Kidney transplantation in the elderly

Current Opinion in Organ Transplantation

Volumn 14, Issue 4, 2009, Pages 380-385

  Singh, Neeraj ^a   Nori, Uday ^a   Pesavento, Todd ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Aging; Elderly patients; Immunosuppression; Kidney transplantation; Outcomes

Indexed keywords

HEALTH CARE POLICY; HUMAN; KIDNEY TRANSPLANTATION; LIVING DONOR; MEDICAL ETHICS; MORTALITY; ORGAN DONOR; REVIEW; UNITED STATES;

AGE FACTORS; HEALTH POLICY; HEALTH SERVICES FOR THE AGED; HUMANS; IMMUNOSUPPRESSION; KIDNEY TRANSPLANTATION; PATIENT SELECTION; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; TREATMENT OUTCOME; UNITED STATES; WAITING LISTS;

EID: 68849107523     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32832dbd06     Document Type: Review

References (81)

1. US Renal Data System: Annual Data Report. Bethesda, MD: National Institute of Health, National Institutes of Diabetes and Digestive and Kidney Diseases; 2008. http://www.usrdsorg/adr.htm
2. Organ Procurement and Transplantation Network (OPTN) National data. http://www.optn.org/latestData/step2.asp?. [Accessed 13 February 2009]
3. 2003 OPTN/SRTR. Annual Report 1993-2002. HHS/HRSA//HSB/DOT; UNOS; Arbor Research Collaborative for Health. http://www.ustransplant. org/annual-reports/ archives/2003/501-age-ki.htm
4. Cantarovich D, Baranger T, Tirouvanziam A, et al. One-hundred and five cadaveric kidney transplants with cyclosporine in recipients more than 60 years of age. Transplant Proc 1993; 25:1323. (Pubitemid 23079004)
5. Ismail N, Hakim RM, Helderman JH. Renal replacement therapies in the elderly. Part II: Renal transplantation. Am J Kidney Dis 1994; 23:1-15. (Pubitemid 24021741)
6. 2007 OPTN/SRTR. Annual Report 2002-2006. HHS/HRSA//HSB/DOT; UNOS; Arbor Research for Health. http://www.ustransplant.org/annual-reports/current/501b- age-ki.htm
7. Danovitch GM. A kidney for all ages. Am J Transplant 2006; 6:1267-1268.
8. Meier-Kriesche HU, Schold JD, Gaston RS, et al. Kidneys from deceased donors: maximizing the value of a scarce resource. Am J Transplant 2005; 5:1725-1730.
9. Curtis JJ. Ageism and kidney transplantation. Am J Transplant 2006; 6:1264-1266.
10. Saidi RF, Kennealey PT, Elias N, et al. Deceased donor kidney transplantation in elderly patients: is there a difference in outcomes? Transplant Proc 2008; 40:3413-3417.
11. Frei U, Noeldeke J, Machold-Fabrizii V, et al. Prospective age-matching in elderly kidney transplant recipients - a 5-year analysis of the Eurotransplant Senior Program. Am J Transplant 2008; 8:50-57. This study shows that acceptable patient and graft outcomes can be obtained with allocation of older kidneys to elderly recipients, a practice that is now routine in many European nations.
12. Wolfe RA, McCullough KP, Schaubel DE, et al. Calculating life years from transplant (LYFT): methods for kidney and kidney-pancreas candidates. Am J Transplant 2008; 8:997-1011. This article highlights the key components of a new deceased donor kidney allocation system that the Organ Procurement and Transplantation Network (OPTN) is actively considering. This new allocation system is based on a strategy to estimate life years from transplant or LYFT with an aim to increase total years of life among both transplant candidates and recipients.
13. Rosengard BR, Feng S, Alfrey EJ, et al. Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor. Am J Transplant 2002; 2:701-711. (Pubitemid 36342613)
14. Stratta RJ, Sundberg AK, Rohr MS, et al. Optimal use of older donors and recipients in kidney transplantation. Surgery 2006; 139:324-333.
15. Oniscu GC, Brown H, Forsythe JL. How old is old for transplantation? Am J Transplant 2004; 4:2067-2074.
16. Jassal SV, Krahn MD, Naglie G, et al. Kidney transplantation in the elderly: a decision analysis. J Soc Nephrol 2003; 14:187-196. (Pubitemid 36026309)
17. Cosio FG, Alamir A, Yim S, et al. Patient survival after renal transplantation. I: The impact of dialysis pretransplant. Kidney Int 1998; 53:767-772.
18. Laupacis A, Keown P, Pus N, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int 1996; 50:235-242. (Pubitemid 26323718)
19. Eggers P. Comparison of treatment costs between dialysis and transplantation. Semin Nephrol 1992; 12:284-289.
20. Saidi RF, Elias N, Kawai T, et al. Outcome of kidney transplantation using expanded criteria and donation after cardiac death kidneys: realities and costs. Am J Transplant 2007; 7:2769-2774. (Pubitemid 350045769)
21. Rabbat CG, Thorpe KE, Russell JD, Churchill DN. Comparison of mortality risk for dialysis patients and cadaveric first renal transplant recipients in Ontario, Canada. J Am Soc Nephrol 2000; 11:917-922.
22. Wu C, Shapiro R, Tan H, et al. Kidney transplantation in elderly people: the influence of recipient comorbidity and living kidney donors. J Am Geriatr Soc 2008; 56:231-238. This study reviewed the donor and recipient characteristics associated with transplant outcomes in elderly kidney transplant recipients. A significant finding was that comorbidity was a significant predictor of patient survival in elderly recipients but not in the subset of elderly patients of living donor kidneys. (Pubitemid 351160691)
23. Gill J, Bunnapradist S, Danovitch GM, et al. Outcomes of kidney transplantation from older living donors to older recipients. Am J Kidney Dis 2008; 52:541-552.
24. Gill JS, Gill J, Rose C, et al. The older living kidney donor: part of the solution to the organ shortage. Transplantation 2006; 82:1662-1666. (Pubitemid 46035648)
25. Sakai K, Okamoto M, Suzuki T, et al. The excellent results of spousal kidney transplantation: experience in a Japanese single center. Transplant Proc 2008; 40:2118-2120.
26. Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med 1995; 333:333-336.
27. Locke JE, Segev DL, Warren DS, et al. Outcomes of kidneys from donors after cardiac death: implications for allocation and preservation. Am J Transplant 2007; 7:1797-1807. (Pubitemid 46905442)
28. D'Alessandro AM, Fernandez LA, Chin LT, et al. Donation after cardiac death: the University of Wisconsin experience. Ann Transplant 2004; 9:68-71.
29. Metzger RA, Delmonico FL, Feng S, et al. Expanded criteria donors for kidney transplantation. Am J Transplant 2003; 3 (Suppl 4):114-125. (Pubitemid 36612389)
30. Pfaff WW, Howard RJ, Patton PR, et al. Delayed graft function after renal transplantation. Transplantation 1998; 65:219-223. (Pubitemid 28099215)
31. Matas AJ, Gillingham KJ, Elick BA, et al. Risk factors for prolonged hospitalization after kidney transplants. Clin Transplant 1997; 11:259-264. (Pubitemid 27331154)
32. Shoskes DA, Cecka JM. Deleterious effects of delayed graft function in cadaveric renal recipients independent of acute rejection. Transplantation 1998; 66:1697-1701.
33. Reutzel-Selke A, Filatenkov A, Jurisch A, et al. Grafts from elderly donors elicit a stronger in the early period posttransplantation: a study in a rat model. Transplant Proc 2005; 37:382-383. (Pubitemid 40459794)
34. Melk A, Schmidt BM, Braun H, et al. Effects of donor age and cell senescence on kidney allograft survival. Am J Transplant 2009; 9:114-123.
35. Merion RM, Ashby VB, Wolfe RA, et al. Deceased-donor characteristics and the survival benefit of kidney transplantation. JAMA 2005; 294:2726-2733. (Pubitemid 41770102)
36. Marks WH, Wagner D, Pearson TC, et al. Organdonation and utilization,1995-2004: entering the collaborative era. Am J Transplant 2006; 6:1101-1110.
37. Schold JD, Meier-Kriesche HU. Which renal transplant candidates should accept marginal kidneys in exchange for a shorter waiting time on dialysis? Clin J Am Soc Nephrol 2006; 1:532-538.
38. Sellers MT, Velidedeoglu E, Bloom RD, et al. Expanded-criteria donor kidneys: a single-center clinical and short-term financial analysis - cause for concern in retransplantation. Transplantation 2004; 78:1670-1675. (Pubitemid 39648442)
39. Miles CD, Schaubel DE, Jia X, et al. Mortality experience in recipients undergoing repeat transplantation with expanded criteria donor and non-ECD deceased-donor kidneys. Am J Transplant 2007; 7:1140-1147. (Pubitemid 46643097)
40. Stratta RJ, Rohr MS, Sundberg AK, et al. Increased kidney transplantation utilizing expanded criteria deceased organ donors with results comparable to standard criteria donor transplant. Ann Surg 2004; 239:688-695; discussion 695-1687
41. Fritsche L, Horstrup J, Budde K, et al. Old-for-old kidney allocation allows successful expansion of the donor and recipient pool. Am J Transplant 2003; 3:1434-1439. (Pubitemid 37288090)
42. Delmonico FL, Burdick JF. Maximizing the success of transplantation with kidneys from older donors. N Engl J Med 2006; 354:411-413. (Pubitemid 43145068)
43. Lopes JA, Moreso F, Riera L, et al. Evaluation of preimplantation kidney biopsies: comparison of Banff criteria to a morphometric approach. Kidney Int 2005; 67:1595-1600. (Pubitemid 40463140)
44. Pokorna E, Vitko S, Chadimova M, et al. Proportion of glomerulosclerosis in procurement wedge renal biopsy cannot alone discriminate for acceptance of marginal donors. Transplantation 2000; 69:36-43. (Pubitemid 30062605)
45. Nyberg SL, Matas AJ, Rogers M, et al. Donor scoring system for cadaveric renal transplantation. Am J Transplant 2001; 1:162-170. (Pubitemid 33674157)
46. Tesi RJ, Elkhammas EA, Davies EA, et al. Pulsatile kidney perfusion for evaluation of high-risk kidney donors safely expands the donor pool. Clin Transplant 1994; 8:134-138.
47. Kusaka M, Kubota Y, Sasaki H, et al. Is pulsatile perfusion necessary for renal transplantation engrafting kidneys from cardiac death donors? Transplant Proc 2006; 38:3388-3389.
48. Tan JC, Alfrey EJ, Dafoe DC, et al. Dual-kidney transplantation with organs from expanded criteria donors: a long-term follow-up. Transplantation 2004; 78:692-696.
49. Remuzzi G, Grinyo J, Ruggenenti P, et al. Early experience with dual kidney transplantation in adults using expanded donor criteria. Double Kidney Transplant Group (DKG). J Am Soc Nephrol 1999; 10:2591-2598.
50. Gill J, Cho YW, Danovitch GM, et al. Outcomes of dual adult kidney transplants in the United States: an analysis of the OPTN/UNOS database. Transplantation 2008; 85:62-68.
51. Andres A, Morales JM, Herrero JC, et al. Double versus single renal allografts from aged donors. Transplantation 2000; 69:2060-2066. (Pubitemid 30395034)
52. Dharnidharka VR, Stevens G, Howard RJ. En-bloc kidney transplantation in the United states: an analysis of united network of organ sharing (UNOS) data from 1987 to 2003. Am J Transplant 2005; 5:1513-1517.
53. Friedman AL, Goker O, Kalish MA, et al. Renal transplant recipients over aged 60 have diminished immune activity and a low risk of rejection. Int Urol Nephrol 2004; 36:451-456.
54. Becker BN, Ismail N, Becker YT, et al. Renal transplantation in the older end stage renal disease patient. Semin Nephrol 1996; 16:353-362. (Pubitemid 26244195)
55. Stratta P, Morellini V, Musetti C, et al. Malignancy after kidney transplantation: results of 400 patients from a single center. Clin Transplant 2008; 22:424-427.
56. Meier-Kriesche HU, Ojo AO, Hanson JA, Kaplan B. Exponentially increased risk of infectious death in older renal transplant recipients. Kidney Int 2001; 59:1539-1543. (Pubitemid 32281245)
57. Giessing M, Budde K, Fritsche L, et al. 'Old-for-old' cadaveric renal transplantation: surgical findings, perioperative complications and outcome. Eur Urol 2003; 44:701-708.
58. Danovitch GM, Gill J, Bunnapradist S. Immunosuppression of the elderly kidney transplant recipient. Transplantation 2007; 84:285-291. (Pubitemid 47258313)
59. Sommer BG, Ferguson RM, Davin TD, et al. Renal transplantation in patients over 50 years of age. Transplant Proc 1981; 13:33-35.
60. Lundgren G, Fehrman I, Gunnarsson R, et al. Cadaveric renal transplantation in patients over 55 years of age with special emphasis on immunosuppressive therapy. Transplant Proc 1982; 14:601-604. (Pubitemid 13197341)
61. Hutchinson TA, Thomas DC, Lemieux JC, Harvey CE. Prognostically controlled comparison of dialysis and renal transplantation. Kidney Int 1984; 26:44-51. (Pubitemid 14060587)
62. Roodnat JI, Zietse R, Mulder PG, et al. The vanishing importance of age in renal transplantation. Transplantation 1999; 67:576-580. (Pubitemid 29114221)
63. Kappes U, Schanz G, Gerhardt U, et al. Influence of age on the prognosis of renal transplant recipients. Am J Nephrol 2001; 21:259-263. (Pubitemid 32757308)
64. Schnuelle P, Lorenz D, Trede M, Van Der Woude FJ. Impact of renal cadaveric transplantation on survival in end-stage renal failure: evidence for reduced mortality risk compared with hemodialysis during long-term follow-up. J Am Soc Nephrol 1998; 9:2135-2141. (Pubitemid 28482164)
65. Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999; 341:1725-1730.
66. Johnson DW, Herzig K, Purdie D, et al. A comparison of the effects of dialysis and renal transplantation on the survival of older uremic patients. Transplantation 2000; 69:794-799. (Pubitemid 30174099)
67. Ojo AO, Hanson JA, Meier-Kriesche H, et al. Survival in recipients of marginal cadaveric donor kidneys compared with other recipients and wait-listed transplant candidates. J Am Soc Nephrol 2001; 12:589-597. (Pubitemid 32180029)
68. Whiting JF, Woodward RS, Zavala EY, et al. Economic cost of expanded criteria donors in cadaveric renal transplantation: analysis of Medicare payments. Transplantation 2000; 70:755-760.
69. Rao PS, Merion RM, Ashby VB, et al. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation 2007; 83:1069-1074.
70. Buchler M, Halimi JM, Najjar AA, et al. Living with a functioning kidney transplant at 74 yr or older: a national epidemiological study. Clin Transplant 2004; 18:681-685. (Pubitemid 39496981)
71. Jofre R, Lopez-Gomez JM, Moreno F, et al. Changes in quality of life after renal transplantation. Am J Kidney Dis 1998; 32:93-100. (Pubitemid 28311876)
72. Humar A, Denny R, Matas AJ, Najarian JS. Graft and quality of life outcomes in older recipients of a kidney transplant. Exp Clin Transplant 2003; 1:69-72.
73. Griva K, Thompson D, Jayasena D, et al. Cognitive functioning pre to postkidney transplantation - a prospective study. Nephrol Dial Transplant 2006; 21:3275-3282. (Pubitemid 44567105)
74. Ojo AO, Hanson JA, Wolfe RA, et al. Long-term survival in renal transplant recipients with graft function. Kidney Int 2000; 57:307-313. (Pubitemid 30227779)
75. Jassal SV, Opelz G, Cole E. Transplantation in the elderly: a review. Geriatr Nephrol Urol 1997; 7:157-165.
76. Sato K, Ogawa K, Onumata O, et al. Cause of death in renal transplant patients: a comparison between azathioprine and ciclosporin. Surg Today 2001; 31:681-687. (Pubitemid 32757435)
77. Foo SM, Wong HS, Morad Z. Risk factors and incidence of posttransplant diabetes mellitus in renal transplant recipients. Transplant Proc 2004; 36:2139-2140. (Pubitemid 39424356)
78. Rosas SE, Mensah K, Weinstein RB, et al. Coronary artery calcification in renal transplant recipients. Am J Transplant 2005; 5:1942-1947. (Pubitemid 41039869)
79. Cardinal H, Hebert MJ, Rahme E, et al. Modifiable factors predicting patient survival in elderly kidney transplant recipients. Kidney Int 2005; 68: 345-351. (Pubitemid 43181394)
80. Cecka JM. The UNOS renal transplant registry. Clin Transpl 2001:1-18.
81. Tesi RJ, Elkhammas EA, Davies EA, et al. Renal transplantation in older people. Lancet 1994; 343:461-464.