메뉴 건너뛰기




Volumn 288, Issue 43, 2013, Pages 31299-31312

The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-κB ligand (RANKL)-induced Osteoclast differentiation

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHORETIC MOBILITY SHIFT; HOMEODOMAIN TRANSCRIPTION FACTOR; NEGATIVE REGULATORS; NUCLEAR FACTOR OF ACTIVATED T-CELLS; OSTEOCLAST DIFFERENTIATION; OSTEOCLAST FORMATION; REGULATORY CIRCUITS; REGULATORY FACTORS;

EID: 84886715809     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.461848     Document Type: Article
Times cited : (20)

References (64)
  • 1
    • 0033304730 scopus 로고    scopus 로고
    • Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
    • Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., and Martin, T. J. (1999) Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.. Endocr. Rev. 20, 345-357
    • (1999) Endocr. Rev. , vol.20 , pp. 345-357
    • Suda, T.1    Takahashi, N.2    Udagawa, N.3    Jimi, E.4    Gillespie, M.T.5    Martin, T.J.6
  • 2
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty, G., and Wagner, E. F. (2002) Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406
    • (2002) Dev. Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 3
    • 0034455103 scopus 로고    scopus 로고
    • Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
    • Manolagas, S. C. (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis.. Endocr. Rev. 21, 115-137
    • (2000) Endocr. Rev. , vol.21 , pp. 115-137
    • Manolagas, S.C.1
  • 4
    • 0036218666 scopus 로고    scopus 로고
    • RANk-L and RANk: T cells, bone loss, and mammalian evolution
    • Theill, L. E., Boyle, W. J., and Penninger, J. M. (2002) RANk-L and RANk: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20, 795-823
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 7
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S. L. (2000) Bone resorption by osteoclasts. Science 289, 1504-1508
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 11
    • 0026486816 scopus 로고
    • Pleiotropic effects of a null mutation in the c-fos proto-oncogene
    • Johnson, R. S., Spiegelman, B. M., and Papaioannou, V. (1992) Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71, 577-586
    • (1992) Cell , vol.71 , pp. 577-586
    • Johnson, R.S.1    Spiegelman, B.M.2    Papaioannou, V.3
  • 14
    • 0027204149 scopus 로고
    • Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
    • Hodgkinson, C. A., Moore, K. J., Nakayama, A., Steingrímsson, E., Copeland, N. G., Jenkins, N. A., and Arnheiter, H. (1993) Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein.. Cell 74, 395-404
    • (1993) Cell , vol.74 , pp. 395-404
    • Hodgkinson, C.A.1    Moore, K.J.2    Nakayama, A.3    Steingrímsson, E.4    Copeland, N.G.5    Jenkins, N.A.6    Arnheiter, H.7
  • 15
    • 0034613188 scopus 로고    scopus 로고
    • Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand
    • Matsumoto, M., Sudo, T., Saito, T., Osada, H., and Tsujimoto, M. (2000) Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand. J. Biol. Chem. 275, 31155-31161
    • (2000) J. Biol. Chem. , vol.275 , pp. 31155-31161
    • Matsumoto, M.1    Sudo, T.2    Saito, T.3    Osada, H.4    Tsujimoto, M.5
  • 16
    • 0035980129 scopus 로고    scopus 로고
    • Regulation of receptor activator of NF-kB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factor
    • Matsumoto, M., Hisatake, K., Nogi, Y., and Tsujimoto, M. (2001) Regulation of receptor activator of NF-kB ligand-induced tartrate-resistant acid phosphatase gene expression by PU.1-interacting protein/interferon regulatory factor-4. Synergism with microphthalmia transcription factor. J. Biol. Chem. 276, 33086-33092
    • (2001) J. Biol. Chem. , vol.276 , pp. 33086-33092
    • Matsumoto, M.1    Hisatake, K.2    Nogi, Y.3    Tsujimoto, M.4
  • 18
    • 8544267975 scopus 로고    scopus 로고
    • Essential role of p38 mitogen-activated protein kinase in cathepsin k gene expression during osteoclastogenesis through association of NFATc1 and PU.1
    • Matsumoto, M., Kogawa, M., Wada, S., Takayanagi, H, Tsujimoto, M., Katayama, S., Hisatake, K., and Nogi, Y. (2004) Essential role of p38 mitogen-activated protein kinase in cathepsin k gene expression during osteoclastogenesis through association of NFATc1 and PU.1.. J. Biol. Chem. 279, 45969-45979
    • (2004) J. Biol. Chem. , vol.279 , pp. 45969-45979
    • Matsumoto, M.1    Kogawa, M.2    Wada, S.3    Takayanagi, H.4    Tsujimoto, M.5    Katayama, S.6    Hisatake, K.7    Nogi, Y.8
  • 19
    • 0022904751 scopus 로고
    • Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila
    • Bopp, D., Burri, M., Baumgartner, S., Frigerio, G., and Noll, M. (1986) Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.. Cell 47, 1033-1040
    • (1986) Cell , vol.47 , pp. 1033-1040
    • Bopp, D.1    Burri, M.2    Baumgartner, S.3    Frigerio, G.4    Noll, M.5
  • 20
    • 0031239122 scopus 로고    scopus 로고
    • Pax genes and organogenesis
    • Dahl, E., Koseki, H., and Balling, R. (1997) Pax genes and organogenesis. BioEssays 19, 755-765
    • (1997) BioEssays , vol.19 , pp. 755-765
    • Dahl, E.1    Koseki, H.2    Balling, R.3
  • 21
    • 0029953417 scopus 로고    scopus 로고
    • Pax2 contributes to inner ear patterning and optic nerve trajectory
    • Torres, M., Gómez-Pardo, E., and Gruss, P. (1996) Pax2 contributes to inner ear patterning and optic nerve trajectory. Development 122, 3381-3391
    • (1996) Development , vol.122 , pp. 3381-3391
    • Torres, M.1    Gómez-Pardo, E.2    Gruss, P.3
  • 22
    • 0033900034 scopus 로고    scopus 로고
    • Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp (2H))/Pax3 mouse mutant
    • Conway, S. J., Bundy, J., Chen, J., Dickman, E., Rogers, R., and Will, B. M. (2000) Decreased neural crest stem cell expansion is responsible for the conotruncal heart defects within the splotch (Sp (2H))/Pax3 mouse mutant.. Cardiovasc. Res. 47, 314-328
    • (2000) Cardiovasc. Res. , vol.47 , pp. 314-328
    • Conway, S.J.1    Bundy, J.2    Chen, J.3    Dickman, E.4    Rogers, R.5    Will, B.M.6
  • 24
    • 0031668375 scopus 로고    scopus 로고
    • Characterization of three novel members of the zebrafish Pax2/5/8 family: Dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function
    • Pfeffer, P. L., Gerster, T., Lun, K., Brand, M., Busslinger, M. (1998) Characterization of three novel members of the zebrafish Pax2/5/8 family: dependency of Pax5 and Pax8 expression on the Pax2.1 (noi) function.. Development 125, 3063-3074
    • (1998) Development , vol.125 , pp. 3063-3074
    • Pfeffer, P.L.1    Gerster, T.2    Lun, K.3    Brand, M.4    Busslinger, M.5
  • 25
    • 33644978463 scopus 로고    scopus 로고
    • Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells
    • Delogu, A., Schebesta, A., Sun, Q., Aschenbrenner, K., Perlot, T., and Busslinger, M. (2006) Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells.. Immunity 24, 269-281
    • (2006) Immunity , vol.24 , pp. 269-281
    • Delogu, A.1    Schebesta, A.2    Sun, Q.3    Aschenbrenner, K.4    Perlot, T.5    Busslinger, M.6
  • 27
    • 84864607961 scopus 로고    scopus 로고
    • A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development
    • Bharti, K., Gasper, M., Ou, J., Brucato, M., Clore-Gronenborn, K., Pickel, J., and Arnheiter, H. (2012) A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development.. PLoS Genet. 8, e1002757
    • (2012) PLoS Genet. , vol.8
    • Bharti, K.1    Gasper, M.2    Ou, J.3    Brucato, M.4    Clore-Gronenborn, K.5    Pickel, J.6    Arnheiter, H.7
  • 28
    • 33645325642 scopus 로고    scopus 로고
    • Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE
    • Hasson, P., and Paroush, Z. (2006) Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE.. Br. J. Cancer 94, 771-775
    • (2006) Br. J. Cancer , vol.94 , pp. 771-775
    • Hasson, P.1    Paroush, Z.2
  • 29
    • 2942585303 scopus 로고    scopus 로고
    • Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice
    • Wang, W., Wang, Y. G., Reginato, A. M., Glotzer, D. J., Fukai, N, Plotkina, S., Karsenty, G., and Olsen, B. R. (2004) Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.. Dev. Biol. 270, 364-381
    • (2004) Dev. Biol. , vol.270 , pp. 364-381
    • Wang, W.1    Wang, Y.G.2    Reginato, A.M.3    Glotzer, D.J.4    Fukai, N.5    Plotkina, S.6    Karsenty, G.7    Olsen, B.R.8
  • 37
    • 0034548760 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor
    • Matsumoto, M., Sudo, T., Maruyama, M., Osada, H, and Tsujimoto, M. (2000) Activation of p38 mitogen-activated protein kinase is crucial in osteoclastogenesis induced by tumor necrosis factor.. FEBS Lett. 486, 23-28
    • (2000) FEBS Lett. , vol.486 , pp. 23-28
    • Matsumoto, M.1    Sudo, T.2    Maruyama, M.3    Osada, H.4    Tsujimoto, M.5
  • 39
    • 28544452658 scopus 로고    scopus 로고
    • Role of RANkL in physiological and pathological bone resorption and therapeutics targeting the RANkL-RANk signaling system
    • Tanaka, S., Nakamura, K., Takahasi, N, and Suda, T. (2005) Role of RANkL in physiological and pathological bone resorption and therapeutics targeting the RANkL-RANk signaling system.. Immunol. Rev. 208, 30-49
    • (2005) Immunol. Rev. , vol.208 , pp. 30-49
    • Tanaka, S.1    Nakamura, K.2    Takahasi, N.3    Suda, T.4
  • 41
    • 0034052945 scopus 로고    scopus 로고
    • The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts
    • Luchin, A., Purdom, G., Murphy, K., Clark, M. Y., Angel, N, Cassady, A. I., Hume, D. A., and Ostrowski, M. C. (2000) The microphthalmia transcription factor regulates expression of the tartrate-resistant acid phosphatase gene during terminal differentiation of osteoclasts. J. Bone Miner. Res. 15, 451-460
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 451-460
    • Luchin, A.1    Purdom, G.2    Murphy, K.3    Clark, M.Y.4    Angel, N.5    Cassady, A.I.6    Hume, D.A.7    Ostrowski, M.C.8
  • 42
    • 1842330860 scopus 로고    scopus 로고
    • Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
    • Sander, M., Neubüser, A., Kalamaras, J., Ee, H. C, Martin, G. R., and German, M. S. (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.. Genes Dev. 11, 1662-1673
    • (1997) Genes Dev. , vol.11 , pp. 1662-1673
    • Sander, M.1    Neubüser, A.2    Kalamaras, J.3    Ee, H.C.4    Martin, G.R.5    German, M.S.6
  • 43
    • 0028074973 scopus 로고
    • PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects
    • Glaser, T., Jepeal, L., Edwards, J. G., Young, S. R., Favor, J., and Maas, R. L. (1994) PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects.. Nat. Genet. 7, 463-471
    • (1994) Nat. Genet. , vol.7 , pp. 463-471
    • Glaser, T.1    Jepeal, L.2    Edwards, J.G.3    Young, S.R.4    Favor, J.5    Maas, R.L.6
  • 44
    • 0030914931 scopus 로고    scopus 로고
    • Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
    • St-Onge, L., Sosa-Pineda, B., Chowdhury, K., Mansouri, A., and Gruss, P. (1997) Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas. Nature 387, 406-409
    • (1997) Nature , vol.387 , pp. 406-409
    • St-Onge, L.1    Sosa-Pineda, B.2    Chowdhury, K.3    Mansouri, A.4    Gruss, P.5
  • 45
    • 0028239775 scopus 로고
    • Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes
    • Epstein, J., Cai, J., Glaser, T., Jepeal, L., and Maas, R. (1994) Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269, 8355-8361
    • (1994) J. Biol. Chem. , vol.269 , pp. 8355-8361
    • Epstein, J.1    Cai, J.2    Glaser, T.3    Jepeal, L.4    Maas, R.5
  • 46
    • 16544393313 scopus 로고    scopus 로고
    • Corecruitment of the Grg4 repressor by PU. 1 is critical for Pax5-mediated repression of B-cell-specific genes
    • Linderson, Y., Eberhard, D., Malin, S., Johansson, A., Busslinger, M., and Pettersson, S. (2004) Corecruitment of the Grg4 repressor by PU. 1 is critical for Pax5-mediated repression of B-cell-specific genes. EMBORep. 5, 291-296
    • (2004) EMBORep. , vol.5 , pp. 291-296
    • Linderson, Y.1    Eberhard, D.2    Malin, S.3    Johansson, A.4    Busslinger, M.5    Pettersson, S.6
  • 48
    • 0142137133 scopus 로고    scopus 로고
    • Groucho suppresses Pax2 transactivation by inhibition of JNk-mediated phosphorylation
    • Cai, Y., Brophy, P. D., Levitan, I., Stifani, S., and Dressler, G. R. (2003) Groucho suppresses Pax2 transactivation by inhibition of JNk-mediated phosphorylation. EMBO J. 22, 5522-5529
    • (2003) EMBO J. , vol.22 , pp. 5522-5529
    • Cai, Y.1    Brophy, P.D.2    Levitan, I.3    Stifani, S.4    Dressler, G.R.5
  • 49
    • 0037139578 scopus 로고    scopus 로고
    • Complex regulatory element within the γE- and γF-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid
    • Králová, J., Czerny, T., Spanielová, H, Ratajová, V., and Kozmik, Z. (2002) Complex regulatory element within the γE- and γF-crystallin enhancers mediates Pax6 regulation and is required for induction by retinoic acid.. Gene 286, 271-282
    • (2002) Gene , vol.286 , pp. 271-282
    • Králová, J.1    Czerny, T.2    Spanielová, H.3    Ratajová, V.4    Kozmik, Z.5
  • 50
    • 28544439295 scopus 로고    scopus 로고
    • Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation
    • Marçal, N, Patel, H, Dong, Z., Belanger-Jasmin, S., Hoffman, B., Helgason, C. D., Dang, J., and Stifani, S. (2005) Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation.. Mol. Cell. Biol. 25, 10916-10929
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 10916-10929
    • Marçal, N.1    Patel, H.2    Dong, Z.3    Belanger-Jasmin, S.4    Hoffman, B.5    Helgason, C.D.6    Dang, J.7    Stifani, S.8
  • 51
    • 0029851956 scopus 로고    scopus 로고
    • Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis
    • Hayman, A. R., Jones, S. J., Boyde, A., Foster, D., Colledge, W. H, Carlton, M. B., Evans, M. J., and Cox, T. M. (1996) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disrupted endochondral ossification and mild osteopetrosis.. Development 122, 3151-3162
    • (1996) Development , vol.122 , pp. 3151-3162
    • Hayman, A.R.1    Jones, S.J.2    Boyde, A.3    Foster, D.4    Colledge, W.H.5    Carlton, M.B.6    Evans, M.J.7    Cox, T.M.8
  • 52
    • 0035965217 scopus 로고    scopus 로고
    • Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation
    • Luchin, A., Suchting, S., Merson, T., Rosol, T. J., Hume, D. A., Cassady, A. I., and Ostrowski, M. C. (2001) Genetic and physical interactions between Microphthalmia transcription factor and PU.1 are necessary for osteoclast gene expression and differentiation.. J. Biol. Chem. 276, 36703-36710
    • (2001) J. Biol. Chem. , vol.276 , pp. 36703-36710
    • Luchin, A.1    Suchting, S.2    Merson, T.3    Rosol, T.J.4    Hume, D.A.5    Cassady, A.I.6    Ostrowski, M.C.7
  • 53
    • 0036139494 scopus 로고    scopus 로고
    • Getting your Pax straight: Pax proteins in development and disease
    • Chi, N, and Epstein, J. A. (2002) Getting your Pax straight: Pax proteins in development and disease. Trends Genet. 18, 41-47
    • (2002) Trends Genet. , vol.18 , pp. 41-47
    • Chi, N.1    Epstein, J.A.2
  • 54
    • 0343183096 scopus 로고    scopus 로고
    • Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family
    • Eberhard, D., Jiménez, G., Heavey, B., and Busslinger, M. (2000) Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.. EMBO J. 19, 2292-2303
    • (2000) EMBO J. , vol.19 , pp. 2292-2303
    • Eberhard, D.1    Jiménez, G.2    Heavey, B.3    Busslinger, M.4
  • 55
    • 80052836185 scopus 로고    scopus 로고
    • Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP
    • Elvenes, J, Thomassen, E. I, Johnsen, S. S., Kaino, K, Sjøttem, E., and Johansen, T. (2011) Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP.. PLoS One 6, e24659
    • (2011) PLoS One , vol.6
    • Elvenes, J.1    Thomassen, E.I.2    Johnsen, S.S.3    Kaino, K.4    Sjøttem, E.5    Johansen, T.6
  • 57
    • 77951454833 scopus 로고    scopus 로고
    • The Groucho/TLE/Grg family of transcriptional co-repressors
    • Jennings, B. H., and Ish-Horowicz, D. (2008) The Groucho/TLE/Grg family of transcriptional co-repressors. Genome Biol. 9, 205
    • (2008) Genome Biol. , vol.9 , pp. 205
    • Jennings, B.H.1    Ish-Horowicz, D.2
  • 58
    • 0032127990 scopus 로고    scopus 로고
    • Groucho proteins: Transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
    • Fisher, A. L., and Caudy, M. (1998) Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates.. Genes Dev. 12, 1931-1940
    • (1998) Genes Dev. , vol.12 , pp. 1931-1940
    • Fisher, A.L.1    Caudy, M.2
  • 59
    • 0042744757 scopus 로고    scopus 로고
    • IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: Irreversible inhibition of the differentiation program activated by RANkL
    • Moreno, J. L., Kaczmarek, M., Keegan, A. D., and Tondravi, M. (2003) IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANkL.. Blood 102, 1078-1086
    • (2003) Blood , vol.102 , pp. 1078-1086
    • Moreno, J.L.1    Kaczmarek, M.2    Keegan, A.D.3    Tondravi, M.4
  • 61
    • 0032169255 scopus 로고    scopus 로고
    • Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
    • Peters, H., Neubüser, A., Kratochwil, K., and Balling, R. (1998) Pax9-deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities.. Genes Dev. 12, 2735-2747
    • (1998) Genes Dev. , vol.12 , pp. 2735-2747
    • Peters, H.1    Neubüser, A.2    Kratochwil, K.3    Balling, R.4
  • 62
    • 0027439075 scopus 로고
    • Mutations in the paired domain of the human PAX3 gene cause klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I). Am
    • Hoth, C. F., Milunsky, A., Lipsky, N., Sheffer, R., Clarren, S. K., and Baldwin, C. T. (1993) Mutations in the paired domain of the human PAX3 gene cause klein-Waardenburg syndrome (WS-III) as well as Waardenburg syndrome type I (WS-I). Am.. J. Hum. Genet. 52, 455-462
    • (1993) J. Hum. Genet. , vol.52 , pp. 455-462
    • Hoth, C.F.1    Milunsky, A.2    Lipsky, N.3    Sheffer, R.4    Clarren, S.K.5    Baldwin, C.T.6
  • 64
    • 0034992555 scopus 로고    scopus 로고
    • IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB. J
    • Abu-Amer, Y. (2001) IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB. J. Clin. Invest. 107, 1375-1385
    • (2001) Clin. Invest. , vol.107 , pp. 1375-1385
    • Abu-Amer, Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.