Impaired autophagy in hilar mossy cells of the dentate gyrus and its implication in schizophrenia

Journal of Genetics and Genomics

Volumn 42, Issue 1, 2015, Pages 1-8

  Yuan, Yefeng ^a,b   Wang, Hao ^a   Wei, Zongbo ^a,b   Li, Wei ^a,c  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

Author keywords

Autophagy; Dysbindin 1; Mossy cell; Neurodegeneration; Schizophrenia

Indexed keywords

CASPASE 3; DYSBINDIN; NECDIN; PROTEIN P53; DTNBP1 PROTEIN, MOUSE; DYSTROPHIN ASSOCIATED PROTEIN; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL LOSS; CONTROLLED STUDY; DENTATE GYRUS; GENE OVEREXPRESSION; HILAR MOSSY CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOSSY FIBER; MOUSE; MOUSE MODEL; NICK END LABELING; NONHUMAN; SCHIZOPHRENIA; STEADY STATE; ANIMAL; C57BL MOUSE; DBA MOUSE; HEK293 CELL LINE; HIPPOCAMPAL MOSSY FIBER; HUMAN; KNOCKOUT MOUSE; MALE; METABOLISM; NERVE CELL; PATHOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; AUTOPHAGY; CASPASE 3; CELL LINE, TUMOR; DENTATE GYRUS; DYSTROPHIN-ASSOCIATED PROTEINS; HEK293 CELLS; HUMANS; MALE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; MOSSY FIBERS, HIPPOCAMPAL; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; SCHIZOPHRENIA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84921603483     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2014.12.001     Document Type: Article

References (33)

1. Balu D.T., Coyle J.T. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci. Biobehav. Rev. 2011, 35:848-870.
2. Berry D.L., Baehrecke E.H. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007, 131:1137-1148.
3. Bhardwaj S.K., Baharnoori M., Sharif-Askari B., Kamath A., Williams S., Srivastava L.K. Behavioral characterization of dysbindin-1 deficient sandy mice. Behav. Brain Res. 2009, 197:435-441.
4. Boya P., Gonzalez-Polo R.A., Casares N., Perfettini J.L., Dessen P., Larochette N., Metivier D., Meley D., Souquere S., Yoshimori T., Pierron G., Codogno P., Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol. 2005, 25:1025-1040.
5. Chen X.W., Feng Y.Q., Hao C.J., Guo X.L., He X., Zhou Z.Y., Guo N., Huang H.P., Xiong W., Zheng H., Zuo P.L., Zhang C.X., Li W., Zhou Z. DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J. Cell Biol. 2008, 181:791-801.
6. Cho D.H., Jo Y.K., Hwang J.J., Lee Y.M., Roh S.A., Kim J.C. Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells. Cancer Lett. 2009, 274:95-100.
7. Fanous A.H., Kendler K.S. Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature. Curr. Psychiatry Rep. 2008, 10:164-170.
8. Fei E., Ma X., Zhu C., Xue T., Yan J., Xu Y., Zhou J., Wang G. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. J. Biol. Chem. 2010, 285:38630-38640.
9. Feng Y.Q., Zhou Z.Y., He X., Wang H., Guo X.L., Hao C.J., Guo Y., Zhen X.C., Li W. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia. Schizophr. Res. 2008, 106:218-228.
10. Hasegawa K., Yoshikawa K. Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons. J. Neurosci. 2008, 28:8772-8784.
11. Hattori S., Murotani T., Matsuzaki S., Ishizuka T., Kumamoto N., Takeda M., Tohyama M., Yamatodani A., Kunugi H., Hashimoto R. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem. Biophys. Res. Commun. 2008, 373:298-302.
12. Huang L., Kuo Y.M., Gitschier J. The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. Nat. Genet. 1999, 23:329-332.
13. Kempermann G., Krebs J., Fabel K. The contribution of failing adult hippocampal neurogenesis to psychiatric disorders. Curr. Opin. Psychiatry 2008, 21:290-295.
14. Larimore J., Zlatic S.A., Gokhale A., Tornieri K., Singleton K.S., Mullin A.P., Tang J., Talbot K., Faundez V. Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes. J. Biol. Chem. 2014, 289:14291-14300.
15. Li W., Feng Y., Hao C., Guo X., Cui Y., He M., He X. The BLOC interactomes form a network in endosomal transport. J. Genet. Genomics 2007, 34:669-682.
16. Li W., He M., Zhou H., Bourne J.W., Liang P. Mutational data integration in gene-oriented files of the Hermansky-Pudlak syndrome database. Hum. Mutat. 2006, 27:402-407.
17. Li W., Zhang Q., Oiso N., Novak E.K., Gautam R., O'Brien E.P., Tinsley C.L., Blake D.J., Spritz R.A., Copeland N.G., Jenkins N.A., Amato D., Roe B.A., Starcevic M., Dell'Angelica E.C., Elliott R.W., Mishra V., Kingsmore S.F., Paylor R.E., Swank R.T. Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat. Genet. 2003, 35:84-89.
18. Ma X., Fei E., Fu C., Ren H., Wang G. Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53. Mol. Psychiatry 2011, 16:1105-1116.
19. Mah L.Y., Ryan K.M. Autophagy and cancer. Cold Spring Harb. Perspect. Biol. 2012, 4. a008821.
20. Meng Y., Yong Y., Yang G., Ding H., Fan Z., Tang Y., Luo J., Ke Z.J. Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J. Neurochem. 2013, 126:805-818.
21. Merenlender-Wagner A., Malishkevich A., Shemer Z., Udawela M., Gibbons A., Scarr E., Dean B., Levine J., Agam G., Gozes I. Autophagy has a key role in the pathophysiology of schizophrenia. Mol. Psychiatry 2013, 10.1038/mp.2013.174.
22. Ming G.L., Song H. Adult neurogenesis in the mammalian brain: significant answers and significant questions. Neuron 2011, 70:687-702.
23. Nelson M.P., Shacka J.J. Autophagy modulation in disease therapy: where do we stand?. Curr. Pathobiol. Rep. 2013, 1:239-245.
24. Nixon R.A., Yang D.S. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb. Perspect. Biol. 2012, 4. a008839.
25. Scott R.C., Juhasz G., Neufeld T.P. Direct induction of autophagy by Atg1 inhibits cell growth and induces apoptotic cell death. Curr. Biol. 2007, 17:1-11.
26. Straub R.E., Jiang Y., MacLean C.J., Ma Y., Webb B.T., Myakishev M.V., Harris-Kerr C., Wormley B., Sadek H., Kadambi B., Cesare A.J., Gibberman A., Wang X., O'Neill F.A., Walsh D., Kendler K.S. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am. J. Hum. Genet. 2002, 71:337-348.
27. Takao K., Toyama K., Nakanishi K., Hattori S., Takamura H., Takeda M., Miyakawa T., Hashimoto R. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol. Brain 2008, 1:11.
28. Talbot K., Louneva N., Cohen J.W., Kazi H., Blake D.J., Arnold S.E. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS One 2011, 6. e16886.
29. Talbot K., Ong W.Y., Blake D.J., Tang J., Louneva N., Carlson G.C., Arnold S.E. Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia. Handbook of Neurochemistry and Molecular Neurobiology 2009, 107-241. Springer Science, New York. D. Javitt, J. Kantrowitz (Eds.).
30. Taniura H., Matsumoto K., Yoshikawa K. Physical and functional interactions of neuronal growth suppressor necdin with p53. J. Biol. Chem. 1999, 274:16242-16248.
31. Wang H., Yuan Y., Zhang Z., Yan H., Feng Y., Li W. Dysbindin-1C is required for the survival of hilar mossy cells and the maturation of adult newborn neurons in dentate gyrus. J. Biol. Chem. 2014, 289:29060-29072.
32. Wei A.H., Li W. Hermansky-Pudlak syndrome: pigmentary and non-pigmentary defects and their pathogenesis. Pigment Cell Melanoma Res. 2013, 26:176-192.
33. Zhang Q., Li W., Novak E.K., Karim A., Mishra V.S., Kingsmore S.F., Roe B.A., Suzuki T., Swank R.T. The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking. Hum. Mol. Genet. 2002, 11:697-706.