Clinical outcomes in elderly kidney transplant recipients are related to acute rejection episodes rather than pretransplant comorbidity

Transplantation

Volumn 87, Issue 7, 2009, Pages 1045-1051

  Heldal, Kristian ^a,b,c,e   Hartmann, Anders ^b,c   Leivestad, Torbjørn ^b   Svendsen, Martin V ^d   Foss, Aksel ^b   Lien, Bjørn ^b   Midtvedt, Karsten ^b  

^a Clinic of Internal Medicine   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

^c UNIVERSITY OF OSLO   (Norway)

^d Sykehuset Telemark HF   (Norway)

^e Clinic of Internal Medicine   (Norway)

Author keywords

Elderly donors; Elderly patients; Epidemiology; Kidney graft survival; Kidney transplantation; Patient survival

Indexed keywords

HLA ANTIBODY;

ACUTE GRAFT REJECTION; ADULT; AGED; ARTICLE; CHARLSON COMORBIDITY INDEX; COMORBIDITY; CONTROLLED STUDY; DELAYED GRAFT FUNCTION; DIALYSIS; FEMALE; GRAFT FAILURE; GRAFT RECIPIENT; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RISK FACTOR; SCORING SYSTEM; TREATMENT OUTCOME; CHRONIC KIDNEY FAILURE; GRAFT REJECTION; IMMUNOLOGY; MIDDLE AGED; MORTALITY; NORWAY; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; REGRESSION ANALYSIS; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; STATISTICS; SURVIVAL; SURVIVOR;

AGED; AGED, 80 AND OVER; COMORBIDITY; GRAFT REJECTION; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; MIDDLE AGED; NORWAY; PROPORTIONAL HAZARDS MODELS; REGRESSION ANALYSIS; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; SURVIVORS; TREATMENT OUTCOME;

EID: 65549148066     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31819cdddd     Document Type: Article

References (25)

1. Jager KJ, van Dijk PC, Dekker FW, et al. The epidemic of aging in renal replacement therapy: An update on elderly patients and their outcomes. Clin Nephrol 2003; 60: 352.
2. Macrae J, Friedman AL, Friedman EA, et al. Live and deceased donor kidney transplantation in patients aged 75 years and older in the United States. Int Urol Nephrol 2005; 37: 641.
3. Danovitch GM, Cohen DJ, Weir MR, et al. Current status of kidney and pancreas transplantation in the United States, 1994-2003. Am J Transplant 2005; 5: 904.
4. Port FK, Merion RM, Roys EC, et al. Trends in organ donation and transplantation in the United States, 1997-2006.AmJ Transplant 2008; 8: 911.
5. Laupacis A, Keown P, Pus N, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int 1996; 50: 235.
6. Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med 1999; 341: 1725.
7. Heldal K, Leivestad T, Hartmann A, et al. Kidney transplantation in the elderly-The Norwegian experience. Nephrol Dial Transplant 2008; 23: 1026.
8. Oniscu GC, Brown H, Forsythe JL. How old is old for transplantation? Am J Transplant 2004; 4: 2067.
9. Rao PS, Merion RM, Ashby VB, et al. Renal transplantation in elderly patients older than 70 years of age: Results from the Scientific Registry of Transplant Recipients. Transplantation 2007; 83: 1069.
10. Rebollo P, Ortega F, Baltar JM, et al. Health-related quality of life (HRQOL) in end stage renal disease (ESRD) patients over 65 years. Geriatr Nephrol Urol 1998; 8: 85.
11. Rebollo P, Ortega F, Baltar JM, et al. Health related quality of life (HRQOL) of kidney transplanted patients: Variables that influence it. Clin Transpl 2000; 14: 199.
12. Petersen E, Baird BC, Shihab F, et al. The impact of recipient history of cardiovascular disease on kidney transplant outcome. ASAIO J 2007; 53: 601.
13. Jassal SV, Schaubel DE, Fenton SS. Baseline comorbidity in kidney transplant recipients: A comparison of comorbidity indices. Am J Kidney Dis 2005; 46: 136.
14. WuC, Shapiro R, Tan H, et al. Kidney transplantation in elderly people: The influence of recipient comorbidity and living kidney donors. J Am Geriatr Soc 2008; 56: 231.
15. Fritsche L, Horstrup J, Budde K, et al. Old-for-old kidney allocation allows successful expansion of the donor and recipient pool. Am J Transplant 2003; 3: 1434.
16. Frei U, Noeldeke J, hold-Fabrizii V, et al. Prospective age-matching in elderly kidney transplant recipients-A 5-year analysis of the Eurotransplant Senior Program. Am J Transplant 2008; 8: 50.
17. van Manen JG, van Dijk PCW, Stel VS, et al. Confounding effect of comorbidity in survival studies in patients on renal replacement therapy. Nephrol Dial Transplant 2007; 22: 187.
18. Kauffman H, McBride M, Cors C, et al. Early mortality rates in older kidney recipients with comorbid risk factors. Transplantation 2007; 83: 404.
19. Cohen DJ, Martin L, Christensen LL, et al. Kidney and pancreas transplantation in the United States, 1995-2004. Am J Transplant 2006; 6: 1153.
20. Quiroga I, McShane P, Koo DDH, et al. Major effects of delayed graft function and cold ischaemia time on renal allograft survival. Nephrol Dial Transplant 2006; 21: 1689.
21. Zukowski M, Bohatyrewicz R, Krawczyk AA. Factors influencing serum creatinine level in kidney recipients in a multivariate analysis. Transplant Proc 2007; 39: 2724.
22. Opelz G, Dohler B. Multicenter analysis of kidney preservation. Transplantation 2007; 83: 247.
23. Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal disease. Am J Transplant 2004; 4: 1662.
24. Goldfarb-Rumyantzev A, Hurdle JF, Scandling J, et al. Duration of end-stage renal disease and kidney transplant outcome. Nephrol Dial Transplant 2005; 20: 167.
25. Kim SJ, Schaubel DE, Fenton SSA, et al. Mortality after kidney transplantation: A comparison between the United States and Canada. Am J Transplant 2006; 6: 109.