Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration

Molecular Pharmacology

Volumn 87, Issue 3, 2015, Pages 477-491

  Zhang, Jianye ^a   Dong, Zhiqian ^a   Mundla, Sreenivasa Reddy ^b   Hu, X Eric ^c   Seibel, William ^d   Papoian, Ruben ^d   Palczewski, Krzysztof ^a   Golczak, Marcin ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Sreeni Labs Private Limited   (India)

^c Aroz Technologies LLC   (United States)

^d UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOMERASE; LECITHIN RETINOL ACYLTRANSFERASE; RETINAL; RETINOID DERIVATIVE; RETINOID ISOMERASE; RETINYLAMINE; UNCLASSIFIED DRUG; DITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATOPHORE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME SPECIFICITY; EYE PROTECTION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIGHT; MALE; METABOLITE; MOUSE; NONHUMAN; ORGAN PRESERVATION; PRIORITY JOURNAL; RETINA DEGENERATION; VISION; VISUAL FIELD; ANIMAL; BOVINAE; DRUG EFFECTS; KNOCKOUT MOUSE; METABOLISM; PHOTOSTIMULATION; PIGMENT EPITHELIUM; RADIATION RESPONSE; RETINAL DEGENERATION;

ANIMALS; CATTLE; DITERPENES; FEMALE; MALE; MICE; MICE, KNOCKOUT; PHOTIC STIMULATION; RETINAL DEGENERATION; RETINAL PIGMENT EPITHELIUM; RETINALDEHYDE;

EID: 84921527889     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.114.096560     Document Type: Article

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