS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ANIMALIA;

EID: 79959861037     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.05.018     Document Type: Article

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