A novel treatment for tinnitus and tinnitus-related cognitive difficulties using computer-based cognitive training and D-cycloserine

JAMA Otolaryngology - Head and Neck Surgery

Volumn 141, Issue 1, 2015, Pages 18-26

  Krings, James G ^a,b,c   Winel, Andre ^a   Kallogjeri, Dorina ^a   Rodebaugh, Thomas L ^d   Nicklaus, Joyce ^a   Lenze, Eric J ^a   Piccirillo, Jay F ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSERINE; PLACEBO;

ADULT; ARTICLE; ASSESSMENT OF HUMANS; CLINICAL ARTICLE; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HEADACHE; HUMAN; MALE; MEDICATION COMPLIANCE; MENIERE DISEASE; NERVE CELL PLASTICITY; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SKIN TINGLING; TELEPHONE INTERVIEW; TINNITUS; TINNITUS FUNCTIONAL INDEX; TREATMENT OUTCOME; TREATMENT RESPONSE; AGED; COGNITION DISORDERS; COGNITIVE THERAPY; COMPLICATION; FEASIBILITY STUDY; MIDDLE AGED; PROCEDURES;

ADULT; AGED; COGNITION DISORDERS; COGNITIVE THERAPY; CYCLOSERINE; DOUBLE-BLIND METHOD; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT COMPLIANCE; TINNITUS;

EID: 84921506833     PISSN: 21686181     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaoto.2014.2669     Document Type: Article

References (76)

1. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res. 2005;48(5):1204-1235.
2. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med. 2010;123(8):711-718.
3. Lockwood AH, Salvi RJ, Burkard RF, Galantowicz PJ, Coad ML, Wack DS. Neuroanatomy of tinnitus. Scand Audiol Suppl. 1999;51:47-52.
4. Lockwood AH, Salvi RJ, Burkard RF. Tinnitus. N Engl J Med. 2002;347(12):904-910.
5. Kaltenbach JA. Neurophysiologic mechanisms of tinnitus. J Am Acad Audiol. 2000;11(3):125-137.
6. Lenarz T, Schreiner C, Snyder RL, Ernst A. Neural mechanisms of tinnitus. Eur Arch Otorhinolaryngol. 1993;249(8):441-446.
7. Bauer CA. Mechanisms of tinnitus generation. Curr Opin Otolaryngol Head Neck Surg. 2004;12(5):413-417.
8. Smits M, Kovacs S, de Ridder D, Peeters RR, van Hecke P, Sunaert S. Lateralization of functional magnetic resonance imaging (fMRI) activation in the auditory pathway of patients with lateralized tinnitus. Neuroradiology. 2007;49(8):669-679.
9. Adjamian P, Sereda M, Hall DA. The mechanisms of tinnitus: perspectives from human functional neuroimaging. Hear Res. 2009;253(1-2):15-31.
10. Schecklmann M, Landgrebe M, Poeppl TB, et al. Neural correlates of tinnitus duration and distress: a positron emission tomography study. Hum Brain Mapp. 2013;34(1):233-240.
11. Hallam RS, McKenna L, Shurlock L. Tinnitus impairs cognitive efficiency. Int J Audiol. 2004;43(4):218-226.
12. Andersson G, McKenna L. The role of cognition in tinnitus. Acta Otolaryngol Suppl. 2006;(556):39-43.
13. Broadbent DE, Cooper PF, FitzGerald P, Parkes KR. The Cognitive Failures Questionnaire (CFQ) and its correlates. Br J Clin Psychol. 1982;21(pt 1):1-16.
14. Andersson G, Lyttkens L, Larsen HC. Distinguishing levels of tinnitus distress. Clin Otolaryngol Allied Sci. 1999;24(5):404-410.
15. Pierce KJ, Kallogjeri D, Piccirillo JF, Garcia KS, Nicklaus JE, Burton H. Effects of severe bothersome tinnitus on cognitive function measured with standardized tests. J Clin Exp Neuropsychol. 2012;34(2):126-134.
16. Rossiter S, Stevens C, Walker G. Tinnitus and its effect on working memory and attention. J Speech Lang Hear Res. 2006;49(1):150-160.
17. Stevens C, Walker G, Boyer M, Gallagher M. Severe tinnitus and its effect on selective and divided attention. Int J Audiol. 2007;46(5):208-216.
18. Cramer SC, Sur M, Dobkin BH, et al. Harnessing neuroplasticity for clinical applications. Brain. 2011;134(pt 6):1591-1609.
19. Bherer L, Kramer AF, Peterson MS, Colcombe S, Erickson K, Becic E. Transfer effects in task-set cost and dual-task cost after dual-task training in older and younger adults: further evidence for cognitive plasticity in attentional control in late adulthood. Exp Aging Res. 2008;34(3):188-219.
20. Erickson KI, Colcombe SJ, Wadhwa R, et al. Training-induced plasticity in older adults: effects of training on hemispheric asymmetry. Neurobiol Aging. 2007;28(2):272-283.
21. Mahncke HW, Bronstone A, Merzenich MM. Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Prog Brain Res. 2006;157:81-109.
22. Mahncke HW, Connor BB, Appelman J, et al. Memory enhancement in healthy older adults using a brain plasticity-based training program: a randomized, controlled study. Proc Natl Acad Sci U S A. 2006;103(33):12523-12528.
23. Wolinsky FD, Mahncke H, Vander Weg MW, et al. Speed of processing training protects self-rated health in older adults: enduring effects observed in the multi-site ACTIVE randomized controlled trial. Int Psychogeriatr. 2010;22(3):470-478.
24. Smith GE, Housen P, Yaffe K, et al. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc. 2009;57(4):594-603.
25. Willis SL, Tennstedt SL, Marsiske M, et al ACTIVE Study Group. Long-term effects of cognitive training on everyday functional outcomes in older adults. JAMA. 2006;296(23):2805-2814.
26. Klingberg T, Fernell E, Olesen PJ, et al. Computerized training of working memory in children with ADHD - a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry. 2005;44(2):177-186.
27. Barnes DE, Yaffe K, Belfor N, et al. Computer-based cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord. 2009;23(3):205-210.
28. Morimoto SS, Wexler BE, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for geriatric depression. Int J Geriatr Psychiatry. 2012;27(12):1239-1247.
29. Fisher M, Holland C, Merzenich MM, Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am J Psychiatry. 2009;166(7):805-811.
30. Bell M, Bryson G, Greig T, Corcoran C, Wexler BE. Neurocognitive enhancement therapy with work therapy: effects on neuropsychological test performance. Arch Gen Psychiatry. 2001;58(8):763-768.
31. Dickinson D, Tenhula W, Morris S, et al. A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia. Am J Psychiatry. 2010;167(2):170-180.
32. Otto MW, Tolin DF, Simon NM, et al. Efficacy of D-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder. Biol Psychiatry. 2010;67(4):365-370.
33. Guastella AJ, Richardson R, Lovibond PF, et al. A randomized controlled trial of D-cycloserine enhancement of exposure therapy for social anxiety disorder. Biol Psychiatry. 2008;63(6):544-549.
34. Wilhelm S, Buhlmann U, Tolin DF, et al. Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder. Am J Psychiatry. 2008;165(3):335-341.
35. Kushner MG, Kim SW, Donahue C, et al. D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biol Psychiatry. 2007;62(8):835-838.
36. Heresco-Levy U, Kremer I, Javitt DC, et al. Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2002;5(4):301-307.
37. Adeleye A, Shohami E, Nachman D, et al. D-cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window. Eur J Pharmacol. 2010;629(1-3):25-30.
38. Tsai GE, Falk WE, Gunther J, Coyle JT. Improved cognition in Alzheimer's disease with short-term D-cycloserine treatment. Am J Psychiatry. 1999;156(3):467-469.
39. Schwartz BL, Hashtroudi S, Herting RL, Schwartz P, Deutsch SI. D-Cycloserine enhances implicit memory in Alzheimer patients. Neurology. 1996;46(2):420-424.
40. Posey DJ, Kem DL, Swiezy NB, Sweeten TL, Wiegand RE, McDougle CJ. A pilot study of D-cycloserine in subjects with autistic disorder. Am J Psychiatry. 2004;161(11):2115-2117.
41. Ressler KJ, Rothbaum BO, Tannenbaum L, et al. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004;61(11):1136-1144.
42. Krystal JH, Tolin DF, Sanacora G, et al. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Drug Discov Today. 2009;14(13-14):690-697.
43. Goff DC. D-Cycloserine: an evolving role in learning and neuroplasticity in schizophrenia. Schizophr Bull. 2012;38(5):936-941.
44. Rouaud E, Billard JM. D-Cycloserine facilitates synaptic plasticity but impairs glutamatergic neurotransmission in rat hippocampal slices. Br J Pharmacol. 2003;140(6):1051-1056.
45. Yaka R, Biegon A, Grigoriadis N, et al. D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury. FASEB J. 2007;21(9):2033-2041.
46. Hofmann SG, Meuret AE, Smits JA, et al. Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Arch Gen Psychiatry. 2006;63(3):298-304.
47. Storch EA, Murphy TK, Goodman WK, et al. A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biol Psychiatry. 2010;68(11):1073-1076.
48. Temple MD, Hamm RJ. Chronic, post-injury administration of D-cycloserine, an NMDA partial agonist, enhances cognitive performance following experimental brain injury. Brain Res. 1996;741(1-2):246-251.
49. Gottlieb JD, Cather C, Shanahan M, Creedon T, Macklin EA, Goff DC. D-Cycloserine facilitation of cognitive behavioral therapy for delusions in schizophrenia. Schizophr Res. 2011;131(1-3):69-74.
50. Goff DC, Herz L, Posever T, et al. A six-month, placebo-controlled trial of D-cycloserine co-administered with conventional antipsychotics in schizophrenia patients. Psychopharmacology (Berl). 2005;179(1):144-150.
51. Heresco-Levy U, Javitt DC, Ermilov M, Silipo G, Shimoni J. Double-blind, placebo-controlled, crossover trial of D-cycloserine adjuvant therapy for treatment-resistant schizophrenia. Int J Neuropsychopharmacol. 1998;1(2):131-135.
52. Kamboj SK, Massey-Chase R, Rodney L, et al. Changes in cue reactivity and attentional bias following experimental cue exposure and response prevention: a laboratory study of the effects of D-cycloserine in heavy drinkers. Psychopharmacology (Berl). 2011;217(1):25-37.
53. Norberg MM, Krystal JH, Tolin DF. Ameta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol Psychiatry. 2008;63(12):1118-1126.
54. Newman CW, Jacobson GP, Spitzer JB. Development of the Tinnitus Handicap Inventory. Arch Otolaryngol Head Neck Surg. 1996;122(2):143-148.
55. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-613.
56. Meikle MB, Henry JA, Griest SE, et al. The Tinnitus Functional Index: development of a new clinical measure for chronic, intrusive tinnitus. Ear Hear. 2012;33(2):153-176.
57. Golden C. Stroop Color and Word Test: A Manual for Clinical and Experimental Uses. Chicago, IL: Skoelting; 1978.
58. Stroop J. Studies of interference in serial verbal reactions. J Exp Psychol. 1935;18:643-662.
59. Gronwall DM. Paced auditory serial-addition task: a measure of recovery from concussion. Percept Mot Skills. 1977;44(2):367-373.
60. Behar E, McHugh RK, Peckham A, Otto MW. D-Cycloserine for the augmentation of an attentional training intervention for trait anxiety. J Anxiety Disord. 2010;24(4):440-445.
61. Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap) - a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377-381.
62. Erlandsson SI, Hallberg LR. Prediction of quality of life in patients with tinnitus. Br J Audiol. 2000;34(1):11-20.
63. Parnas AS, Weber M, Richardson R. Effects of multiple exposures to D-cycloserine on extinction of conditioned fear in rats. Neurobiol Learn Mem. 2005;83(3):224-231.
64. Cima RF, Maes IH, Joore MA, et al. Specialised treatment based on cognitive behaviour therapy versus usual care for tinnitus: a randomised controlled trial. Lancet. 2012;379(9830):1951-1959.
65. Andersson G, Lyttkens L. Ameta-analytic review of psychological treatments for tinnitus. Br J Audiol. 1999;33(4):201-210.
66. Hesser H, Weise C, Westin VZ, Andersson G. A systematic review and meta-analysis of randomized controlled trials of cognitive-behavioral therapy for tinnitus distress. Clin Psychol Rev. 2011;31(4):545-553.
67. Andersson G. Psychological aspects of tinnitus and the application of cognitive-behavioral therapy. Clin Psychol Rev. 2002;22(7):977-990.
68. Lohnberg JA, Altmaier EM. A review of psychosocial factors in complex regional pain syndrome. J Clin Psychol Med Settings. 2013;20(2):247-254.
69. Møller AR. Tinnitus and pain. Prog Brain Res. 2007;166:47-53.
70. Møller AR. Similarities between chronic pain and tinnitus. Am J Otol. 1997;18(5):577-585.
71. Moller AR. Similarities between severe tinnitus and chronic pain. J Am Acad Audiol. 2000;11(3):115-124.
72. Robinson P, Wicksell RKOGL. AT with chronic pain patients. In: Hayes SC, Strohsahl KD, eds. A Practical Guide to Acceptance and Commitment Therapy. New York, NY: Springer; 2004:315-345.
73. McCracken LM. Contextual Cognitive-Behavioral Therapy for Chronic Pain, Progress in Pain Research and Management. Seattle, WA: IASP Press; 2005.
74. Kabat-Zinn J. Full Catastrope Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain, and Illness. New York, NY: Dell Publishing; 1990.
75. Kabat-Zinn J, Massion AO, Kristeller J, et al. Effectiveness of a meditation-based stress reduction program in the treatment of anxiety disorders. Am J Psychiatry. 1992;149(7):936-943.
76. Harrop-Griffiths J, Katon W, Dobie R, Sakai C, Russo J. Chronic tinnitus: association with psychiatric diagnoses. J Psychosom Res. 1987;31(5):613-621.