Intravenous curcumin efficacy on healing and scar formation in rabbit ear wounds under nonischemic, ischemic, and ischemia-reperfusion conditions

Wound Repair and Regeneration

Volumn 22, Issue 6, 2014, Pages 730-739

  Jia, Shengxian ^a   Xie, Ping ^a   Hong, Seok Jong ^a   Galiano, Robert ^a   Singer, Adam ^b   Clark, Richard A F ^c   Mustoe, Thomas A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c St Francis Hospital The Heart Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CURCUMIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; NONSTEROID ANTIINFLAMMATORY AGENT;

ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; EAR WOUND; EPITHELIZATION; GRANULATION TISSUE; HEALING IMPAIRMENT; NONHUMAN; PRIORITY JOURNAL; RABBIT; REPERFUSION INJURY; SCAR FORMATION; WOUND; WOUND HEALING; ANIMAL; CICATRIX, HYPERTROPHIC; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EXTERNAL EAR; INJURIES; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIA; WOUNDS AND INJURIES;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CICATRIX, HYPERTROPHIC; CURCUMIN; DISEASE MODELS, ANIMAL; EAR, EXTERNAL; GRANULATION TISSUE; INFUSIONS, INTRAVENOUS; ISCHEMIA; RABBITS; REPERFUSION INJURY; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84921486653     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/wrr.12231     Document Type: Article

References (40)

1. Escandon J, Vivas AC, Tang J, Rowland KJ, Kirsner RS,. High mortality in patients with chronic wounds. Wound Repair Regen 2011; 19: 526-528.
2. Ahn ST, Mustoe TA,. Effects of ischemia on ulcer wound healing: a new model in the rabbit ear. Ann Plast Surg 1990; 24: 17-23.
3. Steinberg JP, Gurjala AN, Jia S, Hong SJ, Galiano RD, Mustoe TA,. Evaluating the effects of subclinical, cyclic ischemia-reperfusion injury on wound healing using a novel device in the rabbit ear. Ann Plast Surg 2013; 72: 698-705.
4. Kryger ZB, Sisco M, Roy NK, Lu L, Rosenberg D, Mustoe TA,. Temporal expression of the transforming growth factor-beta pathway in the rabbit ear model of wound healing and scarring. J Am Coll Surg 2007; 205: 78-88.
5. Morris DE, Wu L, Zhao LL, Bolton L, Roth SI, Ladin DA, et al. Acute and chronic animal models for excessive dermal scarring: quantitative studies. Plast Reconstr Surg 1997; 100: 674-681.
6. DeLeo FR, Diep BA, Otto M,. Host defense and pathogenesis in Staphylococcus aureus infections. Infect Dis Clin North Am 2009; 23: 17-34.
7. Jesaitis AJ, Franklin MJ, Berglund D, Sasaki M, Lord CI, Bleazard JB, et al. Compromised host defense on Pseudomonas aeruginosa biofilms: characterization of neutrophil and biofilm interactions. J Immunol 2003; 171: 4329-4339.
8. Mustoe TA,. Scars and keloids. BMJ 2004; 328: 1329-1330.
9. Menon VP, Sudheer AR,. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007; 595: 105-125.
10. Negi PS, Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK,. Antibacterial activity of turmeric oil: a byproduct from curcumin manufacture. J Agric Food Chem 1999; 47: 4297-4300.
11. Yadav VR, Aggarwal BB,. Curcumin: a component of the golden spice, targets multiple angiogenic pathways. Cancer Biol Ther 2011; 11: 236-241.
12. Dewar AM, Clark RA, Singer AJ, Frame MD,. Curcumin mediates both dilation and constriction of peripheral arterioles via adrenergic receptors. J Invest Dermatol 2011; 131: 1754-1760.
13. Kim DC, Ku SK, Bae JS,. Anticoagulant activities of curcumin and its derivative. BMB Rep 2012; 45: 221-226.
14. Nemmar A, Subramaniyan D, Ali BH,. Protective effect of curcumin on pulmonary and cardiovascular effects induced by repeated exposure to diesel exhaust particles in mice. PLoS ONE 2012; 7: e39554.
15. Phan TT, Sun L, Bay BH, Chan SY, Lee ST,. Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring. J Trauma 2003; 54: 1212-1224.
16. Hsu YC, Chen MJ, Yu YM, Ko SY, Chang CC,. Suppression of TGF-beta1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid. Arch Dermatol Res 2010; 302: 717-724.
17. Singer AJ, Taira BR, Lin F, Lim T, Anderson R, McClain SA, et al. Curcumin reduces injury progression in a rat comb burn model. J Burn Care Res 2011; 32: 135-142.
18. Leung MH, Kee TW,. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir 2009; 25: 5773-5777.
19. Pulla Reddy AC, Sudharshan E, Appu Rao AG, Lokesh BR,. Interaction of curcumin with human serum albumin-a spectroscopic study. Lipids 1999; 34: 1025-1029.
20. Stephens P, al-Khateeb T, Davies KJ, Shepherd JP, Thomas DW,. An investigation of the interaction between alcohol and fibroblasts in wound healing. Int J Oral Maxillofac Surg 1996; 25: 161-164.
21. Radek KA, Matthies AM, Burns AL, Heinrich SA, Kovacs EJ, Dipietro LA,. Acute ethanol exposure impairs angiogenesis and the proliferative phase of wound healing. Am J Physiol Heart Circ Physiol 2005; 289: H1084-1090.
22. Jia S, Zhao Y, Law M, Galiano RD, Mustoe TA,. The effect of collagenase on ischemic wound healing: results of an in vivo study. Ostomy Wound Manage 2011; 57: 20-26.
23. Panchatcharam M, Miriyala S, Gayathri VS, Suguna L,. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem 2006; 290: 87-96.
24. Szpaderska AM, DiPietro LA,. Inflammation in surgical wound healing: friend or foe? Surgery 2005; 137: 571-573.
25. Smith MR, Gangireddy SR, Narala VR, Hogaboam CM, Standiford TJ, Christensen PJ, et al. Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2010; 298: L616-625.
26. Zhang SS, Gong ZJ, Li WH, Wang X, Ling TY,. Antifibrotic effect of curcumin in TGF-beta 1-induced myofibroblasts from human oral mucosa. Asian Pac J Cancer Prev 2012; 13: 289-294.
27. Kuwabara N, Tamada S, Iwai T, Teramoto K, Kaneda N, Yukimura T, et al. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006; 67: 440-446.
28. Hu Y, Liang H, Du Y, Zhu Y, Wang X,. Curcumin inhibits transforming growth factor-beta activity via inhibition of Smad signaling in HK-2 cells. Am J Nephrol 2010; 31: 332-341.
29. Chen A, Zheng S,. Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol 2008; 153: 557-567.
30. Vizzutti F, Provenzano A, Galastri S, Milani S, Delogu W, Novo E, et al. Curcumin limits the fibrogenic evolution of experimental steatohepatitis. Lab Invest 2010; 90: 104-115.
31. Stefanska B,. Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus-insights into its mechanisms of action. Br J Pharmacol 2012; 166: 2209-2211.
32. Gourdin MJ, Bree B, De Kock M,. The impact of ischaemia-reperfusion on the blood vessel. Eur J Anaesthesiol 2009; 26: 537-547.
33. Phan TT, See P, Lee ST, Chan SY,. Protective effects of curcumin against oxidative damage on skin cells in vitro: its implication for wound healing. J Trauma 2001; 51: 927-931.
34. Lin CM, Lee JF, Chiang LL, Chen CF, Wang D, Su CL,. The protective effect of curcumin on ischemia-reperfusion-induced liver injury. Transplant Proc 2012; 44: 974-977.
35. Duan W, Yang Y, Yan J, Yu S, Liu J, Zhou J, et al. The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway. Basic Res Cardiol 2012; 107: 263-274.
36. Jeong CW, Yoo KY, Lee SH, Jeong HJ, Lee CS, Kim SJ,. Curcumin protects against regional myocardial ischemia/reperfusion injury through activation of RISK/GSK-3beta and inhibition of p38 MAPK and JNK. J Cardiovasc Pharmacol Ther 2012; 17: 387-394.
37. Gaddipati JP, Sundar SV, Calemine J, Seth P, Sidhu GS, Maheshwari RK,. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Shock 2003; 19: 150-156.
38. Dovi JV, He LK, DiPietro LA,. Accelerated wound closure in neutrophil-depleted mice. J Leukoc Biol 2003; 73: 448-455.
39. Abbott RE, Corral CJ, MacIvor DM, Lin X, Ley TJ, Mustoe TA,. Augmented inflammatory responses and altered wound healing in cathepsin G-deficient mice. Arch Surg 1998; 133: 1002-1006.
40. Quitschke WW,. Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications. BMC Biotechnol 2008; 8: 84.