Clinical issues in renal transplantation in the elderly

Clinical Transplantation

Volumn 29, Issue 2, 2015, Pages 167-175

  Hod, Tammy ^a   Goldfarb Rumyantzev, Alexander S ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Elderly; End stage renal disease; Outcome; Transplantation

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

ACUTE GRAFT REJECTION; AGED; COMORBIDITY; END STAGE RENAL DISEASE; GERIATRIC SURGERY; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HIGH RISK PATIENT; HLA MATCHING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTIOUS COMPLICATION; KIDNEY TRANSPLANTATION; LONG TERM SURVIVAL; ORGAN DONOR; PRIORITY JOURNAL; QUALITY OF LIFE; RENAL REPLACEMENT THERAPY; REVIEW; DONOR; HEALTH; KIDNEY FAILURE, CHRONIC; POSTOPERATIVE COMPLICATIONS;

AGED; GLOBAL HEALTH; GRAFT SURVIVAL; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; TISSUE DONORS;

EID: 84921494245     PISSN: 09020063     EISSN: 13990012     Source Type: Journal    
DOI: 10.1111/ctr.12481     Document Type: Review

References (72)

1. Danovitch GM, Cohen DJ, Weir MR et al. Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant 2005: 5: 904.
2. Port FK, Merion RM, Roys EC, Wolfe RA. Trends in organ donation and transplantation in the United States, 1997-2006. Am J Transplant 2008: 8: 911.
3. Port FK, Wolfe RA, Mauger EA, Berling DP, Jiang K. Comparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. JAMA 1993: 270: 1339.
4. Wolfe RA, Ashby VB, Milford EL et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999: 341: 1725.
5. Danovitch G, Savransky E. Challenges in the counseling and management of older kidney transplant candidates. Am J Kidney Dis 2006: 47: S86.
6. Tesi RJ, Elkhammas EA, Davies EA, Henry ML, Ferguson RM. Renal transplantation in older people. Lancet 1994: 343: 461.
7. Heldal K, Hartmann A, Grootendorst DC et al. Benefit of kidney transplantation beyond 70 years of age. Nephrol Dial Transplant 2010: 25: 1680.
8. Rockwood K, Song X, MacKnight C et al. A global clinical measure of fitness and frailty in elderly people. CMAJ 2005: 173: 489.
9. Gill JS, Tonelli M, Johnson N, Kiberd B, Landsberg D, Pereira BJ. The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation. Kidney Int 2005: 68: 2345.
10. McKay D, Jameson J. Kidney transplantation and the ageing immune system. Nat Rev Nephrol 2012: 8: 700.
11. Tullius SG, Milford E. Kidney allocation and the aging immune response. N Engl J Med 2011: 364: 1369.
12. Friedman AL, Goker O, Kalish MA et al. Renal transplant recipients over aged 60 have diminished immune activity and a low risk of rejection. Int Urol Nephrol 2004: 36: 451.
13. Mendonca HM, Dos Reis Made Castro de Cintra Sesso R, Camara NO, Pacheco-Silva A. Renal transplantation outcomes: a comparative analysis between elderly and younger recipients. Clin Transplant 2007: 21: 755.
14. Pedroso S, Martins L, Fonseca I et al. Renal transplantation in patients over 60 years of age: a single-center experience. Transplant Proc 2006: 38: 1885.
15. Heldal K, Leivestad T, Hartmann A, Svendsen MV, Lien BH, Midtvedt K. Kidney transplantation in the elderly-the Norwegian experience. Nephrol Dial Transplant 2008: 23: 1026.
16. Heldal K, Hartmann A, Leivestad T et al. Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity. Transplantation 2009: 87: 1045.
17. Murasko DM, Weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 1987: 70: 440.
18. Suvas S. Advancing age and immune cell dysfunction: is it reversible or not? Expert Opin Biol Ther 2008: 8: 657.
19. Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med 2008: 205: 711.
20. Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci USA 2003: 100: 15053.
21. Rosenberg AS, Sechler JM, Horvath JA, Maniero TG, Bloom ET. Assessment of alloreactive T cell subpopulations of aged mice in vivo. CD4+ but not CD8+ T cell-mediated rejection response declines with advanced age. Eur J Immunol 1994: 24: 1312.
22. Tesar BM, Du W, Shirali AC, Walker WE, Shen H, Goldstein DR. Aging augments IL-17 T-cell alloimmune responses. Am J Transplant 2009: 9: 54.
23. Denecke C, Bedi DS, Ge X et al. Prolonged graft survival in older recipient mice is determined by impaired effector T-cell but intact regulatory T-cell responses. PLoS One 2010: 5: e9232.
24. Linton PJ, Haynes L, Klinman NR, Swain SL. Antigen-independent changes in naive CD4 T cells with aging. J Exp Med 1996: 184: 1891.
25. Mu XY, Thoman ML. The age-dependent cytokine production by murine CD8+ T cells as determined by four-color flow cytometry analysis. J Gerontol A Biol Sci Med Sci 1999: 54: B116.
26. Messaoudi I, Lemaoult J, Guevara-Patino JA, Metzner BM, Nikolich-Zugich J. Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense. J Exp Med 2004: 200: 1347.
27. Badowski M, Gurk-Turner C, Cangro C et al. The impact of reduced immunosuppression on graft outcomes in elderly renal transplant recipients. Clin Transplant 2009: 23: 930.
28. Heldal K, Midtvedt K. Managing transplant rejection in the elderly: the benefits of less aggressive immunosuppressive regimens. Drugs Aging 2013: 30: 459.
29. Doyle SE, Matas AJ, Gillingham K, Rosenberg ME. Predicting clinical outcome in the elderly renal transplant recipient. Kidney Int 2000: 57: 2144.
30. Schratzberger G, Mayer G. Age and renal transplantation: an interim analysis. Nephrol Dial Transplant 2003: 18: 471.
31. Ismail N, Hakim RM, Helderman JH. Renal replacement therapies in the elderly: Part II. Renal transplantation. Am J Kidney Dis 1994: 23: 1.
32. Goldfarb-Rumyantzev AS, Scandling JD, Pappas L, Smout RJ, Horn S. Prediction of 3-yr cadaveric graft survival based on pre-transplant variables in a large national dataset. Clin Transplant 2003: 17: 485.
33. Molnar MZ, Streja E, Kovesdy CP et al. Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes. Am J Kidney Dis 2012: 59: 841.
34. Tullius SG, Tran H, Guleria I, Malek SK, Tilney NL, Milford E. The combination of donor and recipient age is critical in determining host immunoresponsiveness and renal transplant outcome. Ann Surg 2010: 252: 662.
35. Nankivell BJ, Borrows RJ, Fung CL, O'Connell PJ, Allen RD, Chapman JR. The natural history of chronic allograft nephropathy. N Engl J Med 2003: 349: 2326.
36. Saudan P, Berney T, Leski M, Morel P, Bolle JF, Martin PY. Renal transplantation in the elderly: a long-term, single-centre experience. Nephrol Dial Transplant 2001: 16: 824.
37. Bentas W, Jones J, Karaoguz A et al. Renal transplantation in the elderly: surgical complications and outcome with special emphasis on the Eurotransplant Senior Programme. Nephrol Dial Transplant 2008: 23: 2043.
38. Fabrizii V, Winkelmayer WC, Klauser R et al. Patient and graft survival in older kidney transplant recipients: does age matter? J Am Soc Nephrol 2004: 15: 1052.
39. Faravardeh A, Eickhoff M, Jackson S, Spong R, Kukla A. Issa N et al. Predictors of graft failure and death in elderly kidney transplant recipients. Transplantation, 2013: 96: 1089.
40. Kauffman HM, McBride MA, Cors CS, Roza AM, Wynn JJ. Early mortality rates in older kidney recipients with comorbid risk factors. Transplantation 2007: 83: 404.
41. Wu C, Shapiro R, Tan H et al. Kidney transplantation in elderly people: the influence of recipient comorbidity and living kidney donors. J Am Geriatr Soc 2008: 56: 231.
42. Oniscu GC, Brown H, Forsythe JL. How old is old for transplantation? Am J Transplant 2004: 4: 2067.
43. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK. Long-term survival in renal transplant recipients with graft function. Kidney Int 2000: 57: 307.
44. Hatamizadeh P, Molnar MZ, Streja E et al. Recipient-related predictors of kidney transplantation outcomes in the elderly. Clin Transplant 2013: 27: 436.
45. Singh N, Nori U, Pesavento T. Kidney transplantation in the elderly. Curr Opin Organ Transplant 2009: 14: 380.
46. Lenihan CR, Hurley MP, Tan JC. Comorbidities and kidney transplant evaluation in the elderly. Am J Nephrol 2013: 38: 204.
47. Thompson WW, Shay DK, Weintraub E et al. Influenza-associated hospitalizations in the United States. JAMA 2004: 292: 1333.
48. Pawelec G, Barnett Y, Forsey R et al. T cells and aging, January 2002 update. Front Biosci 2002: 7: d1056.
49. de Fijter JW, Mallat MJ, Doxiadis II et al. Increased immunogenicity and cause of graft loss of old donor kidneys. J Am Soc Nephrol 2001: 12: 1538.
50. Oberhuber R, Ge XTullius SG. Donor age-specific injury and immune responses. Am J Transplant 2012: 12: 38.
51. Gill J, Sampaio M, Gill JS et al. Induction immunosuppressive therapy in the elderly kidney transplant recipient in the United States. Clin J Am Soc Nephrol 2011: 6: 1168.
52. Giessing M, Fuller TF, Tuellmann M, Slowinski T, Budde K, Liefeldt L. Steroid- and calcineurin inhibitor free immunosuppression in kidney transplantation: state of the art and future developments. World J Urol 2007: 25: 325.
53. Jacobson PA, Schladt D, Oetting WS et al. Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs. Am J Transplant 2012: 12: 3326.
54. Falck P, Asberg A, Byberg KT et al. Reduced elimination of cyclosporine A in elderly (>65 years) kidney transplant recipients. Transplantation 2008: 86: 1379.
55. Patel SJ, Knight RJ, Suki WN et al. Rabbit antithymocyte induction and dosing in deceased donor renal transplant recipients over 60 yr of age. Clin Transplant 2011: 25: E250.
56. Ramalho AL, Custodio FB, Tokuda BM et al. Clinical and histopathologic comparative analysis between kidney transplant recipients from expanded-criteria donors and standard-criteria donors. Transplant Proc 2013: 45: 3234.
57. Wolfe RA, McCullough KP, Leichtman AB. Predictability of survival models for waiting list and transplant patients: calculating LYFT. Am J Transplant 2009: 9: 1523.
58. Wolfe RA, McCullough KP, Schaubel DE et al. Calculating life years from transplant (LYFT): methods for kidney and kidney-pancreas candidates. Am J Transplant 2008: 8: 997.
59. Rao PS, Schaubel DE, Guidinger MK et al. A comprehensive risk quantification score for deceased donor kidneys: the kidney donor risk index. Transplantation 2009: 88: 231.
60. van Walraven C, Austin PC, Knoll G. Predicting potential survival benefit of renal transplantation in patients with chronic kidney disease. CMAJ 2010: 182: 666.
61. Hanf W, Petruzzo P, Meas-Yedid V, Berthiller J, Martin X, Morelon E et al. Dual kidney transplantation from uncontrolled deceased donors after cardiac arrest: a possible option. Int J Urol 2014: 21: 204.
62. Klair T, Gregg A, Phair J, Kayler LK. Outcomes of adult dual kidney transplants by KDRI in the United States. Am J Transplant 2013: 13: 2433.
63. Ekser B, Furian L, Broggiato A et al. Technical aspects of unilateral dual kidney transplantation from expanded criteria donors: experience of 100 patients. Am J Transplant 2010: 10: 2000.
64. Remuzzi G, Cravedi P, Perna A et al.; Dual Kidney Transplant Group. Long-term outcome of renal transplantation from older donors. N Engl J Med 2006: 354: 343.
65. Ojo AO, Hanson JA, Meier-Kriesche H et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001: 12: 589.
66. Klop KW, Dols LF, Weimar W, Dooper IM, Ijzermans JN, Kok NF. Quality of life of elderly live kidney donors. Transplantation 2013: 96: 644.
67. Merion RM, Ashby VB, Wolfe RA et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA 2005: 294: 2726.
68. Fritsche L, Horstrup J, Budde K et al. Old-for-old kidney allocation allows successful expansion of the donor and recipient pool. Am J Transplant 2003: 3: 1434.
69. Cohen B, Smits JM, Haase B, Persijn G, Vanrenterghem Y, Frei U. Expanding the donor pool to increase renal transplantation. Nephrol Dial Transplant 2005: 20: 34.
70. Arns W, Citterio F, Campistol JM. 'Old-for-old'-new strategies for renal transplantation. Nephrol Dial Transplant 2007: 22: 336.
71. Oppenheimer F, Aljama P, Asensio Peinado C, Bustamante Bustamante J, Crespo Albiach JF, Guirado Perich L. The impact of donor age on the results of renal transplantation. Nephrol Dial Transplant 2004: 19(Suppl 3): iii11.
72. Irish WD, Ilsley JN, Schnitzler MA, Feng S, Brennan DC. A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation. Am J Transplant 2010: 10: 2279.