메뉴 건너뛰기




Volumn 10, Issue 1, 2015, Pages 57-71

Berberine-loaded targeted nanoparticles as specific Helicobacter pylori eradication therapy: In vitro and in vivo study

Author keywords

berberine; fucose conjugated nanoparticle; gastric inflammation; Helicobacter pylori; heparin

Indexed keywords

BERBERINE; CHITOSAN; FUCOSE; HEPARIN; NANOPARTICLE; TREHALOSE;

EID: 84921522655     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.14.76     Document Type: Article
Times cited : (76)

References (53)
  • 1
    • 33846818867 scopus 로고    scopus 로고
    • EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells
    • Beil W, Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine 14(6), 5-8 (2007).
    • (2007) Phytomedicine , vol.14 , Issue.6 , pp. 5-8
    • Beil, W.1    Kilian, P.2
  • 2
    • 0024494239 scopus 로고
    • Campylobacter pylori and peptic ulcer disease
    • Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology 96(2), 615-625 (1989).
    • (1989) Gastroenterology , vol.96 , Issue.2 , pp. 615-625
    • Graham, D.Y.1
  • 3
    • 0022634633 scopus 로고
    • Campylobacter pyloridis and gastritis: Association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium
    • Hazell SL, Lee A, Brady L, Hennessy W. Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. J. Infect. Dis. 153(4), 658-663 (1986).
    • (1986) J. Infect. Dis. , vol.153 , Issue.4 , pp. 658-663
    • Hazell, S.L.1    Lee, A.2    Brady, L.3    Hennessy, W.4
  • 4
    • 28444489667 scopus 로고    scopus 로고
    • Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability
    • Fedwick JP, Lapointe TK, Meddings JB, Sherman PM, Buret AG. Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect. Immun. 73(12), 7844-7852 (2005).
    • (2005) Infect. Immun. , vol.73 , Issue.12 , pp. 7844-7852
    • Fedwick, J.P.1    Lapointe, T.K.2    Meddings, J.B.3    Sherman, P.M.4    Buret, A.G.5
  • 5
    • 0027512558 scopus 로고
    • An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium
    • Falk P, Roth KA, Borén T, Westblom TU, Gordon JI, Normark S. An in vitro adherence assay reveals that Helicobacter pylori exhibits cell lineage-specific tropism in the human gastric epithelium. Proc. Natl Acad. Sci. USA 90(5), 2035-2039 (1993).
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.5 , pp. 2035-2039
    • Falk, P.1    Roth, K.A.2    Borén, T.3    Westblom, T.U.4    Gordon, J.I.5    Normark, S.6
  • 6
    • 84875589647 scopus 로고    scopus 로고
    • Genipin-cross-linked fucose-chitosan/heparin nanoparticles for the eradication of Helicobacter pylori
    • Lin YH, Tsai SC, Lai CH, Lee CH, He ZS, Tseng GC. Genipin-cross-linked fucose-chitosan/heparin nanoparticles for the eradication of Helicobacter pylori. Biomaterials 34(18), 4466-4479 (2013).
    • (2013) Biomaterials , vol.34 , Issue.18 , pp. 4466-4479
    • Lin, Y.H.1    Tsai, S.C.2    Lai, C.H.3    Lee, C.H.4    He, Z.S.5    Tseng, G.C.6
  • 7
    • 77957680025 scopus 로고    scopus 로고
    • Effectiveness of different treatment regimens in Helicobacter pylori eradication: Ten-year experience of a single institution
    • Özden A, Seven G, BektaM. Effectiveness of different treatment regimens in Helicobacter pylori eradication: ten-year experience of a single institution. Turk. J. Gastroenterol. 21(3), 218-223 (2010).
    • (2010) Turk. J. Gastroenterol. , vol.21 , Issue.3 , pp. 218-223
    • Özden, A.1    Seven, G.2    Bekta, M.3
  • 8
    • 77952559286 scopus 로고    scopus 로고
    • Synthesis of Ag/CNT hybrid nanoparticles and fabrication of their nylon-6 polymer nanocomposite fibers for antimicrobial applications
    • Rangari VK, Mohammad GM, Jeelani S et al. Synthesis of Ag/CNT hybrid nanoparticles and fabrication of their nylon-6 polymer nanocomposite fibers for antimicrobial applications. Nanotechnology 21(9), 095102 (2010).
    • (2010) Nanotechnology , vol.21 , Issue.9 , pp. 095102
    • Rangari, V.K.1    Mohammad, G.M.2    Jeelani, S.3
  • 9
    • 1542475460 scopus 로고    scopus 로고
    • Clinical evaluation of four one-week triple therapy regimens in eradicating Helicobacter pylori infection
    • Guo CY, Wu YB, Liu HL, Wu JY, Zhong MZ. Clinical evaluation of four one-week triple therapy regimens in eradicating Helicobacter pylori infection. World J. Gastroenterol. 10(5), 747-749 (2004).
    • (2004) World J. Gastroenterol. , vol.10 , Issue.5 , pp. 747-749
    • Guo, C.Y.1    Wu, Y.B.2    Liu, H.L.3    Wu, J.Y.4    Zhong, M.Z.5
  • 10
    • 33746798775 scopus 로고    scopus 로고
    • Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe
    • Koletzko S, Richy F, Bontems P et al. Prospective multicentre study on antibiotic resistance of Helicobacter pylori strains obtained from children living in Europe. Gut 55(12), 1711-1716 (2006).
    • (2006) Gut , vol.55 , Issue.12 , pp. 1711-1716
    • Koletzko, S.1    Richy, F.2    Bontems, P.3
  • 11
    • 34247862031 scopus 로고    scopus 로고
    • Helicobacter pylori eradication: A randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics
    • de Bortoli N, Leonardi G, Ciancia E et al. Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics. Am. J. Gastroenterol. 102(5), 951-956 (2007).
    • (2007) Am. J. Gastroenterol. , vol.102 , Issue.5 , pp. 951-956
    • De Bortoli, N.1    Leonardi, G.2    Ciancia, E.3
  • 12
    • 71749087714 scopus 로고    scopus 로고
    • Antibacterial activity of 20 kinds of Chinese medicinal materials for Helicobacter pylori in vitro
    • Du P, Zhu S, Lü P. Antibacterial activity of 20 kinds of Chinese medicinal materials for Helicobacter pylori in vitro. Zhong Yao Cai. 24(3), 188-189 (2001).
    • (2001) Zhong Yao Cai. , vol.24 , Issue.3 , pp. 188-189
    • Du, P.1    Zhu, S.2    Lü, P.3
  • 13
    • 48649101917 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators
    • Yang P, Song DQ, Li YH et al. Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. Bioorg. Med. Chem. Lett. 18(16), 4675-4677 (2008).
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , Issue.16 , pp. 4675-4677
    • Yang, P.1    Song, D.Q.2    Li, Y.H.3
  • 14
    • 70349971732 scopus 로고    scopus 로고
    • Berberine and Coptidis rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations
    • Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J. Ethnopharmacol. 126(1), 5-17 (2009).
    • (2009) J. Ethnopharmacol. , vol.126 , Issue.1 , pp. 5-17
    • Tang, J.1    Feng, Y.2    Tsao, S.3    Wang, N.4    Curtain, R.5    Wang, Y.6
  • 15
    • 0014569720 scopus 로고
    • Berberine sulfate: Antimicrobial activity, bioassay, and mode of action
    • Amin AH, Subbaiah TV, Abbasi KM. Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can. J. Microbiol. 15(9), 1067-1076 (1969).
    • (1969) Can. J. Microbiol. , vol.15 , Issue.9 , pp. 1067-1076
    • Amin, A.H.1    Subbaiah, T.V.2    Abbasi, K.M.3
  • 16
    • 21544431889 scopus 로고    scopus 로고
    • Inhibitory actions of berberine on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients
    • Chung JG, Wu LT, Chang SH, Lo HH, Hsieh SE. Inhibitory actions of berberine on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients. Int. J. Toxicol. 18(1), 35-40 (1999).
    • (1999) Int. J. Toxicol. , vol.18 , Issue.1 , pp. 35-40
    • Chung, J.G.1    Wu, L.T.2    Chang, S.H.3    Lo, H.H.4    Hsieh, S.E.5
  • 17
    • 0344406943 scopus 로고    scopus 로고
    • In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis
    • Mahady GB, Pendland SL, Stoia A, Chadwick LR. In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. Phytother. Res. 17(3), 217-221 (2003).
    • (2003) Phytother. Res. , vol.17 , Issue.3 , pp. 217-221
    • Mahady, G.B.1    Pendland, S.L.2    Stoia, A.3    Chadwick, L.R.4
  • 18
    • 0030734061 scopus 로고    scopus 로고
    • Ionic mechanism responsible for prolongation of cardiac action-potential duration by berberine
    • Wang YX, Zheng YM. Ionic mechanism responsible for prolongation of cardiac action-potential duration by berberine. J. Cardiovasc. Pharmacol. 30(2), 214-222 (1997).
    • (1997) J. Cardiovasc. Pharmacol. , vol.30 , Issue.2 , pp. 214-222
    • Wang, Y.X.1    Zheng, Y.M.2
  • 19
    • 0037462997 scopus 로고    scopus 로고
    • Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    • Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55(3), 329-347 (2003).
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , Issue.3 , pp. 329-347
    • Panyam, J.1    Labhasetwar, V.2
  • 20
    • 40049094851 scopus 로고    scopus 로고
    • Fabrication of {198Au0} radioactive composite nanodevices and their use for nanobrachytherapy
    • Khan MK, Minc LD, Nigavekar SS et al. Fabrication of {198Au0} radioactive composite nanodevices and their use for nanobrachytherapy. Nanomedicine 4(1), 57-69 (2008).
    • (2008) Nanomedicine , vol.4 , Issue.1 , pp. 57-69
    • Khan, M.K.1    Minc, L.D.2    Nigavekar, S.S.3
  • 21
    • 33745674687 scopus 로고    scopus 로고
    • Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems
    • Pinto Reis C, Neufeld RJ, Ribeiro AJ, Veiga F. Nanoencapsulation II. Biomedical applications and current status of peptide and protein nanoparticulate delivery systems. Nanomedicine 2(2), 53-65 (2006).
    • (2006) Nanomedicine , vol.2 , Issue.2 , pp. 53-65
    • Pinto Reis, C.1    Neufeld, R.J.2    Ribeiro, A.J.3    Veiga, F.4
  • 22
    • 78650731439 scopus 로고    scopus 로고
    • Development of novel nanoparticles shelled with heparin for berberine delivery to treat Helicobacter pylori
    • Chang CH, Huang WY, Lai CH et al. Development of novel nanoparticles shelled with heparin for berberine delivery to treat Helicobacter pylori. Acta Biomater. 7(2), 593-603 (2011).
    • (2011) Acta Biomater. , vol.7 , Issue.2 , pp. 593-603
    • Chang, C.H.1    Huang, W.Y.2    Lai, C.H.3
  • 23
    • 0038495798 scopus 로고    scopus 로고
    • Fucose: Biosynthesis and biological function in mammals
    • Becker DJ, Lowe JB. Fucose: biosynthesis and biological function in mammals. Glycobiology 13(7), 41R-53R (2003).
    • (2003) Glycobiology , vol.13 , Issue.7 , pp. 41R-53R
    • Becker, D.J.1    Lowe, J.B.2
  • 24
    • 0036895829 scopus 로고    scopus 로고
    • Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients
    • Mitchell E, Houles C, Sudakevitz D et al. Structural basis for oligosaccharide-mediated adhesion of Pseudomonas aeruginosa in the lungs of cystic fibrosis patients. Nat. Struct. Biol. 9(12), 918-921 (2002).
    • (2002) Nat. Struct. Biol. , vol.9 , Issue.12 , pp. 918-921
    • Mitchell, E.1    Houles, C.2    Sudakevitz, D.3
  • 25
    • 0042667040 scopus 로고    scopus 로고
    • Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa
    • Loris R, Tielker D, Jaeger KE, Wyns L. Structural basis of carbohydrate recognition by the lectin LecB from Pseudomonas aeruginosa. J. Mol. Biol. 331(4), 861-870 (2003).
    • (2003) J. Mol. Biol. , vol.331 , Issue.4 , pp. 861-870
    • Loris, R.1    Tielker, D.2    Jaeger, K.E.3    Wyns, L.4
  • 26
    • 0035478758 scopus 로고    scopus 로고
    • Chitosan and its derivatives as intestinal absorption enhancers
    • Thanou M, Verhoef JC, Junginger HE. Chitosan and its derivatives as intestinal absorption enhancers. Adv. Drug Deliv. Rev. 50(1), S91-S101 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.50 , Issue.1 , pp. S91-S101
    • Thanou, M.1    Verhoef, J.C.2    Junginger, H.E.3
  • 27
    • 28744456012 scopus 로고    scopus 로고
    • Characterization of folate-chitosan-DNA nanoparticles for gene therapy
    • Mansouri S, Cuie Y, Winnik F et al. Characterization of folate-chitosan-DNA nanoparticles for gene therapy. Biomaterials 27(9), 2060-2065 (2006).
    • (2006) Biomaterials , vol.27 , Issue.9 , pp. 2060-2065
    • Mansouri, S.1    Cuie, Y.2    Winnik, F.3
  • 28
    • 0141992059 scopus 로고    scopus 로고
    • Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery
    • Sameti M, Bohr G, Ravi Kumar MN et al. Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery. Int. J. Pharm. 266(1-2), 51-60 (2003).
    • (2003) Int. J. Pharm. , vol.266 , Issue.1-2 , pp. 51-60
    • Sameti, M.1    Bohr, G.2    Ravi Kumar, M.N.3
  • 29
    • 0038056150 scopus 로고    scopus 로고
    • New insights on trehalose: A multifunctional molecule
    • Elbein AD, Pan YT, Pastuszak I, Carroll D. New insights on trehalose: a multifunctional molecule. Glycobiology 13(4), 17R-27R (2003).
    • (2003) Glycobiology , vol.13 , Issue.4 , pp. 17R-27R
    • Elbein, A.D.1    Pan, Y.T.2    Pastuszak, I.3    Carroll, D.4
  • 30
    • 4444246205 scopus 로고    scopus 로고
    • Chemically modified chitin and chitosan as biomaterials
    • Sashiwa H, Aiba S. Chemically modified chitin and chitosan as biomaterials. Prog. Polym. Sci. 29(9), 887-908 (2004).
    • (2004) Prog. Polym. Sci. , vol.29 , Issue.9 , pp. 887-908
    • Sashiwa, H.1    Aiba, S.2
  • 31
    • 4444370653 scopus 로고    scopus 로고
    • The aggregation of pig articular chondrocyte and synthesis of extracellular matrix by a lactose-modified chitosan
    • Donati I, Stredanska S, Silvestrini G et al. The aggregation of pig articular chondrocyte and synthesis of extracellular matrix by a lactose-modified chitosan. Biomaterials 26(9), 987-998 (2005).
    • (2005) Biomaterials , vol.26 , Issue.9 , pp. 987-998
    • Donati, I.1    Stredanska, S.2    Silvestrini, G.3
  • 32
    • 0041765107 scopus 로고    scopus 로고
    • Determination of berberine in decocted liquid from shenshu granules with water by reversed-phase liquid chromatography
    • Wang SD, Song BS, Li K. Determination of berberine in decocted liquid from shenshu granules with water by reversed-phase liquid chromatography. Se Pu. 18(3), 261-262 (2000).
    • (2000) Se Pu. , vol.18 , Issue.3 , pp. 261-262
    • Wang, S.D.1    Song, B.S.2    Li, K.3
  • 34
    • 78650855801 scopus 로고    scopus 로고
    • Multifunctional gentamicin supplementation of poly (glutamic acid)-based hydrogels for wound dressing application
    • Lin YH, Lin JH, Peng SF et al. Multifunctional gentamicin supplementation of poly (glutamic acid)-based hydrogels for wound dressing application. J. Appl. Polym. Sci. 120(2), 1057-1068 (2011).
    • (2011) J. Appl. Polym. Sci. , vol.120 , Issue.2 , pp. 1057-1068
    • Lin, Y.H.1    Lin, J.H.2    Peng, S.F.3
  • 35
    • 84863325712 scopus 로고    scopus 로고
    • Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing
    • Huang WY, Yeh CL, Lin JH, Yang JS, Ko TH, Lin YH. Development of fibroblast culture in three-dimensional activated carbon fiber-based scaffold for wound healing. J. Mater. Sci. Mater. Med. 23(6), 1465-1478 (2012).
    • (2012) J. Mater. Sci. Mater. Med. , vol.23 , Issue.6 , pp. 1465-1478
    • Huang, W.Y.1    Yeh, C.L.2    Lin, J.H.3    Yang, J.S.4    Ko, T.H.5    Lin, Y.H.6
  • 36
    • 84863796085 scopus 로고    scopus 로고
    • Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication
    • Lin YH, Chiou SF, Lai CH et al. Formulation and evaluation of water-in-oil amoxicillin-loaded nanoemulsions using for Helicobacter pylori eradication. Process Biochem. 47(10), 1469-1478 (2012).
    • (2012) Process Biochem. , vol.47 , Issue.10 , pp. 1469-1478
    • Lin, Y.H.1    Chiou, S.F.2    Lai, C.H.3
  • 38
    • 84555190793 scopus 로고    scopus 로고
    • Modification of chitosan nanoparticles for improved gene delivery
    • Ramesan RM, Sharma CP. Modification of chitosan nanoparticles for improved gene delivery. Nanomedicine (Lond). 7(1), 5-8 (2012).
    • (2012) Nanomedicine (Lond). , vol.7 , Issue.1 , pp. 5-8
    • Ramesan, R.M.1    Sharma, C.P.2
  • 40
    • 79959396378 scopus 로고    scopus 로고
    • Fucosylation and gastrointestinal cancer
    • Moriwaki K, Miyoshi E. Fucosylation and gastrointestinal cancer. World J. Hepatol. 2(4), 151-161 (2010).
    • (2010) World J. Hepatol. , vol.2 , Issue.4 , pp. 151-161
    • Moriwaki, K.1    Miyoshi, E.2
  • 41
    • 0020456457 scopus 로고
    • Membrane-associated, fucose-containing glycoproteins and glycolipids of cultured epithelial cells from human colonic adenocarcinoma and fetal intestine
    • Kim YS, Kim YW, Siddiqui B, Tsao D. Membrane-associated, fucose-containing glycoproteins and glycolipids of cultured epithelial cells from human colonic adenocarcinoma and fetal intestine. Eur. J. Cancer Clin. Oncol. 18(12), 1329-1336 (1982).
    • (1982) Eur. J. Cancer Clin. Oncol. , vol.18 , Issue.12 , pp. 1329-1336
    • Kim, Y.S.1    Kim, Y.W.2    Siddiqui, B.3    Tsao, D.4
  • 42
    • 67649395627 scopus 로고    scopus 로고
    • Helicobacter pylori virulence factors in gastric carcinogenesis
    • Wen S, Moss SF. Helicobacter pylori virulence factors in gastric carcinogenesis. Cancer Lett. 282(1), 1-8 (2009).
    • (2009) Cancer Lett. , vol.282 , Issue.1 , pp. 1-8
    • Wen, S.1    Moss, S.F.2
  • 43
    • 78049354889 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric cancer: Factors that modulate disease risk
    • Wroblewski LE, Peek RM Jr, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin. Microbiol. Rev. 23(4), 713-739 (2010).
    • (2010) Clin. Microbiol. Rev. , vol.23 , Issue.4 , pp. 713-739
    • Wroblewski, L.E.1    Peek, R.M.2    Wilson, K.T.3
  • 45
    • 0026800237 scopus 로고
    • In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
    • Lehr CM, Bouwstra JA, Schacht EH, Junginger HE. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78(1-3), 43-48 (1992).
    • (1992) Int. J. Pharm. , vol.78 , Issue.1-3 , pp. 43-48
    • Lehr, C.M.1    Bouwstra, J.A.2    Schacht, E.H.3    Junginger, H.E.4
  • 46
    • 0028241325 scopus 로고
    • Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery
    • Miyazaki S, Nakayama A, Oda M, Takada M, Attwood D. Chitosan and sodium alginate based bioadhesive tablets for intraoral drug delivery. Biol. Pharm. Bull. 17(5), 745-747 (1994).
    • (1994) Biol. Pharm. Bull. , vol.17 , Issue.5 , pp. 745-747
    • Miyazaki, S.1    Nakayama, A.2    Oda, M.3    Takada, M.4    Attwood, D.5
  • 47
    • 33947669907 scopus 로고    scopus 로고
    • Tetracycline-containing chitosan microspheres for local treatment of Helicobacter pylori infection
    • Amiji MM. Tetracycline-containing chitosan microspheres for local treatment of Helicobacter pylori infection. Cellulose 14(1), 3-14 (2007).
    • (2007) Cellulose , vol.14 , Issue.1 , pp. 3-14
    • Amiji, M.M.1
  • 48
    • 48649101917 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators
    • Yang P, Song DQ, Li YH et al. Synthesis and structure-activity relationships of berberine analogues as a novel class of low-density-lipoprotein receptor up-regulators. Bioorg. Med. Chem. Lett. 18(16), 4675-4677 (2008).
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , Issue.16 , pp. 4675-4677
    • Yang, P.1    Song, D.Q.2    Li, Y.H.3
  • 49
    • 0016420420 scopus 로고
    • A conductimetric method for the determination of sulphate and carboxyl groups in heparin and other mucopolysaccharides
    • Casu B, Gennaro U. A conductimetric method for the determination of sulphate and carboxyl groups in heparin and other mucopolysaccharides. Carbohydr. Res. 39(1), 168-176 (1975).
    • (1975) Carbohydr. Res. , vol.39 , Issue.1 , pp. 168-176
    • Casu, B.1    Gennaro, U.2
  • 50
    • 0032764724 scopus 로고    scopus 로고
    • Association of heparin with basic fibroblast growth factor, epidermal growth factor, and constitutive nitric oxide synthase on healing of gastric ulcer in rats
    • Li Y, Wang HY, Cho CH. Association of heparin with basic fibroblast growth factor, epidermal growth factor, and constitutive nitric oxide synthase on healing of gastric ulcer in rats. J. Pharmacol. Exp. Ther. 290(2), 789-796 (1999).
    • (1999) J. Pharmacol. Exp. Ther. , vol.290 , Issue.2 , pp. 789-796
    • Li, Y.1    Wang, H.Y.2    Cho, C.H.3
  • 51
    • 0028789673 scopus 로고
    • Epidermal growth factor and transforming growth factor-alpha: Role in protection and healing of gastric mucosal lesions
    • Konturek PC, Konturek SJ, Brzozowski T, Ernst H. Epidermal growth factor and transforming growth factor-alpha: role in protection and healing of gastric mucosal lesions. Eur. J. Gastroenterol. Hepatol. 7(10), 933-937 (1995).
    • (1995) Eur. J. Gastroenterol. Hepatol. , vol.7 , Issue.10 , pp. 933-937
    • Konturek, P.C.1    Konturek, S.J.2    Brzozowski, T.3    Ernst, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.